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Protein
Submitted name:

High molecular weight kininogen II

Gene

Kng2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionProtease inhibitor, Thiol protease inhibitorPROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
High molecular weight kininogen IIImported
Gene namesi
Name:Kng2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:3027157 Kng2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_500427225724 – 634Sequence analysisAdd BLAST611

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi83 ↔ 96PROSITE-ProRule annotation
Disulfide bondi83 ↔ 94PROSITE-ProRule annotation
Disulfide bondi228 ↔ 247PROSITE-ProRule annotation
Disulfide bondi340 ↔ 359PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotation

Proteomic databases

PeptideAtlasiQ6DMP4

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ6DMP4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 131Cystatin kininogen-typeInterPro annotationAdd BLAST104
Domaini150 – 253Cystatin kininogen-typeInterPro annotationAdd BLAST104
Domaini262 – 365Cystatin kininogen-typeInterPro annotationAdd BLAST104

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IKIQ Eukaryota
ENOG4111ZQ8 LUCA
HOVERGENiHBG006224

Family and domain databases

CDDicd00042 CY, 3 hits
InterProiView protein in InterPro
IPR000010 Cystatin_dom
IPR002395 Kininogen
IPR027358 Kininogen-type_cystatin_dom
IPR018073 Prot_inh_cystat_CS
PfamiView protein in Pfam
PF00031 Cystatin, 3 hits
PRINTSiPR00334 KININOGEN
SMARTiView protein in SMART
SM00043 CY, 3 hits
PROSITEiView protein in PROSITE
PS00287 CYSTATIN, 1 hit
PS51647 CYSTATIN_KININOGEN, 3 hits

Sequencei

Sequence statusi: Complete.

Q6DMP4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLITTLLLC SGLLLTLTQG EEAQEIDCND EAVFQAVDAS LKKLNARLQS
60 70 80 90 100
GNQFVLYRVT KRAKMDGSAT FYSFNYQIKE GNCSAQRGLA WQDCDFKDSE
110 120 130 140 150
EAATGECTAT MGKKENKFFI VTQTCKITPG KGPIVTEEYH CASCVHPISA
160 170 180 190 200
DNPDLEPVLK HAIEYFNNNT GHSHLFALRE VKSAQGQVVG GLNFDIIYTI
210 220 230 240 250
VQTNCSKERF PSLRGDCVAL PNGDGGECRG NAFLDTDNKI EDFTQSCDLH
260 270 280 290 300
PGDDLVEALP KPCPPELKEV LGHSIAQLNT ENDHPFYFKI DTVKKATSQV
310 320 330 340 350
VAGTNYVIEF IARETKCSKE SNTELTEDCE IKHLGQSLDC NANVYMRPWE
360 370 380 390 400
NKVIPTVKCQ ALDKTIPIRR RPPGFSPFRS AKVQETKAGT TVSPPYIVRE
410 420 430 440 450
QKEGNGWLNE KQIKAKNHSG HKYGHDHAHW SPRRHGLGHG HQKPHGLGHG
460 470 480 490 500
HRLKLDYLRH QREDGSDHTH TEGHGYGHGH GHGHGHGHSH GLGHGHDKQT
510 520 530 540 550
NKDKSSVKQT AQRTEPLASS SEYSTTSTQM QGRTEGPTLT PPRAQPTVTS
560 570 580 590 600
SGFQDSDFIE DVVAITPPYD TGAPDDLIPD IHVQPDSLSF KLISDFPEAT
610 620 630
SQKCPGRPWK PASWKDPNTE TTEFSDFDLL DVLS
Length:634
Mass (Da):70,178
Last modified:August 16, 2004 - v1
Checksum:i5ABCA2F23F0846B9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY660572 mRNA Translation: AAT52205.1
UniGeneiMm.440414

Similar proteinsi

Entry informationi

Entry nameiQ6DMP4_MOUSE
AccessioniPrimary (citable) accession number: Q6DMP4
Entry historyiIntegrated into UniProtKB/TrEMBL: August 16, 2004
Last sequence update: August 16, 2004
Last modified: May 23, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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