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Protein
Submitted name:

Neuregulin 1

Gene

Nrg1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

  • chemorepellent activity Source: MGI
  • ErbB-2 class receptor binding Source: MGI
  • receptor tyrosine kinase binding Source: MGI
  • transcription cofactor activity Source: MGI

GO - Biological processi

  • axon ensheathment Source: MGI
  • brain development Source: MGI
  • cardiac conduction system development Source: MGI
  • cardiac muscle cell differentiation Source: BHF-UCL
  • cardiac muscle tissue development Source: MGI
  • cell migration Source: MGI
  • cell morphogenesis Source: MGI
  • cellular protein complex disassembly Source: MGI
  • chemorepulsion involved in interneuron migration from the subpallium to the cortex Source: MGI
  • embryo development Source: InterPro
  • glial cell differentiation Source: MGI
  • glial cell fate commitment Source: MGI
  • heart development Source: MGI
  • locomotory behavior Source: MGI
  • MAPK cascade Source: MGI
  • muscle organ development Source: MGI
  • negative regulation of neuron migration Source: MGI
  • negative regulation of protein catabolic process Source: MGI
  • negative regulation of transcription, DNA-templated Source: MGI
  • nervous system development Source: MGI
  • neurogenesis Source: MGI
  • neuron fate commitment Source: MGI
  • neurotransmitter receptor metabolic process Source: MGI
  • oligodendrocyte differentiation Source: MGI
  • peripheral nervous system development Source: MGI
  • positive regulation of axon extension Source: MGI
  • positive regulation of calcineurin-NFAT signaling cascade Source: MGI
  • positive regulation of cardiac muscle cell differentiation Source: Ensembl
  • positive regulation of dendritic spine development Source: MGI
  • positive regulation of gene expression Source: MGI
  • positive regulation of myelination Source: MGI
  • positive regulation of peptidyl-tyrosine phosphorylation Source: MGI
  • positive regulation of phosphatidylinositol 3-kinase signaling Source: MGI
  • positive regulation of protein kinase activity Source: MGI
  • positive regulation of protein kinase B signaling Source: MGI
  • positive regulation of protein localization to cell surface Source: MGI
  • positive regulation of Ras protein signal transduction Source: MGI
  • positive regulation of striated muscle cell differentiation Source: BHF-UCL
  • positive regulation of transcription by RNA polymerase II Source: MGI
  • regulation of cell differentiation Source: MGI
  • startle response Source: MGI
  • synapse assembly Source: MGI

Enzyme and pathway databases

ReactomeiR-MMU-1227986 Signaling by ERBB2
R-MMU-1236394 Signaling by ERBB4
R-MMU-1250196 SHC1 events in ERBB2 signaling
R-MMU-1250342 PI3K events in ERBB4 signaling
R-MMU-1250347 SHC1 events in ERBB4 signaling
R-MMU-1257604 PIP3 activates AKT signaling
R-MMU-1306955 GRB7 events in ERBB2 signaling
R-MMU-1358803 Downregulation of ERBB2:ERBB3 signaling
R-MMU-1963640 GRB2 events in ERBB2 signaling
R-MMU-1963642 PI3K events in ERBB2 signaling
R-MMU-5673001 RAF/MAP kinase cascade
R-MMU-6785631 ERBB2 Regulates Cell Motility
R-MMU-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-MMU-8847993 ERBB2 Activates PTK6 Signaling
R-MMU-8863795 Downregulation of ERBB2 signaling

Names & Taxonomyi

Protein namesi
Submitted name:
Neuregulin 1Imported
Submitted name:
Neuregulin-1 type I beta1-aImported
Gene namesi
Name:Nrg1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:96083 Nrg1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei248 – 269HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi212 ↔ 221PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000062991

Interactioni

GO - Molecular functioni

  • chemorepellent activity Source: MGI
  • ErbB-2 class receptor binding Source: MGI
  • receptor tyrosine kinase binding Source: MGI

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 128Ig-likeInterPro annotationAdd BLAST92
Domaini178 – 222EGF-likeInterPro annotationAdd BLAST45

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IEU9 Eukaryota
ENOG4110ST7 LUCA
GeneTreeiENSGT00900000140940
HOGENOMiHOG000273863
HOVERGENiHBG006531

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR002154 Neuregulin_C
IPR018250 NRG1
PANTHERiPTHR11100:SF7 PTHR11100:SF7, 1 hit
PfamiView protein in Pfam
PF07679 I-set, 1 hit
PF02158 Neuregulin, 1 hit
PRINTSiPR01089 NEUREGULIN
SMARTiView protein in SMART
SM00181 EGF, 1 hit
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 1 hit
PS50026 EGF_3, 1 hit
PS50835 IG_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

Q6DR98-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSERKEGRGK GKGKKKDRGS RGKPAPAEGD PSPALPPRLK EMKSQESAAG
60 70 80 90 100
SKLVLRCETS SEYSSLRFKW FKNGNELNRR NKPQNVKIQK KPGKSELRIN
110 120 130 140 150
KASLADSGEY MCKVISKLGN DSASANITIV ESNDLTTGMS ASTERPYVSS
160 170 180 190 200
ESPIRISVST EGANTSSSTS TSTTGTSHLI KCAEKEKTFC VNGGECFMVK
210 220 230 240 250
DLSNPSRYLC KCPNEFTGDR CQNYVMASFY KHLGIEFMEA EELYQKRVLT
260 270 280 290 300
ITGICIALLV VGIMCVVAYC KTKKQRQKLH DRLRQSLRSE RNNMVNIANG
310 320 330 340 350
PHHPNPPPEN VQLVNQYVSK NVISSEHIVE REVETSFSTS HYTSTAHHST
360 370 380 390 400
TVTQTPSHSW SNGHTESIIS ESHSVIMMSS VENSRHSSPA GGPRGRLHGL
410 420 430 440 450
GGPRECNSFL RHARETPDSY RDSPHSERYV SAMTTPARMS PVDFHTPSSP
460 470 480 490 500
KSPPSEMSPP VSSMTVSMPS VAVSPFVEEE RPLLLVTPPR LREKKYDHHP
510 520 530 540 550
QQLNSFHHNP AHQSTSLPPS PLRIVEDEEY ETTQEYEPIQ EPIKKVTNSR
560 570 580 590 600
RAKRTKPNGH IANRLEMDSN PSSVSSNSES ETEDERVGED TPFLGIQNPL
610 620 630 640
AASLEVAPAF RLAESRTNPA GRFSTQEELQ ARLSSVIANQ DPIAV
Length:645
Mass (Da):71,382
Last modified:August 16, 2004 - v1
Checksum:i7E575AEF73F55047
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC113586 Genomic DNA No translation available.
AC127369 Genomic DNA No translation available.
AC127374 Genomic DNA No translation available.
AC132256 Genomic DNA No translation available.
AC132407 Genomic DNA No translation available.
AC133091 Genomic DNA No translation available.
AC134895 Genomic DNA No translation available.
AC136147 Genomic DNA No translation available.
AY648976 mRNA Translation: AAT68241.1
RefSeqiXP_006509143.1, XM_006509080.3
UniGeneiMm.153432
Mm.460675

Genome annotation databases

EnsembliENSMUST00000207470; ENSMUSP00000146456; ENSMUSG00000062991
GeneIDi211323
UCSCiuc009ljp.1 mouse

Similar proteinsi

Entry informationi

Entry nameiQ6DR98_MOUSE
AccessioniPrimary (citable) accession number: Q6DR98
Entry historyiIntegrated into UniProtKB/TrEMBL: August 16, 2004
Last sequence update: August 16, 2004
Last modified: May 23, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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