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Protein

H/ACA ribonucleoprotein complex subunit 3

Gene

nop10

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • primitive hemopoiesis Source: ZFIN
  • pseudouridine synthesis Source: InterPro
  • rRNA processing Source: ZFIN
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

Ribosome biogenesis, rRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
H/ACA ribonucleoprotein complex subunit 3
Alternative name(s):
Nucleolar protein 10
Nucleolar protein family A member 3
snoRNP protein NOP10
Gene namesi
Name:nop10
Synonyms:nola3
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 7

Organism-specific databases

ZFINiZDB-GENE-041007-4. nop10.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6464H/ACA ribonucleoprotein complex subunit 3PRO_0000149003Add
BLAST

Proteomic databases

PaxDbiQ6DRH5.
PRIDEiQ6DRH5.

Expressioni

Gene expression databases

BgeeiQ6DRH5.

Interactioni

Subunit structurei

Component of the small nucleolar ribonucleoprotein particle containing H/ACA-type snoRNAs (H/ACA snoRNPs). Component of the telomerase holoenzyme complex (By similarity).By similarity

Protein-protein interaction databases

STRINGi7955.ENSDARP00000107682.

Structurei

3D structure databases

ProteinModelPortaliQ6DRH5.
SMRiQ6DRH5. Positions 1-58.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NOP10 family.Curated

Phylogenomic databases

eggNOGiKOG3503. Eukaryota.
COG2260. LUCA.
GeneTreeiENSGT00390000012563.
HOGENOMiHOG000159681.
HOVERGENiHBG080280.
InParanoidiQ6DRH5.
KOiK11130.
OMAiQRVTLKK.
OrthoDBiEOG79CZ2H.
PhylomeDBiQ6DRH5.
TreeFamiTF300211.

Family and domain databases

InterProiIPR007264. H/ACA_rnp_Nop10.
[Graphical view]
PANTHERiPTHR13305. PTHR13305. 1 hit.
PfamiPF04135. Nop10p. 1 hit.
[Graphical view]
SUPFAMiSSF144210. SSF144210. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6DRH5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLQFYLNEN GERVYTLKKV DPSGQPTSSA HPARFSPDDK FSRHRVTIKK
60
RFGLLLTQQP RPVL
Length:64
Mass (Da):7,446
Last modified:August 16, 2004 - v1
Checksum:i3651D096C9131E6F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY648784 mRNA. Translation: AAT68102.1.
BC095081 mRNA. Translation: AAH95081.1.
RefSeqiNP_001003868.1. NM_001003868.2.
UniGeneiDr.78253.

Genome annotation databases

EnsembliENSDART00000161015; ENSDARP00000132783; ENSDARG00000104227.
GeneIDi445391.
KEGGidre:445391.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY648784 mRNA. Translation: AAT68102.1.
BC095081 mRNA. Translation: AAH95081.1.
RefSeqiNP_001003868.1. NM_001003868.2.
UniGeneiDr.78253.

3D structure databases

ProteinModelPortaliQ6DRH5.
SMRiQ6DRH5. Positions 1-58.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000107682.

Proteomic databases

PaxDbiQ6DRH5.
PRIDEiQ6DRH5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000161015; ENSDARP00000132783; ENSDARG00000104227.
GeneIDi445391.
KEGGidre:445391.

Organism-specific databases

CTDi55505.
ZFINiZDB-GENE-041007-4. nop10.

Phylogenomic databases

eggNOGiKOG3503. Eukaryota.
COG2260. LUCA.
GeneTreeiENSGT00390000012563.
HOGENOMiHOG000159681.
HOVERGENiHBG080280.
InParanoidiQ6DRH5.
KOiK11130.
OMAiQRVTLKK.
OrthoDBiEOG79CZ2H.
PhylomeDBiQ6DRH5.
TreeFamiTF300211.

Miscellaneous databases

NextBioi20832096.
PROiQ6DRH5.

Gene expression databases

BgeeiQ6DRH5.

Family and domain databases

InterProiIPR007264. H/ACA_rnp_Nop10.
[Graphical view]
PANTHERiPTHR13305. PTHR13305. 1 hit.
PfamiPF04135. Nop10p. 1 hit.
[Graphical view]
SUPFAMiSSF144210. SSF144210. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.

Entry informationi

Entry nameiNOP10_DANRE
AccessioniPrimary (citable) accession number: Q6DRH5
Secondary accession number(s): Q504C4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: August 16, 2004
Last modified: December 9, 2015
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.