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Protein

Signal transducer and activator of transcription 3

Gene

STAT3

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor that binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes.By similarity

GO - Molecular functioni

  1. DNA binding Source: UniProtKB
  2. ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Source: Ensembl
  3. protein dimerization activity Source: UniProtKB
  4. protein kinase binding Source: UniProtKB
  5. sequence-specific DNA binding Source: Ensembl
  6. signal transducer activity Source: InterPro
  7. transcription factor binding Source: AgBase
  8. transcription regulatory region DNA binding Source: Ensembl

GO - Biological processi

  1. astrocyte differentiation Source: Ensembl
  2. cell proliferation Source: Ensembl
  3. eating behavior Source: UniProtKB
  4. eye photoreceptor cell differentiation Source: UniProtKB
  5. glucose homeostasis Source: UniProtKB
  6. interleukin-6-mediated signaling pathway Source: Ensembl
  7. JAK-STAT cascade involved in growth hormone signaling pathway Source: UniProtKB
  8. negative regulation of cell proliferation Source: Ensembl
  9. negative regulation of glycolytic process Source: Ensembl
  10. negative regulation of neuron migration Source: Ensembl
  11. phosphorylation Source: Ensembl
  12. positive regulation of Notch signaling pathway Source: Ensembl
  13. positive regulation of transcription, DNA-templated Source: UniProtKB
  14. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  15. protein import into nucleus Source: Ensembl
  16. radial glial cell differentiation Source: Ensembl
  17. regulation of multicellular organism growth Source: AgBase
  18. regulation of transcription, DNA-templated Source: AgBase
  19. regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  20. response to estradiol Source: Ensembl
  21. sexual reproduction Source: UniProtKB
  22. stem cell maintenance Source: Ensembl
  23. temperature homeostasis Source: UniProtKB
  24. transcription from RNA polymerase II promoter Source: AgBase
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_288933. Signaling by SCF-KIT.
REACT_306408. Signaling by Leptin.
REACT_309755. Signalling to STAT3.
REACT_317917. Signaling by FGFR1 fusion mutants.
REACT_327422. Growth hormone receptor signaling.
REACT_333012. Downstream signal transduction.
REACT_344336. Interleukin-6 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Signal transducer and activator of transcription 3
Gene namesi
Name:STAT3
ORF Names:RCJMB04_38l20
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539 Componenti: Chromosome 27

Subcellular locationi

  1. Cytoplasm
  2. Nucleus

  3. Note: Shuttles between the nucleus and the cytoplasm. Constitutive nuclear presence is independent of tyrosine phosphorylation (By similarity).By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. nucleus Source: UniProtKB
  3. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 771771Signal transducer and activator of transcription 3PRO_0000347217Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei706 – 7061Phosphotyrosine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6DV79.
PRIDEiQ6DV79.

Interactioni

Subunit structurei

Forms a homodimer or a heterodimer with a related family member, such as STAT1.By similarity

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini580 – 67091SH2PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi150 – 16213Essential for nuclear importBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the transcription factor STAT family.Curated
Contains 1 SH2 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiNOG303257.
GeneTreeiENSGT00760000119236.
HOGENOMiHOG000220792.
HOVERGENiHBG055669.
InParanoidiQ6DV79.
KOiK04692.
OMAiNKESHAT.
PhylomeDBiQ6DV79.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.10.532.10. 1 hit.
1.20.1050.20. 1 hit.
2.60.40.630. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR008967. p53-like_TF_DNA-bd.
IPR000980. SH2.
IPR001217. STAT.
IPR013800. STAT_TF_alpha.
IPR015988. STAT_TF_coiled-coil.
IPR013801. STAT_TF_DNA-bd.
IPR012345. STAT_TF_DNA-bd_sub.
IPR013799. STAT_TF_prot_interaction.
[Graphical view]
PANTHERiPTHR11801. PTHR11801. 1 hit.
PfamiPF00017. SH2. 1 hit.
PF01017. STAT_alpha. 1 hit.
PF02864. STAT_bind. 1 hit.
PF02865. STAT_int. 1 hit.
[Graphical view]
SMARTiSM00252. SH2. 1 hit.
SM00964. STAT_int. 1 hit.
[Graphical view]
SUPFAMiSSF47655. SSF47655. 1 hit.
SSF48092. SSF48092. 1 hit.
SSF49417. SSF49417. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6DV79-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQWNQLQQL DTRYLEQLHQ LYSDSFPMEL RQFLAPWIES QDWAYAANKE
60 70 80 90 100
SHATLVFHNL LGEIDQQYSR FLQESNVLYQ HNLRRIKQFL QSRYLEKPME
110 120 130 140 150
IARIVARCLW EESRLLQTAA TAAQQGGQAT HPTAAVVTEK QQMLEQHLQD
160 170 180 190 200
VRKRVQDLEQ KMKVVENLQD DFDFNYKTLK SQGDMQDLNG NNQSVTRQKM
210 220 230 240 250
QQLEQMLTAL DQMRRGIVSE LAGLLSAMEY VQKMLADEEL ADWKRRQQIA
260 270 280 290 300
CIGGPPNICL DRLENWITSL AESQLQTRQQ IKKLEELQQK VSYKGDPIVQ
310 320 330 340 350
HRPMLEERIV ELFRNLMKSA FVVERQPCMP MHPDRPLVIK TGVQFTTKVR
360 370 380 390 400
LLVKFPELNY QLKIKVCIDK DSGDVAALRG SRKFNILGTN TKVMNMEESN
410 420 430 440 450
NGSLSAEFKH LTLREQRCGN GGRANCDASL IVTEELHLIT FETEVYHQGL
460 470 480 490 500
KIDLETHSLP VVVISNICQM PNAWASILWY NMLTNNPKNV NFFTKPPIGT
510 520 530 540 550
WDQVAEVLSW QFSSTTKRGL SIEQLTTLAE KLLGPGVNYS GCQITWAKFC
560 570 580 590 600
KENMAGKGFS FWVWLDNIID LVKKYILALW NEGYIMGFIS KERERAILST
610 620 630 640 650
KPPGTFLLRF SESSKEGGIT FTWVEKDISG KTQIQSVEPY TKQQLNSMSF
660 670 680 690 700
AEIIMGYKIM DATNILVSPL VYLYPDIPKE EAFGKYCRSE SQEHSEATDS
710 720 730 740 750
GSAAPYLKTK FICVTPTSFS NTIDLPMSPR TLDSLMQFGN SSEGAEANAG
760 770
GQFESLTFDM ELTQECASSP M
Length:771
Mass (Da):88,171
Last modified:September 2, 2008 - v2
Checksum:iBC4B668CE787010B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti23 – 231S → G in AAT64887 (Ref. 1) Curated
Sequence conflicti339 – 3391I → F in AAT64887 (Ref. 1) Curated
Sequence conflicti542 – 5421Missing in CAH65453 (PubMed:15642098).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY641397 mRNA. Translation: AAT64887.1.
AJ851819 mRNA. Translation: CAH65453.1.
RefSeqiNP_001026102.1. NM_001030931.1.
UniGeneiGga.32114.

Genome annotation databases

EnsembliENSGALT00000005170; ENSGALP00000005161; ENSGALG00000003267.
GeneIDi420027.
KEGGigga:420027.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY641397 mRNA. Translation: AAT64887.1.
AJ851819 mRNA. Translation: CAH65453.1.
RefSeqiNP_001026102.1. NM_001030931.1.
UniGeneiGga.32114.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiQ6DV79.
PRIDEiQ6DV79.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000005170; ENSGALP00000005161; ENSGALG00000003267.
GeneIDi420027.
KEGGigga:420027.

Organism-specific databases

CTDi6774.

Phylogenomic databases

eggNOGiNOG303257.
GeneTreeiENSGT00760000119236.
HOGENOMiHOG000220792.
HOVERGENiHBG055669.
InParanoidiQ6DV79.
KOiK04692.
OMAiNKESHAT.
PhylomeDBiQ6DV79.

Enzyme and pathway databases

ReactomeiREACT_288933. Signaling by SCF-KIT.
REACT_306408. Signaling by Leptin.
REACT_309755. Signalling to STAT3.
REACT_317917. Signaling by FGFR1 fusion mutants.
REACT_327422. Growth hormone receptor signaling.
REACT_333012. Downstream signal transduction.
REACT_344336. Interleukin-6 signaling.

Miscellaneous databases

NextBioi20822997.
PROiQ6DV79.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.10.532.10. 1 hit.
1.20.1050.20. 1 hit.
2.60.40.630. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR008967. p53-like_TF_DNA-bd.
IPR000980. SH2.
IPR001217. STAT.
IPR013800. STAT_TF_alpha.
IPR015988. STAT_TF_coiled-coil.
IPR013801. STAT_TF_DNA-bd.
IPR012345. STAT_TF_DNA-bd_sub.
IPR013799. STAT_TF_prot_interaction.
[Graphical view]
PANTHERiPTHR11801. PTHR11801. 1 hit.
PfamiPF00017. SH2. 1 hit.
PF01017. STAT_alpha. 1 hit.
PF02864. STAT_bind. 1 hit.
PF02865. STAT_int. 1 hit.
[Graphical view]
SMARTiSM00252. SH2. 1 hit.
SM00964. STAT_int. 1 hit.
[Graphical view]
SUPFAMiSSF47655. SSF47655. 1 hit.
SSF48092. SSF48092. 1 hit.
SSF49417. SSF49417. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of 5' flanking sequence of chicken SOCS2 gene."
    Zhou G.Y., Leung F.C.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: CB.
    Tissue: Bursa of Fabricius.
  3. "Biological activity of recombinant chicken interleukin-6 in chicken hybridoma cells."
    Nishimichi N., Aosasa M., Kawashima T., Horiuchi H., Furusawa S., Matsuda H.
    Vet. Immunol. Immunopathol. 106:97-105(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, PHOSPHORYLATION AT TYR-706.

Entry informationi

Entry nameiSTAT3_CHICK
AccessioniPrimary (citable) accession number: Q6DV79
Secondary accession number(s): Q5F331
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: September 2, 2008
Last modified: April 1, 2015
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Involved in the gp130-mediated signaling pathway.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.