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Protein

Nucleoredoxin

Gene

NXN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as a redox-dependent negative regulator of the Wnt signaling pathway, possibly by preventing ubiquitination of DVL3 by the BCR(KLHL12) complex. May also function as a transcriptional regulator act as a regulator of protein phosphatase 2A (PP2A) (By similarity).By similarity

Caution

Catalytic activityi

Protein dithiol + NAD(P)+ = protein disulfide + NAD(P)H.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Oxidoreductase
Biological processDifferentiation, Wnt signaling pathway
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoredoxin (EC:1.8.1.8)
Gene namesi
Name:NXN
Synonyms:NRX
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000167693.16
HGNCiHGNC:18008 NXN
MIMi612895 gene
neXtProtiNX_Q6DKJ4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi64359
OpenTargetsiENSG00000167693
PharmGKBiPA31863

Polymorphism and mutation databases

BioMutaiNXN
DMDMi187471109

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00003329332 – 435NucleoredoxinAdd BLAST434

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ6DKJ4
MaxQBiQ6DKJ4
PaxDbiQ6DKJ4
PeptideAtlasiQ6DKJ4
PRIDEiQ6DKJ4

PTM databases

iPTMnetiQ6DKJ4
PhosphoSitePlusiQ6DKJ4

Expressioni

Gene expression databases

BgeeiENSG00000167693
CleanExiHS_NXN
ExpressionAtlasiQ6DKJ4 baseline and differential
GenevisibleiQ6DKJ4 HS

Organism-specific databases

HPAiHPA023566

Interactioni

Subunit structurei

Associates with the phosphatase 2A holoenzyme. Interacts with PPP2CA; the interaction is direct. Interacts with DVL1 (via PDZ domain); the interaction is direct and regulated by oxidative stress (By similarity).By similarity

Protein-protein interaction databases

BioGridi12214418 interactors.
IntActiQ6DKJ4 6 interactors.
MINTiQ6DKJ4
STRINGi9606.ENSP00000337443

Structurei

3D structure databases

ProteinModelPortaliQ6DKJ4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini167 – 321ThioredoxinPROSITE-ProRule annotationAdd BLAST155

Sequence similaritiesi

Belongs to the nucleoredoxin family.Curated

Phylogenomic databases

eggNOGiKOG2501 Eukaryota
ENOG410ZIWC LUCA
GeneTreeiENSGT00530000063279
HOGENOMiHOG000007309
HOVERGENiHBG053461
InParanoidiQ6DKJ4
KOiK17609
OMAiNAVQLHE
OrthoDBiEOG091G079A
PhylomeDBiQ6DKJ4
TreeFamiTF331873

Family and domain databases

InterProiView protein in InterPro
IPR012336 Thioredoxin-like_fold
IPR036249 Thioredoxin-like_sf
IPR013766 Thioredoxin_domain
PfamiView protein in Pfam
PF13905 Thioredoxin_8, 2 hits
SUPFAMiSSF52833 SSF52833, 3 hits
PROSITEiView protein in PROSITE
PS51352 THIOREDOXIN_2, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6DKJ4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGFLEELLG EKLVTGGGEE VDVHSLGARG ISLLGLYFGC SLSAPCAQLS
60 70 80 90 100
ASLAAFYGRL RGDAAAGPGP GAGAGAAAEP EPRRRLEIVF VSSDQDQRQW
110 120 130 140 150
QDFVRDMPWL ALPYKEKHRK LKLWNKYRIS NIPSLIFLDA TTGKVVCRNG
160 170 180 190 200
LLVIRDDPEG LEFPWGPKPF REVIAGPLLR NNGQSLESSS LEGSHVGVYF
210 220 230 240 250
SAHWCPPCRS LTRVLVESYR KIKEAGQNFE IIFVSADRSE ESFKQYFSEM
260 270 280 290 300
PWLAVPYTDE ARRSRLNRLY GIQGIPTLIM LDPQGEVITR QGRVEVLNDE
310 320 330 340 350
DCREFPWHPK PVLELSDSNA AQLNEGPCLV LFVDSEDDGE SEAAKQLIQP
360 370 380 390 400
IAEKIIAKYK AKEEEAPLLF FVAGEDDMTD SLRDYTNLPE AAPLLTILDM
410 420 430
SARAKYVMDV EEITPAIVEA FVNDFLAEKL KPEPI
Length:435
Mass (Da):48,392
Last modified:April 29, 2008 - v2
Checksum:iB67927F001BE4E5B
GO
Isoform 2 (identifier: Q6DKJ4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-113: Missing.
     114-120: YKEKHRK → MQELRNS
     275-290: IPTLIMLDPQGEVITR → RRSRPRLRVAPGNLLT
     291-435: Missing.

Note: No experimental confirmation available.
Show »
Length:177
Mass (Da):20,328
Checksum:iD36156E815E83ACF
GO
Isoform 3 (identifier: Q6DKJ4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-108: Missing.
     109-120: WLALPYKEKHRK → MADVSLHRNPAT

Show »
Length:327
Mass (Da):36,871
Checksum:iA9343547616F7A95
GO

Sequence cautioni

The sequence BAB14171 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB55122 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti124W → K in BAB55122 (PubMed:14702039).Curated1
Sequence conflicti165W → K in BAB14171 (PubMed:14702039).Curated1
Sequence conflicti372V → I in AAH73845 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0333921 – 113Missing in isoform 2. 1 PublicationAdd BLAST113
Alternative sequenceiVSP_0427921 – 108Missing in isoform 3. 1 PublicationAdd BLAST108
Alternative sequenceiVSP_042793109 – 120WLALP…EKHRK → MADVSLHRNPAT in isoform 3. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_033393114 – 120YKEKHRK → MQELRNS in isoform 2. 1 Publication7
Alternative sequenceiVSP_033394275 – 290IPTLI…EVITR → RRSRPRLRVAPGNLLT in isoform 2. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_033395291 – 435Missing in isoform 2. 1 PublicationAdd BLAST145

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022676 mRNA Translation: BAB14171.1 Different initiation.
AK027451 mRNA Translation: BAB55122.1 Different initiation.
AK302073 mRNA Translation: BAG63462.1
AC015884 Genomic DNA No translation available.
AC036164 Genomic DNA No translation available.
AC087392 Genomic DNA No translation available.
CH471108 Genomic DNA Translation: EAW90640.1
CH471108 Genomic DNA Translation: EAW90641.1
BC009327 mRNA Translation: AAH09327.2
BC063828 mRNA Translation: AAH63828.1
BC073845 mRNA Translation: AAH73845.1
BC104634 mRNA Translation: AAI04635.1
CCDSiCCDS10998.1 [Q6DKJ4-1]
CCDS56013.1 [Q6DKJ4-3]
RefSeqiNP_001192248.1, NM_001205319.1 [Q6DKJ4-3]
NP_071908.2, NM_022463.4 [Q6DKJ4-1]
UniGeneiHs.527989

Genome annotation databases

EnsembliENST00000336868; ENSP00000337443; ENSG00000167693 [Q6DKJ4-1]
ENST00000575801; ENSP00000461038; ENSG00000167693 [Q6DKJ4-3]
GeneIDi64359
KEGGihsa:64359
UCSCiuc002fsa.4 human [Q6DKJ4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiNXN_HUMAN
AccessioniPrimary (citable) accession number: Q6DKJ4
Secondary accession number(s): B4DXQ0
, D3DTH2, Q3SWW6, Q6P3U6, Q7L4C6, Q9H9Q1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: March 28, 2018
This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome