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Protein

Interleukin-31

Gene

Il31

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR (PubMed:15184896). May function in skin immunity (PubMed:15184896). Enhances myeloid progenitor cell survival in vitro (PubMed:17379091). Induces RETNLA and serum amyloid A protein expression in macrophages (PubMed:25847241).3 Publications

GO - Molecular functioni

  • cytokine activity Source: MGI
  • cytokine receptor binding Source: MGI
  • oncostatin-M receptor binding Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Immunity

Enzyme and pathway databases

ReactomeiR-MMU-449147. Signaling by Interleukins.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-31
Short name:
IL-31
Gene namesi
Name:Il31
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1923649. Il31.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000027457124 – 163Interleukin-31Add BLAST140

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi55N-linked (GlcNAc...)Sequence analysis1
Glycosylationi84N-linked (GlcNAc...)Sequence analysis1
Glycosylationi124N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6EAL8.
PRIDEiQ6EAL8.

Expressioni

Gene expression databases

BgeeiENSMUSG00000029437.
CleanExiMM_IL31.
ExpressionAtlasiQ6EAL8. differential.
GenevisibleiQ6EAL8. MM.

Interactioni

GO - Molecular functioni

  • cytokine activity Source: MGI
  • cytokine receptor binding Source: MGI
  • oncostatin-M receptor binding Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031389.

Structurei

3D structure databases

ProteinModelPortaliQ6EAL8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J1CB. Eukaryota.
ENOG4111BHC. LUCA.
GeneTreeiENSGT00390000018074.
HOGENOMiHOG000113047.
InParanoidiQ6EAL8.
PhylomeDBiQ6EAL8.
TreeFamiTF339844.

Family and domain databases

InterProiIPR027987. IL-31.
[Graphical view]
PANTHERiPTHR38652. PTHR38652. 1 hit.
PfamiPF15209. IL31. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6EAL8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIFHTGTTKP TLVLLCCIGT WLATCSLSFG APISKEDLRT TIDLLKQESQ
60 70 80 90 100
DLYNNYSIKQ ASGMSADESI QLPCFSLDRE ALTNISVIIA HLEKVKVLSE
110 120 130 140 150
NTVDTSWVIR WLTNISCFNP LNLNISVPGN TDESYDCKVF VLTVLKQFSN
160
CMAELQAKDN TTC
Length:163
Mass (Da):18,120
Last modified:August 16, 2004 - v1
Checksum:iB10487274DF8DFF4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY509149 mRNA. Translation: AAS82846.1.
BC117082 mRNA. Translation: AAI17083.1.
BC117084 mRNA. Translation: AAI17085.1.
CCDSiCCDS51645.1.
RefSeqiNP_083870.1. NM_029594.1.
XP_006530561.1. XM_006530498.1.
UniGeneiMm.75049.

Genome annotation databases

EnsembliENSMUST00000031389; ENSMUSP00000031389; ENSMUSG00000029437.
GeneIDi76399.
KEGGimmu:76399.
UCSCiuc008zns.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY509149 mRNA. Translation: AAS82846.1.
BC117082 mRNA. Translation: AAI17083.1.
BC117084 mRNA. Translation: AAI17085.1.
CCDSiCCDS51645.1.
RefSeqiNP_083870.1. NM_029594.1.
XP_006530561.1. XM_006530498.1.
UniGeneiMm.75049.

3D structure databases

ProteinModelPortaliQ6EAL8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031389.

Proteomic databases

PaxDbiQ6EAL8.
PRIDEiQ6EAL8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031389; ENSMUSP00000031389; ENSMUSG00000029437.
GeneIDi76399.
KEGGimmu:76399.
UCSCiuc008zns.2. mouse.

Organism-specific databases

CTDi386653.
MGIiMGI:1923649. Il31.

Phylogenomic databases

eggNOGiENOG410J1CB. Eukaryota.
ENOG4111BHC. LUCA.
GeneTreeiENSGT00390000018074.
HOGENOMiHOG000113047.
InParanoidiQ6EAL8.
PhylomeDBiQ6EAL8.
TreeFamiTF339844.

Enzyme and pathway databases

ReactomeiR-MMU-449147. Signaling by Interleukins.

Miscellaneous databases

PROiQ6EAL8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029437.
CleanExiMM_IL31.
ExpressionAtlasiQ6EAL8. differential.
GenevisibleiQ6EAL8. MM.

Family and domain databases

InterProiIPR027987. IL-31.
[Graphical view]
PANTHERiPTHR38652. PTHR38652. 1 hit.
PfamiPF15209. IL31. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIL31_MOUSE
AccessioniPrimary (citable) accession number: Q6EAL8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: August 16, 2004
Last modified: November 30, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Il31 transgenic mice develop dermatitis. A similar phenotype is caused by local delivery of Il31.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.