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Protein

Jouberin

Gene

Ahi1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in vesicle trafficking and required for ciliogenesis, formation of primary non-motile cilium, and recruitment of RAB8A to the basal body of primary cilium. Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Involved in neuronal differentiation.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cilium biogenesis/degradation, Differentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Jouberin
Alternative name(s):
Abelson helper integration site 1 protein homolog
Short name:
AHI-1
Gene namesi
Name:Ahi1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1303040. Ahi1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell projection, Cilium, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000508401 – 1047JouberinAdd BLAST1047

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei854PhosphoserineBy similarity1
Modified residuei975PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6DTM3.
PRIDEiQ6DTM3.

PTM databases

iPTMnetiQ6DTM3.
PhosphoSitePlusiQ6DTM3.

Interactioni

Subunit structurei

Self-associates. Part of the tectonic-like complex (also named B9 complex). Interacts with MKS1. Interacts with NPHP1; probably as heterodimers and/or AHI12:NPHP12 heterotetramers. Interacts (via SH3 domain) with the dynamin GTPase DNM2. Interacts with HAP1; probably as AHI12:HAP12 heterotetramers. Interacts with RAB8A. Interacts with CEND1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019077.

Structurei

3D structure databases

ProteinModelPortaliQ6DTM3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati458 – 500WD 1Add BLAST43
Repeati503 – 542WD 2Add BLAST40
Repeati546 – 586WD 3Add BLAST41
Repeati593 – 632WD 4Add BLAST40
Repeati649 – 688WD 5Add BLAST40
Repeati692 – 731WD 6Add BLAST40
Repeati736 – 777WD 7Add BLAST42
Domaini903 – 963SH3PROSITE-ProRule annotationAdd BLAST61

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 285Interaction with HAP1By similarityAdd BLAST285

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi87 – 95Poly-Lys9

Sequence similaritiesi

Contains 1 SH3 domain.PROSITE-ProRule annotation
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, SH3 domain, WD repeat

Phylogenomic databases

eggNOGiENOG410IQ0Z. Eukaryota.
ENOG410XVKN. LUCA.
HOGENOMiHOG000033864.
HOVERGENiHBG080824.
InParanoidiQ6DTM3.
KOiK16740.
PhylomeDBiQ6DTM3.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR001452. SH3_domain.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00018. SH3_1. 1 hit.
PF00400. WD40. 2 hits.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00326. SH3. 1 hit.
SM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF50978. SSF50978. 1 hit.
PROSITEiPS50002. SH3. 1 hit.
PS50082. WD_REPEATS_2. 4 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6DTM3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQETPEKVD SAQEKVRGKS QPADDSEDSR EKAGTEGTGE LTEAYELQVA
60 70 80 90 100
EEMAKEIKKK IRRKLKEQLT YFPPDTLLHD DKLGSEKRKK KKKKKVPVPA
110 120 130 140 150
KPETSPSDVC DSAAEGEQKK EGAPEGSHHR EGGCSTEQNA DASVPENTKP
160 170 180 190 200
KPKKMKKKPK AVSEDNEETN GDGVHEITGR DSPVHPKCLL DDDLVMGVYI
210 220 230 240 250
HRTDRLKSDF MISHPMVKIH VVDEHTGQYV KKDDSERPVS SYYEKDNVDY
260 270 280 290 300
ILPIMTQPYD FKKLKSRLPE WEEQVIFNEN FPYLLREFDE CPKVILFFEI
310 320 330 340 350
LDFLSMDEIK NNSEFQNQEC GFRKIAWAFL KLLGANGNAN INSKLRLQLY
360 370 380 390 400
YPPTKPRSQP NVVEVFEWWS KCPRNRYPST LYVTVRGLKV PDCIKPSYRS
410 420 430 440 450
MMALQEERGT PVYCERHRET SSVDTEPGLE DSKEEVKWKR LPGQACRIPN
460 470 480 490 500
KHLFSLNAGE RGCFCLDFSH NGRILAAACA SRDGYPIILY EIPSGRFMRE
510 520 530 540 550
LCGHLNIIYD LDWSKDDRYL VTSSSDGTAR VWKNEINSTS TFRVLPHPSF
560 570 580 590 600
VYTARFHPAT RELVVTGCYD SMIRIWKVDA REDAAILVRQ LDVHKSFVNS
610 620 630 640 650
ICFDDEGHHM YSGDCIGVIA VWDTYVKVTD VQHSVRHWTI NKEIKETEFR
660 670 680 690 700
GVPVSYLEVH PNGKRLLIHT KDSTLRIMDL RILAARKFVG AANYREKIHS
710 720 730 740 750
TLTPCGTLLF SGSEDGIVYV WNPETGEQVA MYSELPFKST IRDISYHPFE
760 770 780 790 800
NMVAFCAFGQ SEPILLYIYD FQVAQQEAEM LKRYSGTVPL PGIHLSEDAL
810 820 830 840 850
CTCPKLPQQG SFQIDEFVNT ENNSSRKIQL VKQRLETVTE VIRSCAAKVN
860 870 880 890 900
KNLSITSPPP GPAKKPRVKQ SFVLTTDQII HQFGVPQTAF ISIERRPFMR
910 920 930 940 950
PVDPPPMVVA LYDYTASRSD ELTIHRGDII RVFFKDNEDW WYGSLGKGQE
960 970 980 990 1000
GFFPANHVAS ETLYRDSPPK VKERSPPLTP KEKAKMEKPP ASRKSLIKDR
1010 1020 1030 1040
FLDSRLGSKP MGHSEKGRDQ NFEERGHKSD MEMKKSEPTV RKVTLIE
Length:1,047
Mass (Da):119,687
Last modified:August 16, 2004 - v1
Checksum:i7753D672860ECA58
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY647140 mRNA. Translation: AAT66919.1.
RefSeqiNP_001002277.1. NM_001002277.1.
UniGeneiRn.155144.

Genome annotation databases

GeneIDi308923.
KEGGirno:308923.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY647140 mRNA. Translation: AAT66919.1.
RefSeqiNP_001002277.1. NM_001002277.1.
UniGeneiRn.155144.

3D structure databases

ProteinModelPortaliQ6DTM3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019077.

PTM databases

iPTMnetiQ6DTM3.
PhosphoSitePlusiQ6DTM3.

Proteomic databases

PaxDbiQ6DTM3.
PRIDEiQ6DTM3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi308923.
KEGGirno:308923.

Organism-specific databases

CTDi54806.
RGDi1303040. Ahi1.

Phylogenomic databases

eggNOGiENOG410IQ0Z. Eukaryota.
ENOG410XVKN. LUCA.
HOGENOMiHOG000033864.
HOVERGENiHBG080824.
InParanoidiQ6DTM3.
KOiK16740.
PhylomeDBiQ6DTM3.

Miscellaneous databases

PROiQ6DTM3.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR001452. SH3_domain.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00018. SH3_1. 1 hit.
PF00400. WD40. 2 hits.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00326. SH3. 1 hit.
SM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF50978. SSF50978. 1 hit.
PROSITEiPS50002. SH3. 1 hit.
PS50082. WD_REPEATS_2. 4 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAHI1_RAT
AccessioniPrimary (citable) accession number: Q6DTM3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: August 16, 2004
Last modified: November 30, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.