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Q6DV79

- STAT3_CHICK

UniProt

Q6DV79 - STAT3_CHICK

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Protein
Signal transducer and activator of transcription 3
Gene
STAT3, RCJMB04_38l20
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Transcription factor that binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes By similarity.1 Publication

GO - Molecular functioni

  1. DNA binding Source: UniProtKB
  2. calcium ion binding Source: InterPro
  3. ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Source: Ensembl
  4. protein dimerization activity Source: UniProtKB
  5. protein kinase binding Source: UniProtKB
  6. sequence-specific DNA binding Source: Ensembl
  7. signal transducer activity Source: InterPro
  8. transcription factor binding Source: AgBase
  9. transcription regulatory region DNA binding Source: Ensembl

GO - Biological processi

  1. JAK-STAT cascade involved in growth hormone signaling pathway Source: UniProtKB
  2. astrocyte differentiation Source: Ensembl
  3. cell proliferation Source: Ensembl
  4. eating behavior Source: UniProtKB
  5. eye photoreceptor cell differentiation Source: UniProtKB
  6. glucose homeostasis Source: UniProtKB
  7. interleukin-6-mediated signaling pathway Source: Ensembl
  8. negative regulation of neuron migration Source: Ensembl
  9. phosphorylation Source: Ensembl
  10. positive regulation of Notch signaling pathway Source: Ensembl
  11. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  12. positive regulation of transcription, DNA-templated Source: UniProtKB
  13. protein import into nucleus Source: Ensembl
  14. radial glial cell differentiation Source: Ensembl
  15. regulation of multicellular organism growth Source: AgBase
  16. regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  17. regulation of transcription, DNA-templated Source: AgBase
  18. sexual reproduction Source: UniProtKB
  19. stem cell maintenance Source: Ensembl
  20. temperature homeostasis Source: UniProtKB
  21. transcription from RNA polymerase II promoter Source: AgBase
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_194391. Signaling by SCF-KIT.
REACT_194398. Signaling by Leptin.
REACT_197119. Interleukin-6 signaling.
REACT_197455. Growth hormone receptor signaling.
REACT_198215. Signaling by FGFR1 fusion mutants.

Names & Taxonomyi

Protein namesi
Recommended name:
Signal transducer and activator of transcription 3
Gene namesi
Name:STAT3
ORF Names:RCJMB04_38l20
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Chromosome 27

Subcellular locationi

Cytoplasm. Nucleus
Note: Shuttles between the nucleus and the cytoplasm. Constitutive nuclear presence is independent of tyrosine phosphorylation By similarity.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. nucleus Source: UniProtKB
  3. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 771771Signal transducer and activator of transcription 3
PRO_0000347217Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei706 – 7061Phosphotyrosine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6DV79.
PRIDEiQ6DV79.

Interactioni

Subunit structurei

Forms a homodimer or a heterodimer with a related family member, such as STAT1 By similarity.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini580 – 67091SH2
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi150 – 16213Essential for nuclear import By similarity
Add
BLAST

Sequence similaritiesi

Contains 1 SH2 domain.

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiNOG303257.
GeneTreeiENSGT00750000117596.
HOGENOMiHOG000220792.
HOVERGENiHBG055669.
InParanoidiQ6DV79.
KOiK04692.
PhylomeDBiQ6DV79.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.10.532.10. 1 hit.
1.20.1050.20. 1 hit.
2.60.40.630. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR008967. p53-like_TF_DNA-bd.
IPR000980. SH2.
IPR001217. STAT.
IPR013800. STAT_TF_alpha.
IPR015988. STAT_TF_coiled-coil.
IPR013801. STAT_TF_DNA-bd.
IPR012345. STAT_TF_DNA-bd_sub.
IPR013799. STAT_TF_prot_interaction.
[Graphical view]
PANTHERiPTHR11801. PTHR11801. 1 hit.
PfamiPF00017. SH2. 1 hit.
PF01017. STAT_alpha. 1 hit.
PF02864. STAT_bind. 1 hit.
PF02865. STAT_int. 1 hit.
[Graphical view]
SMARTiSM00252. SH2. 1 hit.
SM00964. STAT_int. 1 hit.
[Graphical view]
SUPFAMiSSF47655. SSF47655. 1 hit.
SSF48092. SSF48092. 1 hit.
SSF49417. SSF49417. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6DV79-1 [UniParc]FASTAAdd to Basket

« Hide

MAQWNQLQQL DTRYLEQLHQ LYSDSFPMEL RQFLAPWIES QDWAYAANKE    50
SHATLVFHNL LGEIDQQYSR FLQESNVLYQ HNLRRIKQFL QSRYLEKPME 100
IARIVARCLW EESRLLQTAA TAAQQGGQAT HPTAAVVTEK QQMLEQHLQD 150
VRKRVQDLEQ KMKVVENLQD DFDFNYKTLK SQGDMQDLNG NNQSVTRQKM 200
QQLEQMLTAL DQMRRGIVSE LAGLLSAMEY VQKMLADEEL ADWKRRQQIA 250
CIGGPPNICL DRLENWITSL AESQLQTRQQ IKKLEELQQK VSYKGDPIVQ 300
HRPMLEERIV ELFRNLMKSA FVVERQPCMP MHPDRPLVIK TGVQFTTKVR 350
LLVKFPELNY QLKIKVCIDK DSGDVAALRG SRKFNILGTN TKVMNMEESN 400
NGSLSAEFKH LTLREQRCGN GGRANCDASL IVTEELHLIT FETEVYHQGL 450
KIDLETHSLP VVVISNICQM PNAWASILWY NMLTNNPKNV NFFTKPPIGT 500
WDQVAEVLSW QFSSTTKRGL SIEQLTTLAE KLLGPGVNYS GCQITWAKFC 550
KENMAGKGFS FWVWLDNIID LVKKYILALW NEGYIMGFIS KERERAILST 600
KPPGTFLLRF SESSKEGGIT FTWVEKDISG KTQIQSVEPY TKQQLNSMSF 650
AEIIMGYKIM DATNILVSPL VYLYPDIPKE EAFGKYCRSE SQEHSEATDS 700
GSAAPYLKTK FICVTPTSFS NTIDLPMSPR TLDSLMQFGN SSEGAEANAG 750
GQFESLTFDM ELTQECASSP M 771
Length:771
Mass (Da):88,171
Last modified:September 2, 2008 - v2
Checksum:iBC4B668CE787010B
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti23 – 231S → G in AAT64887. 1 Publication
Sequence conflicti339 – 3391I → F in AAT64887. 1 Publication
Sequence conflicti542 – 5421Missing in CAH65453. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY641397 mRNA. Translation: AAT64887.1.
AJ851819 mRNA. Translation: CAH65453.1.
RefSeqiNP_001026102.1. NM_001030931.1.
UniGeneiGga.32114.

Genome annotation databases

EnsembliENSGALT00000005170; ENSGALP00000005161; ENSGALG00000003267.
GeneIDi420027.
KEGGigga:420027.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY641397 mRNA. Translation: AAT64887.1 .
AJ851819 mRNA. Translation: CAH65453.1 .
RefSeqi NP_001026102.1. NM_001030931.1.
UniGenei Gga.32114.

3D structure databases

ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi Q6DV79.
PRIDEi Q6DV79.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSGALT00000005170 ; ENSGALP00000005161 ; ENSGALG00000003267 .
GeneIDi 420027.
KEGGi gga:420027.

Organism-specific databases

CTDi 6774.

Phylogenomic databases

eggNOGi NOG303257.
GeneTreei ENSGT00750000117596.
HOGENOMi HOG000220792.
HOVERGENi HBG055669.
InParanoidi Q6DV79.
KOi K04692.
PhylomeDBi Q6DV79.

Enzyme and pathway databases

Reactomei REACT_194391. Signaling by SCF-KIT.
REACT_194398. Signaling by Leptin.
REACT_197119. Interleukin-6 signaling.
REACT_197455. Growth hormone receptor signaling.
REACT_198215. Signaling by FGFR1 fusion mutants.

Miscellaneous databases

NextBioi 20822997.
PROi Q6DV79.

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
1.10.532.10. 1 hit.
1.20.1050.20. 1 hit.
2.60.40.630. 1 hit.
3.30.505.10. 1 hit.
InterProi IPR011992. EF-hand-dom_pair.
IPR008967. p53-like_TF_DNA-bd.
IPR000980. SH2.
IPR001217. STAT.
IPR013800. STAT_TF_alpha.
IPR015988. STAT_TF_coiled-coil.
IPR013801. STAT_TF_DNA-bd.
IPR012345. STAT_TF_DNA-bd_sub.
IPR013799. STAT_TF_prot_interaction.
[Graphical view ]
PANTHERi PTHR11801. PTHR11801. 1 hit.
Pfami PF00017. SH2. 1 hit.
PF01017. STAT_alpha. 1 hit.
PF02864. STAT_bind. 1 hit.
PF02865. STAT_int. 1 hit.
[Graphical view ]
SMARTi SM00252. SH2. 1 hit.
SM00964. STAT_int. 1 hit.
[Graphical view ]
SUPFAMi SSF47655. SSF47655. 1 hit.
SSF48092. SSF48092. 1 hit.
SSF49417. SSF49417. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEi PS50001. SH2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of 5' flanking sequence of chicken SOCS2 gene."
    Zhou G.Y., Leung F.C.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: CB.
    Tissue: Bursa of Fabricius.
  3. "Biological activity of recombinant chicken interleukin-6 in chicken hybridoma cells."
    Nishimichi N., Aosasa M., Kawashima T., Horiuchi H., Furusawa S., Matsuda H.
    Vet. Immunol. Immunopathol. 106:97-105(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, PHOSPHORYLATION AT TYR-706.

Entry informationi

Entry nameiSTAT3_CHICK
AccessioniPrimary (citable) accession number: Q6DV79
Secondary accession number(s): Q5F331
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: September 2, 2008
Last modified: September 3, 2014
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Involved in the gp130-mediated signaling pathway.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi