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Protein

Zinc finger protein 470

Gene

ZNF470

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri228 – 250C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri256 – 278C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri284 – 306C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri312 – 334C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri340 – 362C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri368 – 391C2H2-type 6PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri397 – 419C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri425 – 447C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri453 – 475C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri481 – 503C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri509 – 531C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri537 – 559C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri565 – 587C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri593 – 615C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri621 – 643C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri649 – 671C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri677 – 699C2H2-type 17PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 470
Alternative name(s):
Chondrogenesis zinc finger protein 1
Short name:
CZF-1
Gene namesi
Name:ZNF470
Synonyms:CZF1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:22220. ZNF470.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000197016.
PharmGKBiPA145007252.

Polymorphism and mutation databases

BioMutaiZNF470.
DMDMi313104257.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002804131 – 717Zinc finger protein 470Add BLAST717

Proteomic databases

MaxQBiQ6ECI4.
PaxDbiQ6ECI4.
PeptideAtlasiQ6ECI4.
PRIDEiQ6ECI4.

PTM databases

iPTMnetiQ6ECI4.
PhosphoSitePlusiQ6ECI4.

Expressioni

Tissue specificityi

Highly expressed in testis. Very low expression in thymus. No expression in other tissues tested. Expressed in a differentiation stage-specific manner in mesenchymal chondrogenic progenitor cells.1 Publication

Gene expression databases

BgeeiENSG00000197016.
CleanExiHS_ZNF470.
ExpressionAtlasiQ6ECI4. baseline and differential.
GenevisibleiQ6ECI4. HS.

Organism-specific databases

HPAiHPA029000.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000333223.

Structurei

3D structure databases

ProteinModelPortaliQ6ECI4.
SMRiQ6ECI4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 94KRABPROSITE-ProRule annotationAdd BLAST72

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi216 – 219Nuclear localization signalSequence analysis4
Motifi385 – 388Nuclear localization signalSequence analysis4

Sequence similaritiesi

Contains 17 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri228 – 250C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri256 – 278C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri284 – 306C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri312 – 334C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri340 – 362C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri368 – 391C2H2-type 6PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri397 – 419C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri425 – 447C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri453 – 475C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri481 – 503C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri509 – 531C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri537 – 559C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri565 – 587C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri593 – 615C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri621 – 643C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri649 – 671C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri677 – 699C2H2-type 17PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00860000133674.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ6ECI4.
KOiK09228.
OMAiHKQDCGE.
OrthoDBiEOG091G02KC.
PhylomeDBiQ6ECI4.
TreeFamiTF341817.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 17 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 5 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 17 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 17 hits.
PS50157. ZINC_FINGER_C2H2_2. 17 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6ECI4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKSQEEVEVA GIKLCKAMSL GSVTFTDVAI DFSQDEWEWL NLAQRSLYKK
60 70 80 90 100
VMLENYRNLV SVGLCISKPD VISLLEQEKD PWVIKGGMNR GLCPDLECVW
110 120 130 140 150
VTKSLSLNQD IYEEKLPPAI IMERLKSYDL ECSTLGKNWK CEDLFERELV
160 170 180 190 200
NQKTHFRQET ITHIDTLIEK RDHSNKSGTV FHLNTLSYIK QIFPMEERIF
210 220 230 240 250
NFHTDKKSLK THSVVKKHKQ DRGEKKLLKC NDCEKIFSKI STLTLHQRIH
260 270 280 290 300
TGEKPYECIE CGKAFSQSAH LAQHQRIHTG EKPFECTECG KAFSQNAHLV
310 320 330 340 350
QHQRVHTGEK PYQCKQCNKA FSQLAHLAQH QRVHTGEKPY ECIECGKAFS
360 370 380 390 400
DCSSLAHHRR IHTGKRPYEC IDCGKAFRQN ASLIRHRRYY HTGEKPFDCI
410 420 430 440 450
DCGKAFTDHI GLIQHKRTHT GERPYKCNVC GKAFSHGSSL TVHQRIHTGE
460 470 480 490 500
KPYECNICEK AFSHRGSLTL HQRVHTGEKP YECKECGKAF RQSTHLAHHQ
510 520 530 540 550
RIHTGEKPYE CKECSKTFSQ NAHLAQHQKI HTGEKPYECK ECGKAFSQIA
560 570 580 590 600
HLVQHQRVHT GEKPYECIEC GKAFSDGSYL VQHQRLHSGK RPYECLECGK
610 620 630 640 650
AFRQRASLIC HQRCHTGEKP YECNVCGKAF SHRKSLTLHQ RIHTGEKPYE
660 670 680 690 700
CKECSKAFSQ VAHLTLHKRI HTGERPYECK ECGKAFRQSV HLAHHQRIHT
710
GESSVILSSA LPYHQVL
Length:717
Mass (Da):82,650
Last modified:November 30, 2010 - v3
Checksum:i3CE8F2E9FC5603A3
GO
Isoform 2 (identifier: Q6ECI4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     63-63: G → GKSIFLLLPPHDSVVFYAIIRISHSFPQHRQFLYVFLHAG
     95-251: Missing.

Note: No experimental confirmation available.
Show »
Length:599
Mass (Da):68,573
Checksum:iDEA044259E409522
GO

Sequence cautioni

The sequence BAC85218 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti542C → R in AAS64219 (PubMed:15302581).Curated1
Sequence conflicti584Q → P in AAS64219 (PubMed:15302581).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03114323V → L.1 PublicationCorresponds to variant rs10421285dbSNPEnsembl.1
Natural variantiVAR_031144254K → R.Corresponds to variant rs3752179dbSNPEnsembl.1
Natural variantiVAR_031145418T → I.2 PublicationsCorresponds to variant rs4801177dbSNPEnsembl.1
Natural variantiVAR_061950642I → T.Corresponds to variant rs35077804dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02366063G → GKSIFLLLPPHDSVVFYAII RISHSFPQHRQFLYVFLHAG in isoform 2. Curated1
Alternative sequenceiVSP_02366195 – 251Missing in isoform 2. CuratedAdd BLAST157

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY484591 mRNA. Translation: AAS64219.1.
AC007228 Genomic DNA. Translation: AAD23607.1.
BC136762 mRNA. Translation: AAI36763.1.
AK129686 mRNA. Translation: BAC85218.1. Different initiation.
CCDSiCCDS33122.1. [Q6ECI4-1]
RefSeqiNP_001001668.3. NM_001001668.3. [Q6ECI4-1]
UniGeneiHs.204449.

Genome annotation databases

EnsembliENST00000330619; ENSP00000333223; ENSG00000197016. [Q6ECI4-1]
ENST00000391709; ENSP00000375590; ENSG00000197016. [Q6ECI4-1]
GeneIDi388566.
KEGGihsa:388566.
UCSCiuc002qnl.5. human. [Q6ECI4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY484591 mRNA. Translation: AAS64219.1.
AC007228 Genomic DNA. Translation: AAD23607.1.
BC136762 mRNA. Translation: AAI36763.1.
AK129686 mRNA. Translation: BAC85218.1. Different initiation.
CCDSiCCDS33122.1. [Q6ECI4-1]
RefSeqiNP_001001668.3. NM_001001668.3. [Q6ECI4-1]
UniGeneiHs.204449.

3D structure databases

ProteinModelPortaliQ6ECI4.
SMRiQ6ECI4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000333223.

PTM databases

iPTMnetiQ6ECI4.
PhosphoSitePlusiQ6ECI4.

Polymorphism and mutation databases

BioMutaiZNF470.
DMDMi313104257.

Proteomic databases

MaxQBiQ6ECI4.
PaxDbiQ6ECI4.
PeptideAtlasiQ6ECI4.
PRIDEiQ6ECI4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000330619; ENSP00000333223; ENSG00000197016. [Q6ECI4-1]
ENST00000391709; ENSP00000375590; ENSG00000197016. [Q6ECI4-1]
GeneIDi388566.
KEGGihsa:388566.
UCSCiuc002qnl.5. human. [Q6ECI4-1]

Organism-specific databases

CTDi388566.
GeneCardsiZNF470.
HGNCiHGNC:22220. ZNF470.
HPAiHPA029000.
neXtProtiNX_Q6ECI4.
OpenTargetsiENSG00000197016.
PharmGKBiPA145007252.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00860000133674.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ6ECI4.
KOiK09228.
OMAiHKQDCGE.
OrthoDBiEOG091G02KC.
PhylomeDBiQ6ECI4.
TreeFamiTF341817.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii388566.
PROiQ6ECI4.

Gene expression databases

BgeeiENSG00000197016.
CleanExiHS_ZNF470.
ExpressionAtlasiQ6ECI4. baseline and differential.
GenevisibleiQ6ECI4. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 17 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 5 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 17 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 17 hits.
PS50157. ZINC_FINGER_C2H2_2. 17 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN470_HUMAN
AccessioniPrimary (citable) accession number: Q6ECI4
Secondary accession number(s): A8MTW0
, B9EGU1, Q6ZPA1, Q9Y2N9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: November 30, 2010
Last modified: November 30, 2016
This is version 114 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.