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Protein
Submitted name:

HLA class I histocompatibility antigen, alpha chain E

Gene

HLA-E

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the presentation of foreign antigens to the immune system.SAAS annotation

GO - Biological processi

Keywordsi

Biological processImmunity

Names & Taxonomyi

Protein namesi
Submitted name:
HLA class I histocompatibility antigen, alpha chain EImported
Submitted name:
HLA-E proteinImported
Submitted name:
MHC class I antigenImported
Submitted name:
MHC class Ib antigenImported
Submitted name:
Major histocompatibility complex, class I, EImported
Gene namesi
Name:HLA-EImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000204592.8.
HGNCiHGNC:4962. HLA-E.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei305 – 329HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane, MHC ISAAS annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000204592.
PharmGKBiPA35081.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_501097424822 – 358Sequence analysisAdd BLAST337

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSG00000204592.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini206 – 294Ig-likeInterPro annotationAdd BLAST89

Sequence similaritiesi

Belongs to the MHC class I family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiENOG410JD1V. Eukaryota.
ENOG410YKQA. LUCA.
GeneTreeiENSGT00760000118960.
HOVERGENiHBG016709.
KOiK06751.
OMAiSALTKTW.
OrthoDBiEOG091G09OH.
TreeFamiTF336617.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiView protein in InterPro
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
PfamiView protein in Pfam
PF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
PRINTSiPR01638. MHCCLASSI.
SMARTiView protein in SMART
SM00407. IGc1. 1 hit.
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6DU44-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVDGTLLLLL SEALALTQTW AGSHSLKYFH TSVSRPGRGE PRFISVGYVD
60 70 80 90 100
DTQFVRFDND AASPRMVPRA PWMEQEGSEY WDRETRSARD TAQIFRVNLR
110 120 130 140 150
TLRGYYNQSE AGSHTLQWMH GCELGPDGRF LRGYEQFAYD GKDYLTLNED
160 170 180 190 200
LRSWTAVDTA AQISEQKSND ASEAEHQRAY LEDTCVEWLH KYLEKGKETL
210 220 230 240 250
LHLEPPKTHV THHPISDHEA TLRCWALGFY PAEITLTWQQ DGEGHTQDTE
260 270 280 290 300
LVETRPAGDG TFQKWAAVVV PSGEEQRYTC HVQHEGLPEP VTLRWKPASQ
310 320 330 340 350
PTIPIVGIIA GLVLLGSVVS GAVVAAVIWR KKSSGGKGGS YSKAEWSDSA

QGSESHSL
Length:358
Mass (Da):40,058
Last modified:May 10, 2005 - v1
Checksum:i6B3001CA9F3B7FE3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL662873 Genomic DNA. No translation available.
CR382280 Genomic DNA. No translation available.
CR936916 Genomic DNA. No translation available.
BC040479 mRNA. Translation: AAH40479.1.
AY645727 Genomic DNA. Translation: AAT73210.1.
AY645731 Genomic DNA. Translation: AAT73214.1.
AY645733 Genomic DNA. Translation: AAT73216.1.
AY645736 Genomic DNA. Translation: AAT73219.1.
AY645737 Genomic DNA. Translation: AAT73220.1.
AY645738 Genomic DNA. Translation: AAT73221.1.
AY645740 Genomic DNA. Translation: AAT73223.1.
AY645741 Genomic DNA. Translation: AAT73224.1.
AB103600 Genomic DNA. Translation: BAF31260.1.
LM654512 Genomic DNA. Translation: CDX10595.1.
LT618796 Genomic DNA. Translation: SCQ83612.1.
RefSeqiNP_005507.3. NM_005516.5.
UniGeneiHs.650174.

Genome annotation databases

EnsembliENST00000376630; ENSP00000365817; ENSG00000204592.
ENST00000425603; ENSP00000402694; ENSG00000236632.
ENST00000444683; ENSP00000400458; ENSG00000225201.
GeneIDi3133.
KEGGihsa:3133.
UCSCiuc003nqg.4. human.

Similar proteinsi

Entry informationi

Entry nameiQ6DU44_HUMAN
AccessioniPrimary (citable) accession number: Q6DU44
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: September 27, 2017
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported