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Q6DLV0 (Q6DLV0_9FLAV) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
OrganismDengue virus 3 EMBL AAT75224.1
Taxonomic identifier11069 [NCBI]
Taxonomic lineageVirusesssRNA positive-strand viruses, no DNA stageFlaviviridaeFlavivirusDengue virus group

Protein attributes

Sequence length3390 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

NTP + H2O = NDP + phosphate.

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). SAAS SAAS007094

Sequence similarities

Contains RdRp catalytic domain. SAAS SAAS007094

Contains helicase ATP-binding domain. SAAS SAAS007094

Contains helicase C-terminal domain. SAAS SAAS007094

Ontologies

Keywords
   Biological processFusion of virus membrane with host endosomal membrane SAAS SAAS000336
Fusion of virus membrane with host membrane
Host-virus interaction
Viral attachment to host cell SAAS SAAS011998
Viral penetration into host cytoplasm
Viral RNA replication SAAS SAAS007094
Virus entry into host cell
   Cellular componentCapsid protein SAAS SAAS011998
Host membrane SAAS SAAS011998
Membrane
Virion
   DomainTransmembrane
Transmembrane helix SAAS SAAS011998
   LigandATP-binding
Chloride PDB 2J7U
GTP-binding PDB 2J7W
Metal-binding PDB 3VWS PDB 4HHJ PDB 4C11 PDB 2J7U PDB 2J7W
Nucleotide-binding
RNA-binding SAAS SAAS007094
Zinc PDB 3VWS PDB 4HHJ PDB 4C11 PDB 2J7U PDB 2J7W
   Molecular functionHelicase SAAS SAAS007094
Hydrolase
Nucleotidyltransferase
Protease
RNA-directed RNA polymerase SAAS SAAS007094
Serine protease SAAS SAAS000336
Transferase
   PTMDisulfide bond SAAS SAAS000336
   Technical term3D-structure PDB 3VWS PDB 4HHJ PDB 4C11 PDB 2J7U PDB 2J7W
Gene Ontology (GO)
   Biological_processclathrin-mediated endocytosis of virus by host cell

Inferred from electronic annotation. Source: UniProtKB-KW

fusion of virus membrane with host endosome membrane

Inferred from electronic annotation. Source: UniProtKB-KW

viral RNA genome replication

Inferred from electronic annotation. Source: InterPro

virion attachment to host cell

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componenthost cell endoplasmic reticulum membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

viral capsid

Inferred from electronic annotation. Source: UniProtKB-KW

viral envelope

Inferred from electronic annotation. Source: UniProtKB-KW

virion membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

ATP-dependent helicase activity

Inferred from electronic annotation. Source: InterPro

GTP binding

Inferred from electronic annotation. Source: UniProtKB-KW

RNA helicase activity

Inferred from electronic annotation. Source: InterPro

RNA-directed RNA polymerase activity

Inferred from electronic annotation. Source: UniProtKB-KW

double-stranded RNA binding

Inferred from electronic annotation. Source: InterPro

mRNA (guanine-N7-)-methyltransferase activity

Inferred from electronic annotation. Source: InterPro

mRNA (nucleoside-2'-O-)-methyltransferase activity

Inferred from electronic annotation. Source: InterPro

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

serine-type endopeptidase activity

Inferred from electronic annotation. Source: InterPro

serine-type exopeptidase activity

Inferred from electronic annotation. Source: InterPro

structural molecule activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding3284 – 32852GTP PDB 2J7W

Sites

Metal binding29271Zinc 1 PDB 3VWS PDB 4HHJ PDB 4C11 PDB 2J7U PDB 2J7W
Metal binding29311Zinc 1; via tele nitrogen PDB 3VWS PDB 4HHJ PDB 4C11 PDB 2J7U PDB 2J7W
Metal binding29361Zinc 1 PDB 3VWS PDB 4HHJ PDB 4C11 PDB 2J7U PDB 2J7W
Metal binding29391Zinc 1 PDB 3VWS PDB 4HHJ PDB 4C11 PDB 2J7U PDB 2J7W
Metal binding32021Zinc 2; via tele nitrogen PDB 3VWS PDB 4HHJ PDB 4C11 PDB 2J7U PDB 2J7W
Metal binding32041Zinc 2; via tele nitrogen PDB 3VWS PDB 4HHJ PDB 4C11 PDB 2J7U PDB 2J7W
Metal binding32181Zinc 2 PDB 3VWS PDB 4HHJ PDB 4C11 PDB 2J7U PDB 2J7W
Metal binding33371Zinc 2 PDB 3VWS PDB 4HHJ PDB 4C11 PDB 2J7U PDB 2J7W
Binding site29821Chloride
Binding site30971Chloride; via amide nitrogen
Binding site32001GTP PDB 2J7W
Binding site32021Hexaethylene glycol PDB 4HHJ
Binding site32191GTP PDB 2J7W
Binding site32271GTP PDB 2J7W

Sequences

Sequence LengthMass (Da)Tools
Q6DLV0 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: 11781239F669266E

FASTA3,390377,913
        10         20         30         40         50         60 
MNNQRKKTGK PSINMLKRVR NRVSTGSQLA KRFSKGLLNG QGPMKLVMAF IAFLRFLAIP 

        70         80         90        100        110        120 
PTAGVLARWG TFKKSGAIKV LKGFKKEISN MLSIINKRKK TSLCLMMILP AALAFHLTSR 

       130        140        150        160        170        180 
DGEPRMIVGK NERGKSLLFK TASGINMCTL IAMDLGEMCD DTVTYKCPHI TEVEPEDIDC 

       190        200        210        220        230        240 
WCNLTSTWVT YGTCNQAGEH RRDKRSVALA PHVGMGLDTR TQTWMSAEGA WRQVEKVETW 

       250        260        270        280        290        300 
ALRHPGFTIL ALFLAHYIGT SLTQKVVIFI LLMLVTPSMT MRCVGVGNRD FVEGLSGATW 

       310        320        330        340        350        360 
VDVVLEHGGC VTTMAKNKPT LDIELQKTEA TQLATLRKLC IEGKITNITT DSRCPTQGEA 

       370        380        390        400        410        420 
VLPEEQDQNY VCKHTYVDRG WGNGCGLFGK GSLVTCAKFQ CLEPIEGKVV QYENLKYTVI 

       430        440        450        460        470        480 
ITVHTGDQHQ VGNETQGVTA EITPQASTTE AILPEYGTLG LECSPRTGLD FNEMILLTMK 

       490        500        510        520        530        540 
NKAWMVHRQW FFDLPLPWAS GATTETPTWN RKELLVTFKN AHAKKQEVVV LGSQEGAMHT 

       550        560        570        580        590        600 
ALTGATEIQN SGGTSIFAGH LKCRLKMDKL ELKGMSYAMC TNTFVLKKEV SETQHGTILI 

       610        620        630        640        650        660 
KVEYKGEDAP CKIPFSTEDG QGKAHNGRLI TANPVVTKKE EPVNIEAEPP FGESNIVIGI 

       670        680        690        700        710        720 
GDNALKINWY KKGSSIGKMF EATARGARRM AILGDTAWDF GSVGGVLNSL GKMVHQIFGS 

       730        740        750        760        770        780 
AYTALFSGVS WVMKIGIGVL LTWIGLNSKN TSMSFSCIAI GIITLYLGAV VQADMGCVIN 

       790        800        810        820        830        840 
WKGKELKCGS GIFVTNEVHT WTEQYKFQAD SPKRLATAIA GAWENGVCGI RSTTRMENLL 

       850        860        870        880        890        900 
WKQIANELNY ILWENNIKLT VVVGDTIGVL EQGKRTLTPQ PMELKYSWKT WGKAKIVTAE 

       910        920        930        940        950        960 
TQNSSFIIDG PNTPECPSAS RAWNVWEVED YGFGVFTTNI WLKLREVYTQ LCDHRLMSAA 

       970        980        990       1000       1010       1020 
VKDERAVHAD MGYWIESQKN GSWKLEKASL IEVKTCTWPK SHTLWSNGVL ESDMIIPKSL 

      1030       1040       1050       1060       1070       1080 
AGPISQHNYR PGYHTQTAGP WHLGKLELDF NYCEGTTVVI TESCGTRGPS LRTTTVSGKL 

      1090       1100       1110       1120       1130       1140 
IHEWCCRSCT LPPLRYMGED GCWYGMEIRP ISEKEENMVK SLVSAGSGKV DNFTMGVLCL 

      1150       1160       1170       1180       1190       1200 
AILFEEVMRG KFGKKHMIAG VFFTFVLLLS GQITWRDMAH TLIMIGSNAS DRMGMGVTYL 

      1210       1220       1230       1240       1250       1260 
ALIATFKIQP FLALGFFLRK LTSRENLLLG VGLAMATTLQ LPEDIEQMAN GIALGLMALK 

      1270       1280       1290       1300       1310       1320 
LITQFETYQL WTALVSLTCS NTIFTLTVAW RTATLILAGV SLLPVCQSSS MRKTDWLPMT 

      1330       1340       1350       1360       1370       1380 
VAAMGVPPLP LFIFSLKDTL KRRSWPLNEG VMAVGLVSIL ASSLLRNDVP MAGPLVAGGL 

      1390       1400       1410       1420       1430       1440 
LIACYVITGT SADLTVEKAA DVTWEEEAEQ TGVSHNLMIT VDDDGTMRIK DDETENILTV 

      1450       1460       1470       1480       1490       1500 
LLKTALLIVS GIFPYSIPAT LLVWHTWQKQ TQRSGVLWDV PSPPETQKAE LEEGVYRIKQ 

      1510       1520       1530       1540       1550       1560 
QGIFGKTQVG VGVQKEGVFH TMWHVTRGAV LTHNGKRLEP NWASVKKDLI SYGGGWRLSA 

      1570       1580       1590       1600       1610       1620 
QWQKGEEVQV IAVEPGKNPK NFQTMPGTFQ TTTGEIGAIA LDFKPGTSGS PIINREGKVV 

      1630       1640       1650       1660       1670       1680 
GLYGNGVVTK NGGYVSGIAQ TNAEPDGPTP ELEEEMFKKR NLTIMDLHPG SGKTRKYLPA 

      1690       1700       1710       1720       1730       1740 
IVREAIKRRL RTLILAPTRV VAAEMEEALK GLPIRYQTTA TKSEHTGREI VDLMCHATFT 

      1750       1760       1770       1780       1790       1800 
MRLLSPVRVP NYNLIIMDEA HFTDPASIAA RGYISTRVGM GEAAAIFMTA TPPGTADAFP 

      1810       1820       1830       1840       1850       1860 
QSNAPIQDEE RDIPERSWNS GNEWITDFAG KTVWFVPSIK AGNDIANCLR KNGKKVIQLS 

      1870       1880       1890       1900       1910       1920 
RKTFDTEYQK SKLNDWDFVV TTDISEMGAN FKADRVIDPR RCLKPVILTD GPERVILAGP 

      1930       1940       1950       1960       1970       1980 
MPVTAASAAQ RRGRVGRNPQ KENDQYIFTG QPLNNDEDHA HWTEAKMLLD NINTPEGIIP 

      1990       2000       2010       2020       2030       2040 
ALFEPEREKS AAIDGEYRLK GESRKTFVEL MRRGDLPVWL AHKVASEGIK YTDRKWCFDG 

      2050       2060       2070       2080       2090       2100 
QRNNQILEEN MDVEIWTKEG EKRKLRPRWL DARTYSDPLA LKEFKDFAAG RKSIALDLVT 

      2110       2120       2130       2140       2150       2160 
EIGRVPSHLA HRTRNALDNL VMLHTSEHGG RAYRHAVEEL PETMETLLLL GLMILLTGGA 

      2170       2180       2190       2200       2210       2220 
MLFLISGKGI GKTSIGLICV IASSGMLWMA EVPLQWIASA IVLEFFMMVL LIPEPEKQRT 

      2230       2240       2250       2260       2270       2280 
PQDNQLAYVV IGILTLAAII AANEMGLLET TKRDLGMSKE PGVVSPTSYL DVDLHPASAW 

      2290       2300       2310       2320       2330       2340 
TLYAVATTVI TPMLRHTIEN STANVSLAAI ANQAVVLMGL DKGWPISKMD LGVPLLALGC 

      2350       2360       2370       2380       2390       2400 
YSQVNPLTLT AAVLLLITHY AIIGPGLQAK ATREAQKRTA AGIMKNPTVD GIMTIDLDPV 

      2410       2420       2430       2440       2450       2460 
IYDSKFEKQL GQVMLLVLCA VQLLLMRTSW ALCEALTLAT GPITTLWEGS PGKFWNTTIA 

      2470       2480       2490       2500       2510       2520 
VSMANIFRGS YLAGAGLAFS IMKSVGTGKR GTGSQGETLG EKWKKKLNQL SRKEFDLYKK 

      2530       2540       2550       2560       2570       2580 
SGITEVDRTE AKEGLKRGET THHAVSRGSA KLQWFVERNM VVPEGRVIDL GCGRGGWSYY 

      2590       2600       2610       2620       2630       2640 
CAGLKKVTEV RGYTKGGPGH EEPVPMSTYG WNIVKLMSGK DVFYLPPEKC DTLLCDIGES 

      2650       2660       2670       2680       2690       2700 
SPSPTVEESR TIRVLKMVEP WLKNNQFCIK VLNPYMPTVI EHLERLQRKH GGMLVRNPLS 

      2710       2720       2730       2740       2750       2760 
RNSTHEMYWI SNGTGNIVSS VNMVSRLLLN RFTMTHRRPT IEKDVDLGAG TRHVNAEPET 

      2770       2780       2790       2800       2810       2820 
PNMDVIGERI KRIKEEHNST WHYDDENPYK TWAYHGSYEV KATGSASSMI NGVVKLLTKP 

      2830       2840       2850       2860       2870       2880 
WDVVPMVTQM AMTDTTPFGQ QRVFKEKVDT RTPRPLPGTR KVMGITAEWL WRTLGRNKRP 

      2890       2900       2910       2920       2930       2940 
RLCTREEFTK KVRTNAAMGA VFTEENQWDS AKAAVEDEEF WKLVDREREL HKLGKCGSCV 

      2950       2960       2970       2980       2990       3000 
YNMMGKREKK LGEFGKAKGS RAIWYMWLGV RYLEFEALGF LNEDHWFSRE NSYSGVEGEG 

      3010       3020       3030       3040       3050       3060 
LHKLGYILRD ISKIPGGAMY ADDTAGWDTR ITEDDLHNEE KIIQQMDPEH RQLANAIFKL 

      3070       3080       3090       3100       3110       3120 
TYQNKVVKVQ RPTPTGTVMD IISRKDQRGS GQVGTYGLNT FTNMEAQLVR QMEGEGVLTK 

      3130       3140       3150       3160       3170       3180 
ADLENPHLLE KKITQWLETK GVERLKRMAI SGDDCVVKPI DDRFANALLA LNDMGKVRKD 

      3190       3200       3210       3220       3230       3240 
IPQWQPSKGW HDWQQVPFCS HHFHELIMKD GRKLVVPCRP QDELIGRARI SQGAGWSLRE 

      3250       3260       3270       3280       3290       3300 
TACLGKAYAQ MWSLMYFHRR DLRLASNAIC SAVPVHWVPT SRTTWSIHAH HQWMTTEDML 

      3310       3320       3330       3340       3350       3360 
TVWNRVWIEE NPWMEDKTPV TTWENVPYLG KREDQWCGSL IGLTSRATWA QNIPTAIQQV 

      3370       3380       3390 
RSLIGNEEFL DYMPSMKRFR KEEESEGAIW 

« Hide

References

[1]"Full length genomic sequence of a Dengue virus of serotype 3 from Singapore."
Lim S.P., Ooi E.E., Vasudevan S.G.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
[2]"Crystal structure of the dengue virus RNA-dependent RNA polymerase catalytic domain at 1.85-angstrom resolution."
Yap T.L., Xu T., Chen Y.L., Malet H., Egloff M.P., Canard B., Vasudevan S.G., Lescar J.
J. Virol. 81:4753-4765(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) OF 2762-3390 IN COMPLEX WITH CHLORIDE; GTP AND ZINC.
[3]"A crystal structure of the dengue virus non-structural protein 5 (NS5) polymerase delineates interdomain amino acid residues that enhance its thermostability and de novo initiation activities."
Lim S.P., Koh J.H., Seh C.C., Liew C.W., Davidson A.D., Chua L.S., Chandrasekaran R., Cornvik T.C., Shi P.Y., Lescar J.
J. Biol. Chem. 288:31105-31114(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) OF 2753-3390 IN COMPLEX WITH ZINC.
[4]"Conformational flexibility of the Dengue virus RNA-dependent RNA polymerase revealed by a complex with an inhibitor."
Noble C.G., Lim S.P., Chen Y.L., Liew C.W., Yap L., Lescar J., Shi P.Y.
J. Virol. 87:5291-5295(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.79 ANGSTROMS) OF 2762-3390 IN COMPLEX WITH HEXAETHYLENE GLYCOL AND ZINC.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY662691 Genomic RNA. Translation: AAT75224.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2J7UX-ray1.85A2762-3390[»]
2J7WX-ray2.60A2763-3390[»]
3VWSX-ray2.10A2762-3390[»]
4C11X-ray2.60A/B2753-3390[»]
4HHJX-ray1.79A2762-3390[»]
ProteinModelPortalQ6DLV0.
SMRQ6DLV0. Positions 21-100, 281-672, 1493-2092, 2497-2757, 2763-3373.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSS07.001.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D2.60.40.350. 1 hit.
2.60.98.10. 2 hits.
3.30.387.10. 1 hit.
3.40.50.150. 1 hit.
3.40.50.300. 2 hits.
InterProIPR011492. DEAD_Flavivir.
IPR000069. Env_glycoprot_M_flavivir.
IPR013755. Flav_gly_cen_dom_subdom1.
IPR001122. Flavi_capsidC.
IPR026470. Flavi_E_Stem/Anchor_dom.
IPR001157. Flavi_NS1.
IPR000752. Flavi_NS2A.
IPR000487. Flavi_NS2B.
IPR000404. Flavi_NS4A.
IPR001528. Flavi_NS4B.
IPR002535. Flavi_propep.
IPR000336. Flavivir/Alphavir_Ig-like.
IPR001850. Flavivirus_NS3_S7.
IPR027287. Flavovir_Ig-like.
IPR014412. Gen_Poly_FLV.
IPR011998. Glycoprot_cen/dimer.
IPR013754. GlyE_dim.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR014756. Ig_E-set.
IPR026490. mRNA_cap_0/1_MeTrfase.
IPR027417. P-loop_NTPase.
IPR000208. RNA-dir_pol_flavivirus.
IPR007094. RNA-dir_pol_PSvirus.
IPR002877. rRNA_MeTrfase_FtsJ_dom.
IPR029063. SAM-dependent_MTases-like.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamPF01003. Flavi_capsid. 1 hit.
PF07652. Flavi_DEAD. 1 hit.
PF02832. Flavi_glycop_C. 1 hit.
PF00869. Flavi_glycoprot. 1 hit.
PF01004. Flavi_M. 1 hit.
PF00948. Flavi_NS1. 1 hit.
PF01005. Flavi_NS2A. 1 hit.
PF01002. Flavi_NS2B. 1 hit.
PF01350. Flavi_NS4A. 1 hit.
PF01349. Flavi_NS4B. 1 hit.
PF00972. Flavi_NS5. 1 hit.
PF01570. Flavi_propep. 1 hit.
PF01728. FtsJ. 1 hit.
PF00271. Helicase_C. 1 hit.
PF00949. Peptidase_S7. 1 hit.
[Graphical view]
PIRSFPIRSF003817. Gen_Poly_FLV. 1 hit.
SMARTSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMSSF50494. SSF50494. 1 hit.
SSF52540. SSF52540. 2 hits.
SSF53335. SSF53335. 1 hit.
SSF56983. SSF56983. 1 hit.
SSF81296. SSF81296. 1 hit.
TIGRFAMsTIGR04240. flavi_E_stem. 1 hit.
PROSITEPS51527. FLAVIVIRUS_NS2B. 1 hit.
PS51528. FLAVIVIRUS_NS3PRO. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS50507. RDRP_SSRNA_POS. 1 hit.
PS51591. RNA_CAP01_NS5_MT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ6DLV0.

Entry information

Entry nameQ6DLV0_9FLAV
AccessionPrimary (citable) accession number: Q6DLV0
Entry history
Integrated into UniProtKB/TrEMBL: August 16, 2004
Last sequence update: August 16, 2004
Last modified: July 9, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)