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Protein

Interleukin-31

Gene

IL31

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR. IL31 may function in skin immunity.1 Publication

GO - Biological processi

  1. immune system process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Immunity

Enzyme and pathway databases

SignaLinkiQ6EBC2.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-31
Short name:
IL-31
Gene namesi
Name:IL31
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:19372. IL31.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134957950.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 164141Interleukin-31PRO_0000274570Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi67 – 671N-linked (GlcNAc...)Sequence Analysis
Glycosylationi100 – 1001N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6EBC2.
PRIDEiQ6EBC2.

Expressioni

Tissue specificityi

Detected at low levels in testis, bone marrow, skeletal muscle, kidney, colon, thymus, small intestine and trachea.1 Publication

Inductioni

Up-regulated in skin homing T-cells of patients with atopic dermatitis (AD) and in activated circulating T-cells. Up-regulated in lesional biopsies of patients with allergic contact dermatitis (ACD).2 Publications

Gene expression databases

BgeeiQ6EBC2.
CleanExiHS_IL31.
GenevestigatoriQ6EBC2.

Organism-specific databases

HPAiCAB025657.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000366234.

Structurei

3D structure databases

ProteinModelPortaliQ6EBC2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG131172.
GeneTreeiENSGT00390000018074.
HOGENOMiHOG000113046.
InParanoidiQ6EBC2.
OMAiFSECMDL.
OrthoDBiEOG7W1563.
PhylomeDBiQ6EBC2.
TreeFamiTF339844.

Family and domain databases

InterProiIPR027987. IL-31.
[Graphical view]
PfamiPF15209. IL31. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6EBC2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASHSGPSTS VLFLFCCLGG WLASHTLPVR LLRPSDDVQK IVEELQSLSK
60 70 80 90 100
MLLKDVEEEK GVLVSQNYTL PCLSPDAQPP NNIHSPAIRA YLKTIRQLDN
110 120 130 140 150
KSVIDEIIEH LDKLIFQDAP ETNISVPTDT HECKRFILTI SQQFSECMDL
160
ALKSLTSGAQ QATT
Length:164
Mass (Da):18,205
Last modified:August 16, 2004 - v1
Checksum:i1D61824CB6049445
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY499343 mRNA. Translation: AAS86448.1.
BC132998 mRNA. Translation: AAI32999.1.
BC133000 mRNA. Translation: AAI33001.1.
CCDSiCCDS31919.1.
RefSeqiNP_001014358.1. NM_001014336.1.
UniGeneiHs.569071.

Genome annotation databases

EnsembliENST00000377035; ENSP00000366234; ENSG00000204671.
GeneIDi386653.
KEGGihsa:386653.
UCSCiuc001ubv.3. human.

Polymorphism databases

DMDMi74709232.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY499343 mRNA. Translation: AAS86448.1.
BC132998 mRNA. Translation: AAI32999.1.
BC133000 mRNA. Translation: AAI33001.1.
CCDSiCCDS31919.1.
RefSeqiNP_001014358.1. NM_001014336.1.
UniGeneiHs.569071.

3D structure databases

ProteinModelPortaliQ6EBC2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000366234.

Polymorphism databases

DMDMi74709232.

Proteomic databases

PaxDbiQ6EBC2.
PRIDEiQ6EBC2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377035; ENSP00000366234; ENSG00000204671.
GeneIDi386653.
KEGGihsa:386653.
UCSCiuc001ubv.3. human.

Organism-specific databases

CTDi386653.
GeneCardsiGC12M122656.
HGNCiHGNC:19372. IL31.
HPAiCAB025657.
MIMi609509. gene.
neXtProtiNX_Q6EBC2.
PharmGKBiPA134957950.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG131172.
GeneTreeiENSGT00390000018074.
HOGENOMiHOG000113046.
InParanoidiQ6EBC2.
OMAiFSECMDL.
OrthoDBiEOG7W1563.
PhylomeDBiQ6EBC2.
TreeFamiTF339844.

Enzyme and pathway databases

SignaLinkiQ6EBC2.

Miscellaneous databases

GeneWikiiInterleukin_31.
GenomeRNAii386653.
NextBioi100956.
PROiQ6EBC2.
SOURCEiSearch...

Gene expression databases

BgeeiQ6EBC2.
CleanExiHS_IL31.
GenevestigatoriQ6EBC2.

Family and domain databases

InterProiIPR027987. IL-31.
[Graphical view]
PfamiPF15209. IL31. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Tissue: Peripheral blood.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "IL-31 is associated with cutaneous lymphocyte antigen-positive skin homing T cells in patients with atopic dermatitis."
    Bilsborough J., Leung D.Y.M., Maurer M., Howell M., Boguniewicz M., Yao L., Storey H., LeCiel C., Harder B., Gross J.A.
    J. Allergy Clin. Immunol. 117:418-425(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  4. "Enhanced expression levels of IL-31 correlate with IL-4 and IL-13 in atopic and allergic contact dermatitis."
    Neis M.M., Peters B., Dreuw A., Wenzel J., Bieber T., Mauch C., Krieg T., Stanzel S., Heinrich P.C., Merk H.F., Bosio A., Baron J.M., Hermanns H.M.
    J. Allergy Clin. Immunol. 118:930-937(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.

Entry informationi

Entry nameiIL31_HUMAN
AccessioniPrimary (citable) accession number: Q6EBC2
Secondary accession number(s): A2RUQ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: August 16, 2004
Last modified: January 7, 2015
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.