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Protein

60S ribosomal protein L7-like 1

Gene

RPL7L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L7-like 1
Alternative name(s):
Large ribosomal subunit protein uL30-like 1
Gene namesi
Name:RPL7L1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000146223.14
HGNCiHGNC:21370 RPL7L1
MIMi617417 gene
neXtProtiNX_Q6DKI1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134977157

Polymorphism and mutation databases

BioMutaiRPL7L1
DMDMi52783289

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001046591 – 24660S ribosomal protein L7-like 1Add BLAST246

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei54PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6DKI1
MaxQBiQ6DKI1
PaxDbiQ6DKI1
PeptideAtlasiQ6DKI1
PRIDEiQ6DKI1

PTM databases

iPTMnetiQ6DKI1
PhosphoSitePlusiQ6DKI1

Expressioni

Gene expression databases

BgeeiENSG00000146223
CleanExiHS_RPL7L1
ExpressionAtlasiQ6DKI1 baseline and differential
GenevisibleiQ6DKI1 HS

Organism-specific databases

HPAiHPA046049
HPA050478

Interactioni

Protein-protein interaction databases

BioGridi130234, 78 interactors
IntActiQ6DKI1, 7 interactors
MINTiQ6DKI1
STRINGi9606.ENSP00000346063

Structurei

3D structure databases

ProteinModelPortaliQ6DKI1
SMRiQ6DKI1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3184 Eukaryota
COG1841 LUCA
HOGENOMiHOG000170917
HOVERGENiHBG003280
InParanoidiQ6DKI1
OMAiQSNTMVE
OrthoDBiEOG091G0IHS
PhylomeDBiQ6DKI1
TreeFamiTF300740

Family and domain databases

CDDicd01657 Ribosomal_L7_archeal_euk, 1 hit
Gene3Di1.10.15.30, 1 hit
3.30.1390.20, 2 hits
InterProiView protein in InterPro
IPR036919 L30_ferredoxin-like_sf
IPR023106 Ribosomal_L30_central_dom_arc
IPR018038 Ribosomal_L30_CS
IPR016082 Ribosomal_L30_ferredoxin-like
IPR012988 Ribosomal_L30_N
IPR005998 Ribosomal_L7_euk
IPR035808 Ribosomal_L7_euk_arc
PfamiView protein in Pfam
PF00327 Ribosomal_L30, 1 hit
PF08079 Ribosomal_L30_N, 1 hit
SUPFAMiSSF55129 SSF55129, 1 hit
TIGRFAMsiTIGR01310 uL30_euk, 1 hit
PROSITEiView protein in PROSITE
PS00634 RIBOSOMAL_L30, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6DKI1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEQEQRKIP LVPENLLKKR KAYQALKATQ AKQALLAKKE QKKGKGLRFK
60 70 80 90 100
RLESFLHDSW RQKRDKVRLR RLEVKPHALE LPDKHSLAFV VRIERIDGVS
110 120 130 140 150
LLVQRTIARL RLKKIFSGVF VKVTPQNLKM LRIVEPYVTW GFPNLKSVRE
160 170 180 190 200
LILKRGQAKV KNKTIPLTDN TVIEEHLGKF GVICLEDLIH EIAFPGKHFQ
210 220 230 240
EISWFLCPFH LSVARHATKN RVGFLKEMGT PGYRGERINQ LIRQLN
Length:246
Mass (Da):28,661
Last modified:August 16, 2004 - v1
Checksum:i2A90B350255BF618
GO
Isoform 2 (identifier: Q6DKI1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     142-246: FPNLKSVREL...RINQLIRQLN → EVWRHLLGRPHS

Note: No experimental confirmation available.
Show »
Length:153
Mass (Da):18,056
Checksum:i6F2ABFAAF18BA2A4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti191E → G in AAH58020 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056504142 – 246FPNLK…IRQLN → EVWRHLLGRPHS in isoform 2. 1 PublicationAdd BLAST105

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK299816 mRNA Translation: BAH13138.1
AK291949 mRNA Translation: BAF84638.1
AL035587 Genomic DNA No translation available.
BC058020 mRNA Translation: AAH58020.1
BC073890 mRNA Translation: AAH73890.1
RefSeqiNP_940888.3, NM_198486.3
UniGeneiHs.520133

Genome annotation databases

EnsembliENST00000304734; ENSP00000346063; ENSG00000146223
ENST00000493763; ENSP00000418221; ENSG00000146223
GeneIDi285855
KEGGihsa:285855
UCSCiuc003ost.4 human [Q6DKI1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRL7L_HUMAN
AccessioniPrimary (citable) accession number: Q6DKI1
Secondary accession number(s): A8K7D4
, B7Z652, Q5TFZ5, Q6PEK3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: August 16, 2004
Last modified: March 28, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

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