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Protein

Fc receptor-like protein 6

Gene

FCRL6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Fc receptor-like protein 6
Short name:
FcR-like protein 6
Short name:
FcRL6
Alternative name(s):
Fc receptor homolog 6
Short name:
FcRH6
IFGP6
Gene namesi
Name:FCRL6
Synonyms:FCRH6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:31910. FCRL6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 307288ExtracellularSequence analysisAdd
BLAST
Transmembranei308 – 32821HelicalSequence analysisAdd
BLAST
Topological domaini329 – 434106CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • external side of plasma membrane Source: MGI
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi356 – 3561Y → F: No change of phosphorylation implicated in interaction with PTPN11. 1 Publication
Mutagenesisi371 – 3711Y → F: Loss of phosphorylation implicated in interaction with PTPN11. 1 Publication

Organism-specific databases

PharmGKBiPA142671770.

Polymorphism and mutation databases

BioMutaiFCRL6.
DMDMi134034126.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 434415Fc receptor-like protein 6PRO_0000280213Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi39 ↔ 83PROSITE-ProRule annotation
Glycosylationi65 – 651N-linked (GlcNAc...)Sequence analysis
Disulfide bondi132 ↔ 180PROSITE-ProRule annotation
Disulfide bondi228 ↔ 276PROSITE-ProRule annotation
Glycosylationi273 – 2731N-linked (GlcNAc...)Sequence analysis
Modified residuei371 – 3711Phosphotyrosine1 Publication

Post-translational modificationi

Phosphorylated on Tyr residue, inducing association with PTPN11.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ6DN72.
PRIDEiQ6DN72.
TopDownProteomicsiQ6DN72-3. [Q6DN72-3]

PTM databases

iPTMnetiQ6DN72.
PhosphoSiteiQ6DN72.

Expressioni

Tissue specificityi

Expressed by cytolytic cells including NK cells, effector and effector-memory CD8+ T-cells. Expression among T-cells is greatly expanded in HIV-1 infected individuals, and includes not only effector and effector-memory CD8+ T-cells but also populations of CD4+ T-cells.1 Publication

Gene expression databases

BgeeiQ6DN72.
CleanExiHS_FCRL6.
ExpressionAtlasiQ6DN72. baseline and differential.

Interactioni

Subunit structurei

Interacts with PTPN11.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ6DN72.
SMRiQ6DN72. Positions 19-280.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 9576Ig-like C2-type 1Add
BLAST
Domaini111 – 19787Ig-like C2-type 2Add
BLAST
Domaini207 – 29387Ig-like C2-type 3Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi369 – 3746ITIM motif

Domaini

Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). The phosphorylated ITIM motif is involved in PTPN11 binding.1 Publication

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J025. Eukaryota.
ENOG41117EG. LUCA.
GeneTreeiENSGT00760000119130.
HOGENOMiHOG000112562.
InParanoidiQ6DN72.
KOiK17273.
OMAiNWLVPWL.
PhylomeDBiQ6DN72.
TreeFamiTF335097.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF13895. Ig_2. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6DN72-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLLWTAVLLF VPCVGKTVWL YLQAWPNPVF EGDALTLRCQ GWKNTPLSQV
60 70 80 90 100
KFYRDGKFLH FSKENQTLSM GAATVQSRGQ YSCSGQVMYI PQTFTQTSET
110 120 130 140 150
AMVQVQELFP PPVLSAIPSP EPREGSLVTL RCQTKLHPLR SALRLLFSFH
160 170 180 190 200
KDGHTLQDRG PHPELCIPGA KEGDSGLYWC EVAPEGGQVQ KQSPQLEVRV
210 220 230 240 250
QAPVSRPVLT LHHGPADPAV GDMVQLLCEA QRGSPPILYS FYLDEKIVGN
260 270 280 290 300
HSAPCGGTTS LLFPVKSEQD AGNYSCEAEN SVSRERSEPK KLSLKGSQVL
310 320 330 340 350
FTPASNWLVP WLPASLLGLM VIAAALLVYV RSWRKAGPLP SQIPPTAPGG
360 370 380 390 400
EQCPLYANVH HQKGKDEGVV YSVVHRTSKR SEARSAEFTV GRKDSSIICA
410 420 430
EVRCLQPSEV SSTEVNMRSR TLQEPLSDCE EVLC
Length:434
Mass (Da):47,748
Last modified:March 20, 2007 - v2
Checksum:i469C1E503AB2CDDE
GO
Isoform 2 (identifier: Q6DN72-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLPSLGPM
     394-406: DSSIICAEVRCLQ → FYHLCGGEMPAAQ
     407-434: Missing.

Show »
Length:413
Mass (Da):45,309
Checksum:i8618AE9172BAE4F1
GO
Isoform 3 (identifier: Q6DN72-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     383-397: ARSAEFTVGRKDSSI → GQFYHLCGGEMPAAQ
     398-434: Missing.

Show »
Length:397
Mass (Da):43,595
Checksum:i33F9DF84E0D52EE4
GO
Isoform 4 (identifier: Q6DN72-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     105-199: Missing.
     394-406: DSSIICAEVRCLQ → FYHLCGGEMPAAQ
     407-434: Missing.

Show »
Length:311
Mass (Da):34,128
Checksum:i28F4161B10AB4FD9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti51 – 522KF → RL in AAP47270 (Ref. 2) Curated
Sequence conflicti59 – 591L → P in AAP47270 (Ref. 2) Curated
Sequence conflicti114 – 1141L → P in AAP47270 (Ref. 2) Curated
Sequence conflicti123 – 1231R → Q in AAP47270 (Ref. 2) Curated
Sequence conflicti250 – 2501N → S in AAT66025 (Ref. 2) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti427 – 4271S → G.
Corresponds to variant rs4443889 [ dbSNP | Ensembl ].
VAR_031090

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MLPSLGPM in isoform 2. 1 PublicationVSP_023565
Alternative sequencei105 – 19995Missing in isoform 4. 1 PublicationVSP_023566Add
BLAST
Alternative sequencei383 – 39715ARSAE…KDSSI → GQFYHLCGGEMPAAQ in isoform 3. 1 PublicationVSP_023567Add
BLAST
Alternative sequencei394 – 40613DSSII…VRCLQ → FYHLCGGEMPAAQ in isoform 2 and isoform 4. 2 PublicationsVSP_023568Add
BLAST
Alternative sequencei398 – 43437Missing in isoform 3. 1 PublicationVSP_023569Add
BLAST
Alternative sequencei407 – 43428Missing in isoform 2 and isoform 4. 2 PublicationsVSP_023570Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY513661 mRNA. Translation: AAS82876.1.
AY212514 mRNA. Translation: AAP47270.1.
AY654627 mRNA. Translation: AAT66024.1.
AY654628 mRNA. Translation: AAT66025.1.
AK131201 mRNA. Translation: BAD18394.1.
AL590560 Genomic DNA. Translation: CAM14070.1.
AL590560 Genomic DNA. Translation: CAM14071.1.
AL590560 Genomic DNA. Translation: CAM14072.1.
CCDSiCCDS30912.1. [Q6DN72-1]
CCDS60312.1. [Q6DN72-2]
RefSeqiNP_001004310.2. NM_001004310.2. [Q6DN72-1]
NP_001271146.1. NM_001284217.1. [Q6DN72-2]
UniGeneiHs.196955.

Genome annotation databases

EnsembliENST00000321935; ENSP00000320625; ENSG00000181036. [Q6DN72-2]
ENST00000339348; ENSP00000340949; ENSG00000181036. [Q6DN72-3]
ENST00000368106; ENSP00000357086; ENSG00000181036. [Q6DN72-1]
ENST00000392235; ENSP00000376068; ENSG00000181036. [Q6DN72-4]
GeneIDi343413.
KEGGihsa:343413.
UCSCiuc001fuc.4. human. [Q6DN72-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY513661 mRNA. Translation: AAS82876.1.
AY212514 mRNA. Translation: AAP47270.1.
AY654627 mRNA. Translation: AAT66024.1.
AY654628 mRNA. Translation: AAT66025.1.
AK131201 mRNA. Translation: BAD18394.1.
AL590560 Genomic DNA. Translation: CAM14070.1.
AL590560 Genomic DNA. Translation: CAM14071.1.
AL590560 Genomic DNA. Translation: CAM14072.1.
CCDSiCCDS30912.1. [Q6DN72-1]
CCDS60312.1. [Q6DN72-2]
RefSeqiNP_001004310.2. NM_001004310.2. [Q6DN72-1]
NP_001271146.1. NM_001284217.1. [Q6DN72-2]
UniGeneiHs.196955.

3D structure databases

ProteinModelPortaliQ6DN72.
SMRiQ6DN72. Positions 19-280.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ6DN72.
PhosphoSiteiQ6DN72.

Polymorphism and mutation databases

BioMutaiFCRL6.
DMDMi134034126.

Proteomic databases

PaxDbiQ6DN72.
PRIDEiQ6DN72.
TopDownProteomicsiQ6DN72-3. [Q6DN72-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000321935; ENSP00000320625; ENSG00000181036. [Q6DN72-2]
ENST00000339348; ENSP00000340949; ENSG00000181036. [Q6DN72-3]
ENST00000368106; ENSP00000357086; ENSG00000181036. [Q6DN72-1]
ENST00000392235; ENSP00000376068; ENSG00000181036. [Q6DN72-4]
GeneIDi343413.
KEGGihsa:343413.
UCSCiuc001fuc.4. human. [Q6DN72-1]

Organism-specific databases

CTDi343413.
GeneCardsiFCRL6.
H-InvDBHIX0028649.
HGNCiHGNC:31910. FCRL6.
MIMi613562. gene.
neXtProtiNX_Q6DN72.
PharmGKBiPA142671770.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J025. Eukaryota.
ENOG41117EG. LUCA.
GeneTreeiENSGT00760000119130.
HOGENOMiHOG000112562.
InParanoidiQ6DN72.
KOiK17273.
OMAiNWLVPWL.
PhylomeDBiQ6DN72.
TreeFamiTF335097.

Miscellaneous databases

GenomeRNAii343413.
PROiQ6DN72.
SOURCEiSearch...

Gene expression databases

BgeeiQ6DN72.
CleanExiHS_FCRL6.
ExpressionAtlasiQ6DN72. baseline and differential.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF13895. Ig_2. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "FcRL6, a new ITIM-bearing receptor on cytolytic cells, is broadly expressed by lymphocytes following HIV-1 infection."
    Wilson T.J., Presti R.M., Tassi I., Overton E.T., Cella M., Colonna M.
    Blood 109:3786-3793(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PTM, DOMAIN, TISSUE SPECIFICITY, INTERACTION WITH PTPN11, PHOSPHORYLATION AT TYR-371, MUTAGENESIS OF TYR-356 AND TYR-371.
  2. "Human FcR-like transmembrane receptor IFGP6."
    Ershova S.A.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 3 AND 4).
    Tissue: Tonsil.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Spleen.
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiFCRL6_HUMAN
AccessioniPrimary (citable) accession number: Q6DN72
Secondary accession number(s): A1KXW6
, A2A4D6, Q6DN73, Q6XRC3, Q6ZNI1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: June 8, 2016
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.