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Q6EBC2

- IL31_HUMAN

UniProt

Q6EBC2 - IL31_HUMAN

Protein

Interleukin-31

Gene

IL31

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR. IL31 may function in skin immunity.1 Publication

    GO - Biological processi

    1. immune system process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Immunity

    Enzyme and pathway databases

    SignaLinkiQ6EBC2.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-31
    Short name:
    IL-31
    Gene namesi
    Name:IL31
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:19372. IL31.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134957950.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 164141Interleukin-31PRO_0000274570Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi67 – 671N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi100 – 1001N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ6EBC2.
    PRIDEiQ6EBC2.

    Expressioni

    Tissue specificityi

    Detected at low levels in testis, bone marrow, skeletal muscle, kidney, colon, thymus, small intestine and trachea.1 Publication

    Inductioni

    Up-regulated in skin homing T-cells of patients with atopic dermatitis (AD) and in activated circulating T-cells. Up-regulated in lesional biopsies of patients with allergic contact dermatitis (ACD).2 Publications

    Gene expression databases

    BgeeiQ6EBC2.
    CleanExiHS_IL31.
    GenevestigatoriQ6EBC2.

    Organism-specific databases

    HPAiCAB025657.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000366234.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6EBC2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG131172.
    HOGENOMiHOG000113046.
    InParanoidiQ6EBC2.
    OMAiKRFILTI.
    OrthoDBiEOG7W1563.
    PhylomeDBiQ6EBC2.
    TreeFamiTF339844.

    Family and domain databases

    InterProiIPR027987. IL-31.
    [Graphical view]
    PfamiPF15209. IL31. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6EBC2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASHSGPSTS VLFLFCCLGG WLASHTLPVR LLRPSDDVQK IVEELQSLSK    50
    MLLKDVEEEK GVLVSQNYTL PCLSPDAQPP NNIHSPAIRA YLKTIRQLDN 100
    KSVIDEIIEH LDKLIFQDAP ETNISVPTDT HECKRFILTI SQQFSECMDL 150
    ALKSLTSGAQ QATT 164
    Length:164
    Mass (Da):18,205
    Last modified:August 16, 2004 - v1
    Checksum:i1D61824CB6049445
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY499343 mRNA. Translation: AAS86448.1.
    BC132998 mRNA. Translation: AAI32999.1.
    BC133000 mRNA. Translation: AAI33001.1.
    CCDSiCCDS31919.1.
    RefSeqiNP_001014358.1. NM_001014336.1.
    UniGeneiHs.569071.

    Genome annotation databases

    EnsembliENST00000377035; ENSP00000366234; ENSG00000204671.
    GeneIDi386653.
    KEGGihsa:386653.
    UCSCiuc001ubv.3. human.

    Polymorphism databases

    DMDMi74709232.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY499343 mRNA. Translation: AAS86448.1 .
    BC132998 mRNA. Translation: AAI32999.1 .
    BC133000 mRNA. Translation: AAI33001.1 .
    CCDSi CCDS31919.1.
    RefSeqi NP_001014358.1. NM_001014336.1.
    UniGenei Hs.569071.

    3D structure databases

    ProteinModelPortali Q6EBC2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000366234.

    Polymorphism databases

    DMDMi 74709232.

    Proteomic databases

    PaxDbi Q6EBC2.
    PRIDEi Q6EBC2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000377035 ; ENSP00000366234 ; ENSG00000204671 .
    GeneIDi 386653.
    KEGGi hsa:386653.
    UCSCi uc001ubv.3. human.

    Organism-specific databases

    CTDi 386653.
    GeneCardsi GC12M122656.
    HGNCi HGNC:19372. IL31.
    HPAi CAB025657.
    MIMi 609509. gene.
    neXtProti NX_Q6EBC2.
    PharmGKBi PA134957950.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG131172.
    HOGENOMi HOG000113046.
    InParanoidi Q6EBC2.
    OMAi KRFILTI.
    OrthoDBi EOG7W1563.
    PhylomeDBi Q6EBC2.
    TreeFami TF339844.

    Enzyme and pathway databases

    SignaLinki Q6EBC2.

    Miscellaneous databases

    GeneWikii Interleukin_31.
    NextBioi 100956.
    PROi Q6EBC2.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q6EBC2.
    CleanExi HS_IL31.
    Genevestigatori Q6EBC2.

    Family and domain databases

    InterProi IPR027987. IL-31.
    [Graphical view ]
    Pfami PF15209. IL31. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
      Tissue: Peripheral blood.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "IL-31 is associated with cutaneous lymphocyte antigen-positive skin homing T cells in patients with atopic dermatitis."
      Bilsborough J., Leung D.Y.M., Maurer M., Howell M., Boguniewicz M., Yao L., Storey H., LeCiel C., Harder B., Gross J.A.
      J. Allergy Clin. Immunol. 117:418-425(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    4. "Enhanced expression levels of IL-31 correlate with IL-4 and IL-13 in atopic and allergic contact dermatitis."
      Neis M.M., Peters B., Dreuw A., Wenzel J., Bieber T., Mauch C., Krieg T., Stanzel S., Heinrich P.C., Merk H.F., Bosio A., Baron J.M., Hermanns H.M.
      J. Allergy Clin. Immunol. 118:930-937(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.

    Entry informationi

    Entry nameiIL31_HUMAN
    AccessioniPrimary (citable) accession number: Q6EBC2
    Secondary accession number(s): A2RUQ1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 6, 2007
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3