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Protein

Signal transducer and activator of transcription 3

Gene

STAT3

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor that binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes.By similarity1 Publication

Miscellaneous

Involved in the gp130-mediated signaling pathway.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-GGA-1059683 Interleukin-6 signaling
R-GGA-1266695 Interleukin-7 signaling
R-GGA-1433557 Signaling by SCF-KIT
R-GGA-186763 Downstream signal transduction
R-GGA-6783783 Interleukin-10 signaling
R-GGA-6785807 Interleukin-4 and 13 signaling
R-GGA-8854691 Interleukin-20 family signaling
R-GGA-8875791 MET activates STAT3
R-GGA-8983432 Interleukin-15 signaling
R-GGA-8984722 Interleukin-35 Signalling
R-GGA-9008059 Interleukin-37 signaling
R-GGA-9020933 Interleukin-23 signaling
R-GGA-9020956 Interleukin-27 signaling
R-GGA-9020958 Interleukin-21 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Signal transducer and activator of transcription 3
Gene namesi
Name:STAT3
ORF Names:RCJMB04_38l20
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 27

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003472171 – 771Signal transducer and activator of transcription 3Add BLAST771

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei706Phosphotyrosine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6DV79
PRIDEiQ6DV79

PTM databases

iPTMnetiQ6DV79

Expressioni

Gene expression databases

BgeeiENSGALG00000003267

Interactioni

Subunit structurei

Forms a homodimer or a heterodimer with a related family member, such as STAT1. Interacts with OCAD1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000005161

Structurei

3D structure databases

SMRiQ6DV79
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini580 – 670SH2PROSITE-ProRule annotationAdd BLAST91

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi150 – 162Essential for nuclear importBy similarityAdd BLAST13

Sequence similaritiesi

Belongs to the transcription factor STAT family.Curated

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiKOG3667 Eukaryota
ENOG410XPN8 LUCA
GeneTreeiENSGT00760000119236
HOGENOMiHOG000220792
HOVERGENiHBG055669
InParanoidiQ6DV79
KOiK04692
OMAiECASSPM
OrthoDBiEOG091G03O3
PhylomeDBiQ6DV79

Family and domain databases

CDDicd10374 SH2_STAT3, 1 hit
Gene3Di1.10.532.10, 1 hit
2.60.40.630, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR008967 p53-like_TF_DNA-bd
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR001217 STAT
IPR035855 STAT3_SH2
IPR036535 STAT_N_sf
IPR013800 STAT_TF_alpha
IPR015988 STAT_TF_coiled-coil
IPR013801 STAT_TF_DNA-bd
IPR012345 STAT_TF_DNA-bd_N
IPR013799 STAT_TF_prot_interaction
PANTHERiPTHR11801 PTHR11801, 1 hit
PfamiView protein in Pfam
PF00017 SH2, 1 hit
PF01017 STAT_alpha, 1 hit
PF02864 STAT_bind, 1 hit
PF02865 STAT_int, 1 hit
SMARTiView protein in SMART
SM00964 STAT_int, 1 hit
SUPFAMiSSF47655 SSF47655, 1 hit
SSF48092 SSF48092, 1 hit
SSF49417 SSF49417, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001 SH2, 1 hit

Sequencei

Sequence statusi: Complete.

Q6DV79-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQWNQLQQL DTRYLEQLHQ LYSDSFPMEL RQFLAPWIES QDWAYAANKE
60 70 80 90 100
SHATLVFHNL LGEIDQQYSR FLQESNVLYQ HNLRRIKQFL QSRYLEKPME
110 120 130 140 150
IARIVARCLW EESRLLQTAA TAAQQGGQAT HPTAAVVTEK QQMLEQHLQD
160 170 180 190 200
VRKRVQDLEQ KMKVVENLQD DFDFNYKTLK SQGDMQDLNG NNQSVTRQKM
210 220 230 240 250
QQLEQMLTAL DQMRRGIVSE LAGLLSAMEY VQKMLADEEL ADWKRRQQIA
260 270 280 290 300
CIGGPPNICL DRLENWITSL AESQLQTRQQ IKKLEELQQK VSYKGDPIVQ
310 320 330 340 350
HRPMLEERIV ELFRNLMKSA FVVERQPCMP MHPDRPLVIK TGVQFTTKVR
360 370 380 390 400
LLVKFPELNY QLKIKVCIDK DSGDVAALRG SRKFNILGTN TKVMNMEESN
410 420 430 440 450
NGSLSAEFKH LTLREQRCGN GGRANCDASL IVTEELHLIT FETEVYHQGL
460 470 480 490 500
KIDLETHSLP VVVISNICQM PNAWASILWY NMLTNNPKNV NFFTKPPIGT
510 520 530 540 550
WDQVAEVLSW QFSSTTKRGL SIEQLTTLAE KLLGPGVNYS GCQITWAKFC
560 570 580 590 600
KENMAGKGFS FWVWLDNIID LVKKYILALW NEGYIMGFIS KERERAILST
610 620 630 640 650
KPPGTFLLRF SESSKEGGIT FTWVEKDISG KTQIQSVEPY TKQQLNSMSF
660 670 680 690 700
AEIIMGYKIM DATNILVSPL VYLYPDIPKE EAFGKYCRSE SQEHSEATDS
710 720 730 740 750
GSAAPYLKTK FICVTPTSFS NTIDLPMSPR TLDSLMQFGN SSEGAEANAG
760 770
GQFESLTFDM ELTQECASSP M
Length:771
Mass (Da):88,171
Last modified:September 2, 2008 - v2
Checksum:iBC4B668CE787010B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23S → G in AAT64887 (Ref. 1) Curated1
Sequence conflicti339I → F in AAT64887 (Ref. 1) Curated1
Sequence conflicti542Missing in CAH65453 (PubMed:15642098).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY641397 mRNA Translation: AAT64887.1
AJ851819 mRNA Translation: CAH65453.1
RefSeqiNP_001026102.1, NM_001030931.1
XP_015155084.1, XM_015299598.1
XP_015155085.1, XM_015299599.1
UniGeneiGga.32114
Gga.48605

Genome annotation databases

EnsembliENSGALT00000005170; ENSGALP00000005161; ENSGALG00000003267
GeneIDi420027
KEGGigga:420027

Similar proteinsi

Entry informationi

Entry nameiSTAT3_CHICK
AccessioniPrimary (citable) accession number: Q6DV79
Secondary accession number(s): Q5F331
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: September 2, 2008
Last modified: April 25, 2018
This is version 114 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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