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Protein

Transmembrane protein PVRIG

Gene

PVRIG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Cell surface receptor for NECTIN2. May act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals. Following interaction with NECTIN2, inhibits T-cell proliferation. Competes with CD226 for NECTIN2-binding.1 Publication

Enzyme and pathway databases

BioCyciZFISH:G66-33811-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein PVRIG
Alternative name(s):
CD112 receptor
Short name:
CD112R
Poliovirus receptor-related immunoglobulin domain-containing protein
Gene namesi
Name:PVRIG
Synonyms:C7orf15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:32190. PVRIG.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei26 – 46HelicalSequence analysisAdd BLAST21
Transmembranei62 – 78HelicalSequence analysisAdd BLAST17
Transmembranei172 – 192HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi233Y → F: Reduced phosphorylation. 1 Publication1
Mutagenesisi293Y → F: No effect on global phosphorylation. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000213413.
PharmGKBiPA162400434.

Polymorphism and mutation databases

BioMutaiPVRIG.
DMDMi74736413.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003371421 – 326Transmembrane protein PVRIGAdd BLAST326

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei233Phosphotyrosine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6DKI7.
PeptideAtlasiQ6DKI7.
PRIDEiQ6DKI7.

PTM databases

iPTMnetiQ6DKI7.
PhosphoSitePlusiQ6DKI7.

Expressioni

Tissue specificityi

Expressed in some types of immune cells. Expressed at low levels on the surface of freshly isolated T-cells and natural killer (NK) cells, predominantly on CD8+ T-cells (mainly memory/effector, but not naive cells) and on both CD16+ and CD16- NK cells. T-cell expression levels are variable among individuals. Not detected in B-cells, naive or helper T-cells, monocytes, nor neutrophils (at protein level). Not detected in dendritic cells.1 Publication

Inductioni

In T-cells, up-regulated by activation induced by treatment with anti-CD3 and anti-CD28 antibodies.1 Publication

Gene expression databases

BgeeiENSG00000213413.
CleanExiHS_PVRIG.
GenevisibleiQ6DKI7. HS.

Organism-specific databases

HPAiHPA047497.

Interactioni

Subunit structurei

Interacts with NECTIN2, hence competing with CD226.1 Publication

Protein-protein interaction databases

BioGridi299834. 14 interactors.
STRINGi9606.ENSP00000316675.

Structurei

3D structure databases

ProteinModelPortaliQ6DKI7.
SMRiQ6DKI7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF1U. Eukaryota.
ENOG4111EHB. LUCA.
GeneTreeiENSGT00390000017799.
HOGENOMiHOG000115803.
InParanoidiQ6DKI7.
OMAiWASLPTH.
OrthoDBiEOG091G0QZI.
PhylomeDBiQ6DKI7.
TreeFamiTF343319.

Sequencei

Sequence statusi: Complete.

Q6DKI7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTEAQVPAL QPPEPGLEGA MGHRTLVLPW VLLTLCVTAG TPEVWVQVRM
60 70 80 90 100
EATELSSFTI RCGFLGSGSI SLVTVSWGGP NGAGGTTLAV LHPERGIRQW
110 120 130 140 150
APARQARWET QSSISLILEG SGASSPCANT TFCCKFASFP EGSWEACGSL
160 170 180 190 200
PPSSDPGLSA PPTPAPILRA DLAGILGVSG VLLFGCVYLL HLLRRHKHRP
210 220 230 240 250
APRLQPSRTS PQAPRARAWA PSQASQAALH VPYATINTSC RPATLDTAHP
260 270 280 290 300
HGGPSWWASL PTHAAHRPQG PAAWASTPIP ARGSFVSVEN GLYAQAGERP
310 320
PHTGPGLTLF PDPRGPRAME GPLGVR
Length:326
Mass (Da):34,344
Last modified:August 16, 2004 - v1
Checksum:i7D9DF363C523F9CD
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04362481N → D.1 PublicationCorresponds to variant rs2906645dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471091 Genomic DNA. Translation: EAW76566.1.
CH471091 Genomic DNA. Translation: EAW76567.1.
BC001129 mRNA. Translation: AAH01129.1.
BC073861 mRNA. Translation: AAH73861.1.
BC107873 mRNA. Translation: AAI07874.1.
CCDSiCCDS5690.1.
RefSeqiNP_076975.2. NM_024070.3.
XP_011514877.1. XM_011516575.2.
UniGeneiHs.729356.

Genome annotation databases

EnsembliENST00000317271; ENSP00000316675; ENSG00000213413.
GeneIDi79037.
KEGGihsa:79037.
UCSCiuc003uuf.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471091 Genomic DNA. Translation: EAW76566.1.
CH471091 Genomic DNA. Translation: EAW76567.1.
BC001129 mRNA. Translation: AAH01129.1.
BC073861 mRNA. Translation: AAH73861.1.
BC107873 mRNA. Translation: AAI07874.1.
CCDSiCCDS5690.1.
RefSeqiNP_076975.2. NM_024070.3.
XP_011514877.1. XM_011516575.2.
UniGeneiHs.729356.

3D structure databases

ProteinModelPortaliQ6DKI7.
SMRiQ6DKI7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi299834. 14 interactors.
STRINGi9606.ENSP00000316675.

PTM databases

iPTMnetiQ6DKI7.
PhosphoSitePlusiQ6DKI7.

Polymorphism and mutation databases

BioMutaiPVRIG.
DMDMi74736413.

Proteomic databases

PaxDbiQ6DKI7.
PeptideAtlasiQ6DKI7.
PRIDEiQ6DKI7.

Protocols and materials databases

DNASUi79037.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317271; ENSP00000316675; ENSG00000213413.
GeneIDi79037.
KEGGihsa:79037.
UCSCiuc003uuf.2. human.

Organism-specific databases

CTDi79037.
GeneCardsiPVRIG.
HGNCiHGNC:32190. PVRIG.
HPAiHPA047497.
MIMi617012. gene.
neXtProtiNX_Q6DKI7.
OpenTargetsiENSG00000213413.
PharmGKBiPA162400434.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF1U. Eukaryota.
ENOG4111EHB. LUCA.
GeneTreeiENSGT00390000017799.
HOGENOMiHOG000115803.
InParanoidiQ6DKI7.
OMAiWASLPTH.
OrthoDBiEOG091G0QZI.
PhylomeDBiQ6DKI7.
TreeFamiTF343319.

Enzyme and pathway databases

BioCyciZFISH:G66-33811-MONOMER.

Miscellaneous databases

GenomeRNAii79037.
PROiQ6DKI7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000213413.
CleanExiHS_PVRIG.
GenevisibleiQ6DKI7. HS.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiPVRIG_HUMAN
AccessioniPrimary (citable) accession number: Q6DKI7
Secondary accession number(s): D6W5U9, Q9BVK3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: August 16, 2004
Last modified: November 30, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Was named PVRIG for the homology observed between its second exon and the variable immunoglobulin domain of the polio virus receptor (PVR/CD155) and polio virus receptor-like (PVRL) genes.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.