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Protein
Submitted name:

Neuregulin 1

Gene

Nrg1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • activation of MAPK activity Source: Ensembl
  • activation of protein kinase B activity Source: Ensembl
  • activation of transmembrane receptor protein tyrosine kinase activity Source: GO_Central
  • axon ensheathment Source: MGI
  • brain development Source: MGI
  • cardiac conduction system development Source: MGI
  • cardiac muscle cell myoblast differentiation Source: Ensembl
  • cardiac muscle tissue development Source: MGI
  • cell migration Source: MGI
  • cell morphogenesis Source: MGI
  • cellular protein complex disassembly Source: MGI
  • chemorepulsion involved in interneuron migration from the subpallium to the cortex Source: MGI
  • embryo development Source: InterPro
  • endocardial cell differentiation Source: Ensembl
  • ERBB signaling pathway Source: Ensembl
  • glial cell differentiation Source: MGI
  • glial cell fate commitment Source: MGI
  • heart development Source: MGI
  • locomotory behavior Source: MGI
  • MAPK cascade Source: MGI
  • muscle organ development Source: MGI
  • negative regulation of neuron migration Source: MGI
  • negative regulation of protein catabolic process Source: MGI
  • negative regulation of secretion Source: Ensembl
  • negative regulation of transcription, DNA-templated Source: MGI
  • nervous system development Source: MGI
  • neurogenesis Source: MGI
  • neuron fate commitment Source: MGI
  • neurotransmitter receptor metabolic process Source: MGI
  • oligodendrocyte differentiation Source: MGI
  • peripheral nervous system development Source: MGI
  • positive regulation of axon extension Source: MGI
  • positive regulation of calcineurin-NFAT signaling cascade Source: MGI
  • positive regulation of cardiac muscle cell differentiation Source: BHF-UCL
  • positive regulation of cell proliferation Source: Ensembl
  • positive regulation of dendritic spine development Source: MGI
  • positive regulation of gene expression Source: MGI
  • positive regulation of myelination Source: MGI
  • positive regulation of peptidyl-tyrosine phosphorylation Source: MGI
  • positive regulation of phosphatidylinositol 3-kinase signaling Source: MGI
  • positive regulation of protein kinase activity Source: MGI
  • positive regulation of protein kinase B signaling Source: MGI
  • positive regulation of protein localization to cell surface Source: MGI
  • positive regulation of protein targeting to mitochondrion Source: Ensembl
  • positive regulation of Ras protein signal transduction Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • regulation of cell differentiation Source: MGI
  • regulation of protein heterodimerization activity Source: Ensembl
  • startle response Source: MGI
  • synapse assembly Source: MGI
  • ventricular trabecula myocardium morphogenesis Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-1227986. Signaling by ERBB2.
R-MMU-1236394. Signaling by ERBB4.
R-MMU-1250196. SHC1 events in ERBB2 signaling.
R-MMU-1250342. PI3K events in ERBB4 signaling.
R-MMU-1250347. SHC1 events in ERBB4 signaling.
R-MMU-1257604. PIP3 activates AKT signaling.
R-MMU-1306955. GRB7 events in ERBB2 signaling.
R-MMU-1358803. Downregulation of ERBB2:ERBB3 signaling.
R-MMU-1963640. GRB2 events in ERBB2 signaling.
R-MMU-1963642. PI3K events in ERBB2 signaling.
R-MMU-5673001. RAF/MAP kinase cascade.
R-MMU-6785631. ERBB2 Regulates Cell Motility.
R-MMU-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
R-MMU-8847993. ERBB2 Activates PTK6 Signaling.
R-MMU-8863795. Downregulation of ERBB2 signaling.

Names & Taxonomyi

Protein namesi
Submitted name:
Neuregulin 1Imported
Submitted name:
Neuregulin-1 type III beta1-aImported
Submitted name:
Protein Nrg1Imported
Gene namesi
Name:Nrg1Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:96083. Nrg1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei76 – 99HelicalSequence analysisAdd BLAST24
Transmembranei303 – 325HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

  • axolemma Source: MGI
  • axon Source: MGI
  • cell body Source: MGI
  • cytoplasm Source: MGI
  • dendrite Source: MGI
  • external side of plasma membrane Source: MGI
  • extracellular region Source: MGI
  • extracellular space Source: GO_Central
  • integral component of plasma membrane Source: MGI
  • neuromuscular junction Source: MGI
  • nucleus Source: MGI
  • plasma membrane Source: MGI
  • synapse Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSMUSG00000062991.

Interactioni

GO - Molecular functioni

  • ErbB-2 class receptor binding Source: MGI
  • receptor tyrosine kinase binding Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000073546.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini233 – 277EGF-likeInterPro annotationAdd BLAST45

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IEU9. Eukaryota.
ENOG4110ST7. LUCA.
GeneTreeiENSGT00800000124099.
HOGENOMiHOG000273863.
HOVERGENiHBG006531.
KOiK05455.
OrthoDBiEOG091G032E.
TreeFamiTF332469.

Family and domain databases

InterProiIPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR002154. Neuregulin_C.
IPR018250. NRG1.
[Graphical view]
PANTHERiPTHR11100:SF7. PTHR11100:SF7. 1 hit.
PfamiPF02158. Neuregulin. 1 hit.
[Graphical view]
PRINTSiPR01089. NEUREGULIN.
SMARTiSM00181. EGF. 1 hit.
[Graphical view]
PROSITEiPS00022. EGF_1. 1 hit.
PS50026. EGF_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6DR99-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIYPPDMSE GAGGRSSSPS TQLSADPSLD GLPAAEHMPD THTEDGRSPG
60 70 80 90 100
LLGLAVPCCV CLEAERLRGC LNSEKICIVP ILACLVSLCL CIAGLKWVFV
110 120 130 140 150
DKIFEYDSPT HLDPGGLGQD PVISLDPTAA SAVLVSSEAY TSPVSKAQSE
160 170 180 190 200
AEAHVTGQGD HVAVASEPSA VPTRKNRLSA FPPLHSTPPP FPSPARTPEV
210 220 230 240 250
RTPKSGTQPQ TTETNLQTAP KLSTSTSTTG TSHLIKCAEK EKTFCVNGGE
260 270 280 290 300
CFMVKDLSNP SRYLCKCPNE FTGDRCQNYV MASFYKHLGI EFMEAEELYQ
310 320 330 340 350
KRVLTITGIC IALLVVGIMC VVAYCKTKKQ RQKLHDRLRQ SLRSERNNMV
360 370 380 390 400
NIANGPHHPN PPPENVQLVN QYVSKNVISS EHIVEREVET SFSTSHYTST
410 420 430 440 450
AHHSTTVTQT PSHSWSNGHT ESIISESHSV IMMSSVENSR HSSPAGGPRG
460 470 480 490 500
RLHGLGGPRE CNSFLRHARE TPDSYRDSPH SERYVSAMTT PARMSPVDFH
510 520 530 540 550
TPSSPKSPPS EMSPPVSSMT VSMPSVAVSP FVEEERPLLL VTPPRLREKK
560 570 580 590 600
YDHHPQQLNS FHHNPAHQST SLPPSPLRIV EDEEYETTQE YEPIQEPIKK
610 620 630 640 650
VTNSRRAKRT KPNGHIANRL EMDSNPSSVS SNSESETEDE RVGEDTPFLG
660 670 680 690 700
IQNPLAASLE VAPAFRLAES RTNPAGRFST QEELQARLSS VIANQDPIAV
Length:700
Mass (Da):76,505
Last modified:August 16, 2004 - v1
Checksum:i37D7928FD7D49AC9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC113586 Genomic DNA. No translation available.
AC127369 Genomic DNA. No translation available.
AC127374 Genomic DNA. No translation available.
AC132256 Genomic DNA. No translation available.
AC132407 Genomic DNA. No translation available.
AC133091 Genomic DNA. No translation available.
AC134895 Genomic DNA. No translation available.
AC136147 Genomic DNA. No translation available.
BC151113 mRNA. Translation: AAI51114.1.
AY648975 mRNA. Translation: AAT68240.1.
RefSeqiNP_848706.2. NM_178591.2.
UniGeneiMm.153432.
Mm.460675.

Genome annotation databases

EnsembliENSMUST00000073884; ENSMUSP00000073546; ENSMUSG00000062991.
GeneIDi211323.
KEGGimmu:211323.
UCSCiuc009ljo.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC113586 Genomic DNA. No translation available.
AC127369 Genomic DNA. No translation available.
AC127374 Genomic DNA. No translation available.
AC132256 Genomic DNA. No translation available.
AC132407 Genomic DNA. No translation available.
AC133091 Genomic DNA. No translation available.
AC134895 Genomic DNA. No translation available.
AC136147 Genomic DNA. No translation available.
BC151113 mRNA. Translation: AAI51114.1.
AY648975 mRNA. Translation: AAT68240.1.
RefSeqiNP_848706.2. NM_178591.2.
UniGeneiMm.153432.
Mm.460675.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000073546.

Protocols and materials databases

DNASUi211323.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000073884; ENSMUSP00000073546; ENSMUSG00000062991.
GeneIDi211323.
KEGGimmu:211323.
UCSCiuc009ljo.1. mouse.

Organism-specific databases

CTDi3084.
MGIiMGI:96083. Nrg1.

Phylogenomic databases

eggNOGiENOG410IEU9. Eukaryota.
ENOG4110ST7. LUCA.
GeneTreeiENSGT00800000124099.
HOGENOMiHOG000273863.
HOVERGENiHBG006531.
KOiK05455.
OrthoDBiEOG091G032E.
TreeFamiTF332469.

Enzyme and pathway databases

ReactomeiR-MMU-1227986. Signaling by ERBB2.
R-MMU-1236394. Signaling by ERBB4.
R-MMU-1250196. SHC1 events in ERBB2 signaling.
R-MMU-1250342. PI3K events in ERBB4 signaling.
R-MMU-1250347. SHC1 events in ERBB4 signaling.
R-MMU-1257604. PIP3 activates AKT signaling.
R-MMU-1306955. GRB7 events in ERBB2 signaling.
R-MMU-1358803. Downregulation of ERBB2:ERBB3 signaling.
R-MMU-1963640. GRB2 events in ERBB2 signaling.
R-MMU-1963642. PI3K events in ERBB2 signaling.
R-MMU-5673001. RAF/MAP kinase cascade.
R-MMU-6785631. ERBB2 Regulates Cell Motility.
R-MMU-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
R-MMU-8847993. ERBB2 Activates PTK6 Signaling.
R-MMU-8863795. Downregulation of ERBB2 signaling.

Miscellaneous databases

PROiQ6DR99.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000062991.

Family and domain databases

InterProiIPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR002154. Neuregulin_C.
IPR018250. NRG1.
[Graphical view]
PANTHERiPTHR11100:SF7. PTHR11100:SF7. 1 hit.
PfamiPF02158. Neuregulin. 1 hit.
[Graphical view]
PRINTSiPR01089. NEUREGULIN.
SMARTiSM00181. EGF. 1 hit.
[Graphical view]
PROSITEiPS00022. EGF_1. 1 hit.
PS50026. EGF_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ6DR99_MOUSE
AccessioniPrimary (citable) accession number: Q6DR99
Entry historyi
Integrated into UniProtKB/TrEMBL: August 16, 2004
Last sequence update: August 16, 2004
Last modified: November 30, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.