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Q6DR99

- Q6DR99_MOUSE

UniProt

Q6DR99 - Q6DR99_MOUSE

Protein
Submitted name:

Neuregulin 1

Gene

Nrg1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (16 Aug 2004)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. ErbB-2 class receptor binding Source: MGI
    2. protein tyrosine kinase activator activity Source: Ensembl
    3. transcription cofactor activity Source: MGI

    GO - Biological processi

    1. cardiac conduction system development Source: MGI
    2. cardiac muscle cell myoblast differentiation Source: Ensembl
    3. cell migration Source: MGI
    4. cell morphogenesis Source: MGI
    5. cell proliferation Source: Ensembl
    6. cellular protein complex disassembly Source: Ensembl
    7. embryo development Source: InterPro
    8. endocardial cell differentiation Source: Ensembl
    9. ERBB signaling pathway Source: Ensembl
    10. glial cell differentiation Source: MGI
    11. glial cell fate commitment Source: MGI
    12. heart development Source: MGI
    13. locomotory behavior Source: MGI
    14. MAPK cascade Source: MGI
    15. muscle organ development Source: MGI
    16. negative regulation of cardiac muscle cell apoptotic process Source: Ensembl
    17. negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
    18. negative regulation of protein catabolic process Source: MGI
    19. negative regulation of secretion Source: Ensembl
    20. negative regulation of transcription, DNA-templated Source: MGI
    21. nervous system development Source: MGI
    22. neuron fate commitment Source: MGI
    23. neurotransmitter receptor metabolic process Source: MGI
    24. peripheral nervous system development Source: MGI
    25. positive regulation of cardiac muscle cell differentiation Source: BHF-UCL
    26. positive regulation of cardiac muscle cell proliferation Source: Ensembl
    27. positive regulation of cell adhesion Source: Ensembl
    28. positive regulation of cell growth Source: Ensembl
    29. positive regulation of protein kinase activity Source: MGI
    30. positive regulation of protein kinase B signaling Source: MGI
    31. positive regulation of Ras protein signal transduction Source: MGI
    32. regulation of cell differentiation Source: MGI
    33. regulation of protein heterodimerization activity Source: Ensembl
    34. synapse assembly Source: MGI
    35. ventricular cardiac muscle cell differentiation Source: Ensembl
    36. ventricular trabecula myocardium morphogenesis Source: Ensembl
    37. wound healing Source: Ensembl

    Enzyme and pathway databases

    ReactomeiREACT_188191. Signaling by ERBB2.
    REACT_188528. GRB2 events in ERBB2 signaling.
    REACT_188574. SHC1 events in ERBB2 signaling.
    REACT_188579. Signaling by ERBB4.
    REACT_188580. SHC1 events in ERBB4 signaling.
    REACT_196588. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_198574. Nuclear signaling by ERBB4.
    REACT_199058. GRB7 events in ERBB2 signaling.
    REACT_199061. Downregulation of ERBB2:ERBB3 signaling.
    REACT_203296. PI3K events in ERBB4 signaling.
    REACT_215348. PI3K events in ERBB2 signaling.
    REACT_226341. PIP3 activates AKT signaling.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Neuregulin 1Imported
    Submitted name:
    Neuregulin-1 type III beta1-aImported
    Submitted name:
    Protein Nrg1Imported
    Gene namesi
    Name:Nrg1Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:96083. Nrg1.

    Subcellular locationi

    GO - Cellular componenti

    1. apical plasma membrane Source: Ensembl
    2. axon Source: MGI
    3. cytoplasm Source: MGI
    4. extracellular space Source: Ensembl
    5. integral component of plasma membrane Source: MGI
    6. neuromuscular junction Source: MGI
    7. plasma membrane Source: MGI
    8. synapse Source: MGI

    PTM / Processingi

    Miscellaneous databases

    PMAP-CutDBQ6DR99.

    Expressioni

    Gene expression databases

    GenevestigatoriQ6DR99.

    Family & Domainsi

    Phylogenomic databases

    GeneTreeiENSGT00710000106660.
    HOGENOMiHOG000273863.
    HOVERGENiHBG006531.
    InParanoidiQ6DR99.
    KOiK05455.
    OMAiSPFMEEE.
    OrthoDBiEOG7F7W86.
    TreeFamiTF332469.

    Family and domain databases

    InterProiIPR000742. EG-like_dom.
    IPR013032. EGF-like_CS.
    IPR018250. Neuregulin.
    IPR002154. Neuregulin_1_C.
    [Graphical view]
    PfamiPF02158. Neuregulin. 1 hit.
    [Graphical view]
    PRINTSiPR01089. NEUREGULIN.
    SMARTiSM00181. EGF. 1 hit.
    [Graphical view]
    PROSITEiPS00022. EGF_1. 1 hit.
    PS50026. EGF_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6DR99-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEIYPPDMSE GAGGRSSSPS TQLSADPSLD GLPAAEHMPD THTEDGRSPG    50
    LLGLAVPCCV CLEAERLRGC LNSEKICIVP ILACLVSLCL CIAGLKWVFV 100
    DKIFEYDSPT HLDPGGLGQD PVISLDPTAA SAVLVSSEAY TSPVSKAQSE 150
    AEAHVTGQGD HVAVASEPSA VPTRKNRLSA FPPLHSTPPP FPSPARTPEV 200
    RTPKSGTQPQ TTETNLQTAP KLSTSTSTTG TSHLIKCAEK EKTFCVNGGE 250
    CFMVKDLSNP SRYLCKCPNE FTGDRCQNYV MASFYKHLGI EFMEAEELYQ 300
    KRVLTITGIC IALLVVGIMC VVAYCKTKKQ RQKLHDRLRQ SLRSERNNMV 350
    NIANGPHHPN PPPENVQLVN QYVSKNVISS EHIVEREVET SFSTSHYTST 400
    AHHSTTVTQT PSHSWSNGHT ESIISESHSV IMMSSVENSR HSSPAGGPRG 450
    RLHGLGGPRE CNSFLRHARE TPDSYRDSPH SERYVSAMTT PARMSPVDFH 500
    TPSSPKSPPS EMSPPVSSMT VSMPSVAVSP FVEEERPLLL VTPPRLREKK 550
    YDHHPQQLNS FHHNPAHQST SLPPSPLRIV EDEEYETTQE YEPIQEPIKK 600
    VTNSRRAKRT KPNGHIANRL EMDSNPSSVS SNSESETEDE RVGEDTPFLG 650
    IQNPLAASLE VAPAFRLAES RTNPAGRFST QEELQARLSS VIANQDPIAV 700
    Length:700
    Mass (Da):76,505
    Last modified:August 16, 2004 - v1
    Checksum:i37D7928FD7D49AC9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC127374 Genomic DNA. No translation available.
    AC132407 Genomic DNA. No translation available.
    BC151113 mRNA. Translation: AAI51114.1.
    AY648975 mRNA. Translation: AAT68240.1.
    RefSeqiNP_848706.2. NM_178591.2.
    UniGeneiMm.153432.
    Mm.460675.

    Genome annotation databases

    EnsembliENSMUST00000073884; ENSMUSP00000073546; ENSMUSG00000062991.
    GeneIDi211323.
    KEGGimmu:211323.
    UCSCiuc009ljo.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC127374 Genomic DNA. No translation available.
    AC132407 Genomic DNA. No translation available.
    BC151113 mRNA. Translation: AAI51114.1 .
    AY648975 mRNA. Translation: AAT68240.1 .
    RefSeqi NP_848706.2. NM_178591.2.
    UniGenei Mm.153432.
    Mm.460675.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    DNASUi 211323.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000073884 ; ENSMUSP00000073546 ; ENSMUSG00000062991 .
    GeneIDi 211323.
    KEGGi mmu:211323.
    UCSCi uc009ljo.1. mouse.

    Organism-specific databases

    CTDi 3084.
    MGIi MGI:96083. Nrg1.

    Phylogenomic databases

    GeneTreei ENSGT00710000106660.
    HOGENOMi HOG000273863.
    HOVERGENi HBG006531.
    InParanoidi Q6DR99.
    KOi K05455.
    OMAi SPFMEEE.
    OrthoDBi EOG7F7W86.
    TreeFami TF332469.

    Enzyme and pathway databases

    Reactomei REACT_188191. Signaling by ERBB2.
    REACT_188528. GRB2 events in ERBB2 signaling.
    REACT_188574. SHC1 events in ERBB2 signaling.
    REACT_188579. Signaling by ERBB4.
    REACT_188580. SHC1 events in ERBB4 signaling.
    REACT_196588. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_198574. Nuclear signaling by ERBB4.
    REACT_199058. GRB7 events in ERBB2 signaling.
    REACT_199061. Downregulation of ERBB2:ERBB3 signaling.
    REACT_203296. PI3K events in ERBB4 signaling.
    REACT_215348. PI3K events in ERBB2 signaling.
    REACT_226341. PIP3 activates AKT signaling.

    Miscellaneous databases

    NextBioi 373200.
    PMAP-CutDB Q6DR99.
    PROi Q6DR99.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q6DR99.

    Family and domain databases

    InterProi IPR000742. EG-like_dom.
    IPR013032. EGF-like_CS.
    IPR018250. Neuregulin.
    IPR002154. Neuregulin_1_C.
    [Graphical view ]
    Pfami PF02158. Neuregulin. 1 hit.
    [Graphical view ]
    PRINTSi PR01089. NEUREGULIN.
    SMARTi SM00181. EGF. 1 hit.
    [Graphical view ]
    PROSITEi PS00022. EGF_1. 1 hit.
    PS50026. EGF_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: BrainImported.
    2. "Inactivation of the receptor tyrosine kinase ErbB4 disrupts neuroblast migration and placement in the adult forebrain."
      Anton E.S., Ghashghaei H.T., Weber J.L., McCann C., Fischer T.M., Cheung I.D., Gassmann M., Messing A., Klein R., Schwab M.H., Lloyd K.C., Lai C.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57/Bl6JImported.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    4. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiQ6DR99_MOUSE
    AccessioniPrimary (citable) accession number: Q6DR99
    Entry historyi
    Integrated into UniProtKB/TrEMBL: August 16, 2004
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3