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Protein

Galectin-9C

Gene

LGALS9C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Binds galactosides.By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Galectin-9C
Short name:
Gal-9C
Alternative name(s):
Galectin-9-like protein B
Gene namesi
Name:LGALS9C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:33874. LGALS9C.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000171916.
PharmGKBiPA162393930.

Polymorphism and mutation databases

BioMutaiLGALS9C.
DMDMi296434563.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003321311 – 356Galectin-9CAdd BLAST356

Proteomic databases

MaxQBiQ6DKI2.
PaxDbiQ6DKI2.
PeptideAtlasiQ6DKI2.
PRIDEiQ6DKI2.

PTM databases

iPTMnetiQ6DKI2.
PhosphoSitePlusiQ6DKI2.

Expressioni

Gene expression databases

BgeeiENSG00000171916.
CleanExiHS_LGALS9C.
ExpressionAtlasiQ6DKI2. baseline and differential.

Organism-specific databases

HPAiHPA046876.
HPA047218.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
DAB1O755533EBI-9088829,EBI-7875264
PLSCR1O151623EBI-9088829,EBI-740019
RBPMSQ930623EBI-9088829,EBI-740322

Protein-protein interaction databases

BioGridi576335. 27 interactors.
IntActiQ6DKI2. 5 interactors.
STRINGi9606.ENSP00000329932.

Structurei

3D structure databases

ProteinModelPortaliQ6DKI2.
SMRiQ6DKI2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 148Galectin 1PROSITE-ProRule annotationAdd BLAST132
Domaini228 – 356Galectin 2PROSITE-ProRule annotationAdd BLAST129

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni82 – 88Beta-galactoside binding 1By similarity7
Regioni288 – 294Beta-galactoside binding 2By similarity7

Sequence similaritiesi

Contains 2 galectin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3587. Eukaryota.
ENOG4111EA0. LUCA.
GeneTreeiENSGT00760000119105.
HOGENOMiHOG000290194.
HOVERGENiHBG002412.
InParanoidiQ6DKI2.
KOiK10093.
OMAiLAANEWG.
OrthoDBiEOG091G0WP8.
PhylomeDBiQ6DKI2.
TreeFamiTF315551.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR001079. Galectin_CRD.
[Graphical view]
PfamiPF00337. Gal-bind_lectin. 2 hits.
[Graphical view]
SMARTiSM00908. Gal-bind_lectin. 2 hits.
SM00276. GLECT. 2 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 2 hits.
PROSITEiPS51304. GALECTIN. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6DKI2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFSGCQAPY LSPAVPFSGT IQGGLQDGFQ ITVNGAVLSC SGTRFAVDFQ
60 70 80 90 100
TGFSGNDIAF HFNPRFEDGG YVVCNTRQKG TWGPEERKMH MPFQKGMPFD
110 120 130 140 150
LCFLVQSSDF KVMVNGSLFV QYFHRVPFHR VDTISVNGSV QLSYISFQNP
160 170 180 190 200
RAVPVQPAFS TVPFSQPVCF PPRPRGRRQK PPSVRPANPA PITQTVIHTV
210 220 230 240 250
QSASGQMFSQ TPAIPPMMYP HPAYPMPFIT TIPGGLYPSK SIILSGTVLP
260 270 280 290 300
SAQRFHINLC SGSHIAFHMN PRFDENAVVR NTQINNSWGS EERSLPRKMP
310 320 330 340 350
FVRGQSFSVW ILCEAHCLKV AVDGQHVFEY YHRLRNLPTI NKLEVGGDIQ

LTHVQT
Length:356
Mass (Da):39,607
Last modified:May 18, 2010 - v2
Checksum:i539BAFD9FD53EE19
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti81T → R in BAF98709 (PubMed:14702039).Curated1
Sequence conflicti153V → A in BAF98709 (PubMed:14702039).Curated1
Sequence conflicti183S → I in AAH73889 (PubMed:15489334).Curated1
Sequence conflicti306S → C in BAF98709 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_056004126V → M.1 PublicationCorresponds to variant rs3907319dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK315818 mRNA. Translation: BAF98709.1.
AC107983 Genomic DNA. No translation available.
AL353997 Genomic DNA. No translation available.
BC073889 mRNA. Translation: AAH73889.1.
CCDSiCCDS32587.1.
RefSeqiNP_001035167.2. NM_001040078.2.
UniGeneiHs.462402.

Genome annotation databases

EnsembliENST00000328114; ENSP00000329932; ENSG00000171916.
GeneIDi654346.
KEGGihsa:654346.
UCSCiuc002gtw.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK315818 mRNA. Translation: BAF98709.1.
AC107983 Genomic DNA. No translation available.
AL353997 Genomic DNA. No translation available.
BC073889 mRNA. Translation: AAH73889.1.
CCDSiCCDS32587.1.
RefSeqiNP_001035167.2. NM_001040078.2.
UniGeneiHs.462402.

3D structure databases

ProteinModelPortaliQ6DKI2.
SMRiQ6DKI2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi576335. 27 interactors.
IntActiQ6DKI2. 5 interactors.
STRINGi9606.ENSP00000329932.

PTM databases

iPTMnetiQ6DKI2.
PhosphoSitePlusiQ6DKI2.

Polymorphism and mutation databases

BioMutaiLGALS9C.
DMDMi296434563.

Proteomic databases

MaxQBiQ6DKI2.
PaxDbiQ6DKI2.
PeptideAtlasiQ6DKI2.
PRIDEiQ6DKI2.

Protocols and materials databases

DNASUi654346.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000328114; ENSP00000329932; ENSG00000171916.
GeneIDi654346.
KEGGihsa:654346.
UCSCiuc002gtw.4. human.

Organism-specific databases

CTDi654346.
GeneCardsiLGALS9C.
HGNCiHGNC:33874. LGALS9C.
HPAiHPA046876.
HPA047218.
neXtProtiNX_Q6DKI2.
OpenTargetsiENSG00000171916.
PharmGKBiPA162393930.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3587. Eukaryota.
ENOG4111EA0. LUCA.
GeneTreeiENSGT00760000119105.
HOGENOMiHOG000290194.
HOVERGENiHBG002412.
InParanoidiQ6DKI2.
KOiK10093.
OMAiLAANEWG.
OrthoDBiEOG091G0WP8.
PhylomeDBiQ6DKI2.
TreeFamiTF315551.

Miscellaneous databases

GenomeRNAii654346.
PROiQ6DKI2.

Gene expression databases

BgeeiENSG00000171916.
CleanExiHS_LGALS9C.
ExpressionAtlasiQ6DKI2. baseline and differential.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR001079. Galectin_CRD.
[Graphical view]
PfamiPF00337. Gal-bind_lectin. 2 hits.
[Graphical view]
SMARTiSM00908. Gal-bind_lectin. 2 hits.
SM00276. GLECT. 2 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 2 hits.
PROSITEiPS51304. GALECTIN. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLEG9C_HUMAN
AccessioniPrimary (citable) accession number: Q6DKI2
Secondary accession number(s): B0AZM7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 18, 2010
Last modified: November 30, 2016
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The LGALS9-like proteins are encoded by a duplicated regions on chromosome 17; there are at least 3 genes coding for galectin-9-like proteins.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.