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Q6DYE7

- RENI_CANFA

UniProt

Q6DYE7 - RENI_CANFA

Protein

Renin

Gene

REN

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (16 Aug 2004)
      Previous versions | rss
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    Functioni

    Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.By similarity

    Catalytic activityi

    Cleavage of Leu-|-Xaa bond in angiotensinogen to generate angiotensin I.

    Enzyme regulationi

    Interaction with ATP6AP2 results in a 5-fold increased efficiency in angiotensinogen processing.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei103 – 1031PROSITE-ProRule annotation
    Active sitei288 – 2881PROSITE-ProRule annotation

    GO - Molecular functioni

    1. aspartic-type endopeptidase activity Source: UniProtKB-KW

    GO - Biological processi

    1. angiotensin maturation Source: Ensembl
    2. cell maturation Source: Ensembl
    3. drinking behavior Source: Ensembl
    4. hormone-mediated signaling pathway Source: Ensembl
    5. male gonad development Source: Ensembl
    6. mesonephros development Source: Ensembl
    7. regulation of MAPK cascade Source: Ensembl
    8. renin-angiotensin regulation of aldosterone production Source: Ensembl

    Keywords - Molecular functioni

    Aspartyl protease, Hydrolase, Protease

    Enzyme and pathway databases

    BRENDAi3.4.23.15. 9491.
    ReactomeiREACT_204976. Metabolism of Angiotensinogen to Angiotensins.

    Protein family/group databases

    MEROPSiA01.007.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Renin (EC:3.4.23.15)
    Alternative name(s):
    Angiotensinogenase
    Gene namesi
    Name:REN
    OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
    Taxonomic identifieri9615 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
    ProteomesiUP000002254: Chromosome 38

    Subcellular locationi

    Secreted By similarity. Membrane By similarity
    Note: Associated to membranes via binding to ATP6AP2.By similarity

    GO - Cellular componenti

    1. extracellular space Source: Ensembl
    2. intracellular Source: Ensembl
    3. membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Propeptidei23 – 6543Activation peptideBy similarityPRO_0000026079Add
    BLAST
    Chaini66 – 403338ReninPRO_0000026080Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi70 – 701N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi116 ↔ 123By similarity
    Glycosylationi140 – 1401N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi279 ↔ 283By similarity
    Disulfide bondi322 ↔ 359By similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Zymogen

    Interactioni

    Subunit structurei

    Interacts with ATP6AP2.By similarity

    Protein-protein interaction databases

    STRINGi9615.ENSCAFP00000014146.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6DYE7.
    SMRiQ6DYE7. Positions 73-403.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase A1 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG248684.
    GeneTreeiENSGT00710000106265.
    HOGENOMiHOG000197681.
    HOVERGENiHBG000482.
    KOiK01380.
    OMAiIARYYTE.
    OrthoDBiEOG7HQN88.
    TreeFamiTF314990.

    Family and domain databases

    Gene3Di2.40.70.10. 2 hits.
    InterProiIPR001461. Aspartic_peptidase.
    IPR001969. Aspartic_peptidase_AS.
    IPR012848. Aspartic_peptidase_N.
    IPR021109. Peptidase_aspartic_dom.
    [Graphical view]
    PANTHERiPTHR13683. PTHR13683. 1 hit.
    PfamiPF07966. A1_Propeptide. 1 hit.
    PF00026. Asp. 1 hit.
    [Graphical view]
    PRINTSiPR00792. PEPSIN.
    SUPFAMiSSF50630. SSF50630. 1 hit.
    PROSITEiPS00141. ASP_PROTEASE. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6DYE7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARCRMPRWG LLLVLWGSCT FGLPADTGAF RRIFLKKMPS IRESLKERGV    50
    DVAGLGAEWN QFTKRLSSGN STSPVVLTNY LDTQYYGEIG IGTPPQTFKV 100
    VFDTGSANLW VPSTRCSPLY TACEIHCLYD SSESSSYMEN GTTFTIRYGS 150
    GKVKGFLSQD MVTVGGITVT QTFGEVTELP LIPFMLAKFD GVLGMGFPAQ 200
    AVGGVTPVFD HILSQGVLKE EVFSVYYSRN SHLLGGEVVL GGSDPQYYQG 250
    NFHYVSISKT GSWQIKMKGV SVRSATLVCE EGCMVVVDTG ASYISGPTSS 300
    LRLLMDTLGA QELSTNEYVV NCNQVPTLPD ISFHLGGRAY TLTSKDYVLQ 350
    DPYGNEDLCT LALHGLDVPP PTGPVWVLGA SFIRKFYTEF DRHNNRIGFA 400
    LAR 403
    Length:403
    Mass (Da):44,099
    Last modified:August 16, 2004 - v1
    Checksum:iB63101337155AE44
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY630442 mRNA. Translation: AAT68959.1.
    RefSeqiNP_001003194.1. NM_001003194.1.
    UniGeneiCfa.3701.

    Genome annotation databases

    EnsembliENSCAFT00000015286; ENSCAFP00000014146; ENSCAFG00000009623.
    GeneIDi403838.
    KEGGicfa:403838.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY630442 mRNA. Translation: AAT68959.1 .
    RefSeqi NP_001003194.1. NM_001003194.1.
    UniGenei Cfa.3701.

    3D structure databases

    ProteinModelPortali Q6DYE7.
    SMRi Q6DYE7. Positions 73-403.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9615.ENSCAFP00000014146.

    Protein family/group databases

    MEROPSi A01.007.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSCAFT00000015286 ; ENSCAFP00000014146 ; ENSCAFG00000009623 .
    GeneIDi 403838.
    KEGGi cfa:403838.

    Organism-specific databases

    CTDi 5972.

    Phylogenomic databases

    eggNOGi NOG248684.
    GeneTreei ENSGT00710000106265.
    HOGENOMi HOG000197681.
    HOVERGENi HBG000482.
    KOi K01380.
    OMAi IARYYTE.
    OrthoDBi EOG7HQN88.
    TreeFami TF314990.

    Enzyme and pathway databases

    BRENDAi 3.4.23.15. 9491.
    Reactomei REACT_204976. Metabolism of Angiotensinogen to Angiotensins.

    Miscellaneous databases

    NextBioi 20817333.

    Family and domain databases

    Gene3Di 2.40.70.10. 2 hits.
    InterProi IPR001461. Aspartic_peptidase.
    IPR001969. Aspartic_peptidase_AS.
    IPR012848. Aspartic_peptidase_N.
    IPR021109. Peptidase_aspartic_dom.
    [Graphical view ]
    PANTHERi PTHR13683. PTHR13683. 1 hit.
    Pfami PF07966. A1_Propeptide. 1 hit.
    PF00026. Asp. 1 hit.
    [Graphical view ]
    PRINTSi PR00792. PEPSIN.
    SUPFAMi SSF50630. SSF50630. 1 hit.
    PROSITEi PS00141. ASP_PROTEASE. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The cloning and characterization of canine renin."
      Zecher M., Wu Z., Scott B., McGeehan G., Harrison R.
      Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiRENI_CANFA
    AccessioniPrimary (citable) accession number: Q6DYE7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 29, 2005
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3