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Q6EBC2 (IL31_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interleukin-31

Short name=IL-31
Gene names
Name:IL31
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length164 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR. IL31 may function in skin immunity. Ref.1

Subcellular location

Secreted Probable.

Tissue specificity

Detected at low levels in testis, bone marrow, skeletal muscle, kidney, colon, thymus, small intestine and trachea. Ref.1

Induction

Up-regulated in skin homing T-cells of patients with atopic dermatitis (AD) and in activated circulating T-cells. Up-regulated in lesional biopsies of patients with allergic contact dermatitis (ACD). Ref.3 Ref.4

Ontologies

Keywords
   Biological processImmunity
   Cellular componentSecreted
   DomainSignal
   Molecular functionCytokine
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processimmune system process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular space

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 164141Interleukin-31
PRO_0000274570

Amino acid modifications

Glycosylation671N-linked (GlcNAc...) Potential
Glycosylation1001N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q6EBC2 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: 1D61824CB6049445

FASTA16418,205
        10         20         30         40         50         60 
MASHSGPSTS VLFLFCCLGG WLASHTLPVR LLRPSDDVQK IVEELQSLSK MLLKDVEEEK 

        70         80         90        100        110        120 
GVLVSQNYTL PCLSPDAQPP NNIHSPAIRA YLKTIRQLDN KSVIDEIIEH LDKLIFQDAP 

       130        140        150        160 
ETNISVPTDT HECKRFILTI SQQFSECMDL ALKSLTSGAQ QATT 

« Hide

References

« Hide 'large scale' references
[1]"Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice."
Dillon S.R., Sprecher C., Hammond A., Bilsborough J., Rosenfeld-Franklin M., Presnell S.R., Haugen H.S., Maurer M., Harder B., Johnston J., Bort S., Mudri S., Kuijper J.L., Bukowski T., Shea P., Dong D.L., Dasovich M., Grant F.J. expand/collapse author list , Lockwood L., Levin S.D., LeCiel C., Waggie K., Day H., Topouzis S., Kramer J., Kuestner R., Chen Z., Foster D., Parrish-Novak J., Gross J.A.
Nat. Immunol. 5:752-760(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
Tissue: Peripheral blood.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"IL-31 is associated with cutaneous lymphocyte antigen-positive skin homing T cells in patients with atopic dermatitis."
Bilsborough J., Leung D.Y.M., Maurer M., Howell M., Boguniewicz M., Yao L., Storey H., LeCiel C., Harder B., Gross J.A.
J. Allergy Clin. Immunol. 117:418-425(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
[4]"Enhanced expression levels of IL-31 correlate with IL-4 and IL-13 in atopic and allergic contact dermatitis."
Neis M.M., Peters B., Dreuw A., Wenzel J., Bieber T., Mauch C., Krieg T., Stanzel S., Heinrich P.C., Merk H.F., Bosio A., Baron J.M., Hermanns H.M.
J. Allergy Clin. Immunol. 118:930-937(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY499343 mRNA. Translation: AAS86448.1.
BC132998 mRNA. Translation: AAI32999.1.
BC133000 mRNA. Translation: AAI33001.1.
CCDSCCDS31919.1.
RefSeqNP_001014358.1. NM_001014336.1.
UniGeneHs.569071.

3D structure databases

ProteinModelPortalQ6EBC2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000366234.

Polymorphism databases

DMDM74709232.

Proteomic databases

PaxDbQ6EBC2.
PRIDEQ6EBC2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000377035; ENSP00000366234; ENSG00000204671.
GeneID386653.
KEGGhsa:386653.
UCSCuc001ubv.3. human.

Organism-specific databases

CTD386653.
GeneCardsGC12M122656.
HGNCHGNC:19372. IL31.
HPACAB025657.
MIM609509. gene.
neXtProtNX_Q6EBC2.
PharmGKBPA134957950.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG131172.
HOGENOMHOG000113046.
InParanoidQ6EBC2.
OMAKRFILTI.
OrthoDBEOG7W1563.
PhylomeDBQ6EBC2.
TreeFamTF339844.

Enzyme and pathway databases

SignaLinkQ6EBC2.

Gene expression databases

BgeeQ6EBC2.
CleanExHS_IL31.
GenevestigatorQ6EBC2.

Family and domain databases

InterProIPR027987. IL-31.
[Graphical view]
PfamPF15209. IL31. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiInterleukin_31.
NextBio100956.
PROQ6EBC2.
SOURCESearch...

Entry information

Entry nameIL31_HUMAN
AccessionPrimary (citable) accession number: Q6EBC2
Secondary accession number(s): A2RUQ1
Entry history
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: August 16, 2004
Last modified: July 9, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM