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Protein
Submitted name:

Neuregulin-1 type I beta1-a

Gene

Nrg1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • chemorepellent activity Source: MGI
  • ErbB-2 class receptor binding Source: MGI
  • receptor tyrosine kinase binding Source: MGI
  • transcription cofactor activity Source: MGI

GO - Biological processi

  • axon ensheathment Source: MGI
  • brain development Source: MGI
  • cardiac conduction system development Source: MGI
  • cardiac muscle cell differentiation Source: BHF-UCL
  • cardiac muscle tissue development Source: MGI
  • cell migration Source: MGI
  • cell morphogenesis Source: MGI
  • cellular protein complex disassembly Source: MGI
  • chemorepulsion involved in interneuron migration from the subpallium to the cortex Source: MGI
  • embryo development Source: InterPro
  • glial cell differentiation Source: MGI
  • glial cell fate commitment Source: MGI
  • heart development Source: MGI
  • locomotory behavior Source: MGI
  • MAPK cascade Source: MGI
  • muscle organ development Source: MGI
  • negative regulation of neuron migration Source: MGI
  • negative regulation of protein catabolic process Source: MGI
  • negative regulation of transcription, DNA-templated Source: MGI
  • nervous system development Source: MGI
  • neurogenesis Source: MGI
  • neuron fate commitment Source: MGI
  • neurotransmitter receptor metabolic process Source: MGI
  • oligodendrocyte differentiation Source: MGI
  • peripheral nervous system development Source: MGI
  • positive regulation of axon extension Source: MGI
  • positive regulation of calcineurin-NFAT signaling cascade Source: MGI
  • positive regulation of dendritic spine development Source: MGI
  • positive regulation of gene expression Source: MGI
  • positive regulation of myelination Source: MGI
  • positive regulation of peptidyl-tyrosine phosphorylation Source: MGI
  • positive regulation of phosphatidylinositol 3-kinase signaling Source: MGI
  • positive regulation of protein kinase activity Source: MGI
  • positive regulation of protein kinase B signaling Source: MGI
  • positive regulation of protein localization to cell surface Source: MGI
  • positive regulation of Ras protein signal transduction Source: MGI
  • positive regulation of striated muscle cell differentiation Source: BHF-UCL
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • regulation of cell differentiation Source: MGI
  • startle response Source: MGI
  • synapse assembly Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Neuregulin-1 type I beta1-aImported
Submitted name:
Protein Nrg1Imported
Gene namesi
Name:Nrg1Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:96083. Nrg1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei248 – 26922HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • axolemma Source: MGI
  • axon Source: MGI
  • cell body Source: MGI
  • cytoplasm Source: MGI
  • dendrite Source: MGI
  • external side of plasma membrane Source: MGI
  • extracellular region Source: MGI
  • integral component of plasma membrane Source: MGI
  • neuromuscular junction Source: MGI
  • nucleus Source: MGI
  • plasma membrane Source: MGI
  • synapse Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiQ6DR98.
PRIDEiQ6DR98.

PTM databases

PhosphoSiteiQ6DR98.

Interactioni

GO - Molecular functioni

  • ErbB-2 class receptor binding Source: MGI
  • receptor tyrosine kinase binding Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000073546.

Structurei

3D structure databases

ProteinModelPortaliQ6DR98.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini37 – 12892Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST
Domaini178 – 22245EGF-likeInterPro annotationAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IEU9. Eukaryota.
ENOG4110ST7. LUCA.
GeneTreeiENSGT00800000124099.
HOGENOMiHOG000273863.
HOVERGENiHBG006531.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR002154. Neuregulin_C.
IPR018250. NRG1.
[Graphical view]
PANTHERiPTHR11100:SF7. PTHR11100:SF7. 1 hit.
PfamiPF07679. I-set. 1 hit.
PF02158. Neuregulin. 1 hit.
[Graphical view]
PRINTSiPR01089. NEUREGULIN.
SMARTiSM00181. EGF. 1 hit.
SM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS00022. EGF_1. 1 hit.
PS50026. EGF_3. 1 hit.
PS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6DR98-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSERKEGRGK GKGKKKDRGS RGKPAPAEGD PSPALPPRLK EMKSQESAAG
60 70 80 90 100
SKLVLRCETS SEYSSLRFKW FKNGNELNRR NKPQNVKIQK KPGKSELRIN
110 120 130 140 150
KASLADSGEY MCKVISKLGN DSASANITIV ESNDLTTGMS ASTERPYVSS
160 170 180 190 200
ESPIRISVST EGANTSSSTS TSTTGTSHLI KCAEKEKTFC VNGGECFMVK
210 220 230 240 250
DLSNPSRYLC KCPNEFTGDR CQNYVMASFY KHLGIEFMEA EELYQKRVLT
260 270 280 290 300
ITGICIALLV VGIMCVVAYC KTKKQRQKLH DRLRQSLRSE RNNMVNIANG
310 320 330 340 350
PHHPNPPPEN VQLVNQYVSK NVISSEHIVE REVETSFSTS HYTSTAHHST
360 370 380 390 400
TVTQTPSHSW SNGHTESIIS ESHSVIMMSS VENSRHSSPA GGPRGRLHGL
410 420 430 440 450
GGPRECNSFL RHARETPDSY RDSPHSERYV SAMTTPARMS PVDFHTPSSP
460 470 480 490 500
KSPPSEMSPP VSSMTVSMPS VAVSPFVEEE RPLLLVTPPR LREKKYDHHP
510 520 530 540 550
QQLNSFHHNP AHQSTSLPPS PLRIVEDEEY ETTQEYEPIQ EPIKKVTNSR
560 570 580 590 600
RAKRTKPNGH IANRLEMDSN PSSVSSNSES ETEDERVGED TPFLGIQNPL
610 620 630 640
AASLEVAPAF RLAESRTNPA GRFSTQEELQ ARLSSVIANQ DPIAV
Length:645
Mass (Da):71,382
Last modified:August 16, 2004 - v1
Checksum:i7E575AEF73F55047
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC113586 Genomic DNA. No translation available.
AC127369 Genomic DNA. No translation available.
AC127374 Genomic DNA. No translation available.
AC132256 Genomic DNA. No translation available.
AC132407 Genomic DNA. No translation available.
AC133091 Genomic DNA. No translation available.
AC134895 Genomic DNA. No translation available.
AC136147 Genomic DNA. No translation available.
AY648976 mRNA. Translation: AAT68241.1.
RefSeqiXP_006509143.1. XM_006509080.2.
UniGeneiMm.153432.
Mm.460675.

Genome annotation databases

EnsembliENSMUST00000207470; ENSMUSP00000146456; ENSMUSG00000062991.
GeneIDi211323.
UCSCiuc009ljp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC113586 Genomic DNA. No translation available.
AC127369 Genomic DNA. No translation available.
AC127374 Genomic DNA. No translation available.
AC132256 Genomic DNA. No translation available.
AC132407 Genomic DNA. No translation available.
AC133091 Genomic DNA. No translation available.
AC134895 Genomic DNA. No translation available.
AC136147 Genomic DNA. No translation available.
AY648976 mRNA. Translation: AAT68241.1.
RefSeqiXP_006509143.1. XM_006509080.2.
UniGeneiMm.153432.
Mm.460675.

3D structure databases

ProteinModelPortaliQ6DR98.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000073546.

PTM databases

PhosphoSiteiQ6DR98.

Proteomic databases

PaxDbiQ6DR98.
PRIDEiQ6DR98.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000207470; ENSMUSP00000146456; ENSMUSG00000062991.
GeneIDi211323.
UCSCiuc009ljp.1. mouse.

Organism-specific databases

CTDi3084.
MGIiMGI:96083. Nrg1.

Phylogenomic databases

eggNOGiENOG410IEU9. Eukaryota.
ENOG4110ST7. LUCA.
GeneTreeiENSGT00800000124099.
HOGENOMiHOG000273863.
HOVERGENiHBG006531.

Miscellaneous databases

SOURCEiSearch...

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR002154. Neuregulin_C.
IPR018250. NRG1.
[Graphical view]
PANTHERiPTHR11100:SF7. PTHR11100:SF7. 1 hit.
PfamiPF07679. I-set. 1 hit.
PF02158. Neuregulin. 1 hit.
[Graphical view]
PRINTSiPR01089. NEUREGULIN.
SMARTiSM00181. EGF. 1 hit.
SM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS00022. EGF_1. 1 hit.
PS50026. EGF_3. 1 hit.
PS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Inactivation of the receptor tyrosine kinase ErbB4 disrupts neuroblast migration and placement in the adult forebrain."
    Anton E.S., Ghashghaei H.T., Weber J.L., McCann C., Fischer T.M., Cheung I.D., Gassmann M., Messing A., Klein R., Schwab M.H., Lloyd K.C., Lai C.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57/Bl6JImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  3. Ensembl
    Submitted (MAR-2016) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ6DR98_MOUSE
AccessioniPrimary (citable) accession number: Q6DR98
Entry historyi
Integrated into UniProtKB/TrEMBL: August 16, 2004
Last sequence update: August 16, 2004
Last modified: July 6, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.