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Protein

Renin

Gene

REN

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.By similarity

Catalytic activityi

Cleavage of Leu-|-Xaa bond in angiotensinogen to generate angiotensin I.

Enzyme regulationi

Interaction with ATP6AP2 results in a 5-fold increased efficiency in angiotensinogen processing.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei103 – 1031PROSITE-ProRule annotation
Active sitei288 – 2881PROSITE-ProRule annotation

GO - Molecular functioni

  1. aspartic-type endopeptidase activity Source: UniProtKB-KW

GO - Biological processi

  1. angiotensin maturation Source: Ensembl
  2. cell maturation Source: Ensembl
  3. drinking behavior Source: Ensembl
  4. hormone-mediated signaling pathway Source: Ensembl
  5. male gonad development Source: Ensembl
  6. mesonephros development Source: Ensembl
  7. regulation of MAPK cascade Source: Ensembl
  8. renin-angiotensin regulation of aldosterone production Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Aspartyl protease, Hydrolase, Protease

Enzyme and pathway databases

BRENDAi3.4.23.15. 9491.
ReactomeiREACT_204976. Metabolism of Angiotensinogen to Angiotensins.

Protein family/group databases

MEROPSiA01.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Renin (EC:3.4.23.15)
Alternative name(s):
Angiotensinogenase
Gene namesi
Name:REN
OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
ProteomesiUP000002254: Chromosome 38

Subcellular locationi

Secreted By similarity. Membrane By similarity
Note: Associated to membranes via binding to ATP6AP2.By similarity

GO - Cellular componenti

  1. extracellular space Source: Ensembl
  2. intracellular Source: Ensembl
  3. membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Propeptidei23 – 6543Activation peptideBy similarityPRO_0000026079Add
BLAST
Chaini66 – 403338ReninPRO_0000026080Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi70 – 701N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi116 ↔ 123By similarity
Glycosylationi140 – 1401N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi279 ↔ 283By similarity
Disulfide bondi322 ↔ 359By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Zymogen

Interactioni

Subunit structurei

Interacts with ATP6AP2.By similarity

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000014146.

Structurei

3D structure databases

ProteinModelPortaliQ6DYE7.
SMRiQ6DYE7. Positions 73-403.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase A1 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG248684.
GeneTreeiENSGT00760000118929.
HOGENOMiHOG000197681.
HOVERGENiHBG000482.
InParanoidiQ6DYE7.
KOiK01380.
OMAiNFIARYY.
OrthoDBiEOG7HQN88.
TreeFamiTF314990.

Family and domain databases

Gene3Di2.40.70.10. 2 hits.
InterProiIPR001461. Aspartic_peptidase.
IPR001969. Aspartic_peptidase_AS.
IPR012848. Aspartic_peptidase_N.
IPR021109. Peptidase_aspartic_dom.
[Graphical view]
PANTHERiPTHR13683. PTHR13683. 1 hit.
PfamiPF07966. A1_Propeptide. 1 hit.
PF00026. Asp. 1 hit.
[Graphical view]
PRINTSiPR00792. PEPSIN.
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiPS00141. ASP_PROTEASE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6DYE7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MARCRMPRWG LLLVLWGSCT FGLPADTGAF RRIFLKKMPS IRESLKERGV
60 70 80 90 100
DVAGLGAEWN QFTKRLSSGN STSPVVLTNY LDTQYYGEIG IGTPPQTFKV
110 120 130 140 150
VFDTGSANLW VPSTRCSPLY TACEIHCLYD SSESSSYMEN GTTFTIRYGS
160 170 180 190 200
GKVKGFLSQD MVTVGGITVT QTFGEVTELP LIPFMLAKFD GVLGMGFPAQ
210 220 230 240 250
AVGGVTPVFD HILSQGVLKE EVFSVYYSRN SHLLGGEVVL GGSDPQYYQG
260 270 280 290 300
NFHYVSISKT GSWQIKMKGV SVRSATLVCE EGCMVVVDTG ASYISGPTSS
310 320 330 340 350
LRLLMDTLGA QELSTNEYVV NCNQVPTLPD ISFHLGGRAY TLTSKDYVLQ
360 370 380 390 400
DPYGNEDLCT LALHGLDVPP PTGPVWVLGA SFIRKFYTEF DRHNNRIGFA

LAR
Length:403
Mass (Da):44,099
Last modified:August 16, 2004 - v1
Checksum:iB63101337155AE44
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY630442 mRNA. Translation: AAT68959.1.
RefSeqiNP_001003194.1. NM_001003194.1.
UniGeneiCfa.3701.

Genome annotation databases

EnsembliENSCAFT00000015286; ENSCAFP00000014146; ENSCAFG00000009623.
GeneIDi403838.
KEGGicfa:403838.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY630442 mRNA. Translation: AAT68959.1.
RefSeqiNP_001003194.1. NM_001003194.1.
UniGeneiCfa.3701.

3D structure databases

ProteinModelPortaliQ6DYE7.
SMRiQ6DYE7. Positions 73-403.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000014146.

Protein family/group databases

MEROPSiA01.007.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000015286; ENSCAFP00000014146; ENSCAFG00000009623.
GeneIDi403838.
KEGGicfa:403838.

Organism-specific databases

CTDi5972.

Phylogenomic databases

eggNOGiNOG248684.
GeneTreeiENSGT00760000118929.
HOGENOMiHOG000197681.
HOVERGENiHBG000482.
InParanoidiQ6DYE7.
KOiK01380.
OMAiNFIARYY.
OrthoDBiEOG7HQN88.
TreeFamiTF314990.

Enzyme and pathway databases

BRENDAi3.4.23.15. 9491.
ReactomeiREACT_204976. Metabolism of Angiotensinogen to Angiotensins.

Miscellaneous databases

NextBioi20817333.

Family and domain databases

Gene3Di2.40.70.10. 2 hits.
InterProiIPR001461. Aspartic_peptidase.
IPR001969. Aspartic_peptidase_AS.
IPR012848. Aspartic_peptidase_N.
IPR021109. Peptidase_aspartic_dom.
[Graphical view]
PANTHERiPTHR13683. PTHR13683. 1 hit.
PfamiPF07966. A1_Propeptide. 1 hit.
PF00026. Asp. 1 hit.
[Graphical view]
PRINTSiPR00792. PEPSIN.
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiPS00141. ASP_PROTEASE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The cloning and characterization of canine renin."
    Zecher M., Wu Z., Scott B., McGeehan G., Harrison R.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiRENI_CANFA
AccessioniPrimary (citable) accession number: Q6DYE7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: August 16, 2004
Last modified: January 7, 2015
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.