Unreviewed, UniProtKB/TrEMBL Q6DPL2 (Q6DPL2_9INFA)

Names and origin

Protein names

Submitted name:
    Neuraminidase EMBL AAT73329.1
Submitted name:
    Neuraminidase NA EMBL AAW80723.1

Gene names

Name:

NA EMBL AAT73329.1

Organism

Influenza A virus (A/Viet Nam/1203/2004(H5N1)) EMBL AAT73329.1

Taxonomic identifier

284218 [NCBI]

Taxonomic lineage

Viruses › ssRNA negative-strand viruses › Orthomyxoviridae › Influenzavirus A

Protein attributes

Sequence length	449 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates. Spearmint SPM001860
Subunit structure	Homotetramer By similarity. Spearmint SPM001860

Ontologies

Keywords
Cellular component	Cell membrane Spearmint SPM001860 Membrane Virion Spearmint SPM001860
Domain	Transmembrane Spearmint SPM001860
Molecular function	Glycosidase Spearmint SPM001860 Hydrolase
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	apical plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW virion membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	exo-alpha-sialidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q6DPL2-1 [UniParc]. Last modified August 16, 2004. Version 1. Checksum: 5FCFA35BAC5F9902	FASTA	449	49,081
	10 20 30 40 50 60 MNPNQKIITI GSICMVTGIV SLMLQIGNMI SIWVSHSIHT GNQHQSEPIS NTNFLTEKAV 70 80 90 100 110 120 ASVKLAGNSS LCPINGWAVY SKDNSIRIGS KGDVFVIREP FISCSHLECR TFFLTQGALL 130 140 150 160 170 180 NDKHSNGTVK DRSPHRTLMS CPVGEAPSPY NSRFESVAWS ASACHDGTSW LTIGISGPDN 190 200 210 220 230 240 GAVAVLKYNG IITDTIKSWR NNILRTQESE CACVNGSCFT VMTDGPSNGQ ASHKIFKMEK 250 260 270 280 290 300 GKVVKSVELD APNYHYEECS CYPNAGEITC VCRDNWHGSN RPWVSFNQNL EYQIGYICSG 310 320 330 340 350 360 VFGDNPRPND GTGSCGPVSS NGAYGVKGFS FKYGNGVWIG RTKSTNSRSG FEMIWDPNGW 370 380 390 400 410 420 TETDSSFSVK QDIVAITDWS GYSGSFVQHP ELTGLDCIRP CFWVELIRGR PKESTIWTSG 430 440 SSISFCGVNS DTVGWSWPDG AELPFTIDK

References

[1]	"Genesis of a highly pathogenic and potentially pandemic H5N1 influenza virus in eastern Asia." Li K.S., Guan Y., Wang J., Smith G.J.D., Xu K.M., Duan L., Rahardjo A.P., Puthavathana P., Buranathai C., Nguyen T.D., Estoepangestie A.T.S., Chaisingh A., Auewarakul P., Long H.T., Hanh N.T.H., Webby R.J., Poon L.L.M., Chen H. , Shortridge K.F., Yuen K.Y., Webster R.G., Peiris J.S.M. Nature 430:209-213(2004) [PubMed: 15241415] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: A/Viet Nam/1203/2004 EMBL AAT73329.1.
[2]	"Evolution of H5N1 avian influenza viruses in Asia." World Health Organization Global Influenza Program Surveillance Network Emerg. Infect. Dis. 11:1515-1521(2005) [PubMed: 16318689] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: A/Viet Nam/1203/2004 EMBL ABP52008.1.
[3]	Xu X. Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: A/Viet Nam/1203/2004 EMBL ABP52008.1.
[4]	"Lethality to ferrets of H5N1 influenza viruses isolated from humans and poultry in 2004." Govorkova E.A., Rehg J.E., Krauss S., Yen H.L., Guan Y., Peiris M., Nguyen T.D., Hanh T.H., Puthavathana P., Long H.T., Buranathai C., Lim W., Webster R.G., Hoffmann E. J. Virol. 79:2191-2198(2005) [PubMed: 15681421] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: A/Viet Nam/1203/2004 EMBL AAW80723.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBLGenBankDDBJ

AY651447 Viral cRNA. Translation: AAT73329.1.
AY818141 Genomic RNA. Translation: AAW80723.1.
EF541467 Viral cRNA. Translation: ABP52008.1.

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2HTY	X-ray	2.50	A/B/C/D/E/F/G/H	63-449	[»]
2HU0	X-ray	2.95	A/B/C/D/E/F/G/H	63-449	[»]
2HU4	X-ray	2.50	A/B/C/D/E/F/G/H	63-449	[»]
3CKZ	X-ray	1.90	A	63-447	[»]
3CL0	X-ray	2.20	A	63-447	[»]
3CL2	X-ray	2.54	A/B/C/D/E/F/G/H	63-447	[»]

ModBase

Search...

Protein family/group databases

CAZy

GH34. Glycoside Hydrolase Family 34.

Family and domain databases

InterPro

IPR001860. Glyco_hydro_34.
[Graphical view]

Pfam

PF00064. Neur. 1 hit.
[Graphical view]

ProDom

PD000431. Glyco_hydro_34. 1 hit.
[Graphical view] [Entries sharing at least one domain]

ProtoNet

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Entry information

Entry name

Q6DPL2_9INFA

Accession

Primary (citable) accession number: Q6DPL2

Entry history

Integrated into UniProtKB/TrEMBL:	August 16, 2004
Last sequence update:	August 16, 2004
Last modified:	June 16, 2009
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)