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Protein
Submitted name:

HLA-G histocompatibility antigen, class I, G, isoform CRA_a

Gene

HLA-G

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Names & Taxonomyi

Protein namesi
Submitted name:
HLA-G histocompatibility antigen, class I, G, isoform CRA_aImported
Submitted name:
MHC class I antigenImported
Submitted name:
MHC class Ib antigenImported
Submitted name:
Truncated MHC class I antigenImported
Gene namesi
Name:HLA-GImported
ORF Names:hCG_1999524Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei308 – 332HelicalSequence analysisAdd BLAST25

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35083.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_501014173025 – 338Sequence analysisAdd BLAST314

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

MaxQBiQ6DU14.

Expressioni

Gene expression databases

BgeeiENSG00000204632.
ExpressionAtlasiQ6DU14. baseline and differential.

Structurei

3D structure databases

SMRiQ6DU14.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini209 – 287Ig-like (immunoglobulin-like)InterPro annotationAdd BLAST79

Sequence similaritiesi

Belongs to the MHC class I family.UniRule annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410II5V. Eukaryota.
ENOG4111K8F. LUCA.
HOVERGENiHBG016709.
KOiK06751.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiView protein in InterPro
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
PfamiView protein in Pfam
PF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PRINTSiPR01638. MHCCLASSI.
SMARTiView protein in SMART
SM00407. IGc1. 1 hit.
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6DU14-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVVMAPRTLF LLLSGALTLT ETWAGSHSMR YFSAAVSRPG RGEPRFIAMG
60 70 80 90 100
YVDDTQFVRF DSDSACPRME PRAPWVEQEG PEYWEEETRN TKAHAQTDRM
110 120 130 140 150
NLQTLRGYYN QSEASSHTLQ WMIGCDLGSD GRLLRGYEQY AYDGKDYLAL
160 170 180 190 200
NEDLRSWTAA DTAAQISKRK CEAANVAEQR RAYLEGTCVE WLHRYLENGK
210 220 230 240 250
EMLQRADPPK THVTHHPVFD YEATLRCWAL GFYPAEIILT WQRDGEDQTQ
260 270 280 290 300
DVELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PEPLMLRWKQ
310 320 330
SSLPTIPIMG IVAGLVVLAA VVTGAAVAAV LWRKKSSD
Length:338
Mass (Da):38,224
Last modified:May 10, 2005 - v1
Checksum:i0678E263BE8962FF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF523298 Genomic DNA. Translation: AAM74993.1.
AF523300 Genomic DNA. Translation: AAM74994.1.
AF523301 Genomic DNA. Translation: AAM74995.1.
AF523302 Genomic DNA. Translation: AAM74996.1.
AF523305 Genomic DNA. Translation: AAM74999.1.
AF523306 Genomic DNA. Translation: AAM75000.1.
AF523309 Genomic DNA. Translation: AAM75003.1.
AY645760 Genomic DNA. Translation: AAT73243.1.
AY645761 Genomic DNA. Translation: AAT73244.1.
AY645762 Genomic DNA. Translation: AAT73245.1.
AY645763 Genomic DNA. Translation: AAT73246.1.
AY645764 Genomic DNA. Translation: AAT73247.1.
AY645765 Genomic DNA. Translation: AAT73248.1.
AY645766 Genomic DNA. Translation: AAT73249.1.
AY645768 Genomic DNA. Translation: AAT73251.1.
AY645769 Genomic DNA. Translation: AAT73252.1.
AY645770 Genomic DNA. Translation: AAT73253.1.
AY645771 Genomic DNA. Translation: AAT73254.1.
AY645774 Genomic DNA. Translation: AAT73257.1.
AY645775 Genomic DNA. Translation: AAT73258.1.
AY645776 Genomic DNA. Translation: AAT73259.1.
FJ805838 Genomic DNA. Translation: ACZ37195.1.
FJ805839 Genomic DNA. Translation: ACZ37196.1.
GU324263 Genomic DNA. Translation: ADB85517.1.
GQ996557 Genomic DNA. Translation: ADN34672.1.
GQ996563 Genomic DNA. Translation: ADN34678.1.
GQ996565 Genomic DNA. Translation: ADN34680.1.
GQ996566 Genomic DNA. Translation: ADN34681.1.
GQ996568 Genomic DNA. Translation: ADN34683.1.
GQ996569 Genomic DNA. Translation: ADN34684.1.
GU070582 Genomic DNA. Translation: ADP21921.1.
GU370776 Genomic DNA. Translation: ADQ89756.1.
HQ441165 Genomic DNA. Translation: AEQ39730.1.
JQ013008 Genomic DNA. Translation: AEZ53223.1.
JQ013009 Genomic DNA. Translation: AEZ53224.1.
CH471081 Genomic DNA. Translation: EAX03231.1.
CH471081 Genomic DNA. Translation: EAX03234.1.
CH471081 Genomic DNA. Translation: EAX03235.1.
RefSeqiNP_002118.1. NM_002127.5.
UniGeneiHs.512152.

Genome annotation databases

GeneIDi3135.
KEGGihsa:3135.
UCSCiuc003nnw.2. human.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiQ6DU14_HUMAN
AccessioniPrimary (citable) accession number: Q6DU14
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: July 5, 2017
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.