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Q6DR99

- Q6DR99_MOUSE

UniProt

Q6DR99 - Q6DR99_MOUSE

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Protein
Submitted name:

Neuregulin 1

Gene

Nrg1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. ErbB-2 class receptor binding Source: MGI
  2. protein tyrosine kinase activator activity Source: Ensembl
  3. transcription cofactor activity Source: MGI

GO - Biological processi

  1. cardiac conduction system development Source: MGI
  2. cardiac muscle cell myoblast differentiation Source: Ensembl
  3. cell migration Source: MGI
  4. cell morphogenesis Source: MGI
  5. cell proliferation Source: Ensembl
  6. cellular protein complex disassembly Source: Ensembl
  7. embryo development Source: InterPro
  8. endocardial cell differentiation Source: Ensembl
  9. ERBB signaling pathway Source: Ensembl
  10. glial cell differentiation Source: MGI
  11. glial cell fate commitment Source: MGI
  12. heart development Source: MGI
  13. locomotory behavior Source: MGI
  14. MAPK cascade Source: MGI
  15. muscle organ development Source: MGI
  16. negative regulation of cardiac muscle cell apoptotic process Source: Ensembl
  17. negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
  18. negative regulation of protein catabolic process Source: MGI
  19. negative regulation of secretion Source: Ensembl
  20. negative regulation of transcription, DNA-templated Source: MGI
  21. nervous system development Source: MGI
  22. neuron fate commitment Source: MGI
  23. neurotransmitter receptor metabolic process Source: MGI
  24. peripheral nervous system development Source: MGI
  25. positive regulation of cardiac muscle cell differentiation Source: BHF-UCL
  26. positive regulation of cardiac muscle cell proliferation Source: Ensembl
  27. positive regulation of cell adhesion Source: Ensembl
  28. positive regulation of cell growth Source: Ensembl
  29. positive regulation of protein kinase activity Source: MGI
  30. positive regulation of protein kinase B signaling Source: MGI
  31. positive regulation of Ras protein signal transduction Source: MGI
  32. regulation of cell differentiation Source: MGI
  33. regulation of protein heterodimerization activity Source: Ensembl
  34. synapse assembly Source: MGI
  35. ventricular cardiac muscle cell differentiation Source: Ensembl
  36. ventricular trabecula myocardium morphogenesis Source: Ensembl
  37. wound healing Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_188191. Signaling by ERBB2.
REACT_188528. GRB2 events in ERBB2 signaling.
REACT_188574. SHC1 events in ERBB2 signaling.
REACT_188579. Signaling by ERBB4.
REACT_188580. SHC1 events in ERBB4 signaling.
REACT_196588. Constitutive PI3K/AKT Signaling in Cancer.
REACT_198574. Nuclear signaling by ERBB4.
REACT_199058. GRB7 events in ERBB2 signaling.
REACT_199061. Downregulation of ERBB2:ERBB3 signaling.
REACT_203296. PI3K events in ERBB4 signaling.
REACT_215348. PI3K events in ERBB2 signaling.
REACT_226341. PIP3 activates AKT signaling.

Names & Taxonomyi

Protein namesi
Submitted name:
Neuregulin 1Imported
Submitted name:
Neuregulin-1 type III beta1-aImported
Submitted name:
Protein Nrg1Imported
Gene namesi
Name:Nrg1Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:96083. Nrg1.

Subcellular locationi

GO - Cellular componenti

  1. apical plasma membrane Source: Ensembl
  2. axon Source: MGI
  3. cytoplasm Source: MGI
  4. extracellular space Source: Ensembl
  5. integral component of plasma membrane Source: MGI
  6. neuromuscular junction Source: MGI
  7. plasma membrane Source: MGI
  8. synapse Source: MGI
Complete GO annotation...

PTM / Processingi

Miscellaneous databases

PMAP-CutDBQ6DR99.

Expressioni

Gene expression databases

GenevestigatoriQ6DR99.

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00710000106660.
HOGENOMiHOG000273863.
HOVERGENiHBG006531.
KOiK05455.
OMAiSPFMEEE.
OrthoDBiEOG7F7W86.
TreeFamiTF332469.

Family and domain databases

InterProiIPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR018250. Neuregulin.
IPR002154. Neuregulin_1_C.
[Graphical view]
PfamiPF02158. Neuregulin. 1 hit.
[Graphical view]
PRINTSiPR01089. NEUREGULIN.
SMARTiSM00181. EGF. 1 hit.
[Graphical view]
PROSITEiPS00022. EGF_1. 1 hit.
PS50026. EGF_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6DR99-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEIYPPDMSE GAGGRSSSPS TQLSADPSLD GLPAAEHMPD THTEDGRSPG
60 70 80 90 100
LLGLAVPCCV CLEAERLRGC LNSEKICIVP ILACLVSLCL CIAGLKWVFV
110 120 130 140 150
DKIFEYDSPT HLDPGGLGQD PVISLDPTAA SAVLVSSEAY TSPVSKAQSE
160 170 180 190 200
AEAHVTGQGD HVAVASEPSA VPTRKNRLSA FPPLHSTPPP FPSPARTPEV
210 220 230 240 250
RTPKSGTQPQ TTETNLQTAP KLSTSTSTTG TSHLIKCAEK EKTFCVNGGE
260 270 280 290 300
CFMVKDLSNP SRYLCKCPNE FTGDRCQNYV MASFYKHLGI EFMEAEELYQ
310 320 330 340 350
KRVLTITGIC IALLVVGIMC VVAYCKTKKQ RQKLHDRLRQ SLRSERNNMV
360 370 380 390 400
NIANGPHHPN PPPENVQLVN QYVSKNVISS EHIVEREVET SFSTSHYTST
410 420 430 440 450
AHHSTTVTQT PSHSWSNGHT ESIISESHSV IMMSSVENSR HSSPAGGPRG
460 470 480 490 500
RLHGLGGPRE CNSFLRHARE TPDSYRDSPH SERYVSAMTT PARMSPVDFH
510 520 530 540 550
TPSSPKSPPS EMSPPVSSMT VSMPSVAVSP FVEEERPLLL VTPPRLREKK
560 570 580 590 600
YDHHPQQLNS FHHNPAHQST SLPPSPLRIV EDEEYETTQE YEPIQEPIKK
610 620 630 640 650
VTNSRRAKRT KPNGHIANRL EMDSNPSSVS SNSESETEDE RVGEDTPFLG
660 670 680 690 700
IQNPLAASLE VAPAFRLAES RTNPAGRFST QEELQARLSS VIANQDPIAV
Length:700
Mass (Da):76,505
Last modified:August 16, 2004 - v1
Checksum:i37D7928FD7D49AC9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC127374 Genomic DNA. No translation available.
AC132407 Genomic DNA. No translation available.
BC151113 mRNA. Translation: AAI51114.1.
AY648975 mRNA. Translation: AAT68240.1.
RefSeqiNP_848706.2. NM_178591.2.
UniGeneiMm.153432.
Mm.460675.

Genome annotation databases

EnsembliENSMUST00000073884; ENSMUSP00000073546; ENSMUSG00000062991.
GeneIDi211323.
KEGGimmu:211323.
UCSCiuc009ljo.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC127374 Genomic DNA. No translation available.
AC132407 Genomic DNA. No translation available.
BC151113 mRNA. Translation: AAI51114.1 .
AY648975 mRNA. Translation: AAT68240.1 .
RefSeqi NP_848706.2. NM_178591.2.
UniGenei Mm.153432.
Mm.460675.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

DNASUi 211323.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000073884 ; ENSMUSP00000073546 ; ENSMUSG00000062991 .
GeneIDi 211323.
KEGGi mmu:211323.
UCSCi uc009ljo.1. mouse.

Organism-specific databases

CTDi 3084.
MGIi MGI:96083. Nrg1.

Phylogenomic databases

GeneTreei ENSGT00710000106660.
HOGENOMi HOG000273863.
HOVERGENi HBG006531.
KOi K05455.
OMAi SPFMEEE.
OrthoDBi EOG7F7W86.
TreeFami TF332469.

Enzyme and pathway databases

Reactomei REACT_188191. Signaling by ERBB2.
REACT_188528. GRB2 events in ERBB2 signaling.
REACT_188574. SHC1 events in ERBB2 signaling.
REACT_188579. Signaling by ERBB4.
REACT_188580. SHC1 events in ERBB4 signaling.
REACT_196588. Constitutive PI3K/AKT Signaling in Cancer.
REACT_198574. Nuclear signaling by ERBB4.
REACT_199058. GRB7 events in ERBB2 signaling.
REACT_199061. Downregulation of ERBB2:ERBB3 signaling.
REACT_203296. PI3K events in ERBB4 signaling.
REACT_215348. PI3K events in ERBB2 signaling.
REACT_226341. PIP3 activates AKT signaling.

Miscellaneous databases

NextBioi 373200.
PMAP-CutDB Q6DR99.
PROi Q6DR99.
SOURCEi Search...

Gene expression databases

Genevestigatori Q6DR99.

Family and domain databases

InterProi IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR018250. Neuregulin.
IPR002154. Neuregulin_1_C.
[Graphical view ]
Pfami PF02158. Neuregulin. 1 hit.
[Graphical view ]
PRINTSi PR01089. NEUREGULIN.
SMARTi SM00181. EGF. 1 hit.
[Graphical view ]
PROSITEi PS00022. EGF_1. 1 hit.
PS50026. EGF_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: BrainImported.
  2. "Inactivation of the receptor tyrosine kinase ErbB4 disrupts neuroblast migration and placement in the adult forebrain."
    Anton E.S., Ghashghaei H.T., Weber J.L., McCann C., Fischer T.M., Cheung I.D., Gassmann M., Messing A., Klein R., Schwab M.H., Lloyd K.C., Lai C.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57/Bl6JImported.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  4. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ6DR99_MOUSE
AccessioniPrimary (citable) accession number: Q6DR99
Entry historyi
Integrated into UniProtKB/TrEMBL: August 16, 2004
Last sequence update: August 16, 2004
Last modified: October 29, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3