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Q6DYE7 (RENI_CANFA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Renin

EC=3.4.23.15
Alternative name(s):
Angiotensinogenase
Gene names
Name:REN
OrganismCanis familiaris (Dog) (Canis lupus familiaris) [Reference proteome]
Taxonomic identifier9615 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis

Protein attributes

Sequence length403 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney By similarity.

Catalytic activity

Cleavage of Leu-|-Xaa bond in angiotensinogen to generate angiotensin I.

Enzyme regulation

Interaction with ATP6AP2 results in a 5-fold increased efficiency in angiotensinogen processing By similarity.

Subunit structure

Interacts with ATP6AP2 By similarity.

Subcellular location

Secreted By similarity. Membrane By similarity. Note: Associated to membranes via binding to ATP6AP2 By similarity.

Sequence similarities

Belongs to the peptidase A1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Propeptide23 – 6543Activation peptide By similarity
PRO_0000026079
Chain66 – 403338Renin
PRO_0000026080

Sites

Active site1031 By similarity
Active site2881 By similarity

Amino acid modifications

Glycosylation701N-linked (GlcNAc...) Potential
Glycosylation1401N-linked (GlcNAc...) Potential
Disulfide bond116 ↔ 123 By similarity
Disulfide bond279 ↔ 283 By similarity
Disulfide bond322 ↔ 359 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6DYE7 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: B63101337155AE44

FASTA40344,099
        10         20         30         40         50         60 
MARCRMPRWG LLLVLWGSCT FGLPADTGAF RRIFLKKMPS IRESLKERGV DVAGLGAEWN 

        70         80         90        100        110        120 
QFTKRLSSGN STSPVVLTNY LDTQYYGEIG IGTPPQTFKV VFDTGSANLW VPSTRCSPLY 

       130        140        150        160        170        180 
TACEIHCLYD SSESSSYMEN GTTFTIRYGS GKVKGFLSQD MVTVGGITVT QTFGEVTELP 

       190        200        210        220        230        240 
LIPFMLAKFD GVLGMGFPAQ AVGGVTPVFD HILSQGVLKE EVFSVYYSRN SHLLGGEVVL 

       250        260        270        280        290        300 
GGSDPQYYQG NFHYVSISKT GSWQIKMKGV SVRSATLVCE EGCMVVVDTG ASYISGPTSS 

       310        320        330        340        350        360 
LRLLMDTLGA QELSTNEYVV NCNQVPTLPD ISFHLGGRAY TLTSKDYVLQ DPYGNEDLCT 

       370        380        390        400 
LALHGLDVPP PTGPVWVLGA SFIRKFYTEF DRHNNRIGFA LAR 

« Hide

References

[1]"The cloning and characterization of canine renin."
Zecher M., Wu Z., Scott B., McGeehan G., Harrison R.
Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY630442 mRNA. Translation: AAT68959.1.
RefSeqNP_001003194.1. NM_001003194.1.
UniGeneCfa.3701.

3D structure databases

ProteinModelPortalQ6DYE7.
SMRQ6DYE7. Positions 73-403.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9615.ENSCAFP00000014146.

Protein family/group databases

MEROPSA01.007.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSCAFT00000015286; ENSCAFP00000014146; ENSCAFG00000009623.
GeneID403838.
KEGGcfa:403838.

Organism-specific databases

CTD5972.

Phylogenomic databases

eggNOGNOG248684.
GeneTreeENSGT00710000106265.
HOGENOMHOG000197681.
HOVERGENHBG000482.
KOK01380.
OMAIARYYTE.
OrthoDBEOG7HQN88.
TreeFamTF314990.

Enzyme and pathway databases

BRENDA3.4.23.15. 9491.

Family and domain databases

Gene3D2.40.70.10. 2 hits.
InterProIPR001461. Aspartic_peptidase.
IPR001969. Aspartic_peptidase_AS.
IPR012848. Aspartic_peptidase_N.
IPR021109. Peptidase_aspartic_dom.
[Graphical view]
PANTHERPTHR13683. PTHR13683. 1 hit.
PfamPF07966. A1_Propeptide. 1 hit.
PF00026. Asp. 1 hit.
[Graphical view]
PRINTSPR00792. PEPSIN.
SUPFAMSSF50630. SSF50630. 1 hit.
PROSITEPS00141. ASP_PROTEASE. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio20817333.

Entry information

Entry nameRENI_CANFA
AccessionPrimary (citable) accession number: Q6DYE7
Entry history
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: August 16, 2004
Last modified: February 19, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries