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Q6DV79

- STAT3_CHICK

UniProt

Q6DV79 - STAT3_CHICK

Protein

Signal transducer and activator of transcription 3

Gene

STAT3

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 2 (02 Sep 2008)
      Previous versions | rss
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    Functioni

    Transcription factor that binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes.By similarity

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. DNA binding Source: UniProtKB
    3. ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Source: Ensembl
    4. protein dimerization activity Source: UniProtKB
    5. protein kinase binding Source: UniProtKB
    6. sequence-specific DNA binding Source: Ensembl
    7. signal transducer activity Source: InterPro
    8. transcription factor binding Source: AgBase
    9. transcription regulatory region DNA binding Source: Ensembl

    GO - Biological processi

    1. astrocyte differentiation Source: Ensembl
    2. cell proliferation Source: Ensembl
    3. eating behavior Source: UniProtKB
    4. eye photoreceptor cell differentiation Source: UniProtKB
    5. glucose homeostasis Source: UniProtKB
    6. interleukin-6-mediated signaling pathway Source: Ensembl
    7. JAK-STAT cascade involved in growth hormone signaling pathway Source: UniProtKB
    8. negative regulation of neuron migration Source: Ensembl
    9. phosphorylation Source: Ensembl
    10. positive regulation of Notch signaling pathway Source: Ensembl
    11. positive regulation of transcription, DNA-templated Source: UniProtKB
    12. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    13. protein import into nucleus Source: Ensembl
    14. radial glial cell differentiation Source: Ensembl
    15. regulation of multicellular organism growth Source: AgBase
    16. regulation of transcription, DNA-templated Source: AgBase
    17. regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    18. sexual reproduction Source: UniProtKB
    19. stem cell maintenance Source: Ensembl
    20. temperature homeostasis Source: UniProtKB
    21. transcription from RNA polymerase II promoter Source: AgBase

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_194391. Signaling by SCF-KIT.
    REACT_194398. Signaling by Leptin.
    REACT_197119. Interleukin-6 signaling.
    REACT_197455. Growth hormone receptor signaling.
    REACT_198215. Signaling by FGFR1 fusion mutants.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Signal transducer and activator of transcription 3
    Gene namesi
    Name:STAT3
    ORF Names:RCJMB04_38l20
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Chromosome 27

    Subcellular locationi

    Cytoplasm. Nucleus
    Note: Shuttles between the nucleus and the cytoplasm. Constitutive nuclear presence is independent of tyrosine phosphorylation By similarity.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. nucleus Source: UniProtKB
    3. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 771771Signal transducer and activator of transcription 3PRO_0000347217Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei706 – 7061Phosphotyrosine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ6DV79.
    PRIDEiQ6DV79.

    Interactioni

    Subunit structurei

    Forms a homodimer or a heterodimer with a related family member, such as STAT1.By similarity

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini580 – 67091SH2PROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi150 – 16213Essential for nuclear importBy similarityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the transcription factor STAT family.Curated
    Contains 1 SH2 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH2 domain

    Phylogenomic databases

    eggNOGiNOG303257.
    GeneTreeiENSGT00750000117596.
    HOGENOMiHOG000220792.
    HOVERGENiHBG055669.
    InParanoidiQ6DV79.
    KOiK04692.
    PhylomeDBiQ6DV79.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    1.10.532.10. 1 hit.
    1.20.1050.20. 1 hit.
    2.60.40.630. 1 hit.
    3.30.505.10. 1 hit.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR008967. p53-like_TF_DNA-bd.
    IPR000980. SH2.
    IPR001217. STAT.
    IPR013800. STAT_TF_alpha.
    IPR015988. STAT_TF_coiled-coil.
    IPR013801. STAT_TF_DNA-bd.
    IPR012345. STAT_TF_DNA-bd_sub.
    IPR013799. STAT_TF_prot_interaction.
    [Graphical view]
    PANTHERiPTHR11801. PTHR11801. 1 hit.
    PfamiPF00017. SH2. 1 hit.
    PF01017. STAT_alpha. 1 hit.
    PF02864. STAT_bind. 1 hit.
    PF02865. STAT_int. 1 hit.
    [Graphical view]
    SMARTiSM00252. SH2. 1 hit.
    SM00964. STAT_int. 1 hit.
    [Graphical view]
    SUPFAMiSSF47655. SSF47655. 1 hit.
    SSF48092. SSF48092. 1 hit.
    SSF49417. SSF49417. 1 hit.
    SSF55550. SSF55550. 1 hit.
    PROSITEiPS50001. SH2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6DV79-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAQWNQLQQL DTRYLEQLHQ LYSDSFPMEL RQFLAPWIES QDWAYAANKE    50
    SHATLVFHNL LGEIDQQYSR FLQESNVLYQ HNLRRIKQFL QSRYLEKPME 100
    IARIVARCLW EESRLLQTAA TAAQQGGQAT HPTAAVVTEK QQMLEQHLQD 150
    VRKRVQDLEQ KMKVVENLQD DFDFNYKTLK SQGDMQDLNG NNQSVTRQKM 200
    QQLEQMLTAL DQMRRGIVSE LAGLLSAMEY VQKMLADEEL ADWKRRQQIA 250
    CIGGPPNICL DRLENWITSL AESQLQTRQQ IKKLEELQQK VSYKGDPIVQ 300
    HRPMLEERIV ELFRNLMKSA FVVERQPCMP MHPDRPLVIK TGVQFTTKVR 350
    LLVKFPELNY QLKIKVCIDK DSGDVAALRG SRKFNILGTN TKVMNMEESN 400
    NGSLSAEFKH LTLREQRCGN GGRANCDASL IVTEELHLIT FETEVYHQGL 450
    KIDLETHSLP VVVISNICQM PNAWASILWY NMLTNNPKNV NFFTKPPIGT 500
    WDQVAEVLSW QFSSTTKRGL SIEQLTTLAE KLLGPGVNYS GCQITWAKFC 550
    KENMAGKGFS FWVWLDNIID LVKKYILALW NEGYIMGFIS KERERAILST 600
    KPPGTFLLRF SESSKEGGIT FTWVEKDISG KTQIQSVEPY TKQQLNSMSF 650
    AEIIMGYKIM DATNILVSPL VYLYPDIPKE EAFGKYCRSE SQEHSEATDS 700
    GSAAPYLKTK FICVTPTSFS NTIDLPMSPR TLDSLMQFGN SSEGAEANAG 750
    GQFESLTFDM ELTQECASSP M 771
    Length:771
    Mass (Da):88,171
    Last modified:September 2, 2008 - v2
    Checksum:iBC4B668CE787010B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti23 – 231S → G in AAT64887. 1 PublicationCurated
    Sequence conflicti339 – 3391I → F in AAT64887. 1 PublicationCurated
    Sequence conflicti542 – 5421Missing in CAH65453. (PubMed:15642098)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY641397 mRNA. Translation: AAT64887.1.
    AJ851819 mRNA. Translation: CAH65453.1.
    RefSeqiNP_001026102.1. NM_001030931.1.
    UniGeneiGga.32114.

    Genome annotation databases

    EnsembliENSGALT00000005170; ENSGALP00000005161; ENSGALG00000003267.
    GeneIDi420027.
    KEGGigga:420027.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY641397 mRNA. Translation: AAT64887.1 .
    AJ851819 mRNA. Translation: CAH65453.1 .
    RefSeqi NP_001026102.1. NM_001030931.1.
    UniGenei Gga.32114.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi Q6DV79.
    PRIDEi Q6DV79.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSGALT00000005170 ; ENSGALP00000005161 ; ENSGALG00000003267 .
    GeneIDi 420027.
    KEGGi gga:420027.

    Organism-specific databases

    CTDi 6774.

    Phylogenomic databases

    eggNOGi NOG303257.
    GeneTreei ENSGT00750000117596.
    HOGENOMi HOG000220792.
    HOVERGENi HBG055669.
    InParanoidi Q6DV79.
    KOi K04692.
    PhylomeDBi Q6DV79.

    Enzyme and pathway databases

    Reactomei REACT_194391. Signaling by SCF-KIT.
    REACT_194398. Signaling by Leptin.
    REACT_197119. Interleukin-6 signaling.
    REACT_197455. Growth hormone receptor signaling.
    REACT_198215. Signaling by FGFR1 fusion mutants.

    Miscellaneous databases

    NextBioi 20822997.
    PROi Q6DV79.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    1.10.532.10. 1 hit.
    1.20.1050.20. 1 hit.
    2.60.40.630. 1 hit.
    3.30.505.10. 1 hit.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR008967. p53-like_TF_DNA-bd.
    IPR000980. SH2.
    IPR001217. STAT.
    IPR013800. STAT_TF_alpha.
    IPR015988. STAT_TF_coiled-coil.
    IPR013801. STAT_TF_DNA-bd.
    IPR012345. STAT_TF_DNA-bd_sub.
    IPR013799. STAT_TF_prot_interaction.
    [Graphical view ]
    PANTHERi PTHR11801. PTHR11801. 1 hit.
    Pfami PF00017. SH2. 1 hit.
    PF01017. STAT_alpha. 1 hit.
    PF02864. STAT_bind. 1 hit.
    PF02865. STAT_int. 1 hit.
    [Graphical view ]
    SMARTi SM00252. SH2. 1 hit.
    SM00964. STAT_int. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47655. SSF47655. 1 hit.
    SSF48092. SSF48092. 1 hit.
    SSF49417. SSF49417. 1 hit.
    SSF55550. SSF55550. 1 hit.
    PROSITEi PS50001. SH2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of 5' flanking sequence of chicken SOCS2 gene."
      Zhou G.Y., Leung F.C.
      Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: CB.
      Tissue: Bursa of Fabricius.
    3. "Biological activity of recombinant chicken interleukin-6 in chicken hybridoma cells."
      Nishimichi N., Aosasa M., Kawashima T., Horiuchi H., Furusawa S., Matsuda H.
      Vet. Immunol. Immunopathol. 106:97-105(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, PHOSPHORYLATION AT TYR-706.

    Entry informationi

    Entry nameiSTAT3_CHICK
    AccessioniPrimary (citable) accession number: Q6DV79
    Secondary accession number(s): Q5F331
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 2, 2008
    Last sequence update: September 2, 2008
    Last modified: October 1, 2014
    This is version 80 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Involved in the gp130-mediated signaling pathway.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3