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Protein

N-alpha-acetyltransferase 35, NatC auxiliary subunit

Gene

Naa35

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues. Involved in regulation of apoptosis and proliferation of smooth muscle cells.2 Publications

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
N-alpha-acetyltransferase 35, NatC auxiliary subunit
Alternative name(s):
Corneal wound-healing-related protein
Embryonic growth-associated protein
Protein MAK10 homolog
Gene namesi
Name:Naa35
Synonyms:Egap, Emb8, Mak10
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 17

Organism-specific databases

RGDi621771. Naa35.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 725725N-alpha-acetyltransferase 35, NatC auxiliary subunitPRO_0000308618Add
BLAST

Proteomic databases

PaxDbiQ6DKG0.
PRIDEiQ6DKG0.

Expressioni

Tissue specificityi

Expressed in primary spermatocytes, basal epidermis, interstitial fibroblasts of skeletal muscle, and intestinal crypts.1 Publication

Developmental stagei

Widely expressed in the embryo. Expressed in embryonic aorta and pulmonary arteries from E12 to E19.1 Publication

Inductioni

In carotid arteries, after mechanic injury.1 Publication

Gene expression databases

BgeeiENSRNOG00000018417.
GenevisibleiQ6DKG0. RN.

Interactioni

Subunit structurei

Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, NAA38 and NAA30.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025096.

Family & Domainsi

Sequence similaritiesi

Belongs to the MAK10 family.Curated

Phylogenomic databases

eggNOGiKOG2343. Eukaryota.
ENOG410XS3T. LUCA.
GeneTreeiENSGT00390000002445.
HOVERGENiHBG099871.
InParanoidiQ6DKG0.
OMAiNHQAKDY.
PhylomeDBiQ6DKG0.
TreeFamiTF320627.

Family and domain databases

InterProiIPR007244. NatC_AcTrfase_Mak10.
[Graphical view]
PfamiPF04112. Mak10. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6DKG0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVMKAAVDDD ASGWELNVPE KMEKSSTSWV DITQDFEDAC RELKLGELLH
60 70 80 90 100
DKLFGLFEAM SAIEMMDPKM DAGMIGNQVN RKVLNFEQAV KDGTIKIKDL
110 120 130 140 150
SLPELIGIMD TCFCCLITWL EGHSLAQTVF TCLYIHNPDF IEDPAMKAFA
160 170 180 190 200
LGILKICDIA REKVNKAAVF EEEDFQSMTY GFKMANGVTD LRVTGMLKDV
210 220 230 240 250
EDDMQRRVKS TRSRQGEERD PEVELEHQQC LAAFSRVKFT RVLLTVLIAF
260 270 280 290 300
TKKETSAVAE AQKLMVQAAD LLSAIHTSLH HGIQAQNGTT KGDHPIMMGF
310 320 330 340 350
EPLVNQRLLP PTFPRYAKII KREEMVNYFS RLIDRIKTVC EVVNLPNLHC
360 370 380 390 400
ILDFFCEFSE QSPCVLSRSL LQTTFLVDNK KVFGTHLMQD MVKDALRSFV
410 420 430 440 450
SPPVLSPKCC LYNNHQAKDC IDSFVTHCVR PFCSLVQIHG HNRARQRDKL
460 470 480 490 500
GHILEEFATL QDEAEKVDAA LHTMLLKQEP QRQHLACLGT WVLYHSLRIM
510 520 530 540 550
IQYLLSGFEL ELYSMHEYYY IYWYLSEFLY AWLMSTLSRA DGSQMAEERI
560 570 580 590 600
MEEQQKGRSS KKTKKKKKVR PLSREITMSQ AYQNMCAGMF KTMVAFDMDG
610 620 630 640 650
KVRKPKFELD SEQVRYEHRF APFNSVMTPP PVHYLQFKEM SDLSKYSPPP
660 670 680 690 700
QPPELYVAAS KHFQQAKMIL ESIPNADREV SRILKVAKPN FVVMKLLAGG
710 720
HKKESKVPPE FDFSVHKYFP VVKLV
Length:725
Mass (Da):83,210
Last modified:August 16, 2004 - v1
Checksum:i62B08A63C05CD288
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti169 – 1691V → A in AAF81791 (PubMed:10855038).Curated
Sequence conflicti396 – 3961L → P in AAF81791 (PubMed:10855038).Curated
Sequence conflicti509 – 5091E → D in AAF81791 (PubMed:10855038).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF272892 mRNA. Translation: AAF81791.1.
BC074005 mRNA. Translation: AAH74005.1.
RefSeqiNP_579858.1. NM_133324.1.
XP_006253588.1. XM_006253526.2.
UniGeneiRn.73698.

Genome annotation databases

EnsembliENSRNOT00000025096; ENSRNOP00000025096; ENSRNOG00000018417.
ENSRNOT00000090032; ENSRNOP00000071899; ENSRNOG00000018417.
GeneIDi64472.
KEGGirno:64472.
UCSCiRGD:621771. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF272892 mRNA. Translation: AAF81791.1.
BC074005 mRNA. Translation: AAH74005.1.
RefSeqiNP_579858.1. NM_133324.1.
XP_006253588.1. XM_006253526.2.
UniGeneiRn.73698.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025096.

Proteomic databases

PaxDbiQ6DKG0.
PRIDEiQ6DKG0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000025096; ENSRNOP00000025096; ENSRNOG00000018417.
ENSRNOT00000090032; ENSRNOP00000071899; ENSRNOG00000018417.
GeneIDi64472.
KEGGirno:64472.
UCSCiRGD:621771. rat.

Organism-specific databases

CTDi60560.
RGDi621771. Naa35.

Phylogenomic databases

eggNOGiKOG2343. Eukaryota.
ENOG410XS3T. LUCA.
GeneTreeiENSGT00390000002445.
HOVERGENiHBG099871.
InParanoidiQ6DKG0.
OMAiNHQAKDY.
PhylomeDBiQ6DKG0.
TreeFamiTF320627.

Miscellaneous databases

PROiQ6DKG0.

Gene expression databases

BgeeiENSRNOG00000018417.
GenevisibleiQ6DKG0. RN.

Family and domain databases

InterProiIPR007244. NatC_AcTrfase_Mak10.
[Graphical view]
PfamiPF04112. Mak10. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNAA35_RAT
AccessioniPrimary (citable) accession number: Q6DKG0
Secondary accession number(s): Q9JI01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: August 16, 2004
Last modified: September 7, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.