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Protein

Polycomb group RING finger protein 1

Gene

Pcgf1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the Polycomb group (PcG) multiprotein BCOR complex, a complex required to maintain the transcriptionally repressive state of some genes, such as BCL6 and the cyclin-dependent kinase inhibitor, CDKN1A. Transcriptional repressor that may be targeted to the DNA by BCL6; this transcription repressor activity may be related to PKC signaling pathway. Represses CDKN1A expression by binding to its promoter, and this repression is dependent on the retinoic acid response element (RARE element). Promotes cell cycle progression and enhances cell proliferation as well. May have a positive role in tumor cell growth by down-regulating CDKN1A. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Regulates the expression of DPPA4 and NANOG in the NT2 embryonic carcinoma cells (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri35 – 7440RING-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • aging Source: RGD
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Polycomb group RING finger protein 1
Alternative name(s):
Nervous system Polycomb-1
Short name:
NSPc1
Gene namesi
Name:Pcgf1
Synonyms:Nspc1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1549782. Pcgf1.

Subcellular locationi

  • Nucleus By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 243›243Polycomb group RING finger protein 1PRO_0000277857Add
BLAST

Proteomic databases

PaxDbiQ6DLV9.
PRIDEiQ6DLV9.

PTM databases

PhosphoSiteiQ6DLV9.

Expressioni

Tissue specificityi

Highly expressed in brain, cerebellum, heart and testis.1 Publication

Interactioni

Subunit structurei

Component of the repressive BCOR complex containing a Polycomb group subcomplex at least composed of RYBP, RING1 and RNF2/RING2. Specifically interacts with BCOR, RING1 and RNF2/RING2. Also interacts with BCORL1, the interaction is direct (By similarity). Component of a PRC1-like complex. Interacts with CBX6, CBX7 and CBX8. Interacts with DPPA4, NANOG, POU5F1 and RYBP (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011173.

Structurei

3D structure databases

ProteinModelPortaliQ6DLV9.
SMRiQ6DLV9. Positions 23-117.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni74 – 231158Necessary for repressor activityBy similarityAdd
BLAST
Regioni151 – 23989Sufficient for interaction with BCOR and BCORL1By similarityAdd
BLAST

Sequence similaritiesi

Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri35 – 7440RING-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2660. Eukaryota.
ENOG410XPCN. LUCA.
HOGENOMiHOG000231946.
HOVERGENiHBG052826.
InParanoidiQ6DLV9.
KOiK11487.
PhylomeDBiQ6DLV9.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR032443. RAWUL.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF16207. RAWUL. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q6DLV9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLRNQLQSV YKMDPLRNEE EVRVKIKDLN EHIVCCLCAG YFVDATTITE
60 70 80 90 100
CLHTFCKSCI VKYLQTSKYC PMCNIKIHET QPLLNLKLDR VMQDIVYKLV
110 120 130 140 150
PGLQDSEEKR IRDFYQSRGL DRVSQPSGEE PALRGLGLPF TSFDHYYRYD
160 170 180 190 200
EQLSLCLERL SSGKDKNKNV LQNKYVRCSV RAEVRHLRRV LCHRLMLNPQ
210 220 230 240
HVQLLFDNEV LPDHMTMKQL WLSRWFGKPS PLLLQYSVKE KRR
Length:243
Mass (Da):28,782
Last modified:August 16, 2004 - v1
Checksum:i8D6630932F503A55
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY662670 mRNA. Translation: AAT74859.1.
RefSeqiNP_001007001.1. NM_001007000.1.
UniGeneiRn.203514.

Genome annotation databases

GeneIDi312480.
KEGGirno:312480.
UCSCiRGD:1549782. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY662670 mRNA. Translation: AAT74859.1.
RefSeqiNP_001007001.1. NM_001007000.1.
UniGeneiRn.203514.

3D structure databases

ProteinModelPortaliQ6DLV9.
SMRiQ6DLV9. Positions 23-117.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011173.

PTM databases

PhosphoSiteiQ6DLV9.

Proteomic databases

PaxDbiQ6DLV9.
PRIDEiQ6DLV9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi312480.
KEGGirno:312480.
UCSCiRGD:1549782. rat.

Organism-specific databases

CTDi84759.
RGDi1549782. Pcgf1.

Phylogenomic databases

eggNOGiKOG2660. Eukaryota.
ENOG410XPCN. LUCA.
HOGENOMiHOG000231946.
HOVERGENiHBG052826.
InParanoidiQ6DLV9.
KOiK11487.
PhylomeDBiQ6DLV9.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR032443. RAWUL.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF16207. RAWUL. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Rattus norvegicus similar to Nspc1 protein full length cDNA."
    Gong Y., Wang X., Yuan J.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "NSPc1, a mainly nuclear localized protein of novel PcG family members, has a transcription repression activity related to its PKC phosphorylation site at S183."
    Gong Y., Wang X., Liu J., Shi L., Yin B., Peng X., Qiang B., Yuan J.
    FEBS Lett. 579:115-121(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiPCGF1_RAT
AccessioniPrimary (citable) accession number: Q6DLV9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: August 16, 2004
Last modified: June 8, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.