Neuraminidase - Influenza A virus (A/Viet Nam/1203/2004(H5N1))

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Q6DPL2 (Q6DPL2_9INFA) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 58. History...

Clusters with 100%, 90%, 50% identity |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info Customize order

Names and origin

Protein names

Submitted name:
Neuraminidase EMBL AAT73329.1

Submitted name:
Neuraminidase NA EMBL AAW80723.1

Gene names

Name:

NA EMBL AAT73329.1

Organism

Influenza A virus (A/Viet Nam/1203/2004(H5N1)) EMBL AAT73329.1

Taxonomic identifier

284218 [NCBI]

Taxonomic lineage

Viruses › ssRNA negative-strand viruses › Orthomyxoviridae › Influenzavirus A

Protein attributes

Sequence length	449 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates. SAAS SAAS011040
Subunit structure	Homotetramer By similarity. SAAS SAAS011040

Ontologies

Keywords
Cellular component	Host cell membrane SAAS SAAS011040 Host membrane Membrane Virion SAAS SAAS011040
Domain	Transmembrane Transmembrane helix SAAS SAAS011040
Ligand	Calcium PDB 3CL0 PDB 3CKZ PDB 2HTY Metal-binding PDB 3CL0 PDB 3CKZ PDB 2HTY
Molecular function	Glycosidase SAAS SAAS011040 Hydrolase
PTM	Disulfide bond SAAS SAAS011040
Technical term	3D-structure PDB 2HU4 PDB 2HU0 PDB 3CL2 PDB 3CL0 PDB 3CKZ PDB 2HTY
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	host cell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW virion Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	exo-alpha-sialidase activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Sites

Metal binding

274

Calcium; via carbonyl oxygen PDB 3CL0 PDB 3CKZ PDB 2HTY

Metal binding

278

Calcium; via carbonyl oxygen PDB 3CL0 PDB 3CKZ PDB 2HTY

Metal binding

304

Calcium PDB 3CL0 PDB 3CKZ PDB 2HTY

Metal binding

322

Calcium; via carbonyl oxygen PDB 3CL0 PDB 3CKZ PDB 2HTY

Metal binding

324

Calcium PDB 3CL0 PDB 3CKZ PDB 2HTY

Sequences

Sequence

Length

Mass (Da)

Tools

Q6DPL2 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: 5FCFA35BAC5F9902
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FASTA

449

49,081

        10         20         30         40         50         60 
MNPNQKIITI GSICMVTGIV SLMLQIGNMI SIWVSHSIHT GNQHQSEPIS NTNFLTEKAV 

        70         80         90        100        110        120 
ASVKLAGNSS LCPINGWAVY SKDNSIRIGS KGDVFVIREP FISCSHLECR TFFLTQGALL 

       130        140        150        160        170        180 
NDKHSNGTVK DRSPHRTLMS CPVGEAPSPY NSRFESVAWS ASACHDGTSW LTIGISGPDN 

       190        200        210        220        230        240 
GAVAVLKYNG IITDTIKSWR NNILRTQESE CACVNGSCFT VMTDGPSNGQ ASHKIFKMEK 

       250        260        270        280        290        300 
GKVVKSVELD APNYHYEECS CYPNAGEITC VCRDNWHGSN RPWVSFNQNL EYQIGYICSG 

       310        320        330        340        350        360 
VFGDNPRPND GTGSCGPVSS NGAYGVKGFS FKYGNGVWIG RTKSTNSRSG FEMIWDPNGW 

       370        380        390        400        410        420 
TETDSSFSVK QDIVAITDWS GYSGSFVQHP ELTGLDCIRP CFWVELIRGR PKESTIWTSG 

       430        440 
SSISFCGVNS DTVGWSWPDG AELPFTIDK

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References

[1]	"Genesis of a highly pathogenic and potentially pandemic H5N1 influenza virus in eastern Asia." Li K.S., Guan Y., Wang J., Smith G.J.D., Xu K.M., Duan L., Rahardjo A.P., Puthavathana P., Buranathai C., Nguyen T.D., Estoepangestie A.T.S., Chaisingh A., Auewarakul P., Long H.T., Hanh N.T.H., Webby R.J., Poon L.L.M., Chen H. Peiris J.S.M. Nature 430:209-213(2004) [PubMed: 15241415] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: A/Viet Nam/1203/2004 EMBL AAT73329.1.
[2]	"Lethality to ferrets of H5N1 influenza viruses isolated from humans and poultry in 2004." Govorkova E.A., Rehg J.E., Krauss S., Yen H.L., Guan Y., Peiris M., Nguyen T.D., Hanh T.H., Puthavathana P., Long H.T., Buranathai C., Lim W., Webster R.G., Hoffmann E. J. Virol. 79:2191-2198(2005) [PubMed: 15681421] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: A/Viet Nam/1203/2004 EMBL AAW80723.1.
[3]	"The structure of H5N1 avian influenza neuraminidase suggests new opportunities for drug design." Russell R.J., Haire L.F., Stevens D.J., Collins P.J., Lin Y.P., Blackburn G.M., Hay A.J., Gamblin S.J., Skehel J.J. Nature 443:45-49(2006) [PubMed: 16915235] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 63-449 IN COMPLEX WITH CALCIUM.
[4]	"Crystal structures of oseltamivir-resistant influenza virus neuraminidase mutants." Collins P.J., Haire L.F., Lin Y.P., Liu J., Russell R.J., Walker P.A., Skehel J.J., Martin S.R., Hay A.J., Gamblin S.J. Nature 453:1258-1261(2008) [PubMed: 18480754] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) OF 63-447 IN COMPLEX WITH CALCIUM.
[5]	"Evolution of H5N1 avian influenza viruses in Asia." World Health Organization Global Influenza Program Surveillance Network Emerg. Infect. Dis. 11:1515-1521(2005) [PubMed: 16318689] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: A/Viet Nam/1203/2004 EMBL ABP52008.1.
[6]	Xu X. Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: A/Viet Nam/1203/2004 EMBL ABP52008.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AY651447 Viral cRNA. Translation: AAT73329.1.
AY818141 Genomic RNA. Translation: AAW80723.1.
EF541467 Viral cRNA. Translation: ABP52008.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2HTY	X-ray	2.50	A/B/C/D/E/F/G/H	63-449	[»]
2HU0	X-ray	2.95	A/B/C/D/E/F/G/H	63-449	[»]
2HU4	X-ray	2.50	A/B/C/D/E/F/G/H	63-449	[»]
3CKZ	X-ray	1.90	A	63-447	[»]
3CL0	X-ray	2.20	A	63-447	[»]
3CL2	X-ray	2.54	A/B/C/D/E/F/G/H	63-447	[»]

ProteinModelPortal

Q6DPL2.

SMR

Q6DPL2. Positions 63-447.

ModBase

Search...

Protein family/group databases

CAZy

GH34. Glycoside Hydrolase Family 34.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Family and domain databases

InterPro

IPR001860. Glyco_hydro_34.
IPR011040. Neuraminidase.
[Graphical view]

Gene3D

G3DSA:2.120.10.10. Neuraminidase. 1 hit.

Pfam

PF00064. Neur. 1 hit.
[Graphical view]

SUPFAM

SSF50939. Sialidase. 1 hit.

ProtoNet

Search...

Entry information

Entry name

Q6DPL2_9INFA

Accession

Primary (citable) accession number: Q6DPL2

Entry history

Integrated into UniProtKB/TrEMBL:	August 16, 2004
Last sequence update:	August 16, 2004
Last modified:	January 25, 2012
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Sites

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein family/group databases

Protocols and materials databases

Family and domain databases

Entry information