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Q6DR99 (Q6DR99_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names

Neuregulin-1 type III beta1-a EMBL AAT68240.1

Protein Nrg1 Ensembl ENSMUSP00000073546
Gene names
Name:Nrg1 Ensembl ENSMUSP00000073546 EMBL AAI51114.1 MGI 96083
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length700 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

Ontologies

Keywords
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processERBB signaling pathway

Inferred from electronic annotation. Source: Ensembl

MAPK cascade

Inferred from direct assay PubMed 8707830. Source: MGI

cardiac conduction system development

Inferred from direct assay PubMed 12149465. Source: MGI

cardiac muscle cell myoblast differentiation

Inferred from electronic annotation. Source: Ensembl

cell migration

Inferred from genetic interaction PubMed 9247262. Source: MGI

cell morphogenesis

Inferred from direct assay PubMed 9247262. Source: MGI

cell proliferation

Inferred from electronic annotation. Source: Ensembl

cellular protein complex disassembly

Inferred from electronic annotation. Source: Ensembl

embryo development

Inferred from electronic annotation. Source: InterPro

endocardial cell differentiation

Inferred from electronic annotation. Source: Ensembl

glial cell differentiation

Inferred from mutant phenotype PubMed 12649319PubMed 16606832. Source: MGI

glial cell fate commitment

Inferred from direct assay PubMed 21068328. Source: MGI

heart development

Inferred from mutant phenotype PubMed 7477375PubMed 8643489PubMed 9362461. Source: MGI

locomotory behavior

Inferred from mutant phenotype PubMed 10762692. Source: MGI

muscle organ development

Inferred from mutant phenotype PubMed 12495620. Source: MGI

negative regulation of cardiac muscle cell apoptotic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Inferred from electronic annotation. Source: Ensembl

negative regulation of protein catabolic process

Inferred from direct assay PubMed 20448149. Source: MGI

negative regulation of secretion

Inferred from electronic annotation. Source: Ensembl

negative regulation of transcription, DNA-templated

Inferred from sequence orthology PubMed 15073182. Source: MGI

nervous system development

Inferred from mutant phenotype PubMed 8643489. Source: MGI

neuron fate commitment

Inferred from mutant phenotype PubMed 11425901. Source: MGI

neurotransmitter receptor metabolic process

Inferred from mutant phenotype PubMed 9110980. Source: MGI

peripheral nervous system development

Inferred from mutant phenotype PubMed 7477375PubMed 9362461. Source: MGI

positive regulation of Ras protein signal transduction

Inferred from direct assay PubMed 8707830. Source: MGI

positive regulation of cardiac muscle cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell adhesion

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell growth

Inferred from electronic annotation. Source: Ensembl

positive regulation of protein kinase B signaling

Inferred from direct assay PubMed 20448149. Source: MGI

positive regulation of protein kinase activity

Inferred from direct assay PubMed 10597237PubMed 7816098. Source: MGI

regulation of cell differentiation

Inferred from mutant phenotype PubMed 11425901PubMed 9892702. Source: MGI

regulation of protein heterodimerization activity

Inferred from electronic annotation. Source: Ensembl

synapse assembly

Inferred from mutant phenotype PubMed 10707974. Source: MGI

ventricular cardiac muscle cell differentiation

Inferred from electronic annotation. Source: Ensembl

ventricular trabecula myocardium morphogenesis

Inferred from electronic annotation. Source: Ensembl

wound healing

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentapical plasma membrane

Inferred from electronic annotation. Source: Ensembl

axon

Inferred from direct assay PubMed 20220021. Source: MGI

cytoplasm

Inferred from direct assay PubMed 9789034. Source: MGI

extracellular space

Inferred from electronic annotation. Source: Ensembl

integral component of plasma membrane

Inferred from direct assay PubMed 11425901. Source: MGI

neuromuscular junction

Inferred from direct assay PubMed 7589796. Source: MGI

plasma membrane

Inferred from direct assay PubMed 9789034. Source: MGI

synapse

Inferred from direct assay PubMed 7816098. Source: MGI

   Molecular_functionErbB-2 class receptor binding

Inferred from direct assay PubMed 11425901. Source: MGI

protein tyrosine kinase activator activity

Inferred from electronic annotation. Source: Ensembl

transcription cofactor activity

Inferred from sequence orthology PubMed 15073182. Source: MGI

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q6DR99 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: 37D7928FD7D49AC9

FASTA70076,505
        10         20         30         40         50         60 
MEIYPPDMSE GAGGRSSSPS TQLSADPSLD GLPAAEHMPD THTEDGRSPG LLGLAVPCCV 

        70         80         90        100        110        120 
CLEAERLRGC LNSEKICIVP ILACLVSLCL CIAGLKWVFV DKIFEYDSPT HLDPGGLGQD 

       130        140        150        160        170        180 
PVISLDPTAA SAVLVSSEAY TSPVSKAQSE AEAHVTGQGD HVAVASEPSA VPTRKNRLSA 

       190        200        210        220        230        240 
FPPLHSTPPP FPSPARTPEV RTPKSGTQPQ TTETNLQTAP KLSTSTSTTG TSHLIKCAEK 

       250        260        270        280        290        300 
EKTFCVNGGE CFMVKDLSNP SRYLCKCPNE FTGDRCQNYV MASFYKHLGI EFMEAEELYQ 

       310        320        330        340        350        360 
KRVLTITGIC IALLVVGIMC VVAYCKTKKQ RQKLHDRLRQ SLRSERNNMV NIANGPHHPN 

       370        380        390        400        410        420 
PPPENVQLVN QYVSKNVISS EHIVEREVET SFSTSHYTST AHHSTTVTQT PSHSWSNGHT 

       430        440        450        460        470        480 
ESIISESHSV IMMSSVENSR HSSPAGGPRG RLHGLGGPRE CNSFLRHARE TPDSYRDSPH 

       490        500        510        520        530        540 
SERYVSAMTT PARMSPVDFH TPSSPKSPPS EMSPPVSSMT VSMPSVAVSP FVEEERPLLL 

       550        560        570        580        590        600 
VTPPRLREKK YDHHPQQLNS FHHNPAHQST SLPPSPLRIV EDEEYETTQE YEPIQEPIKK 

       610        620        630        640        650        660 
VTNSRRAKRT KPNGHIANRL EMDSNPSSVS SNSESETEDE RVGEDTPFLG IQNPLAASLE 

       670        680        690        700 
VAPAFRLAES RTNPAGRFST QEELQARLSS VIANQDPIAV 

« Hide

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. expand/collapse author list , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain EMBL AAI51114.1.
[2]"Inactivation of the receptor tyrosine kinase ErbB4 disrupts neuroblast migration and placement in the adult forebrain."
Anton E.S., Ghashghaei H.T., Weber J.L., McCann C., Fischer T.M., Cheung I.D., Gassmann M., Messing A., Klein R., Schwab M.H., Lloyd K.C., Lai C.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57/Bl6J EMBL AAT68240.1.
[3]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J Ensembl ENSMUSP00000073546.
[4]Ensembl
Submitted (FEB-2012) to UniProtKB
Cited for: IDENTIFICATION.
Strain: C57BL/6J Ensembl ENSMUSP00000073546.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC127374 Genomic DNA. No translation available.
AC132407 Genomic DNA. No translation available.
BC151113 mRNA. Translation: AAI51114.1.
AY648975 mRNA. Translation: AAT68240.1.
RefSeqNP_848706.2. NM_178591.2.
UniGeneMm.153432.
Mm.460675.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

DNASU211323.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000073884; ENSMUSP00000073546; ENSMUSG00000062991.
GeneID211323.
KEGGmmu:211323.
UCSCuc009ljo.1. mouse.

Organism-specific databases

CTD3084.
MGIMGI:96083. Nrg1.

Phylogenomic databases

GeneTreeENSGT00710000106660.
HOGENOMHOG000273863.
HOVERGENHBG006531.
InParanoidQ6DR99.
KOK05455.
OMASPFMEEE.
OrthoDBEOG7F7W86.
TreeFamTF332469.

Gene expression databases

GenevestigatorQ6DR99.

Family and domain databases

InterProIPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR018250. Neuregulin.
IPR002154. Neuregulin_1_C.
[Graphical view]
PfamPF02158. Neuregulin. 1 hit.
[Graphical view]
PRINTSPR01089. NEUREGULIN.
SMARTSM00181. EGF. 1 hit.
[Graphical view]
PROSITEPS00022. EGF_1. 1 hit.
PS50026. EGF_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio373200.
PMAP-CutDBQ6DR99.
PROQ6DR99.
SOURCESearch...

Entry information

Entry nameQ6DR99_MOUSE
AccessionPrimary (citable) accession number: Q6DR99
Entry history
Integrated into UniProtKB/TrEMBL: August 16, 2004
Last sequence update: August 16, 2004
Last modified: April 16, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)