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Protein

Segment polarity protein dishevelled homolog DVL-3

Gene

dvl3

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in the signal transduction pathway mediated by multiple Wnt genes (By similarity). Required during ciliogenesis for the docking of basal bodies to the apical plasma membrane.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

  • ciliary basal body organization Source: UniProtKB
  • cilium assembly Source: UniProtKB
  • intracellular signal transduction Source: InterPro
  • multicellular organismal development Source: UniProtKB-KW
  • Wnt signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Cilium biogenesis/degradation, Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Segment polarity protein dishevelled homolog DVL-3By similarity
Short name:
Dishevelled-3By similarity
Alternative name(s):
DSH homolog 3
Gene namesi
Name:dvl3By similarity
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-977365. dvl3.

Subcellular locationi

  • Cytoplasm By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 717717Segment polarity protein dishevelled homolog DVL-3PRO_0000354666Add
BLAST

Expressioni

Tissue specificityi

Expressed throughout the epidermis.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ6DKE2.
SMRiQ6DKE2. Positions 246-334, 405-495.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 8282DIXPROSITE-ProRule annotationAdd
BLAST
Domaini248 – 33386PDZPROSITE-ProRule annotationAdd
BLAST
Domaini421 – 49575DEPPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi627 – 64519His-richSequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the DSH family.Sequence Analysis
Contains 1 DEP domain.PROSITE-ProRule annotation
Contains 1 DIX domain.PROSITE-ProRule annotation
Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG005542.
KOiK02353.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.30.42.10. 1 hit.
InterProiIPR000591. DEP_dom.
IPR024580. Dishevelled_C-dom.
IPR008339. Dishevelled_fam.
IPR003351. Dishevelled_protein_dom.
IPR001158. DIX.
IPR015506. Dsh/Dvl-rel.
IPR008342. DVL3.
IPR001478. PDZ.
IPR029071. Ubiquitin-rel_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR10878. PTHR10878. 1 hit.
PTHR10878:SF6. PTHR10878:SF6. 1 hit.
PfamiPF00610. DEP. 1 hit.
PF02377. Dishevelled. 1 hit.
PF00778. DIX. 1 hit.
PF12316. Dsh_C. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view]
PRINTSiPR01760. DISHEVELLED.
SMARTiSM00021. DAX. 1 hit.
SM00049. DEP. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50186. DEP. 1 hit.
PS50841. DIX. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6DKE2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGETKVIYHL DEQETPYLVK LPVPAEKVTL GDFKNILNKP NYKFFFKSMD
60 70 80 90 100
DDFGVVKEEI SDDNAKLPCF NGRVVCWLVS ADGSQSDAGS VCADIQSDLP
110 120 130 140 150
PPIERTGGIG DSRPPSFHPN TRGSQENLDN ETETDSVVSA RRERPGRKET
160 170 180 190 200
SEHATRINGT SKMERRRDTG GYESSSTLMS SELDSTSFFD SDEDDSTSRF
210 220 230 240 250
SNSTEQSSAS RLMRRHKRRR RKPKAPQIER SSSFSSITDS TMSLNIITVT
260 270 280 290 300
LNMEKYNFLG ISIVGQSNER GDGGIYIGSI MKGGAVAADG RIEPGDMLLQ
310 320 330 340 350
VNDTNFENMS NDDAVRVLRD IVHKPGPITL TVAKCWDPSP RNCFTLPRSE
360 370 380 390 400
PIRPIDPAAW VSHTAAMTGT YPAYGMSPSM STITSTSSSI TSSIPETERF
410 420 430 440 450
DDFQLSIHSD MVTIVKAMSS SESGLEVRDR MWLKITIPNA FIGSDVVDWL
460 470 480 490 500
YHHVEGFTDR REARKYASNL LKAGYIRHTV NKITFSEQCY YIFGDLCGNM
510 520 530 540 550
ANLSLNDHDG SSGTSDQDTL APLPHPGAAP WPIAFQYQYP LPHPYSPHPG
560 570 580 590 600
FPDPAYIYGG GSAGSQHSEG SRSSGSNRSS TEKRKDRETK GGDSKSGGSG
610 620 630 640 650
SESDHTTRSS LRRDRAASER SVPASEHSHR SHHSIAHSIR SHHTHQSFGP
660 670 680 690 700
PGIPPLYGAP MMMMPAPVSV MGPPGAPPSR DLASVPPELT ASRQSFRMAM
710
GNPSEFFVDV IKEFWGV
Length:717
Mass (Da):78,770
Last modified:August 16, 2004 - v1
Checksum:i19A97688E4C1BC01
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC074187 mRNA. Translation: AAH74187.1.
RefSeqiNP_001086098.1. NM_001092629.1.
UniGeneiXl.51017.

Genome annotation databases

GeneIDi444527.
KEGGixla:444527.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC074187 mRNA. Translation: AAH74187.1.
RefSeqiNP_001086098.1. NM_001092629.1.
UniGeneiXl.51017.

3D structure databases

ProteinModelPortaliQ6DKE2.
SMRiQ6DKE2. Positions 246-334, 405-495.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi444527.
KEGGixla:444527.

Organism-specific databases

CTDi1857.
XenbaseiXB-GENE-977365. dvl3.

Phylogenomic databases

HOVERGENiHBG005542.
KOiK02353.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.30.42.10. 1 hit.
InterProiIPR000591. DEP_dom.
IPR024580. Dishevelled_C-dom.
IPR008339. Dishevelled_fam.
IPR003351. Dishevelled_protein_dom.
IPR001158. DIX.
IPR015506. Dsh/Dvl-rel.
IPR008342. DVL3.
IPR001478. PDZ.
IPR029071. Ubiquitin-rel_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR10878. PTHR10878. 1 hit.
PTHR10878:SF6. PTHR10878:SF6. 1 hit.
PfamiPF00610. DEP. 1 hit.
PF02377. Dishevelled. 1 hit.
PF00778. DIX. 1 hit.
PF12316. Dsh_C. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view]
PRINTSiPR01760. DISHEVELLED.
SMARTiSM00021. DAX. 1 hit.
SM00049. DEP. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50186. DEP. 1 hit.
PS50841. DIX. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: KidneyImported.
  2. "Dishevelled controls apical docking and planar polarization of basal bodies in ciliated epithelial cells."
    Park T.J., Mitchell B.J., Abitua P.B., Kintner C., Wallingford J.B.
    Nat. Genet. 40:871-879(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiDVL3_XENLA
AccessioniPrimary (citable) accession number: Q6DKE2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: August 16, 2004
Last modified: January 7, 2015
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.