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Protein

Dermokine

Gene

DMKN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May act as a soluble regulator of keratinocyte differentiation.Curated

Names & Taxonomyi

Protein namesi
Recommended name:
Dermokine
Alternative name(s):
Epidermis-specific secreted protein SK30/SK89
Gene namesi
Name:DMKN
ORF Names:UNQ729/PRO1411
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:25063. DMKN.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA145149020.

Polymorphism and mutation databases

BioMutaiDMKN.
DMDMi290457677.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 21211 PublicationAdd
BLAST
Chaini22 – 476455DermokinePRO_0000330764Add
BLAST

Post-translational modificationi

O-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ6E0U4.
PaxDbiQ6E0U4.
PeptideAtlasiQ6E0U4.
PRIDEiQ6E0U4.

PTM databases

iPTMnetiQ6E0U4.
PhosphoSiteiQ6E0U4.

Expressioni

Tissue specificityi

Expressed in epidermis; in the spinous and granular layers and in placenta. Also found in the epithelia of the small intestine, macrophages of the lung and endothelial cells of the lung. Isoform 15 is expressed in epidermis and placenta. Isoform 1 is expressed in epidermis.2 Publications

Gene expression databases

BgeeiENSG00000161249.
CleanExiHS_DMKN.
ExpressionAtlasiQ6E0U4. baseline and differential.
GenevisibleiQ6E0U4. HS.

Organism-specific databases

HPAiHPA029406.

Interactioni

Subunit structurei

Homooligomer. Seems to be able to homodimerize and homotrimerize.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
HSPA5P110213EBI-7943171,EBI-354921

Protein-protein interaction databases

BioGridi125000. 6 interactions.
IntActiQ6E0U4. 2 interactions.
MINTiMINT-8382680.
STRINGi9606.ENSP00000342012.

Structurei

Secondary structure

1
476
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi254 – 2596Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4F20X-ray2.50Q251-262[»]
ProteinModelPortaliQ6E0U4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi17 – 344328Gly-richAdd
BLAST

Sequence similaritiesi

Belongs to the dermokine family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JC0V. Eukaryota.
ENOG4111ARX. LUCA.
GeneTreeiENSGT00570000079107.
HOGENOMiHOG000168236.
HOVERGENiHBG107816.
InParanoidiQ6E0U4.
OMAiNPNTECT.
OrthoDBiEOG091G0NY5.
PhylomeDBiQ6E0U4.
TreeFamiTF338112.

Family and domain databases

InterProiIPR033541. Dermokine.
[Graphical view]
PANTHERiPTHR36881. PTHR36881. 1 hit.

Sequences (16)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 16 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6E0U4-1) [UniParc]FASTAAdd to basket
Also known as: Dermokine beta

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKFQGPLACL LLALCLGSGE AGPLQSGEES TGTNIGEALG HGLGDALSEG
60 70 80 90 100
VGKAIGKEAG GAAGSKVSEA LGQGTREAVG TGVRQVPGFG VADALGNRVG
110 120 130 140 150
EAAHALGNTG HEIGRQAEDV IRHGADAVRG SWQGVPGHNG AWETSGGHGI
160 170 180 190 200
FGSQGGLGGQ GQGNPGGLGT PWVHGYPGNS AGSFGMNPQG APWGQGGNGG
210 220 230 240 250
PPNFGTNTQG AVAQPGYGSV RASNQNEGCT NPPPSGSGGG SSNSGGGSGS
260 270 280 290 300
QSGSSGSGSN GDNNNGSSSG GSSSGSSSGG SSGGSSGGSS GNSGGSRGDS
310 320 330 340 350
GSESSWGSST GSSSGNHGGS GGGNGHKPGC EKPGNEARGS GESGIQNSET
360 370 380 390 400
SPGMFNFDTF WKNFKSKLGF INWDAINKNQ VPPPSTRALL YFSRLWEDFK
410 420 430 440 450
QNTPFLNWKA IIEGADASSL QKRAGRDDQN YNYNQHAYPT AYGGKYSVKT
460 470
PAKGGVSPSS SASRVQPGLL QWVKFW
Length:476
Mass (Da):47,082
Last modified:March 2, 2010 - v3
Checksum:iC412EC42221BEEC8
GO
Isoform 2 (identifier: Q6E0U4-2) [UniParc]FASTAAdd to basket
Also known as: Dermokine beta-2

The sequence of this isoform differs from the canonical sequence as follows:
     247-346: GSGSQSGSSG...ARGSGESGIQ → SSTGSSSGNH...GDAVGGVNTV

Show »
Length:466
Mass (Da):47,082
Checksum:i0695C599941C08C4
GO
Isoform 3 (identifier: Q6E0U4-3) [UniParc]FASTAAdd to basket
Also known as: Dermokine-gamma 1, Dermokine gamma-2

The sequence of this isoform differs from the canonical sequence as follows:
     379-386: NQVPPPST → DQRSSRIP
     387-476: Missing.

Show »
Length:386
Mass (Da):36,989
Checksum:i90226638F70F1D6A
GO
Isoform 4 (identifier: Q6E0U4-4) [UniParc]FASTAAdd to basket
Also known as: Dermokine beta-1

The sequence of this isoform differs from the canonical sequence as follows:
     247-307: Missing.
     346-346: Q → QGQGSSWGSGGGDAVGGVNTV
     429-429: Q → QPGAGWQEVAAVTSK

Show »
Length:449
Mass (Da):45,102
Checksum:i9C8BDA5F10D2788F
GO
Isoform 5 (identifier: Q6E0U4-5) [UniParc]FASTAAdd to basket
Also known as: Dermokine gamma-2

The sequence of this isoform differs from the canonical sequence as follows:
     346-346: Q → QGFRGQGVSSNMR
     379-386: NQVPPPST → DQRSSRIP
     387-476: Missing.

Show »
Length:398
Mass (Da):38,267
Checksum:iD9F7784BF7B2F718
GO
Isoform 6 (identifier: Q6E0U4-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     347-476: NSETSPGMFN...PGLLQWVKFW → GFRGQGVSSN...NKDQRSSRIP

Note: No experimental confirmation available.
Show »
Length:436
Mass (Da):41,944
Checksum:i0C02BEFC2EEE375A
GO
Isoform 7 (identifier: Q6E0U4-7) [UniParc]FASTAAdd to basket
Also known as: Dermokine gamma-1

The sequence of this isoform differs from the canonical sequence as follows:
     330-346: Missing.
     379-386: NQVPPPST → DQRSSRIP
     387-476: Missing.

Show »
Length:369
Mass (Da):35,288
Checksum:iF684C785EC251FB3
GO
Isoform 8 (identifier: Q6E0U4-8) [UniParc]FASTAAdd to basket
Also known as: Dermokine delta

The sequence of this isoform differs from the canonical sequence as follows:
     1-287: Missing.
     288-306: GSSGNSGGSRGDSGSESSW → MLGITSCSDQQAKEGEGLE

Show »
Length:189
Mass (Da):20,419
Checksum:iD812C17E18882C0D
GO
Isoform 9 (identifier: Q6E0U4-9) [UniParc]FASTAAdd to basket
Also known as: Dermokine-delta-4

The sequence of this isoform differs from the canonical sequence as follows:
     1-306: Missing.
     307-346: GSSTGSSSGN...ARGSGESGIQ → MSPPDQGVVE...GDAVGGVNTV

Show »
Length:170
Mass (Da):18,926
Checksum:i1B188C7AD69D62BF
GO
Isoform 10 (identifier: Q6E0U4-10) [UniParc]FASTAAdd to basket
Also known as: Dermokine-delta-1

The sequence of this isoform differs from the canonical sequence as follows:
     1-324: Missing.
     325-346: GHKPGCEKPGNEARGSGESGIQ → MRGQGSSWGSGGGDAVGGVNTV

Show »
Length:152
Mass (Da):16,837
Checksum:iEC6B68B536F8056E
GO
Isoform 11 (identifier: Q6E0U4-11) [UniParc]FASTAAdd to basket
Also known as: Dermokine-delta-3

The sequence of this isoform differs from the canonical sequence as follows:
     1-344: Missing.
     345-346: IQ → MR

Show »
Length:132
Mass (Da):15,106
Checksum:iE58EF713F35C69C3
GO
Isoform 12 (identifier: Q6E0U4-12) [UniParc]FASTAAdd to basket
Also known as: Dermokine-delta-2

The sequence of this isoform differs from the canonical sequence as follows:
     1-344: Missing.
     345-346: IQ → MR
     429-429: Q → QPGAGWQEVAAVTSK

Show »
Length:146
Mass (Da):16,489
Checksum:i39A0105B1329BA2F
GO
Isoform 13 (identifier: Q6E0U4-13) [UniParc]FASTAAdd to basket
Also known as: Dermokine-delta-6

The sequence of this isoform differs from the canonical sequence as follows:
     1-353: Missing.

Show »
Length:123
Mass (Da):14,146
Checksum:i97BF493EF89039CA
GO
Isoform 14 (identifier: Q6E0U4-14) [UniParc]FASTAAdd to basket
Also known as: Dermokine-delta-5

The sequence of this isoform differs from the canonical sequence as follows:
     1-353: Missing.
     429-429: Q → QPGAGWQEVAAVTSK

Show »
Length:137
Mass (Da):15,528
Checksum:i5F40C040AA329563
GO
Isoform 15 (identifier: Q6E0U4-15) [UniParc]FASTAAdd to basket
Also known as: Dermokine-alpha

The sequence of this isoform differs from the canonical sequence as follows:
     1-388: Missing.
     389-413: LLYFSRLWEDFKQNTPFLNWKAIIE → MNMKPATASALLLLLLGLAWTQGSHGW

Show »
Length:90
Mass (Da):9,712
Checksum:i6BF0EECEAE9309DB
GO
Isoform 16 (identifier: Q6E0U4-16) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     247-307: Missing.
     346-346: Q → QGFRGQGVSSNMREISKEGNRLLGGSGDNYRGQGSSWGSGGGDAVGGVNTV

Note: No experimental confirmation available.
Show »
Length:465
Mass (Da):46,944
Checksum:i8D0D334A8EDA8107
GO

Sequence cautioni

The sequence AAX48757 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti111 – 1111H → R in ABN11271 (PubMed:17380110).Curated
Sequence conflicti111 – 1111H → R in ABN11272 (PubMed:17380110).Curated
Sequence conflicti198 – 1981N → D in ABN11273 (PubMed:17380110).Curated
Sequence conflicti214 – 2152QP → PA in ABN11273 (PubMed:17380110).Curated
Sequence conflicti271 – 2711Missing in ABN11273 (PubMed:17380110).Curated
Sequence conflicti271 – 2711Missing in ABN11274 (PubMed:17380110).Curated
Sequence conflicti279 – 2791G → GSSSG in AAQ88778 (PubMed:12975309).Curated
Sequence conflicti378 – 3781K → M in ABN11272 (PubMed:17380110).Curated
Sequence conflicti419 – 4191S → L in ABN11272 (PubMed:17380110).Curated
Sequence conflicti450 – 4501T → S in ABN11272 (PubMed:17380110).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti13 – 131A → D in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_042720
Natural varianti69 – 691E → D.
Corresponds to variant rs12460932 [ dbSNP | Ensembl ].
VAR_056865
Natural varianti91 – 911V → A.5 Publications
Corresponds to variant rs4806163 [ dbSNP | Ensembl ].
VAR_059652
Natural varianti139 – 1391N → S.1 Publication
Corresponds to variant rs7247001 [ dbSNP | Ensembl ].
VAR_056866
Natural varianti280 – 2801G → S.1 Publication
Corresponds to variant rs11667007 [ dbSNP | Ensembl ].
VAR_059653
Natural varianti415 – 4151A → S.
Corresponds to variant rs2293696 [ dbSNP | Ensembl ].
VAR_042721
Natural varianti427 – 4271D → A.4 Publications
Corresponds to variant rs909072 [ dbSNP | Ensembl ].
VAR_047337

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 388388Missing in isoform 15. CuratedVSP_033087Add
BLAST
Alternative sequencei1 – 353353Missing in isoform 13 and isoform 14. 2 PublicationsVSP_033088Add
BLAST
Alternative sequencei1 – 344344Missing in isoform 11 and isoform 12. 1 PublicationVSP_033089Add
BLAST
Alternative sequencei1 – 324324Missing in isoform 10. 1 PublicationVSP_033090Add
BLAST
Alternative sequencei1 – 306306Missing in isoform 9. 1 PublicationVSP_033091Add
BLAST
Alternative sequencei1 – 287287Missing in isoform 8. 1 PublicationVSP_033092Add
BLAST
Alternative sequencei247 – 346100GSGSQ…ESGIQ → SSTGSSSGNHGGSGGGNGHK PGCEKPGNEARGSGESGIQG FRGPGSFPXNMREISKEGNR LLGGSGDNYRGQGSSWGSGG GDAVGGVNTV in isoform 2. 1 PublicationVSP_033093Add
BLAST
Alternative sequencei247 – 30761Missing in isoform 4 and isoform 16. 1 PublicationVSP_033094Add
BLAST
Alternative sequencei288 – 30619GSSGN…SESSW → MLGITSCSDQQAKEGEGLE in isoform 8. 1 PublicationVSP_033095Add
BLAST
Alternative sequencei307 – 34640GSSTG…ESGIQ → MSPPDQGVVESRLWRQMLHK GQGSSWGSGGGDAVGGVNTV in isoform 9. 1 PublicationVSP_033096Add
BLAST
Alternative sequencei325 – 34622GHKPG…ESGIQ → MRGQGSSWGSGGGDAVGGVN TV in isoform 10. 1 PublicationVSP_033097Add
BLAST
Alternative sequencei330 – 34617Missing in isoform 7. 1 PublicationVSP_033098Add
BLAST
Alternative sequencei345 – 3462IQ → MR in isoform 11 and isoform 12. 1 PublicationVSP_033099
Alternative sequencei346 – 3461Q → QGFRGQGVSSNMREISKEGN RLLGGSGDNYRGQGSSWGSG GGDAVGGVNTV in isoform 16. CuratedVSP_047249
Alternative sequencei346 – 3461Q → QGQGSSWGSGGGDAVGGVNT V in isoform 4. 1 PublicationVSP_033100
Alternative sequencei346 – 3461Q → QGFRGQGVSSNMR in isoform 5. 1 PublicationVSP_033101
Alternative sequencei347 – 476130NSETS…WVKFW → GFRGQGVSSNMREISKEGNR LLGGSGDNYRGQGSSWGSGG GDAVGGVNTVNSETSPGMFN FDTFWKNFKSKLGFINWDAI NKDQRSSRIP in isoform 6. 1 PublicationVSP_033102Add
BLAST
Alternative sequencei379 – 3868NQVPPPST → DQRSSRIP in isoform 3, isoform 5 and isoform 7. 2 PublicationsVSP_033103
Alternative sequencei387 – 47690Missing in isoform 3, isoform 5 and isoform 7. 2 PublicationsVSP_033104Add
BLAST
Alternative sequencei389 – 41325LLYFS…KAIIE → MNMKPATASALLLLLLGLAW TQGSHGW in isoform 15. CuratedVSP_033105Add
BLAST
Alternative sequencei429 – 4291Q → QPGAGWQEVAAVTSK in isoform 4, isoform 12 and isoform 14. 3 PublicationsVSP_033106

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY622964 mRNA. Translation: AAT68268.1.
AY622965 mRNA. Translation: AAT68269.1.
AY789695 mRNA. Translation: AAX48745.1.
AY789696 mRNA. Translation: AAX48746.1.
AY789697 mRNA. Translation: AAX48747.1.
AY789698 mRNA. Translation: AAX48748.1.
AY789699 mRNA. Translation: AAX48749.1.
AY789700 mRNA. Translation: AAX48750.1.
AY789701 mRNA. Translation: AAX48751.1.
AY789702 mRNA. Translation: AAX48752.1.
AY789703 mRNA. Translation: AAX48753.1.
AY789704 mRNA. Translation: AAX48754.1.
AY789705 mRNA. Translation: AAX48755.1.
AY789706 mRNA. Translation: AAX48756.1.
AY789707 mRNA. Translation: AAX48757.1. Different initiation.
EF158319 mRNA. Translation: ABN11271.1.
EF158320 mRNA. Translation: ABN11272.1.
EF158321 mRNA. Translation: ABN11273.1.
EF158322 mRNA. Translation: ABN11274.1.
EF158323 mRNA. Translation: ABN11275.1.
AY358412 mRNA. Translation: AAQ88778.1.
AC138125 Genomic DNA. No translation available.
AD001502 Genomic DNA. No translation available.
BC004493 mRNA. Translation: AAH04493.2.
BC011886 mRNA. Translation: AAH11886.1.
BC035311 mRNA. Translation: AAH35311.1.
CCDSiCCDS12463.1. [Q6E0U4-1]
CCDS42549.1. [Q6E0U4-15]
CCDS46051.1. [Q6E0U4-8]
CCDS46052.1. [Q6E0U4-3]
CCDS46053.1. [Q6E0U4-5]
CCDS46054.2. [Q6E0U4-16]
CCDS54250.1. [Q6E0U4-4]
CCDS54251.1. [Q6E0U4-7]
CCDS54252.1. [Q6E0U4-6]
RefSeqiNP_001119528.2. NM_001126056.2.
NP_001119529.2. NM_001126057.2. [Q6E0U4-5]
NP_001119530.2. NM_001126058.2. [Q6E0U4-3]
NP_001119531.1. NM_001126059.2.
NP_001177276.1. NM_001190347.1.
NP_001177277.1. NM_001190348.1. [Q6E0U4-6]
NP_001177278.1. NM_001190349.1. [Q6E0U4-7]
NP_001295309.1. NM_001308380.1.
NP_201574.3. NM_033317.4.
XP_006723556.1. XM_006723493.2. [Q6E0U4-10]
XP_006723557.1. XM_006723494.2. [Q6E0U4-12]
UniGeneiHs.417795.

Genome annotation databases

EnsembliENST00000339686; ENSP00000342012; ENSG00000161249. [Q6E0U4-1]
ENST00000408915; ENSP00000386225; ENSG00000161249. [Q6E0U4-15]
ENST00000414866; ENSP00000392222; ENSG00000161249. [Q6E0U4-8]
ENST00000418261; ENSP00000414743; ENSG00000161249. [Q6E0U4-3]
ENST00000419602; ENSP00000391036; ENSG00000161249. [Q6E0U4-16]
ENST00000424570; ENSP00000388404; ENSG00000161249. [Q6E0U4-5]
ENST00000429837; ENSP00000405503; ENSG00000161249. [Q6E0U4-4]
ENST00000447113; ENSP00000394908; ENSG00000161249. [Q6E0U4-6]
ENST00000451297; ENSP00000409513; ENSG00000161249. [Q6E0U4-7]
ENST00000472252; ENSP00000473341; ENSG00000161249. [Q6E0U4-13]
ENST00000492341; ENSP00000474419; ENSG00000161249. [Q6E0U4-13]
GeneIDi93099.
KEGGihsa:93099.
UCSCiuc002nzi.5. human. [Q6E0U4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY622964 mRNA. Translation: AAT68268.1.
AY622965 mRNA. Translation: AAT68269.1.
AY789695 mRNA. Translation: AAX48745.1.
AY789696 mRNA. Translation: AAX48746.1.
AY789697 mRNA. Translation: AAX48747.1.
AY789698 mRNA. Translation: AAX48748.1.
AY789699 mRNA. Translation: AAX48749.1.
AY789700 mRNA. Translation: AAX48750.1.
AY789701 mRNA. Translation: AAX48751.1.
AY789702 mRNA. Translation: AAX48752.1.
AY789703 mRNA. Translation: AAX48753.1.
AY789704 mRNA. Translation: AAX48754.1.
AY789705 mRNA. Translation: AAX48755.1.
AY789706 mRNA. Translation: AAX48756.1.
AY789707 mRNA. Translation: AAX48757.1. Different initiation.
EF158319 mRNA. Translation: ABN11271.1.
EF158320 mRNA. Translation: ABN11272.1.
EF158321 mRNA. Translation: ABN11273.1.
EF158322 mRNA. Translation: ABN11274.1.
EF158323 mRNA. Translation: ABN11275.1.
AY358412 mRNA. Translation: AAQ88778.1.
AC138125 Genomic DNA. No translation available.
AD001502 Genomic DNA. No translation available.
BC004493 mRNA. Translation: AAH04493.2.
BC011886 mRNA. Translation: AAH11886.1.
BC035311 mRNA. Translation: AAH35311.1.
CCDSiCCDS12463.1. [Q6E0U4-1]
CCDS42549.1. [Q6E0U4-15]
CCDS46051.1. [Q6E0U4-8]
CCDS46052.1. [Q6E0U4-3]
CCDS46053.1. [Q6E0U4-5]
CCDS46054.2. [Q6E0U4-16]
CCDS54250.1. [Q6E0U4-4]
CCDS54251.1. [Q6E0U4-7]
CCDS54252.1. [Q6E0U4-6]
RefSeqiNP_001119528.2. NM_001126056.2.
NP_001119529.2. NM_001126057.2. [Q6E0U4-5]
NP_001119530.2. NM_001126058.2. [Q6E0U4-3]
NP_001119531.1. NM_001126059.2.
NP_001177276.1. NM_001190347.1.
NP_001177277.1. NM_001190348.1. [Q6E0U4-6]
NP_001177278.1. NM_001190349.1. [Q6E0U4-7]
NP_001295309.1. NM_001308380.1.
NP_201574.3. NM_033317.4.
XP_006723556.1. XM_006723493.2. [Q6E0U4-10]
XP_006723557.1. XM_006723494.2. [Q6E0U4-12]
UniGeneiHs.417795.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4F20X-ray2.50Q251-262[»]
ProteinModelPortaliQ6E0U4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125000. 6 interactions.
IntActiQ6E0U4. 2 interactions.
MINTiMINT-8382680.
STRINGi9606.ENSP00000342012.

PTM databases

iPTMnetiQ6E0U4.
PhosphoSiteiQ6E0U4.

Polymorphism and mutation databases

BioMutaiDMKN.
DMDMi290457677.

Proteomic databases

MaxQBiQ6E0U4.
PaxDbiQ6E0U4.
PeptideAtlasiQ6E0U4.
PRIDEiQ6E0U4.

Protocols and materials databases

DNASUi93099.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339686; ENSP00000342012; ENSG00000161249. [Q6E0U4-1]
ENST00000408915; ENSP00000386225; ENSG00000161249. [Q6E0U4-15]
ENST00000414866; ENSP00000392222; ENSG00000161249. [Q6E0U4-8]
ENST00000418261; ENSP00000414743; ENSG00000161249. [Q6E0U4-3]
ENST00000419602; ENSP00000391036; ENSG00000161249. [Q6E0U4-16]
ENST00000424570; ENSP00000388404; ENSG00000161249. [Q6E0U4-5]
ENST00000429837; ENSP00000405503; ENSG00000161249. [Q6E0U4-4]
ENST00000447113; ENSP00000394908; ENSG00000161249. [Q6E0U4-6]
ENST00000451297; ENSP00000409513; ENSG00000161249. [Q6E0U4-7]
ENST00000472252; ENSP00000473341; ENSG00000161249. [Q6E0U4-13]
ENST00000492341; ENSP00000474419; ENSG00000161249. [Q6E0U4-13]
GeneIDi93099.
KEGGihsa:93099.
UCSCiuc002nzi.5. human. [Q6E0U4-1]

Organism-specific databases

CTDi93099.
GeneCardsiDMKN.
HGNCiHGNC:25063. DMKN.
HPAiHPA029406.
neXtProtiNX_Q6E0U4.
PharmGKBiPA145149020.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JC0V. Eukaryota.
ENOG4111ARX. LUCA.
GeneTreeiENSGT00570000079107.
HOGENOMiHOG000168236.
HOVERGENiHBG107816.
InParanoidiQ6E0U4.
OMAiNPNTECT.
OrthoDBiEOG091G0NY5.
PhylomeDBiQ6E0U4.
TreeFamiTF338112.

Miscellaneous databases

ChiTaRSiDMKN. human.
GenomeRNAii93099.
PROiQ6E0U4.

Gene expression databases

BgeeiENSG00000161249.
CleanExiHS_DMKN.
ExpressionAtlasiQ6E0U4. baseline and differential.
GenevisibleiQ6E0U4. HS.

Family and domain databases

InterProiIPR033541. Dermokine.
[Graphical view]
PANTHERiPTHR36881. PTHR36881. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDMKN_HUMAN
AccessioniPrimary (citable) accession number: Q6E0U4
Secondary accession number(s): A3EZ79
, A3EZ80, A3EZ81, A3EZ82, A3EZ83, C9J4P6, C9J5N8, C9JAL3, Q32W58, Q32W62, Q32W63, Q32W64, Q32W65, Q32W66, Q32W67, Q6E0U5, Q6UXC7, Q96EW8, Q9BSY6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: March 2, 2010
Last modified: September 7, 2016
This is version 112 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.