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Protein

60S ribosomal protein L7-like 1

Gene

RPL7L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L7-like 1
Gene namesi
Name:RPL7L1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:21370. RPL7L1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134977157.

Polymorphism and mutation databases

BioMutaiRPL7L1.
DMDMi52783289.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 24624660S ribosomal protein L7-like 1PRO_0000104659Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei54 – 541PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6DKI1.
MaxQBiQ6DKI1.
PaxDbiQ6DKI1.
PeptideAtlasiQ6DKI1.
PRIDEiQ6DKI1.

PTM databases

iPTMnetiQ6DKI1.
PhosphoSiteiQ6DKI1.

Expressioni

Gene expression databases

BgeeiQ6DKI1.
CleanExiHS_RPL7L1.
ExpressionAtlasiQ6DKI1. baseline and differential.
GenevisibleiQ6DKI1. HS.

Interactioni

Protein-protein interaction databases

BioGridi130234. 27 interactions.
IntActiQ6DKI1. 4 interactions.
STRINGi9606.ENSP00000346063.

Structurei

3D structure databases

ProteinModelPortaliQ6DKI1.
SMRiQ6DKI1. Positions 86-142.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L30P family.Curated

Phylogenomic databases

eggNOGiKOG3184. Eukaryota.
COG1841. LUCA.
GeneTreeiENSGT00390000006213.
HOGENOMiHOG000170917.
HOVERGENiHBG003280.
InParanoidiQ6DKI1.
OMAiFVIRIER.
OrthoDBiEOG7K9K3X.
PhylomeDBiQ6DKI1.
TreeFamiTF300740.

Family and domain databases

Gene3Di3.30.1390.20. 2 hits.
InterProiIPR018038. Ribosomal_L30_CS.
IPR016082. Ribosomal_L30_ferredoxin-like.
IPR012988. Ribosomal_L30_N.
IPR005998. Ribosomal_L7_euk.
[Graphical view]
PfamiPF00327. Ribosomal_L30. 1 hit.
PF08079. Ribosomal_L30_N. 1 hit.
[Graphical view]
SUPFAMiSSF55129. SSF55129. 1 hit.
TIGRFAMsiTIGR01310. uL30_euk. 1 hit.
PROSITEiPS00634. RIBOSOMAL_L30. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6DKI1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEQEQRKIP LVPENLLKKR KAYQALKATQ AKQALLAKKE QKKGKGLRFK
60 70 80 90 100
RLESFLHDSW RQKRDKVRLR RLEVKPHALE LPDKHSLAFV VRIERIDGVS
110 120 130 140 150
LLVQRTIARL RLKKIFSGVF VKVTPQNLKM LRIVEPYVTW GFPNLKSVRE
160 170 180 190 200
LILKRGQAKV KNKTIPLTDN TVIEEHLGKF GVICLEDLIH EIAFPGKHFQ
210 220 230 240
EISWFLCPFH LSVARHATKN RVGFLKEMGT PGYRGERINQ LIRQLN
Length:246
Mass (Da):28,661
Last modified:August 16, 2004 - v1
Checksum:i2A90B350255BF618
GO
Isoform 2 (identifier: Q6DKI1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     142-246: FPNLKSVREL...RINQLIRQLN → EVWRHLLGRPHS

Note: No experimental confirmation available.
Show »
Length:153
Mass (Da):18,056
Checksum:i6F2ABFAAF18BA2A4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti191 – 1911E → G in AAH58020 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei142 – 246105FPNLK…IRQLN → EVWRHLLGRPHS in isoform 2. 1 PublicationVSP_056504Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK299816 mRNA. Translation: BAH13138.1.
AK291949 mRNA. Translation: BAF84638.1.
AL035587 Genomic DNA. Translation: CAI21486.1.
BC058020 mRNA. Translation: AAH58020.1.
BC073890 mRNA. Translation: AAH73890.1.
RefSeqiNP_940888.3. NM_198486.3.
UniGeneiHs.520133.

Genome annotation databases

EnsembliENST00000304734; ENSP00000346063; ENSG00000146223. [Q6DKI1-1]
ENST00000493763; ENSP00000418221; ENSG00000146223. [Q6DKI1-1]
GeneIDi285855.
KEGGihsa:285855.
UCSCiuc003ost.4. human. [Q6DKI1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK299816 mRNA. Translation: BAH13138.1.
AK291949 mRNA. Translation: BAF84638.1.
AL035587 Genomic DNA. Translation: CAI21486.1.
BC058020 mRNA. Translation: AAH58020.1.
BC073890 mRNA. Translation: AAH73890.1.
RefSeqiNP_940888.3. NM_198486.3.
UniGeneiHs.520133.

3D structure databases

ProteinModelPortaliQ6DKI1.
SMRiQ6DKI1. Positions 86-142.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130234. 27 interactions.
IntActiQ6DKI1. 4 interactions.
STRINGi9606.ENSP00000346063.

PTM databases

iPTMnetiQ6DKI1.
PhosphoSiteiQ6DKI1.

Polymorphism and mutation databases

BioMutaiRPL7L1.
DMDMi52783289.

Proteomic databases

EPDiQ6DKI1.
MaxQBiQ6DKI1.
PaxDbiQ6DKI1.
PeptideAtlasiQ6DKI1.
PRIDEiQ6DKI1.

Protocols and materials databases

DNASUi285855.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304734; ENSP00000346063; ENSG00000146223. [Q6DKI1-1]
ENST00000493763; ENSP00000418221; ENSG00000146223. [Q6DKI1-1]
GeneIDi285855.
KEGGihsa:285855.
UCSCiuc003ost.4. human. [Q6DKI1-1]

Organism-specific databases

CTDi285855.
GeneCardsiRPL7L1.
H-InvDBHIX0005886.
HGNCiHGNC:21370. RPL7L1.
neXtProtiNX_Q6DKI1.
PharmGKBiPA134977157.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3184. Eukaryota.
COG1841. LUCA.
GeneTreeiENSGT00390000006213.
HOGENOMiHOG000170917.
HOVERGENiHBG003280.
InParanoidiQ6DKI1.
OMAiFVIRIER.
OrthoDBiEOG7K9K3X.
PhylomeDBiQ6DKI1.
TreeFamiTF300740.

Miscellaneous databases

ChiTaRSiRPL7L1. human.
GenomeRNAii285855.
PROiQ6DKI1.

Gene expression databases

BgeeiQ6DKI1.
CleanExiHS_RPL7L1.
ExpressionAtlasiQ6DKI1. baseline and differential.
GenevisibleiQ6DKI1. HS.

Family and domain databases

Gene3Di3.30.1390.20. 2 hits.
InterProiIPR018038. Ribosomal_L30_CS.
IPR016082. Ribosomal_L30_ferredoxin-like.
IPR012988. Ribosomal_L30_N.
IPR005998. Ribosomal_L7_euk.
[Graphical view]
PfamiPF00327. Ribosomal_L30. 1 hit.
PF08079. Ribosomal_L30_N. 1 hit.
[Graphical view]
SUPFAMiSSF55129. SSF55129. 1 hit.
TIGRFAMsiTIGR01310. uL30_euk. 1 hit.
PROSITEiPS00634. RIBOSOMAL_L30. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain.
  2. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Eye.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRL7L_HUMAN
AccessioniPrimary (citable) accession number: Q6DKI1
Secondary accession number(s): A8K7D4
, B7Z652, Q5TFZ5, Q6PEK3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: August 16, 2004
Last modified: July 6, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.