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Q6DLV0

- Q6DLV0_9FLAV

UniProt

Q6DLV0 - Q6DLV0_9FLAV

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Protein
Submitted name:

Polyprotein

Gene
N/A
Organism
Dengue virus 3
Status
Unreviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

NTP + H2O = NDP + phosphate.
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).SAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi2927 – 29271Zinc 1Imported
Metal bindingi2931 – 29311Zinc 1; via tele nitrogenImported
Metal bindingi2936 – 29361Zinc 1Imported
Metal bindingi2939 – 29391Zinc 1Imported
Binding sitei2982 – 29821Chloride
Binding sitei3097 – 30971Chloride; via amide nitrogen
Binding sitei3200 – 32001GTPImported
Metal bindingi3202 – 32021Zinc 2; via tele nitrogenImported
Metal bindingi3204 – 32041Zinc 2; via tele nitrogenImported
Metal bindingi3218 – 32181Zinc 2Imported
Binding sitei3219 – 32191GTPImported
Binding sitei3227 – 32271GTPImported
Metal bindingi3337 – 33371Zinc 2Imported

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi3284 – 32852GTPImported

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ATP-dependent helicase activity Source: InterPro
  3. double-stranded RNA binding Source: InterPro
  4. GTP binding Source: UniProtKB-KW
  5. metal ion binding Source: UniProtKB-KW
  6. mRNA (guanine-N7-)-methyltransferase activity Source: InterPro
  7. mRNA (nucleoside-2'-O-)-methyltransferase activity Source: InterPro
  8. RNA-directed RNA polymerase activity Source: UniProtKB-KW
  9. RNA helicase activity Source: InterPro
  10. serine-type endopeptidase activity Source: InterPro
  11. serine-type exopeptidase activity Source: InterPro
  12. structural molecule activity Source: InterPro

GO - Biological processi

  1. clathrin-mediated endocytosis of virus by host cell Source: UniProtKB-KW
  2. fusion of virus membrane with host endosome membrane Source: UniProtKB-KW
  3. viral RNA genome replication Source: InterPro
  4. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

HelicaseSAAS annotations, Hydrolase, Nucleotidyltransferase, Protease, RNA-directed RNA polymeraseSAAS annotations, Serine proteaseSAAS annotations, Transferase

Keywords - Biological processi

Fusion of virus membrane with host endosomal membraneSAAS annotations, Fusion of virus membrane with host membrane, Host-virus interaction, Viral attachment to host cellSAAS annotations, Viral penetration into host cytoplasm, Viral RNA replicationSAAS annotations, Virus entry into host cell

Keywords - Ligandi

ATP-binding, GTP-bindingImported, Metal-bindingImported, Nucleotide-binding, RNA-bindingSAAS annotations, ZincImported

Protein family/group databases

MEROPSiS07.001.

Names & Taxonomyi

Protein namesi
Submitted name:
PolyproteinImported
OrganismiDengue virus 3Imported
Taxonomic identifieri11069 [NCBI]
Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageFlaviviridaeFlavivirusDengue virus group

Subcellular locationi

GO - Cellular componenti

  1. host cell endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. viral capsid Source: UniProtKB-KW
  4. viral envelope Source: UniProtKB-KW
  5. virion membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Capsid proteinSAAS annotations, Host membraneSAAS annotations, Membrane, Virion

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotations

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2J7UX-ray1.85A2762-3390[»]
2J7WX-ray2.60A2763-3390[»]
3VWSX-ray2.10A2762-3390[»]
4C11X-ray2.60A/B2753-3390[»]
4HHJX-ray1.79A2762-3390[»]
ProteinModelPortaliQ6DLV0.
SMRiQ6DLV0. Positions 21-100, 281-672, 1493-2092, 2497-2757, 2763-3373.

Miscellaneous databases

EvolutionaryTraceiQ6DLV0.

Family & Domainsi

Sequence similaritiesi

Contains RdRp catalytic domain.SAAS annotations
Contains helicase ATP-binding domain.SAAS annotations
Contains helicase C-terminal domain.SAAS annotations

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotations

Family and domain databases

Gene3Di2.60.40.350. 1 hit.
2.60.98.10. 2 hits.
3.30.387.10. 1 hit.
3.40.50.150. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR011492. DEAD_Flavivir.
IPR000069. Env_glycoprot_M_flavivir.
IPR013755. Flav_gly_cen_dom_subdom1.
IPR001122. Flavi_capsidC.
IPR026470. Flavi_E_Stem/Anchor_dom.
IPR001157. Flavi_NS1.
IPR000752. Flavi_NS2A.
IPR000487. Flavi_NS2B.
IPR000404. Flavi_NS4A.
IPR001528. Flavi_NS4B.
IPR002535. Flavi_propep.
IPR000336. Flavivir/Alphavir_Ig-like.
IPR001850. Flavivirus_NS3_S7.
IPR027287. Flavovir_Ig-like.
IPR014412. Gen_Poly_FLV.
IPR011998. Glycoprot_cen/dimer.
IPR013754. GlyE_dim.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR014756. Ig_E-set.
IPR026490. mRNA_cap_0/1_MeTrfase.
IPR027417. P-loop_NTPase.
IPR000208. RNA-dir_pol_flavivirus.
IPR007094. RNA-dir_pol_PSvirus.
IPR002877. rRNA_MeTrfase_FtsJ_dom.
IPR029063. SAM-dependent_MTases-like.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF01003. Flavi_capsid. 1 hit.
PF07652. Flavi_DEAD. 1 hit.
PF02832. Flavi_glycop_C. 1 hit.
PF00869. Flavi_glycoprot. 1 hit.
PF01004. Flavi_M. 1 hit.
PF00948. Flavi_NS1. 1 hit.
PF01005. Flavi_NS2A. 1 hit.
PF01002. Flavi_NS2B. 1 hit.
PF01350. Flavi_NS4A. 1 hit.
PF01349. Flavi_NS4B. 1 hit.
PF00972. Flavi_NS5. 1 hit.
PF01570. Flavi_propep. 1 hit.
PF01728. FtsJ. 1 hit.
PF00271. Helicase_C. 1 hit.
PF00949. Peptidase_S7. 1 hit.
[Graphical view]
PIRSFiPIRSF003817. Gen_Poly_FLV. 1 hit.
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF52540. SSF52540. 2 hits.
SSF53335. SSF53335. 1 hit.
SSF56983. SSF56983. 1 hit.
SSF81296. SSF81296. 1 hit.
TIGRFAMsiTIGR04240. flavi_E_stem. 1 hit.
PROSITEiPS51527. FLAVIVIRUS_NS2B. 1 hit.
PS51528. FLAVIVIRUS_NS3PRO. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS50507. RDRP_SSRNA_POS. 1 hit.
PS51591. RNA_CAP01_NS5_MT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6DLV0-1 [UniParc]FASTAAdd to Basket

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MNNQRKKTGK PSINMLKRVR NRVSTGSQLA KRFSKGLLNG QGPMKLVMAF     50
IAFLRFLAIP PTAGVLARWG TFKKSGAIKV LKGFKKEISN MLSIINKRKK 100
TSLCLMMILP AALAFHLTSR DGEPRMIVGK NERGKSLLFK TASGINMCTL 150
IAMDLGEMCD DTVTYKCPHI TEVEPEDIDC WCNLTSTWVT YGTCNQAGEH 200
RRDKRSVALA PHVGMGLDTR TQTWMSAEGA WRQVEKVETW ALRHPGFTIL 250
ALFLAHYIGT SLTQKVVIFI LLMLVTPSMT MRCVGVGNRD FVEGLSGATW 300
VDVVLEHGGC VTTMAKNKPT LDIELQKTEA TQLATLRKLC IEGKITNITT 350
DSRCPTQGEA VLPEEQDQNY VCKHTYVDRG WGNGCGLFGK GSLVTCAKFQ 400
CLEPIEGKVV QYENLKYTVI ITVHTGDQHQ VGNETQGVTA EITPQASTTE 450
AILPEYGTLG LECSPRTGLD FNEMILLTMK NKAWMVHRQW FFDLPLPWAS 500
GATTETPTWN RKELLVTFKN AHAKKQEVVV LGSQEGAMHT ALTGATEIQN 550
SGGTSIFAGH LKCRLKMDKL ELKGMSYAMC TNTFVLKKEV SETQHGTILI 600
KVEYKGEDAP CKIPFSTEDG QGKAHNGRLI TANPVVTKKE EPVNIEAEPP 650
FGESNIVIGI GDNALKINWY KKGSSIGKMF EATARGARRM AILGDTAWDF 700
GSVGGVLNSL GKMVHQIFGS AYTALFSGVS WVMKIGIGVL LTWIGLNSKN 750
TSMSFSCIAI GIITLYLGAV VQADMGCVIN WKGKELKCGS GIFVTNEVHT 800
WTEQYKFQAD SPKRLATAIA GAWENGVCGI RSTTRMENLL WKQIANELNY 850
ILWENNIKLT VVVGDTIGVL EQGKRTLTPQ PMELKYSWKT WGKAKIVTAE 900
TQNSSFIIDG PNTPECPSAS RAWNVWEVED YGFGVFTTNI WLKLREVYTQ 950
LCDHRLMSAA VKDERAVHAD MGYWIESQKN GSWKLEKASL IEVKTCTWPK 1000
SHTLWSNGVL ESDMIIPKSL AGPISQHNYR PGYHTQTAGP WHLGKLELDF 1050
NYCEGTTVVI TESCGTRGPS LRTTTVSGKL IHEWCCRSCT LPPLRYMGED 1100
GCWYGMEIRP ISEKEENMVK SLVSAGSGKV DNFTMGVLCL AILFEEVMRG 1150
KFGKKHMIAG VFFTFVLLLS GQITWRDMAH TLIMIGSNAS DRMGMGVTYL 1200
ALIATFKIQP FLALGFFLRK LTSRENLLLG VGLAMATTLQ LPEDIEQMAN 1250
GIALGLMALK LITQFETYQL WTALVSLTCS NTIFTLTVAW RTATLILAGV 1300
SLLPVCQSSS MRKTDWLPMT VAAMGVPPLP LFIFSLKDTL KRRSWPLNEG 1350
VMAVGLVSIL ASSLLRNDVP MAGPLVAGGL LIACYVITGT SADLTVEKAA 1400
DVTWEEEAEQ TGVSHNLMIT VDDDGTMRIK DDETENILTV LLKTALLIVS 1450
GIFPYSIPAT LLVWHTWQKQ TQRSGVLWDV PSPPETQKAE LEEGVYRIKQ 1500
QGIFGKTQVG VGVQKEGVFH TMWHVTRGAV LTHNGKRLEP NWASVKKDLI 1550
SYGGGWRLSA QWQKGEEVQV IAVEPGKNPK NFQTMPGTFQ TTTGEIGAIA 1600
LDFKPGTSGS PIINREGKVV GLYGNGVVTK NGGYVSGIAQ TNAEPDGPTP 1650
ELEEEMFKKR NLTIMDLHPG SGKTRKYLPA IVREAIKRRL RTLILAPTRV 1700
VAAEMEEALK GLPIRYQTTA TKSEHTGREI VDLMCHATFT MRLLSPVRVP 1750
NYNLIIMDEA HFTDPASIAA RGYISTRVGM GEAAAIFMTA TPPGTADAFP 1800
QSNAPIQDEE RDIPERSWNS GNEWITDFAG KTVWFVPSIK AGNDIANCLR 1850
KNGKKVIQLS RKTFDTEYQK SKLNDWDFVV TTDISEMGAN FKADRVIDPR 1900
RCLKPVILTD GPERVILAGP MPVTAASAAQ RRGRVGRNPQ KENDQYIFTG 1950
QPLNNDEDHA HWTEAKMLLD NINTPEGIIP ALFEPEREKS AAIDGEYRLK 2000
GESRKTFVEL MRRGDLPVWL AHKVASEGIK YTDRKWCFDG QRNNQILEEN 2050
MDVEIWTKEG EKRKLRPRWL DARTYSDPLA LKEFKDFAAG RKSIALDLVT 2100
EIGRVPSHLA HRTRNALDNL VMLHTSEHGG RAYRHAVEEL PETMETLLLL 2150
GLMILLTGGA MLFLISGKGI GKTSIGLICV IASSGMLWMA EVPLQWIASA 2200
IVLEFFMMVL LIPEPEKQRT PQDNQLAYVV IGILTLAAII AANEMGLLET 2250
TKRDLGMSKE PGVVSPTSYL DVDLHPASAW TLYAVATTVI TPMLRHTIEN 2300
STANVSLAAI ANQAVVLMGL DKGWPISKMD LGVPLLALGC YSQVNPLTLT 2350
AAVLLLITHY AIIGPGLQAK ATREAQKRTA AGIMKNPTVD GIMTIDLDPV 2400
IYDSKFEKQL GQVMLLVLCA VQLLLMRTSW ALCEALTLAT GPITTLWEGS 2450
PGKFWNTTIA VSMANIFRGS YLAGAGLAFS IMKSVGTGKR GTGSQGETLG 2500
EKWKKKLNQL SRKEFDLYKK SGITEVDRTE AKEGLKRGET THHAVSRGSA 2550
KLQWFVERNM VVPEGRVIDL GCGRGGWSYY CAGLKKVTEV RGYTKGGPGH 2600
EEPVPMSTYG WNIVKLMSGK DVFYLPPEKC DTLLCDIGES SPSPTVEESR 2650
TIRVLKMVEP WLKNNQFCIK VLNPYMPTVI EHLERLQRKH GGMLVRNPLS 2700
RNSTHEMYWI SNGTGNIVSS VNMVSRLLLN RFTMTHRRPT IEKDVDLGAG 2750
TRHVNAEPET PNMDVIGERI KRIKEEHNST WHYDDENPYK TWAYHGSYEV 2800
KATGSASSMI NGVVKLLTKP WDVVPMVTQM AMTDTTPFGQ QRVFKEKVDT 2850
RTPRPLPGTR KVMGITAEWL WRTLGRNKRP RLCTREEFTK KVRTNAAMGA 2900
VFTEENQWDS AKAAVEDEEF WKLVDREREL HKLGKCGSCV YNMMGKREKK 2950
LGEFGKAKGS RAIWYMWLGV RYLEFEALGF LNEDHWFSRE NSYSGVEGEG 3000
LHKLGYILRD ISKIPGGAMY ADDTAGWDTR ITEDDLHNEE KIIQQMDPEH 3050
RQLANAIFKL TYQNKVVKVQ RPTPTGTVMD IISRKDQRGS GQVGTYGLNT 3100
FTNMEAQLVR QMEGEGVLTK ADLENPHLLE KKITQWLETK GVERLKRMAI 3150
SGDDCVVKPI DDRFANALLA LNDMGKVRKD IPQWQPSKGW HDWQQVPFCS 3200
HHFHELIMKD GRKLVVPCRP QDELIGRARI SQGAGWSLRE TACLGKAYAQ 3250
MWSLMYFHRR DLRLASNAIC SAVPVHWVPT SRTTWSIHAH HQWMTTEDML 3300
TVWNRVWIEE NPWMEDKTPV TTWENVPYLG KREDQWCGSL IGLTSRATWA 3350
QNIPTAIQQV RSLIGNEEFL DYMPSMKRFR KEEESEGAIW 3390
Length:3,390
Mass (Da):377,913
Last modified:August 16, 2004 - v1
Checksum:i11781239F669266E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY662691 Genomic RNA. Translation: AAT75224.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY662691 Genomic RNA. Translation: AAT75224.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2J7U X-ray 1.85 A 2762-3390 [» ]
2J7W X-ray 2.60 A 2763-3390 [» ]
3VWS X-ray 2.10 A 2762-3390 [» ]
4C11 X-ray 2.60 A/B 2753-3390 [» ]
4HHJ X-ray 1.79 A 2762-3390 [» ]
ProteinModelPortali Q6DLV0.
SMRi Q6DLV0. Positions 21-100, 281-672, 1493-2092, 2497-2757, 2763-3373.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S07.001.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei Q6DLV0.

Family and domain databases

Gene3Di 2.60.40.350. 1 hit.
2.60.98.10. 2 hits.
3.30.387.10. 1 hit.
3.40.50.150. 1 hit.
3.40.50.300. 2 hits.
InterProi IPR011492. DEAD_Flavivir.
IPR000069. Env_glycoprot_M_flavivir.
IPR013755. Flav_gly_cen_dom_subdom1.
IPR001122. Flavi_capsidC.
IPR026470. Flavi_E_Stem/Anchor_dom.
IPR001157. Flavi_NS1.
IPR000752. Flavi_NS2A.
IPR000487. Flavi_NS2B.
IPR000404. Flavi_NS4A.
IPR001528. Flavi_NS4B.
IPR002535. Flavi_propep.
IPR000336. Flavivir/Alphavir_Ig-like.
IPR001850. Flavivirus_NS3_S7.
IPR027287. Flavovir_Ig-like.
IPR014412. Gen_Poly_FLV.
IPR011998. Glycoprot_cen/dimer.
IPR013754. GlyE_dim.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR014756. Ig_E-set.
IPR026490. mRNA_cap_0/1_MeTrfase.
IPR027417. P-loop_NTPase.
IPR000208. RNA-dir_pol_flavivirus.
IPR007094. RNA-dir_pol_PSvirus.
IPR002877. rRNA_MeTrfase_FtsJ_dom.
IPR029063. SAM-dependent_MTases-like.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF01003. Flavi_capsid. 1 hit.
PF07652. Flavi_DEAD. 1 hit.
PF02832. Flavi_glycop_C. 1 hit.
PF00869. Flavi_glycoprot. 1 hit.
PF01004. Flavi_M. 1 hit.
PF00948. Flavi_NS1. 1 hit.
PF01005. Flavi_NS2A. 1 hit.
PF01002. Flavi_NS2B. 1 hit.
PF01350. Flavi_NS4A. 1 hit.
PF01349. Flavi_NS4B. 1 hit.
PF00972. Flavi_NS5. 1 hit.
PF01570. Flavi_propep. 1 hit.
PF01728. FtsJ. 1 hit.
PF00271. Helicase_C. 1 hit.
PF00949. Peptidase_S7. 1 hit.
[Graphical view ]
PIRSFi PIRSF003817. Gen_Poly_FLV. 1 hit.
SMARTi SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
SSF52540. SSF52540. 2 hits.
SSF53335. SSF53335. 1 hit.
SSF56983. SSF56983. 1 hit.
SSF81296. SSF81296. 1 hit.
TIGRFAMsi TIGR04240. flavi_E_stem. 1 hit.
PROSITEi PS51527. FLAVIVIRUS_NS2B. 1 hit.
PS51528. FLAVIVIRUS_NS3PRO. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS50507. RDRP_SSRNA_POS. 1 hit.
PS51591. RNA_CAP01_NS5_MT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Full length genomic sequence of a Dengue virus of serotype 3 from Singapore."
    Lim S.P., Ooi E.E., Vasudevan S.G.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Crystal structure of the dengue virus RNA-dependent RNA polymerase catalytic domain at 1.85-angstrom resolution."
    Yap T.L., Xu T., Chen Y.L., Malet H., Egloff M.P., Canard B., Vasudevan S.G., Lescar J.
    J. Virol. 81:4753-4765(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) OF 2762-3390 IN COMPLEX WITH GTP AND ZINC.
  3. "A crystal structure of the dengue virus non-structural protein 5 (NS5) polymerase delineates interdomain amino acid residues that enhance its thermostability and de novo initiation activities."
    Lim S.P., Koh J.H., Seh C.C., Liew C.W., Davidson A.D., Chua L.S., Chandrasekaran R., Cornvik T.C., Shi P.Y., Lescar J.
    J. Biol. Chem. 288:31105-31114(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) OF 2753-3390 IN COMPLEX WITH ZINC.
  4. "Conformational flexibility of the Dengue virus RNA-dependent RNA polymerase revealed by a complex with an inhibitor."
    Noble C.G., Lim S.P., Chen Y.L., Liew C.W., Yap L., Lescar J., Shi P.Y.
    J. Virol. 87:5291-5295(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.79 ANGSTROMS) OF 2762-3390 IN COMPLEX WITH ZINC.

Entry informationi

Entry nameiQ6DLV0_9FLAV
AccessioniPrimary (citable) accession number: Q6DLV0
Entry historyi
Integrated into UniProtKB/TrEMBL: August 16, 2004
Last sequence update: August 16, 2004
Last modified: September 3, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3

Similar proteinsi