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Protein
Submitted name:

Neuregulin 1

Gene

Nrg1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • chemorepellent activity Source: MGI
  • ErbB-2 class receptor binding Source: MGI
  • receptor tyrosine kinase binding Source: MGI
  • transcription cofactor activity Source: MGI

GO - Biological processi

  • axon ensheathment Source: MGI
  • brain development Source: MGI
  • cardiac conduction system development Source: MGI
  • cardiac muscle cell differentiation Source: BHF-UCL
  • cardiac muscle tissue development Source: MGI
  • cell migration Source: MGI
  • cell morphogenesis Source: MGI
  • cellular protein complex disassembly Source: MGI
  • chemorepulsion involved in interneuron migration from the subpallium to the cortex Source: MGI
  • embryo development Source: InterPro
  • glial cell differentiation Source: MGI
  • glial cell fate commitment Source: MGI
  • heart development Source: MGI
  • locomotory behavior Source: MGI
  • MAPK cascade Source: MGI
  • muscle organ development Source: MGI
  • negative regulation of neuron migration Source: MGI
  • negative regulation of protein catabolic process Source: MGI
  • negative regulation of transcription, DNA-templated Source: MGI
  • nervous system development Source: MGI
  • neurogenesis Source: MGI
  • neuron fate commitment Source: MGI
  • neurotransmitter receptor metabolic process Source: MGI
  • oligodendrocyte differentiation Source: MGI
  • peripheral nervous system development Source: MGI
  • positive regulation of axon extension Source: MGI
  • positive regulation of calcineurin-NFAT signaling cascade Source: MGI
  • positive regulation of cardiac muscle cell differentiation Source: Ensembl
  • positive regulation of dendritic spine development Source: MGI
  • positive regulation of gene expression Source: MGI
  • positive regulation of myelination Source: MGI
  • positive regulation of peptidyl-tyrosine phosphorylation Source: MGI
  • positive regulation of phosphatidylinositol 3-kinase signaling Source: MGI
  • positive regulation of protein kinase activity Source: MGI
  • positive regulation of protein kinase B signaling Source: MGI
  • positive regulation of protein localization to cell surface Source: MGI
  • positive regulation of Ras protein signal transduction Source: MGI
  • positive regulation of striated muscle cell differentiation Source: BHF-UCL
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • regulation of cell differentiation Source: MGI
  • startle response Source: MGI
  • synapse assembly Source: MGI

Enzyme and pathway databases

ReactomeiR-MMU-1227986. Signaling by ERBB2.
R-MMU-1236394. Signaling by ERBB4.
R-MMU-1250196. SHC1 events in ERBB2 signaling.
R-MMU-1250342. PI3K events in ERBB4 signaling.
R-MMU-1250347. SHC1 events in ERBB4 signaling.
R-MMU-1257604. PIP3 activates AKT signaling.
R-MMU-1306955. GRB7 events in ERBB2 signaling.
R-MMU-1358803. Downregulation of ERBB2:ERBB3 signaling.
R-MMU-1963640. GRB2 events in ERBB2 signaling.
R-MMU-1963642. PI3K events in ERBB2 signaling.
R-MMU-5673001. RAF/MAP kinase cascade.
R-MMU-6785631. ERBB2 Regulates Cell Motility.
R-MMU-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
R-MMU-8847993. ERBB2 Activates PTK6 Signaling.
R-MMU-8863795. Downregulation of ERBB2 signaling.

Names & Taxonomyi

Protein namesi
Submitted name:
Neuregulin 1Imported
Submitted name:
Neuregulin-1 type I beta1-aImported
Gene namesi
Name:Nrg1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:96083. Nrg1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei248 – 269HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi212 ↔ 221PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotation

Proteomic databases

PaxDbiQ6DR98.

Expressioni

Gene expression databases

BgeeiENSMUSG00000062991.

Interactioni

GO - Molecular functioni

  • chemorepellent activity Source: MGI
  • ErbB-2 class receptor binding Source: MGI
  • receptor tyrosine kinase binding Source: MGI

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 128Ig-likeInterPro annotationAdd BLAST92
Domaini178 – 222EGF-likeInterPro annotationAdd BLAST45

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IEU9. Eukaryota.
ENOG4110ST7. LUCA.
GeneTreeiENSGT00900000140940.
HOGENOMiHOG000273863.
HOVERGENiHBG006531.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiView protein in InterPro
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR007110. Ig-like_dom.
IPR036179. Ig-like_dom_sf.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR002154. Neuregulin_C.
IPR018250. NRG1.
PANTHERiPTHR11100:SF7. PTHR11100:SF7. 1 hit.
PfamiView protein in Pfam
PF07679. I-set. 1 hit.
PF02158. Neuregulin. 1 hit.
PRINTSiPR01089. NEUREGULIN.
SMARTiView protein in SMART
SM00181. EGF. 1 hit.
SM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiView protein in PROSITE
PS00022. EGF_1. 1 hit.
PS50026. EGF_3. 1 hit.
PS50835. IG_LIKE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6DR98-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSERKEGRGK GKGKKKDRGS RGKPAPAEGD PSPALPPRLK EMKSQESAAG
60 70 80 90 100
SKLVLRCETS SEYSSLRFKW FKNGNELNRR NKPQNVKIQK KPGKSELRIN
110 120 130 140 150
KASLADSGEY MCKVISKLGN DSASANITIV ESNDLTTGMS ASTERPYVSS
160 170 180 190 200
ESPIRISVST EGANTSSSTS TSTTGTSHLI KCAEKEKTFC VNGGECFMVK
210 220 230 240 250
DLSNPSRYLC KCPNEFTGDR CQNYVMASFY KHLGIEFMEA EELYQKRVLT
260 270 280 290 300
ITGICIALLV VGIMCVVAYC KTKKQRQKLH DRLRQSLRSE RNNMVNIANG
310 320 330 340 350
PHHPNPPPEN VQLVNQYVSK NVISSEHIVE REVETSFSTS HYTSTAHHST
360 370 380 390 400
TVTQTPSHSW SNGHTESIIS ESHSVIMMSS VENSRHSSPA GGPRGRLHGL
410 420 430 440 450
GGPRECNSFL RHARETPDSY RDSPHSERYV SAMTTPARMS PVDFHTPSSP
460 470 480 490 500
KSPPSEMSPP VSSMTVSMPS VAVSPFVEEE RPLLLVTPPR LREKKYDHHP
510 520 530 540 550
QQLNSFHHNP AHQSTSLPPS PLRIVEDEEY ETTQEYEPIQ EPIKKVTNSR
560 570 580 590 600
RAKRTKPNGH IANRLEMDSN PSSVSSNSES ETEDERVGED TPFLGIQNPL
610 620 630 640
AASLEVAPAF RLAESRTNPA GRFSTQEELQ ARLSSVIANQ DPIAV
Length:645
Mass (Da):71,382
Last modified:August 16, 2004 - v1
Checksum:i7E575AEF73F55047
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC113586 Genomic DNA. No translation available.
AC127369 Genomic DNA. No translation available.
AC127374 Genomic DNA. No translation available.
AC132256 Genomic DNA. No translation available.
AC132407 Genomic DNA. No translation available.
AC133091 Genomic DNA. No translation available.
AC134895 Genomic DNA. No translation available.
AC136147 Genomic DNA. No translation available.
AY648976 mRNA. Translation: AAT68241.1.
RefSeqiXP_006509143.1. XM_006509080.3.
UniGeneiMm.153432.
Mm.460675.

Genome annotation databases

EnsembliENSMUST00000207470; ENSMUSP00000146456; ENSMUSG00000062991.
GeneIDi211323.
UCSCiuc009ljp.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiQ6DR98_MOUSE
AccessioniPrimary (citable) accession number: Q6DR98
Entry historyiIntegrated into UniProtKB/TrEMBL: August 16, 2004
Last sequence update: August 16, 2004
Last modified: October 25, 2017
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported