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Q6DKE2

- DVL3_XENLA

UniProt

Q6DKE2 - DVL3_XENLA

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Protein
Segment polarity protein dishevelled homolog DVL-3
Gene
dvl3
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

May play a role in the signal transduction pathway mediated by multiple Wnt genes By similarity. Required during ciliogenesis for the docking of basal bodies to the apical plasma membrane.1 Publication

GO - Molecular functioni

  1. beta-catenin binding Source: BHF-UCL
  2. signal transducer activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. Wnt signaling pathway Source: UniProtKB-KW
  2. ciliary basal body organization Source: UniProtKB
  3. cilium assembly Source: UniProtKB
  4. intracellular signal transduction Source: InterPro
  5. multicellular organismal development Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Cilium biogenesis/degradation, Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Segment polarity protein dishevelled homolog DVL-3
Short name:
Dishevelled-3
Alternative name(s):
DSH homolog 3
Gene namesi
Name:dvl3
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-977365. dvl3.

Subcellular locationi

Cytoplasm By similarity By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 717717Segment polarity protein dishevelled homolog DVL-3
PRO_0000354666Add
BLAST

Expressioni

Tissue specificityi

Expressed throughout the epidermis.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ6DKE2.
SMRiQ6DKE2. Positions 246-334, 405-495.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 8282DIX
Add
BLAST
Domaini248 – 33386PDZ
Add
BLAST
Domaini421 – 49575DEP
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi627 – 64519His-rich
Add
BLAST

Sequence similaritiesi

Belongs to the DSH family.
Contains 1 DEP domain.
Contains 1 DIX domain.
Contains 1 PDZ (DHR) domain.

Phylogenomic databases

HOVERGENiHBG005542.
KOiK02353.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.30.42.10. 1 hit.
InterProiIPR000591. DEP_dom.
IPR008342. Dishevelled_3.
IPR024580. Dishevelled_C-dom.
IPR008339. Dishevelled_fam.
IPR003351. Dishevelled_protein_dom.
IPR001158. DIX.
IPR015506. Dsh/Dvl-rel.
IPR001478. PDZ.
IPR029071. Ubiquitin-rel_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR10878. PTHR10878. 1 hit.
PTHR10878:SF6. PTHR10878:SF6. 1 hit.
PfamiPF00610. DEP. 1 hit.
PF02377. Dishevelled. 1 hit.
PF00778. DIX. 1 hit.
PF12316. Dsh_C. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view]
PRINTSiPR01760. DISHEVELLED.
SMARTiSM00021. DAX. 1 hit.
SM00049. DEP. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50186. DEP. 1 hit.
PS50841. DIX. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6DKE2-1 [UniParc]FASTAAdd to Basket

« Hide

MGETKVIYHL DEQETPYLVK LPVPAEKVTL GDFKNILNKP NYKFFFKSMD    50
DDFGVVKEEI SDDNAKLPCF NGRVVCWLVS ADGSQSDAGS VCADIQSDLP 100
PPIERTGGIG DSRPPSFHPN TRGSQENLDN ETETDSVVSA RRERPGRKET 150
SEHATRINGT SKMERRRDTG GYESSSTLMS SELDSTSFFD SDEDDSTSRF 200
SNSTEQSSAS RLMRRHKRRR RKPKAPQIER SSSFSSITDS TMSLNIITVT 250
LNMEKYNFLG ISIVGQSNER GDGGIYIGSI MKGGAVAADG RIEPGDMLLQ 300
VNDTNFENMS NDDAVRVLRD IVHKPGPITL TVAKCWDPSP RNCFTLPRSE 350
PIRPIDPAAW VSHTAAMTGT YPAYGMSPSM STITSTSSSI TSSIPETERF 400
DDFQLSIHSD MVTIVKAMSS SESGLEVRDR MWLKITIPNA FIGSDVVDWL 450
YHHVEGFTDR REARKYASNL LKAGYIRHTV NKITFSEQCY YIFGDLCGNM 500
ANLSLNDHDG SSGTSDQDTL APLPHPGAAP WPIAFQYQYP LPHPYSPHPG 550
FPDPAYIYGG GSAGSQHSEG SRSSGSNRSS TEKRKDRETK GGDSKSGGSG 600
SESDHTTRSS LRRDRAASER SVPASEHSHR SHHSIAHSIR SHHTHQSFGP 650
PGIPPLYGAP MMMMPAPVSV MGPPGAPPSR DLASVPPELT ASRQSFRMAM 700
GNPSEFFVDV IKEFWGV 717
Length:717
Mass (Da):78,770
Last modified:August 16, 2004 - v1
Checksum:i19A97688E4C1BC01
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC074187 mRNA. Translation: AAH74187.1.
RefSeqiNP_001086098.1. NM_001092629.1.
UniGeneiXl.51017.

Genome annotation databases

GeneIDi444527.
KEGGixla:444527.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC074187 mRNA. Translation: AAH74187.1 .
RefSeqi NP_001086098.1. NM_001092629.1.
UniGenei Xl.51017.

3D structure databases

ProteinModelPortali Q6DKE2.
SMRi Q6DKE2. Positions 246-334, 405-495.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 444527.
KEGGi xla:444527.

Organism-specific databases

CTDi 1857.
Xenbasei XB-GENE-977365. dvl3.

Phylogenomic databases

HOVERGENi HBG005542.
KOi K02353.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
2.30.42.10. 1 hit.
InterProi IPR000591. DEP_dom.
IPR008342. Dishevelled_3.
IPR024580. Dishevelled_C-dom.
IPR008339. Dishevelled_fam.
IPR003351. Dishevelled_protein_dom.
IPR001158. DIX.
IPR015506. Dsh/Dvl-rel.
IPR001478. PDZ.
IPR029071. Ubiquitin-rel_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
PANTHERi PTHR10878. PTHR10878. 1 hit.
PTHR10878:SF6. PTHR10878:SF6. 1 hit.
Pfami PF00610. DEP. 1 hit.
PF02377. Dishevelled. 1 hit.
PF00778. DIX. 1 hit.
PF12316. Dsh_C. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view ]
PRINTSi PR01760. DISHEVELLED.
SMARTi SM00021. DAX. 1 hit.
SM00049. DEP. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view ]
SUPFAMi SSF50156. SSF50156. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEi PS50186. DEP. 1 hit.
PS50841. DIX. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  2. "Dishevelled controls apical docking and planar polarization of basal bodies in ciliated epithelial cells."
    Park T.J., Mitchell B.J., Abitua P.B., Kintner C., Wallingford J.B.
    Nat. Genet. 40:871-879(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiDVL3_XENLA
AccessioniPrimary (citable) accession number: Q6DKE2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: August 16, 2004
Last modified: June 11, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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