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Protein
Submitted name:

Neuregulin 1

Gene

Nrg1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

  • activation of MAPK activity Source: Ensembl
  • activation of protein kinase B activity Source: Ensembl
  • axon ensheathment Source: MGI
  • brain development Source: MGI
  • cardiac conduction system development Source: MGI
  • cardiac muscle cell myoblast differentiation Source: Ensembl
  • cardiac muscle tissue development Source: MGI
  • cell migration Source: MGI
  • cell morphogenesis Source: MGI
  • cellular protein complex disassembly Source: MGI
  • chemorepulsion involved in interneuron migration from the subpallium to the cortex Source: MGI
  • embryo development Source: InterPro
  • endocardial cell differentiation Source: Ensembl
  • ERBB3 signaling pathway Source: Ensembl
  • glial cell differentiation Source: MGI
  • glial cell fate commitment Source: MGI
  • heart development Source: MGI
  • locomotory behavior Source: MGI
  • MAPK cascade Source: MGI
  • muscle organ development Source: MGI
  • negative regulation of neuron migration Source: MGI
  • negative regulation of protein catabolic process Source: MGI
  • negative regulation of secretion Source: Ensembl
  • negative regulation of transcription, DNA-templated Source: MGI
  • nervous system development Source: MGI
  • neurogenesis Source: MGI
  • neuron fate commitment Source: MGI
  • neurotransmitter receptor metabolic process Source: MGI
  • oligodendrocyte differentiation Source: MGI
  • peripheral nervous system development Source: MGI
  • positive regulation of axon extension Source: MGI
  • positive regulation of calcineurin-NFAT signaling cascade Source: MGI
  • positive regulation of cardiac muscle cell differentiation Source: BHF-UCL
  • positive regulation of cell proliferation Source: Ensembl
  • positive regulation of dendritic spine development Source: MGI
  • positive regulation of gene expression Source: MGI
  • positive regulation of myelination Source: MGI
  • positive regulation of peptidyl-tyrosine phosphorylation Source: MGI
  • positive regulation of phosphatidylinositol 3-kinase signaling Source: MGI
  • positive regulation of protein kinase activity Source: MGI
  • positive regulation of protein kinase B signaling Source: MGI
  • positive regulation of protein localization to cell surface Source: MGI
  • positive regulation of Ras protein signal transduction Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: MGI
  • regulation of cell differentiation Source: MGI
  • regulation of protein heterodimerization activity Source: Ensembl
  • startle response Source: MGI
  • synapse assembly Source: MGI
  • ventricular trabecula myocardium morphogenesis Source: Ensembl

Enzyme and pathway databases

ReactomeiR-MMU-1227986 Signaling by ERBB2
R-MMU-1236394 Signaling by ERBB4
R-MMU-1250196 SHC1 events in ERBB2 signaling
R-MMU-1250342 PI3K events in ERBB4 signaling
R-MMU-1250347 SHC1 events in ERBB4 signaling
R-MMU-1257604 PIP3 activates AKT signaling
R-MMU-1306955 GRB7 events in ERBB2 signaling
R-MMU-1358803 Downregulation of ERBB2:ERBB3 signaling
R-MMU-1963640 GRB2 events in ERBB2 signaling
R-MMU-1963642 PI3K events in ERBB2 signaling
R-MMU-5673001 RAF/MAP kinase cascade
R-MMU-6785631 ERBB2 Regulates Cell Motility
R-MMU-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-MMU-8847993 ERBB2 Activates PTK6 Signaling
R-MMU-8863795 Downregulation of ERBB2 signaling

Names & Taxonomyi

Protein namesi
Submitted name:
Neuregulin 1Imported
Submitted name:
Neuregulin-1 type III beta1-aImported
Gene namesi
Name:Nrg1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:96083 Nrg1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei76 – 99HelicalSequence analysisAdd BLAST24
Transmembranei303 – 325HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi267 ↔ 276PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000062991

Interactioni

GO - Molecular functioni

  • chemorepellent activity Source: MGI
  • ErbB-2 class receptor binding Source: MGI
  • ErbB-3 class receptor binding Source: Ensembl
  • integrin binding Source: Ensembl
  • receptor tyrosine kinase binding Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000073546

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini233 – 277EGF-likeInterPro annotationAdd BLAST45

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IEU9 Eukaryota
ENOG4110ST7 LUCA
GeneTreeiENSGT00900000140940
HOGENOMiHOG000273863
HOVERGENiHBG006531
KOiK05455
OrthoDBiEOG091G032E
TreeFamiTF332469

Family and domain databases

InterProiView protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR002154 Neuregulin_C
IPR018250 NRG1
PANTHERiPTHR11100:SF7 PTHR11100:SF7, 1 hit
PfamiView protein in Pfam
PF02158 Neuregulin, 1 hit
PRINTSiPR01089 NEUREGULIN
SMARTiView protein in SMART
SM00181 EGF, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 1 hit
PS50026 EGF_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q6DR99-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIYPPDMSE GAGGRSSSPS TQLSADPSLD GLPAAEHMPD THTEDGRSPG
60 70 80 90 100
LLGLAVPCCV CLEAERLRGC LNSEKICIVP ILACLVSLCL CIAGLKWVFV
110 120 130 140 150
DKIFEYDSPT HLDPGGLGQD PVISLDPTAA SAVLVSSEAY TSPVSKAQSE
160 170 180 190 200
AEAHVTGQGD HVAVASEPSA VPTRKNRLSA FPPLHSTPPP FPSPARTPEV
210 220 230 240 250
RTPKSGTQPQ TTETNLQTAP KLSTSTSTTG TSHLIKCAEK EKTFCVNGGE
260 270 280 290 300
CFMVKDLSNP SRYLCKCPNE FTGDRCQNYV MASFYKHLGI EFMEAEELYQ
310 320 330 340 350
KRVLTITGIC IALLVVGIMC VVAYCKTKKQ RQKLHDRLRQ SLRSERNNMV
360 370 380 390 400
NIANGPHHPN PPPENVQLVN QYVSKNVISS EHIVEREVET SFSTSHYTST
410 420 430 440 450
AHHSTTVTQT PSHSWSNGHT ESIISESHSV IMMSSVENSR HSSPAGGPRG
460 470 480 490 500
RLHGLGGPRE CNSFLRHARE TPDSYRDSPH SERYVSAMTT PARMSPVDFH
510 520 530 540 550
TPSSPKSPPS EMSPPVSSMT VSMPSVAVSP FVEEERPLLL VTPPRLREKK
560 570 580 590 600
YDHHPQQLNS FHHNPAHQST SLPPSPLRIV EDEEYETTQE YEPIQEPIKK
610 620 630 640 650
VTNSRRAKRT KPNGHIANRL EMDSNPSSVS SNSESETEDE RVGEDTPFLG
660 670 680 690 700
IQNPLAASLE VAPAFRLAES RTNPAGRFST QEELQARLSS VIANQDPIAV
Length:700
Mass (Da):76,505
Last modified:August 16, 2004 - v1
Checksum:i37D7928FD7D49AC9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC113586 Genomic DNA No translation available.
AC127369 Genomic DNA No translation available.
AC127374 Genomic DNA No translation available.
AC132256 Genomic DNA No translation available.
AC132407 Genomic DNA No translation available.
AC133091 Genomic DNA No translation available.
AC134895 Genomic DNA No translation available.
AC136147 Genomic DNA No translation available.
BC151113 mRNA Translation: AAI51114.1
AY648975 mRNA Translation: AAT68240.1
RefSeqiNP_848706.2, NM_178591.2
UniGeneiMm.153432
Mm.460675

Genome annotation databases

EnsembliENSMUST00000073884; ENSMUSP00000073546; ENSMUSG00000062991
GeneIDi211323
KEGGimmu:211323
UCSCiuc009ljo.1 mouse

Similar proteinsi

Entry informationi

Entry nameiQ6DR99_MOUSE
AccessioniPrimary (citable) accession number: Q6DR99
Entry historyiIntegrated into UniProtKB/TrEMBL: August 16, 2004
Last sequence update: August 16, 2004
Last modified: May 23, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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