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Q6DQ34

- Q6DQ34_9INFA

UniProt

Q6DQ34 - Q6DQ34_9INFA

Protein
Submitted name:

Hemagglutinin

Gene

HA

Organism
Influenza A virus (A/Vietnam/1194/2004(H5N1))
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (16 Aug 2004)
      Previous versions | rss
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    Functioni

    Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei234 – 2341FucoseImported

    GO - Biological processi

    1. clathrin-mediated endocytosis of virus by host cell Source: UniProtKB-KW
    2. fusion of virus membrane with host endosome membrane Source: UniProtKB-KW
    3. fusion of virus membrane with host plasma membrane Source: InterPro
    4. virion attachment to host cell Source: UniProtKB-KW

    Keywords - Molecular functioni

    HemagglutininUniRule annotationSAAS annotation

    Keywords - Biological processi

    Clathrin- and caveolin-independent endocytosis of virus by hostSAAS annotation, Clathrin-mediated endocytosis of virus by hostSAAS annotation, Fusion of virus membrane with host endosomal membraneSAAS annotation, Fusion of virus membrane with host membrane, Host-virus interaction, Viral attachment to host cellSAAS annotation, Viral penetration into host cytoplasm, Virus endocytosis by host, Virus entry into host cell

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    HemagglutininImported
    Gene namesi
    Name:HAImported
    OrganismiInfluenza A virus (A/Vietnam/1194/2004(H5N1))Imported
    Taxonomic identifieri644788 [NCBI]
    Taxonomic lineageiVirusesssRNA negative-strand virusesOrthomyxoviridaeInfluenzavirus A

    Subcellular locationi

    Virion membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation. Host apical cell membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation

    GO - Cellular componenti

    1. host cell plasma membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. viral envelope Source: UniProtKB-KW
    4. virion membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host cell membraneSAAS annotation, Host membrane, Membrane, Viral envelope proteinUniRule annotationSAAS annotation, Virion

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi27 – 271N-linked (GlcNAc...)Imported
    Glycosylationi39 – 391N-linked (GlcNAc...)Imported
    Glycosylationi170 – 1701N-linked (GlcNAc...)Imported
    Glycosylationi181 – 1811N-linked (GlcNAc...)Imported
    Glycosylationi302 – 3021N-linked (GlcNAc...)Imported
    Glycosylationi500 – 5001N-linked (GlcNAc...)Imported

    Keywords - PTMi

    Disulfide bondSAAS annotation

    Interactioni

    Subunit structurei

    Homotrimer of disulfide-linked HA1-HA2.UniRule annotationSAAS annotation

    Protein-protein interaction databases

    DIPiDIP-60226N.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3ZNKX-ray2.71A/C/E17-340[»]
    3ZNLX-ray2.50A/C/E17-340[»]
    B/D/F347-512[»]
    3ZNMX-ray2.40A/C/E17-340[»]
    B/D/F347-512[»]
    3ZP0X-ray2.51E1-340[»]
    F347-506[»]
    3ZP1X-ray2.60E17-342[»]
    F347-512[»]
    3ZP2X-ray2.50E17-342[»]
    F347-512[»]
    3ZP3X-ray2.65E1-340[»]
    F347-506[»]
    3ZP6X-ray2.60E1-340[»]
    F347-506[»]
    3ZPAX-ray2.50E1-340[»]
    F347-506[»]
    3ZPBX-ray2.60E1-340[»]
    F347-506[»]
    4BGWX-ray2.48A17-340[»]
    B347-512[»]
    4BGXX-ray2.48A17-340[»]
    B347-512[»]
    4BGYX-ray2.68A17-340[»]
    B347-512[»]
    4CQPX-ray2.65A17-340[»]
    B347-512[»]
    4CQQX-ray2.55A17-340[»]
    B347-512[»]
    4CQRX-ray2.45A17-340[»]
    B347-512[»]
    4CQSX-ray2.55A17-340[»]
    B347-512[»]
    4CQTX-ray2.55A17-340[»]
    B347-512[»]
    4CQUX-ray2.48A17-340[»]
    B347-512[»]
    4CQZX-ray2.70A17-340[»]
    B347-512[»]
    4CR0X-ray2.65A17-340[»]
    B347-512[»]
    ProteinModelPortaliQ6DQ34.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ6DQ34.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni237 – 2382Galactose bindingImported

    Sequence similaritiesi

    Belongs to the influenza viruses hemagglutinin family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helixSAAS annotation

    Family and domain databases

    Gene3Di2.10.77.10. 1 hit.
    3.90.20.10. 1 hit.
    3.90.209.20. 1 hit.
    InterProiIPR008980. Capsid_hemagglutn.
    IPR013828. Hemagglutn_HA1_a/b_dom.
    IPR013827. Hemagglutn_HA1_b-rbn_dom.
    IPR000149. Hemagglutn_influenz_A.
    IPR001364. Hemagglutn_influenz_A/B.
    IPR013829. Hemagglutn_stalk.
    [Graphical view]
    PfamiPF00509. Hemagglutinin. 1 hit.
    [Graphical view]
    PRINTSiPR00330. HEMAGGLUTN1.
    PR00329. HEMAGGLUTN12.
    SUPFAMiSSF49818. SSF49818. 1 hit.

    Sequencei

    Sequence statusi: Fragment.

    Q6DQ34-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEKIVLLFAI VSLVKSDQIC IGYHANNSTE QVDTIMEKNV TVTHAQDILE    50
    KTHNGKLCDL DGVKPLILRD CSVAGWLLGN PMCDEFINVP EWSYIVEKAN 100
    PVNDLCYPGD FNDYEELKHL LSRINHFEKI QIIPKSSWSS HEASLGVSSA 150
    CPYQGKSSFF RNVVWLIKKN STYPTIKRSY NNTNQEDLLV LWGIHHPNDA 200
    AEQTKLYQNP TTYISVGTST LNQRLVPRIA TRSKVNGQSG RMEFFWTILK 250
    PNDAINFESN GNFIAPEYAY KIVKKGDSTI MKSELEYGNC NTKCQTPMGA 300
    INSSMPFHNI HPLTIGECPK YVKSNRLVLA TGLRNSPQRE RRRKKRGLFG 350
    AIAGFIEGGW QGMVDGWYGY HHSNEQGSGY AADKESTQKA IDGVTNKVNS 400
    IIDKMNTQFE AVGREFNNLE RRIENLNKKM EDGFLDVWTY NAELLVLMEN 450
    ERTLDFHDSN VKNLYDKVRL QLRDNAKELG NGCFEFYHKC DNECMESVRN 500
    GTYDYPQYSE EARLKREEIS GVKLESIGIY QILSIYSTVA SSLALAIMVA 550
    GLSLWMCSNG SLQCR 565
    Length:565
    Mass (Da):64,105
    Last modified:August 16, 2004 - v1
    Checksum:iF2ACE6D25A5A2B34
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei565 – 5651Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY651333 Viral cRNA. Translation: AAT73273.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY651333 Viral cRNA. Translation: AAT73273.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3ZNK X-ray 2.71 A/C/E 17-340 [» ]
    3ZNL X-ray 2.50 A/C/E 17-340 [» ]
    B/D/F 347-512 [» ]
    3ZNM X-ray 2.40 A/C/E 17-340 [» ]
    B/D/F 347-512 [» ]
    3ZP0 X-ray 2.51 E 1-340 [» ]
    F 347-506 [» ]
    3ZP1 X-ray 2.60 E 17-342 [» ]
    F 347-512 [» ]
    3ZP2 X-ray 2.50 E 17-342 [» ]
    F 347-512 [» ]
    3ZP3 X-ray 2.65 E 1-340 [» ]
    F 347-506 [» ]
    3ZP6 X-ray 2.60 E 1-340 [» ]
    F 347-506 [» ]
    3ZPA X-ray 2.50 E 1-340 [» ]
    F 347-506 [» ]
    3ZPB X-ray 2.60 E 1-340 [» ]
    F 347-506 [» ]
    4BGW X-ray 2.48 A 17-340 [» ]
    B 347-512 [» ]
    4BGX X-ray 2.48 A 17-340 [» ]
    B 347-512 [» ]
    4BGY X-ray 2.68 A 17-340 [» ]
    B 347-512 [» ]
    4CQP X-ray 2.65 A 17-340 [» ]
    B 347-512 [» ]
    4CQQ X-ray 2.55 A 17-340 [» ]
    B 347-512 [» ]
    4CQR X-ray 2.45 A 17-340 [» ]
    B 347-512 [» ]
    4CQS X-ray 2.55 A 17-340 [» ]
    B 347-512 [» ]
    4CQT X-ray 2.55 A 17-340 [» ]
    B 347-512 [» ]
    4CQU X-ray 2.48 A 17-340 [» ]
    B 347-512 [» ]
    4CQZ X-ray 2.70 A 17-340 [» ]
    B 347-512 [» ]
    4CR0 X-ray 2.65 A 17-340 [» ]
    B 347-512 [» ]
    ProteinModelPortali Q6DQ34.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-60226N.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei Q6DQ34.

    Family and domain databases

    Gene3Di 2.10.77.10. 1 hit.
    3.90.20.10. 1 hit.
    3.90.209.20. 1 hit.
    InterProi IPR008980. Capsid_hemagglutn.
    IPR013828. Hemagglutn_HA1_a/b_dom.
    IPR013827. Hemagglutn_HA1_b-rbn_dom.
    IPR000149. Hemagglutn_influenz_A.
    IPR001364. Hemagglutn_influenz_A/B.
    IPR013829. Hemagglutn_stalk.
    [Graphical view ]
    Pfami PF00509. Hemagglutinin. 1 hit.
    [Graphical view ]
    PRINTSi PR00330. HEMAGGLUTN1.
    PR00329. HEMAGGLUTN12.
    SUPFAMi SSF49818. SSF49818. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: A/Viet Nam/1194/2004Imported.
    2. "Receptor binding by a ferret-transmissible H5 avian influenza virus."
      Xiong X., Coombs P.J., Martin S.R., Liu J., Xiao H., McCauley J.W., Locher K., Walker P.A., Collins P.J., Kawaoka Y., Skehel J.J., Gamblin S.J.
      Nature 497:392-396(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.48 ANGSTROMS) OF 17-340 AND 347-512 IN COMPLEX WITH GALACTOSE, GLYCOSYLATION AT ASN-39; ASN-181 AND ASN-500.
    3. Cited for: X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 1-340 AND 347-506 IN COMPLEX WITH GALACTOSE, GLYCOSYLATION AT ASN-27; ASN-39 AND ASN-181.
    4. "Recognition of sulphated and fucosylated receptor sialosides by A/Vietnam/1194/2004 (H5N1) influenza virus."
      Xiong X., Tuzikov A., Coombs P.J., Martin S.R., Walker P.A., Gamblin S.J., Bovin N., Skehel J.J.
      Virus Res. 178:12-14(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 17-340 AND 347-512 IN COMPLEX WITH FUCOSE, GLYCOSYLATION AT ASN-39; ASN-181 AND ASN-500.
    5. "Enhanced human receptor binding by H5 haemagglutinins."
      Xiong X., Xiao H., Martin S.R., Coombs P.J., Liu J., Collins P.J., Vachieri S.G., Walker P.A., Lin Y.P., McCauley J.W., Gamblin S.J., Skehel J.J.
      Virology 456-457:179-187(2014) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.45 ANGSTROMS) OF 17-340 AND 347-512 IN COMPLEX WITH GALACTOSE, GLYCOSYLATION AT ASN-27; ASN-39; ASN-170; ASN-181; ASN-302 AND ASN-500.

    Entry informationi

    Entry nameiQ6DQ34_9INFA
    AccessioniPrimary (citable) accession number: Q6DQ34
    Entry historyi
    Integrated into UniProtKB/TrEMBL: August 16, 2004
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3