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Q6DKJ4

- NXN_HUMAN

UniProt

Q6DKJ4 - NXN_HUMAN

Protein

Nucleoredoxin

Gene

NXN

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 2 (29 Apr 2008)
      Previous versions | rss
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    Functioni

    Functions as a redox-dependent negative regulator of the Wnt signaling pathway, possibly by preventing ubiquitination of DVL3 by the BCR(KLHL12) complex. May also function as a transcriptional regulator act as a regulator of protein phosphatase 2A (PP2A) By similarity.By similarity

    Catalytic activityi

    Protein dithiol + NAD(P)+ = protein disulfide + NAD(P)H.

    GO - Molecular functioni

    1. protein-disulfide reductase activity Source: UniProtKB-EC
    2. thioredoxin-disulfide reductase activity Source: Ensembl

    GO - Biological processi

    1. cardiovascular system development Source: UniProtKB
    2. cell differentiation Source: UniProtKB-KW
    3. negative regulation of protein ubiquitination Source: UniProtKB
    4. negative regulation of Wnt signaling pathway Source: UniProtKB
    5. Wnt signaling pathway Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein, Oxidoreductase

    Keywords - Biological processi

    Differentiation, Wnt signaling pathway

    Keywords - Ligandi

    NAD

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nucleoredoxin (EC:1.8.1.8)
    Gene namesi
    Name:NXN
    Synonyms:NRX
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:18008. NXN.

    Subcellular locationi

    Cytoplasmcytosol By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. cytosol Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31863.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 435434NucleoredoxinPRO_0000332933Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ6DKJ4.
    PaxDbiQ6DKJ4.
    PeptideAtlasiQ6DKJ4.
    PRIDEiQ6DKJ4.

    PTM databases

    PhosphoSiteiQ6DKJ4.

    Expressioni

    Gene expression databases

    ArrayExpressiQ6DKJ4.
    BgeeiQ6DKJ4.
    CleanExiHS_NXN.
    GenevestigatoriQ6DKJ4.

    Organism-specific databases

    HPAiHPA022850.
    HPA023566.

    Interactioni

    Subunit structurei

    Associates with the phosphatase 2A holoenzyme. Interacts with PPP2CA; the interaction is direct. Interacts with DVL1 (via PDZ domain); the interaction is direct and regulated by oxidative stress By similarity.By similarity

    Protein-protein interaction databases

    BioGridi122144. 4 interactions.
    IntActiQ6DKJ4. 2 interactions.
    MINTiMINT-4898529.
    STRINGi9606.ENSP00000337443.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6DKJ4.
    SMRiQ6DKJ4. Positions 2-165, 196-296.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini167 – 321155ThioredoxinPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the nucleoredoxin family.Curated
    Contains 1 thioredoxin domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG273116.
    HOGENOMiHOG000007309.
    HOVERGENiHBG053461.
    InParanoidiQ6DKJ4.
    KOiK17609.
    OMAiWQDFVRD.
    OrthoDBiEOG70W3G2.
    PhylomeDBiQ6DKJ4.
    TreeFamiTF331873.

    Family and domain databases

    Gene3Di3.40.30.10. 2 hits.
    InterProiIPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PfamiPF13905. Thioredoxin_8. 2 hits.
    [Graphical view]
    SUPFAMiSSF52833. SSF52833. 3 hits.
    PROSITEiPS51352. THIOREDOXIN_2. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6DKJ4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSGFLEELLG EKLVTGGGEE VDVHSLGARG ISLLGLYFGC SLSAPCAQLS    50
    ASLAAFYGRL RGDAAAGPGP GAGAGAAAEP EPRRRLEIVF VSSDQDQRQW 100
    QDFVRDMPWL ALPYKEKHRK LKLWNKYRIS NIPSLIFLDA TTGKVVCRNG 150
    LLVIRDDPEG LEFPWGPKPF REVIAGPLLR NNGQSLESSS LEGSHVGVYF 200
    SAHWCPPCRS LTRVLVESYR KIKEAGQNFE IIFVSADRSE ESFKQYFSEM 250
    PWLAVPYTDE ARRSRLNRLY GIQGIPTLIM LDPQGEVITR QGRVEVLNDE 300
    DCREFPWHPK PVLELSDSNA AQLNEGPCLV LFVDSEDDGE SEAAKQLIQP 350
    IAEKIIAKYK AKEEEAPLLF FVAGEDDMTD SLRDYTNLPE AAPLLTILDM 400
    SARAKYVMDV EEITPAIVEA FVNDFLAEKL KPEPI 435
    Length:435
    Mass (Da):48,392
    Last modified:April 29, 2008 - v2
    Checksum:iB67927F001BE4E5B
    GO
    Isoform 2 (identifier: Q6DKJ4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-113: Missing.
         114-120: YKEKHRK → MQELRNS
         275-290: IPTLIMLDPQGEVITR → RRSRPRLRVAPGNLLT
         291-435: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:177
    Mass (Da):20,328
    Checksum:iD36156E815E83ACF
    GO
    Isoform 3 (identifier: Q6DKJ4-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-108: Missing.
         109-120: WLALPYKEKHRK → MADVSLHRNPAT

    Show »
    Length:327
    Mass (Da):36,871
    Checksum:iA9343547616F7A95
    GO

    Sequence cautioni

    The sequence BAB14171.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAB55122.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti124 – 1241W → K in BAB55122. (PubMed:14702039)Curated
    Sequence conflicti165 – 1651W → K in BAB14171. (PubMed:14702039)Curated
    Sequence conflicti372 – 3721V → I in AAH73845. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 113113Missing in isoform 2. 1 PublicationVSP_033392Add
    BLAST
    Alternative sequencei1 – 108108Missing in isoform 3. 1 PublicationVSP_042792Add
    BLAST
    Alternative sequencei109 – 12012WLALP…EKHRK → MADVSLHRNPAT in isoform 3. 1 PublicationVSP_042793Add
    BLAST
    Alternative sequencei114 – 1207YKEKHRK → MQELRNS in isoform 2. 1 PublicationVSP_033393
    Alternative sequencei275 – 29016IPTLI…EVITR → RRSRPRLRVAPGNLLT in isoform 2. 1 PublicationVSP_033394Add
    BLAST
    Alternative sequencei291 – 435145Missing in isoform 2. 1 PublicationVSP_033395Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK022676 mRNA. Translation: BAB14171.1. Different initiation.
    AK027451 mRNA. Translation: BAB55122.1. Different initiation.
    AK302073 mRNA. Translation: BAG63462.1.
    AC015884 Genomic DNA. No translation available.
    AC036164 Genomic DNA. No translation available.
    AC087392 Genomic DNA. No translation available.
    CH471108 Genomic DNA. Translation: EAW90640.1.
    CH471108 Genomic DNA. Translation: EAW90641.1.
    BC009327 mRNA. Translation: AAH09327.2.
    BC063828 mRNA. Translation: AAH63828.1.
    BC073845 mRNA. Translation: AAH73845.1.
    BC104634 mRNA. Translation: AAI04635.1.
    CCDSiCCDS10998.1. [Q6DKJ4-1]
    CCDS56013.1. [Q6DKJ4-3]
    RefSeqiNP_001192248.1. NM_001205319.1. [Q6DKJ4-3]
    NP_071908.2. NM_022463.4. [Q6DKJ4-1]
    UniGeneiHs.527989.

    Genome annotation databases

    EnsembliENST00000336868; ENSP00000337443; ENSG00000167693. [Q6DKJ4-1]
    ENST00000537628; ENSP00000446446; ENSG00000167693.
    ENST00000575801; ENSP00000461038; ENSG00000167693. [Q6DKJ4-3]
    GeneIDi64359.
    KEGGihsa:64359.
    UCSCiuc002fsa.3. human. [Q6DKJ4-1]
    uc010vqe.2. human. [Q6DKJ4-3]

    Polymorphism databases

    DMDMi187471109.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK022676 mRNA. Translation: BAB14171.1 . Different initiation.
    AK027451 mRNA. Translation: BAB55122.1 . Different initiation.
    AK302073 mRNA. Translation: BAG63462.1 .
    AC015884 Genomic DNA. No translation available.
    AC036164 Genomic DNA. No translation available.
    AC087392 Genomic DNA. No translation available.
    CH471108 Genomic DNA. Translation: EAW90640.1 .
    CH471108 Genomic DNA. Translation: EAW90641.1 .
    BC009327 mRNA. Translation: AAH09327.2 .
    BC063828 mRNA. Translation: AAH63828.1 .
    BC073845 mRNA. Translation: AAH73845.1 .
    BC104634 mRNA. Translation: AAI04635.1 .
    CCDSi CCDS10998.1. [Q6DKJ4-1 ]
    CCDS56013.1. [Q6DKJ4-3 ]
    RefSeqi NP_001192248.1. NM_001205319.1. [Q6DKJ4-3 ]
    NP_071908.2. NM_022463.4. [Q6DKJ4-1 ]
    UniGenei Hs.527989.

    3D structure databases

    ProteinModelPortali Q6DKJ4.
    SMRi Q6DKJ4. Positions 2-165, 196-296.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122144. 4 interactions.
    IntActi Q6DKJ4. 2 interactions.
    MINTi MINT-4898529.
    STRINGi 9606.ENSP00000337443.

    PTM databases

    PhosphoSitei Q6DKJ4.

    Polymorphism databases

    DMDMi 187471109.

    Proteomic databases

    MaxQBi Q6DKJ4.
    PaxDbi Q6DKJ4.
    PeptideAtlasi Q6DKJ4.
    PRIDEi Q6DKJ4.

    Protocols and materials databases

    DNASUi 64359.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000336868 ; ENSP00000337443 ; ENSG00000167693 . [Q6DKJ4-1 ]
    ENST00000537628 ; ENSP00000446446 ; ENSG00000167693 .
    ENST00000575801 ; ENSP00000461038 ; ENSG00000167693 . [Q6DKJ4-3 ]
    GeneIDi 64359.
    KEGGi hsa:64359.
    UCSCi uc002fsa.3. human. [Q6DKJ4-1 ]
    uc010vqe.2. human. [Q6DKJ4-3 ]

    Organism-specific databases

    CTDi 64359.
    GeneCardsi GC17M000702.
    H-InvDB HIX0013394.
    HGNCi HGNC:18008. NXN.
    HPAi HPA022850.
    HPA023566.
    MIMi 612895. gene.
    neXtProti NX_Q6DKJ4.
    PharmGKBi PA31863.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG273116.
    HOGENOMi HOG000007309.
    HOVERGENi HBG053461.
    InParanoidi Q6DKJ4.
    KOi K17609.
    OMAi WQDFVRD.
    OrthoDBi EOG70W3G2.
    PhylomeDBi Q6DKJ4.
    TreeFami TF331873.

    Miscellaneous databases

    ChiTaRSi NXN. human.
    GenomeRNAii 64359.
    NextBioi 66291.
    PROi Q6DKJ4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q6DKJ4.
    Bgeei Q6DKJ4.
    CleanExi HS_NXN.
    Genevestigatori Q6DKJ4.

    Family and domain databases

    Gene3Di 3.40.30.10. 2 hits.
    InterProi IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    Pfami PF13905. Thioredoxin_8. 2 hits.
    [Graphical view ]
    SUPFAMi SSF52833. SSF52833. 3 hits.
    PROSITEi PS51352. THIOREDOXIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 124-435 (ISOFORM 1).
      Tissue: Teratocarcinoma and Testis.
    2. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), PARTIAL NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 171-435 (ISOFORM 1).
      Tissue: Brain, Liver, Lung and Uterus.
    5. Cited for: IDENTIFICATION IN A COMPLEX WITH PHOSPHATASE 2A.
    6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiNXN_HUMAN
    AccessioniPrimary (citable) accession number: Q6DKJ4
    Secondary accession number(s): B4DXQ0
    , D3DTH2, Q3SWW6, Q6P3U6, Q7L4C6, Q9H9Q1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: April 29, 2008
    Last modified: October 1, 2014
    This is version 94 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3