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Protein
Submitted name:

HLA-G histocompatibility antigen, class I, G, isoform CRA_a

Gene

HLA-G

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
HLA-G histocompatibility antigen, class I, G, isoform CRA_aImported
Submitted name:
MHC class I antigenImported
Submitted name:
MHC class Ib antigenImported
Submitted name:
Truncated MHC class I antigenImported
Gene namesi
Name:HLA-GImported
ORF Names:hCG_1999524Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei308 – 33225HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35083.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence analysisAdd
BLAST
Chaini25 – 338314Sequence analysisPRO_5007707937Add
BLAST

Keywords - PTMi

Disulfide bondSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000353472.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini209 – 28779Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the MHC class I family.UniRule annotation
Contains Ig-like C1-type (immunoglobulin-like) domain.SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiENOG410II5V. Eukaryota.
ENOG4111K8F. LUCA.
GeneTreeiENSGT00760000118960.
HOVERGENiHBG016709.
KOiK06751.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6DU14-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVVMAPRTLF LLLSGALTLT ETWAGSHSMR YFSAAVSRPG RGEPRFIAMG
60 70 80 90 100
YVDDTQFVRF DSDSACPRME PRAPWVEQEG PEYWEEETRN TKAHAQTDRM
110 120 130 140 150
NLQTLRGYYN QSEASSHTLQ WMIGCDLGSD GRLLRGYEQY AYDGKDYLAL
160 170 180 190 200
NEDLRSWTAA DTAAQISKRK CEAANVAEQR RAYLEGTCVE WLHRYLENGK
210 220 230 240 250
EMLQRADPPK THVTHHPVFD YEATLRCWAL GFYPAEIILT WQRDGEDQTQ
260 270 280 290 300
DVELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PEPLMLRWKQ
310 320 330
SSLPTIPIMG IVAGLVVLAA VVTGAAVAAV LWRKKSSD
Length:338
Mass (Da):38,224
Last modified:May 10, 2005 - v1
Checksum:i0678E263BE8962FF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF523298 Genomic DNA. Translation: AAM74993.1.
AF523300 Genomic DNA. Translation: AAM74994.1.
AF523301 Genomic DNA. Translation: AAM74995.1.
AF523302 Genomic DNA. Translation: AAM74996.1.
AF523305 Genomic DNA. Translation: AAM74999.1.
AF523306 Genomic DNA. Translation: AAM75000.1.
AF523309 Genomic DNA. Translation: AAM75003.1.
AY645760 Genomic DNA. Translation: AAT73243.1.
AY645761 Genomic DNA. Translation: AAT73244.1.
AY645762 Genomic DNA. Translation: AAT73245.1.
AY645763 Genomic DNA. Translation: AAT73246.1.
AY645764 Genomic DNA. Translation: AAT73247.1.
AY645765 Genomic DNA. Translation: AAT73248.1.
AY645766 Genomic DNA. Translation: AAT73249.1.
AY645768 Genomic DNA. Translation: AAT73251.1.
AY645769 Genomic DNA. Translation: AAT73252.1.
AY645770 Genomic DNA. Translation: AAT73253.1.
AY645771 Genomic DNA. Translation: AAT73254.1.
AY645774 Genomic DNA. Translation: AAT73257.1.
AY645775 Genomic DNA. Translation: AAT73258.1.
AY645776 Genomic DNA. Translation: AAT73259.1.
FJ805838 Genomic DNA. Translation: ACZ37195.1.
FJ805839 Genomic DNA. Translation: ACZ37196.1.
GU324263 Genomic DNA. Translation: ADB85517.1.
GQ996557 Genomic DNA. Translation: ADN34672.1.
GQ996563 Genomic DNA. Translation: ADN34678.1.
GQ996565 Genomic DNA. Translation: ADN34680.1.
GQ996566 Genomic DNA. Translation: ADN34681.1.
GQ996568 Genomic DNA. Translation: ADN34683.1.
GQ996569 Genomic DNA. Translation: ADN34684.1.
GU070582 Genomic DNA. Translation: ADP21921.1.
GU370776 Genomic DNA. Translation: ADQ89756.1.
HQ441165 Genomic DNA. Translation: AEQ39730.1.
JQ013008 Genomic DNA. Translation: AEZ53223.1.
JQ013009 Genomic DNA. Translation: AEZ53224.1.
CH471081 Genomic DNA. Translation: EAX03231.1.
CH471081 Genomic DNA. Translation: EAX03234.1.
CH471081 Genomic DNA. Translation: EAX03235.1.
RefSeqiNP_002118.1. NM_002127.5.
UniGeneiHs.512152.

Genome annotation databases

GeneIDi3135.
KEGGihsa:3135.
UCSCiuc003nnw.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF523298 Genomic DNA. Translation: AAM74993.1.
AF523300 Genomic DNA. Translation: AAM74994.1.
AF523301 Genomic DNA. Translation: AAM74995.1.
AF523302 Genomic DNA. Translation: AAM74996.1.
AF523305 Genomic DNA. Translation: AAM74999.1.
AF523306 Genomic DNA. Translation: AAM75000.1.
AF523309 Genomic DNA. Translation: AAM75003.1.
AY645760 Genomic DNA. Translation: AAT73243.1.
AY645761 Genomic DNA. Translation: AAT73244.1.
AY645762 Genomic DNA. Translation: AAT73245.1.
AY645763 Genomic DNA. Translation: AAT73246.1.
AY645764 Genomic DNA. Translation: AAT73247.1.
AY645765 Genomic DNA. Translation: AAT73248.1.
AY645766 Genomic DNA. Translation: AAT73249.1.
AY645768 Genomic DNA. Translation: AAT73251.1.
AY645769 Genomic DNA. Translation: AAT73252.1.
AY645770 Genomic DNA. Translation: AAT73253.1.
AY645771 Genomic DNA. Translation: AAT73254.1.
AY645774 Genomic DNA. Translation: AAT73257.1.
AY645775 Genomic DNA. Translation: AAT73258.1.
AY645776 Genomic DNA. Translation: AAT73259.1.
FJ805838 Genomic DNA. Translation: ACZ37195.1.
FJ805839 Genomic DNA. Translation: ACZ37196.1.
GU324263 Genomic DNA. Translation: ADB85517.1.
GQ996557 Genomic DNA. Translation: ADN34672.1.
GQ996563 Genomic DNA. Translation: ADN34678.1.
GQ996565 Genomic DNA. Translation: ADN34680.1.
GQ996566 Genomic DNA. Translation: ADN34681.1.
GQ996568 Genomic DNA. Translation: ADN34683.1.
GQ996569 Genomic DNA. Translation: ADN34684.1.
GU070582 Genomic DNA. Translation: ADP21921.1.
GU370776 Genomic DNA. Translation: ADQ89756.1.
HQ441165 Genomic DNA. Translation: AEQ39730.1.
JQ013008 Genomic DNA. Translation: AEZ53223.1.
JQ013009 Genomic DNA. Translation: AEZ53224.1.
CH471081 Genomic DNA. Translation: EAX03231.1.
CH471081 Genomic DNA. Translation: EAX03234.1.
CH471081 Genomic DNA. Translation: EAX03235.1.
RefSeqiNP_002118.1. NM_002127.5.
UniGeneiHs.512152.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000353472.

Protocols and materials databases

DNASUi3135.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3135.
KEGGihsa:3135.
UCSCiuc003nnw.2. human.

Organism-specific databases

CTDi3135.
PharmGKBiPA35083.

Phylogenomic databases

eggNOGiENOG410II5V. Eukaryota.
ENOG4111K8F. LUCA.
GeneTreeiENSGT00760000118960.
HOVERGENiHBG016709.
KOiK06751.

Miscellaneous databases

ChiTaRSiHLA-G. human.
GenomeRNAii3135.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The sequence of the human genome."
    Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G., Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D., Amanatides P., Ballew R.M., Huson D.H., Wortman J.R., Zhang Q., Kodira C.D., Zheng X.H.
    , Chen L., Skupski M., Subramanian G., Thomas P.D., Zhang J., Gabor Miklos G.L., Nelson C., Broder S., Clark A.G., Nadeau J., McKusick V.A., Zinder N., Levine A.J., Roberts R.J., Simon M., Slayman C., Hunkapiller M., Bolanos R., Delcher A., Dew I., Fasulo D., Flanigan M., Florea L., Halpern A., Hannenhalli S., Kravitz S., Levy S., Mobarry C., Reinert K., Remington K., Abu-Threideh J., Beasley E., Biddick K., Bonazzi V., Brandon R., Cargill M., Chandramouliswaran I., Charlab R., Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K., Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z., Guan P., Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A., Lai Z., Lei Y., Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V., Milshina N., Moore H.M., Naik A.K., Narayan V.A., Neelam B., Nusskern D., Rusch D.B., Salzberg S., Shao W., Shue B., Sun J., Wang Z., Wang A., Wang X., Wang J., Wei M., Wides R., Xiao C., Yan C., Yao A., Ye J., Zhan M., Zhang W., Zhang H., Zhao Q., Zheng L., Zhong F., Zhong W., Zhu S., Zhao S., Gilbert D., Baumhueter S., Spier G., Carter C., Cravchik A., Woodage T., Ali F., An H., Awe A., Baldwin D., Baden H., Barnstead M., Barrow I., Beeson K., Busam D., Carver A., Center A., Cheng M.L., Curry L., Danaher S., Davenport L., Desilets R., Dietz S., Dodson K., Doup L., Ferriera S., Garg N., Gluecksmann A., Hart B., Haynes J., Haynes C., Heiner C., Hladun S., Hostin D., Houck J., Howland T., Ibegwam C., Johnson J., Kalush F., Kline L., Koduru S., Love A., Mann F., May D., McCawley S., McIntosh T., McMullen I., Moy M., Moy L., Murphy B., Nelson K., Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M., Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C., Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N., Tse S., Vech C., Wang G., Wetter J., Williams S., Williams M., Windsor S., Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F., Guigo R., Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A., Mi H., Lazareva B., Hatton T., Narechania A., Diemer K., Muruganujan A., Guo N., Sato S., Bafna V., Istrail S., Lippert R., Schwartz R., Walenz B., Yooseph S., Allen D., Basu A., Baxendale J., Blick L., Caminha M., Carnes-Stine J., Caulk P., Chiang Y.H., Coyne M., Dahlke C., Mays A., Dombroski M., Donnelly M., Ely D., Esparham S., Fosler C., Gire H., Glanowski S., Glasser K., Glodek A., Gorokhov M., Graham K., Gropman B., Harris M., Heil J., Henderson S., Hoover J., Jennings D., Jordan C., Jordan J., Kasha J., Kagan L., Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., Ma D., Majoros W., McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., Nodell M., Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J., Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E., Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.
    Science 291:1304-1351(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. Pyo C.-W., Ishitani A., Moore Y.F., Geraghty D.E.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Afr-Am022Imported, Afr-Am022-1Imported, Afr-Am022-2Imported, Afr-Am022-3Imported, Afr-Am024Imported, CEPH1408Imported, CEPH1416-1Imported, CEPH1416-2Imported, Sea-CauImported, Sea-Cau-1Imported and Sea-Cau-2Imported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
  4. "HLA-E, HLA-F, and HLA-G polymorphism: genomic sequence defines haplotype structure and variation spanning the nonclassical class I genes."
    Pyo C.W., Williams L.M., Moore Y., Hyodo H., Li S.S., Zhao L.P., Sageshima N., Ishitani A., Geraghty D.E.
    Immunogenetics 58:241-251(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Afr-Am022Imported, Afr-Am022-1Imported, Afr-Am022-2Imported, Afr-Am022-3Imported, Afr-Am024Imported, CEPH1408Imported, CEPH1416-1Imported, CEPH1416-2Imported, Sea-CauImported, Sea-Cau-1Imported and Sea-Cau-2Imported.
  5. "The novel HLA-G*01010302 allele differs from G*01010301 by a single nucleotide change in intron 5."
    Cervera I., Herraiz M.A., Roman A., Vidart J., Martinez-Laso J.
    Tissue Antigens 74:463-464(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: CUI65-01Imported and CUI65-02Imported.
  6. "Evolution of MHC-G Alleles."
    Martinez Laso J., Cervera Hernandez I.
    Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  7. "Evolution of MHC-G Alleles."
    Martinez Laso J., Cervera Hernandez I.
    Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  8. "Evolution of MHC-G alleles."
    Jorge M.L., Isabel C.H.
    Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  9. Jorge M.L., Isabel C.H.
    Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  10. "Human leukocyte antigen-G allele polymorphisms have evolved following three different evolutionary lineages based on intron sequences."
    Cervera I., Herraiz M.A., Penaloza J., Barbolla M.L., Jurado M.L., Macedo J., Vidart J.A., Martinez-Laso J.
    Hum. Immunol. 71:1109-1115(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  11. "A new HLA-G allele."
    Martinez Laso J., Cervera I.
    Submitted (OCT-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  12. "Identification of two new HLA-G alleles, G*01:01:03:03 and G*01:01:21, in Brazilian individuals."
    Castelli E.C., de Albuquerque R.S., Veiga-Castelli L.C., Felicio L.P., Beachemin K., Faucher M.C., Moreau P., Donadi E.A., Roger M.
    Tissue Antigens 80:70-71(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ6DU14_HUMAN
AccessioniPrimary (citable) accession number: Q6DU14
Entry historyi
Integrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: July 6, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.