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Protein

Probable G-protein coupled receptor 139

Gene

GPR139

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor. Seems to act through a G(q/11)-mediated pathway.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 139
Alternative name(s):
G(q)-coupled orphan receptor GPRg1
G-protein-coupled receptor PGR3
Gene namesi
Name:GPR139
Synonyms:GPRG1, PGR3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:19995. GPR139.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 29ExtracellularSequence analysisAdd BLAST29
Transmembranei30 – 50Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini51 – 65CytoplasmicSequence analysisAdd BLAST15
Transmembranei66 – 86Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini87 – 102ExtracellularSequence analysisAdd BLAST16
Transmembranei103 – 123Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini124 – 148CytoplasmicSequence analysisAdd BLAST25
Transmembranei149 – 169Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini170 – 181ExtracellularSequence analysisAdd BLAST12
Transmembranei182 – 202Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini203 – 228CytoplasmicSequence analysisAdd BLAST26
Transmembranei229 – 249Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini250 – 268ExtracellularSequence analysisAdd BLAST19
Transmembranei269 – 289Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini290 – 353CytoplasmicSequence analysisAdd BLAST64

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000180269.
PharmGKBiPA134970866.

Chemistry databases

ChEMBLiCHEMBL3632455.
GuidetoPHARMACOLOGYi130.

Polymorphism and mutation databases

BioMutaiGPR139.
DMDMi74762300.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000696151 – 353Probable G-protein coupled receptor 139Add BLAST353

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi11N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6DWJ6.
PRIDEiQ6DWJ6.

PTM databases

iPTMnetiQ6DWJ6.
PhosphoSitePlusiQ6DWJ6.

Expressioni

Tissue specificityi

Expressed almost exclusively in the brain. Detected at very low levels in the peripheral tissues.1 Publication

Gene expression databases

BgeeiENSG00000180269.
CleanExiHS_GPR139.
ExpressionAtlasiQ6DWJ6. baseline and differential.

Organism-specific databases

HPAiHPA046596.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000458791.

Structurei

3D structure databases

ProteinModelPortaliQ6DWJ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00390000006613.
HOGENOMiHOG000231257.
HOVERGENiHBG081564.
InParanoidiQ6DWJ6.
KOiK08428.
OMAiHSHIFSA.
OrthoDBiEOG091G0HIF.
PhylomeDBiQ6DWJ6.
TreeFamiTF334275.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6DWJ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEHTHAHLAA NSSLSWWSPG SACGLGFVPV VYYSLLLCLG LPANILTVII
60 70 80 90 100
LSQLVARRQK SSYNYLLALA AADILVLFFI VFVDFLLEDF ILNMQMPQVP
110 120 130 140 150
DKIIEVLEFS SIHTSIWITV PLTIDRYIAV CHPLKYHTVS YPARTRKVIV
160 170 180 190 200
SVYITCFLTS IPYYWWPNIW TEDYISTSVH HVLIWIHCFT VYLVPCSIFF
210 220 230 240 250
ILNSIIVYKL RRKSNFRLRG YSTGKTTAIL FTITSIFATL WAPRIIMILY
260 270 280 290 300
HLYGAPIQNR WLVHIMSDIA NMLALLNTAI NFFLYCFISK RFRTMAAATL
310 320 330 340 350
KAFFKCQKQP VQFYTNHNFS ITSSPWISPA NSHCIKMLVY QYDKNGKPIK

VSP
Length:353
Mass (Da):40,679
Last modified:August 16, 2004 - v1
Checksum:iCF1088FCE5C84F85
GO

Sequence cautioni

The sequence BAB89307 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY635179 mRNA. Translation: AAT65818.1.
AB196529 mRNA. Translation: BAD97440.1.
AB083594 Genomic DNA. Translation: BAB89307.1. Sequence problems.
AK291384 mRNA. Translation: BAF84073.1.
CH471186 Genomic DNA. Translation: EAW50306.1.
BC137237 mRNA. Translation: AAI37238.1.
BC137238 mRNA. Translation: AAI37239.1.
AY255545 mRNA. Translation: AAO85057.1.
CCDSiCCDS32398.1.
RefSeqiNP_001002911.1. NM_001002911.3.
NP_001305412.1. NM_001318483.1.
UniGeneiHs.446875.

Genome annotation databases

EnsembliENST00000570682; ENSP00000458791; ENSG00000180269.
GeneIDi124274.
KEGGihsa:124274.
UCSCiuc002dgu.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY635179 mRNA. Translation: AAT65818.1.
AB196529 mRNA. Translation: BAD97440.1.
AB083594 Genomic DNA. Translation: BAB89307.1. Sequence problems.
AK291384 mRNA. Translation: BAF84073.1.
CH471186 Genomic DNA. Translation: EAW50306.1.
BC137237 mRNA. Translation: AAI37238.1.
BC137238 mRNA. Translation: AAI37239.1.
AY255545 mRNA. Translation: AAO85057.1.
CCDSiCCDS32398.1.
RefSeqiNP_001002911.1. NM_001002911.3.
NP_001305412.1. NM_001318483.1.
UniGeneiHs.446875.

3D structure databases

ProteinModelPortaliQ6DWJ6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000458791.

Chemistry databases

ChEMBLiCHEMBL3632455.
GuidetoPHARMACOLOGYi130.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ6DWJ6.
PhosphoSitePlusiQ6DWJ6.

Polymorphism and mutation databases

BioMutaiGPR139.
DMDMi74762300.

Proteomic databases

PaxDbiQ6DWJ6.
PRIDEiQ6DWJ6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000570682; ENSP00000458791; ENSG00000180269.
GeneIDi124274.
KEGGihsa:124274.
UCSCiuc002dgu.2. human.

Organism-specific databases

CTDi124274.
GeneCardsiGPR139.
HGNCiHGNC:19995. GPR139.
HPAiHPA046596.
neXtProtiNX_Q6DWJ6.
OpenTargetsiENSG00000180269.
PharmGKBiPA134970866.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00390000006613.
HOGENOMiHOG000231257.
HOVERGENiHBG081564.
InParanoidiQ6DWJ6.
KOiK08428.
OMAiHSHIFSA.
OrthoDBiEOG091G0HIF.
PhylomeDBiQ6DWJ6.
TreeFamiTF334275.

Miscellaneous databases

GeneWikiiGPR139.
GenomeRNAii124274.
PROiQ6DWJ6.

Gene expression databases

BgeeiENSG00000180269.
CleanExiHS_GPR139.
ExpressionAtlasiQ6DWJ6. baseline and differential.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGP139_HUMAN
AccessioniPrimary (citable) accession number: Q6DWJ6
Secondary accession number(s): A8K5R9, Q86SP2, Q8TDU8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: August 16, 2004
Last modified: November 30, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.