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Protein

Autophagy-related protein 9B

Gene

Atg9b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Autophagy

Names & Taxonomyi

Protein namesi
Recommended name:
Autophagy-related protein 9B
Alternative name(s):
APG9-like 2
Nitric oxide synthase 3-overlapping antisense gene protein
Gene namesi
Name:Atg9b
Synonyms:Apg9l2, Nos3as
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2685420. Atg9b.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 206CytoplasmicBy similarityAdd BLAST206
Transmembranei207 – 227HelicalSequence analysisAdd BLAST21
Topological domaini228 – 275LumenalBy similarityAdd BLAST48
Transmembranei276 – 296HelicalSequence analysisAdd BLAST21
Topological domaini297 – 437CytoplasmicBy similarityAdd BLAST141
Transmembranei438 – 458HelicalSequence analysisAdd BLAST21
Topological domaini459 – 523LumenalBy similarityAdd BLAST65
Transmembranei524 – 544HelicalSequence analysisAdd BLAST21
Topological domaini545 – 550CytoplasmicBy similarity6
Transmembranei551 – 571HelicalSequence analysisAdd BLAST21
Topological domaini572 – 624LumenalBy similarityAdd BLAST53
Transmembranei625 – 645HelicalSequence analysisAdd BLAST21
Topological domaini646 – 922CytoplasmicBy similarityAdd BLAST277

GO - Cellular componenti

  • autophagosome Source: MGI
  • autophagosome membrane Source: UniProtKB-SubCell
  • cytoplasm Source: MGI
  • cytoplasmic vesicle Source: UniProtKB-KW
  • integral component of membrane Source: UniProtKB-KW
  • pre-autophagosomal structure Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003148681 – 922Autophagy-related protein 9BAdd BLAST922

Proteomic databases

PaxDbiQ6EBV9.
PRIDEiQ6EBV9.

PTM databases

iPTMnetiQ6EBV9.
PhosphoSitePlusiQ6EBV9.

Expressioni

Tissue specificityi

Expressed in heart, brain, and placenta and testis.2 Publications

Gene expression databases

BgeeiENSMUSG00000038295.
GenevisibleiQ6EBV9. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000051864.

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi86 – 146Pro-richAdd BLAST61

Sequence similaritiesi

Belongs to the ATG9 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2173. Eukaryota.
ENOG410XQBE. LUCA.
GeneTreeiENSGT00390000014839.
HOGENOMiHOG000015255.
HOVERGENiHBG050539.
InParanoidiQ6EBV9.
KOiK17907.
OMAiGQFIFIV.
OrthoDBiEOG091G01WQ.
TreeFamiTF313665.

Family and domain databases

InterProiIPR007241. Autophagy-rel_prot_9.
[Graphical view]
PANTHERiPTHR13038. PTHR13038. 1 hit.
PfamiPF04109. APG9. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6EBV9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRRTGWGGS RRQRGRWGDL GPSSVPLLPM ALPLPASPCR GTGGRRISVF
60 70 80 90 100
SLSPAPRTRS CSSSVFPPAS GSPCLVIQEA GASQTPHNVL PTPTTPSTQA
110 120 130 140 150
HPTMIHTSAS PSWGSHSTPP LASATPPPSC PRPQDHPGLR MGPLIPEQDY
160 170 180 190 200
ERLEDCDPEG SQDSPIHGED HQPLLHVPEG LRGSWHHIQN LDSFFTKIYS
210 220 230 240 250
YHQRNGFACI LLEDVFQLGQ FIFIVTFTTF LLRCVDYNVL FNNQPKNHTR
260 270 280 290 300
RGPLHSKVTL SDAILPSAQC AEKIHDSPLL VFLLVLAAGF WLFQLLRSVC
310 320 330 340 350
NLFSYWDIQV FYREALHIPP EELSSVPWAE VQSRLLELQR SGGLCVQPRP
360 370 380 390 400
LTELDVHHRI LRYTNYQVAL ANKGLLPARC PLPWGSSAAF LSRGLALNVD
410 420 430 440 450
LLLFRGPFSL FRGGWELPEA YKRSDLRGVL ANRWRRTVLL LAAVNLALSP
460 470 480 490 500
LVLAWQVLHA FYSHVELLRR EPGAFGARRW SRLARLQLRH FNELPHELRA
510 520 530 540 550
RLGRAYRPAA AFLRAAEPPA PLRALLARQL VFFSGALFAA LLVLTIYDED
560 570 580 590 600
VLAVEHVLTT MTALGVTATV ARSFIPEEQC QGRSSQLLLQ AALAHMHYLP
610 620 630 640 650
EEPGATGARA SSYWQMAQLL QYRAVSLLEE LLSPLLTPLF LLFWFRPRAL
660 670 680 690 700
EIIDFFHHFT VDVAGVGDIC SFALMDVKRH GHPQWLSEGQ TEASLSQRAE
710 720 730 740 750
DGKTELSLMR FSLAHPQWQP PGHSSKFLGH LRGRVQQDAA AWGAPSTRSP
760 770 780 790 800
PTPGVLSDCT SPLPEAFLAN LLVNPRPPQR DLSPTAPCPA AATASLLASI
810 820 830 840 850
SRMVQDPSCV SPGGTGGQKL TQLPELVSAE MSLHAIYLHQ LHQQQQQELW
860 870 880 890 900
GEASASSPSR PWSSPSQPGS PDEEKPSWSS DGSSPASSPR QQWGTQRAQN
910 920
LFPKGFQENT DTQKEPLTGP LH
Length:922
Mass (Da):101,913
Last modified:October 3, 2012 - v2
Checksum:i3E79390541C3DB9D
GO

Sequence cautioni

The sequence AAS87213 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti29P → H in AAS72555 (PubMed:15234981).Curated1
Sequence conflicti29P → H in AAS87214 (PubMed:15234981).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY495541 mRNA. Translation: AAS72555.1.
AY515312 mRNA. Translation: AAS87213.1. Different initiation.
AY515313 mRNA. Translation: AAS87214.1.
AC113055 Genomic DNA. No translation available.
BK004021 mRNA. Translation: DAA05202.1.
CCDSiCCDS39027.1.
RefSeqiNP_001002897.2. NM_001002897.3.
UniGeneiMm.332252.

Genome annotation databases

EnsembliENSMUST00000059401; ENSMUSP00000051864; ENSMUSG00000038295.
GeneIDi213948.
KEGGimmu:213948.
UCSCiuc033ihy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY495541 mRNA. Translation: AAS72555.1.
AY515312 mRNA. Translation: AAS87213.1. Different initiation.
AY515313 mRNA. Translation: AAS87214.1.
AC113055 Genomic DNA. No translation available.
BK004021 mRNA. Translation: DAA05202.1.
CCDSiCCDS39027.1.
RefSeqiNP_001002897.2. NM_001002897.3.
UniGeneiMm.332252.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000051864.

PTM databases

iPTMnetiQ6EBV9.
PhosphoSitePlusiQ6EBV9.

Proteomic databases

PaxDbiQ6EBV9.
PRIDEiQ6EBV9.

Protocols and materials databases

DNASUi213948.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000059401; ENSMUSP00000051864; ENSMUSG00000038295.
GeneIDi213948.
KEGGimmu:213948.
UCSCiuc033ihy.1. mouse.

Organism-specific databases

CTDi285973.
MGIiMGI:2685420. Atg9b.

Phylogenomic databases

eggNOGiKOG2173. Eukaryota.
ENOG410XQBE. LUCA.
GeneTreeiENSGT00390000014839.
HOGENOMiHOG000015255.
HOVERGENiHBG050539.
InParanoidiQ6EBV9.
KOiK17907.
OMAiGQFIFIV.
OrthoDBiEOG091G01WQ.
TreeFamiTF313665.

Miscellaneous databases

PROiQ6EBV9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038295.
GenevisibleiQ6EBV9. MM.

Family and domain databases

InterProiIPR007241. Autophagy-rel_prot_9.
[Graphical view]
PANTHERiPTHR13038. PTHR13038. 1 hit.
PfamiPF04109. APG9. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATG9B_MOUSE
AccessioniPrimary (citable) accession number: Q6EBV9
Secondary accession number(s): F8VQL8, Q674R6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 3, 2012
Last modified: November 2, 2016
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.