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Q6DKE2

- DVL3_XENLA

UniProt

Q6DKE2 - DVL3_XENLA

Protein

Segment polarity protein dishevelled homolog DVL-3

Gene

dvl3

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (16 Aug 2004)
      Previous versions | rss
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    Functioni

    May play a role in the signal transduction pathway mediated by multiple Wnt genes By similarity. Required during ciliogenesis for the docking of basal bodies to the apical plasma membrane.By similarity1 Publication

    GO - Molecular functioni

    1. beta-catenin binding Source: BHF-UCL
    2. signal transducer activity Source: InterPro

    GO - Biological processi

    1. ciliary basal body organization Source: UniProtKB
    2. cilium assembly Source: UniProtKB
    3. intracellular signal transduction Source: InterPro
    4. multicellular organismal development Source: UniProtKB-KW
    5. Wnt signaling pathway Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Cilium biogenesis/degradation, Wnt signaling pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Segment polarity protein dishevelled homolog DVL-3By similarity
    Short name:
    Dishevelled-3By similarity
    Alternative name(s):
    DSH homolog 3
    Gene namesi
    Name:dvl3By similarity
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-977365. dvl3.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 717717Segment polarity protein dishevelled homolog DVL-3PRO_0000354666Add
    BLAST

    Expressioni

    Tissue specificityi

    Expressed throughout the epidermis.1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliQ6DKE2.
    SMRiQ6DKE2. Positions 246-334, 405-495.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 8282DIXPROSITE-ProRule annotationAdd
    BLAST
    Domaini248 – 33386PDZPROSITE-ProRule annotationAdd
    BLAST
    Domaini421 – 49575DEPPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi627 – 64519His-richSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the DSH family.Sequence Analysis
    Contains 1 DEP domain.PROSITE-ProRule annotation
    Contains 1 DIX domain.PROSITE-ProRule annotation
    Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    HOVERGENiHBG005542.
    KOiK02353.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    2.30.42.10. 1 hit.
    InterProiIPR000591. DEP_dom.
    IPR008342. Dishevelled_3.
    IPR024580. Dishevelled_C-dom.
    IPR008339. Dishevelled_fam.
    IPR003351. Dishevelled_protein_dom.
    IPR001158. DIX.
    IPR015506. Dsh/Dvl-rel.
    IPR001478. PDZ.
    IPR029071. Ubiquitin-rel_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PANTHERiPTHR10878. PTHR10878. 1 hit.
    PTHR10878:SF6. PTHR10878:SF6. 1 hit.
    PfamiPF00610. DEP. 1 hit.
    PF02377. Dishevelled. 1 hit.
    PF00778. DIX. 1 hit.
    PF12316. Dsh_C. 1 hit.
    PF00595. PDZ. 1 hit.
    [Graphical view]
    PRINTSiPR01760. DISHEVELLED.
    SMARTiSM00021. DAX. 1 hit.
    SM00049. DEP. 1 hit.
    SM00228. PDZ. 1 hit.
    [Graphical view]
    SUPFAMiSSF50156. SSF50156. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEiPS50186. DEP. 1 hit.
    PS50841. DIX. 1 hit.
    PS50106. PDZ. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6DKE2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGETKVIYHL DEQETPYLVK LPVPAEKVTL GDFKNILNKP NYKFFFKSMD    50
    DDFGVVKEEI SDDNAKLPCF NGRVVCWLVS ADGSQSDAGS VCADIQSDLP 100
    PPIERTGGIG DSRPPSFHPN TRGSQENLDN ETETDSVVSA RRERPGRKET 150
    SEHATRINGT SKMERRRDTG GYESSSTLMS SELDSTSFFD SDEDDSTSRF 200
    SNSTEQSSAS RLMRRHKRRR RKPKAPQIER SSSFSSITDS TMSLNIITVT 250
    LNMEKYNFLG ISIVGQSNER GDGGIYIGSI MKGGAVAADG RIEPGDMLLQ 300
    VNDTNFENMS NDDAVRVLRD IVHKPGPITL TVAKCWDPSP RNCFTLPRSE 350
    PIRPIDPAAW VSHTAAMTGT YPAYGMSPSM STITSTSSSI TSSIPETERF 400
    DDFQLSIHSD MVTIVKAMSS SESGLEVRDR MWLKITIPNA FIGSDVVDWL 450
    YHHVEGFTDR REARKYASNL LKAGYIRHTV NKITFSEQCY YIFGDLCGNM 500
    ANLSLNDHDG SSGTSDQDTL APLPHPGAAP WPIAFQYQYP LPHPYSPHPG 550
    FPDPAYIYGG GSAGSQHSEG SRSSGSNRSS TEKRKDRETK GGDSKSGGSG 600
    SESDHTTRSS LRRDRAASER SVPASEHSHR SHHSIAHSIR SHHTHQSFGP 650
    PGIPPLYGAP MMMMPAPVSV MGPPGAPPSR DLASVPPELT ASRQSFRMAM 700
    GNPSEFFVDV IKEFWGV 717
    Length:717
    Mass (Da):78,770
    Last modified:August 16, 2004 - v1
    Checksum:i19A97688E4C1BC01
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC074187 mRNA. Translation: AAH74187.1.
    RefSeqiNP_001086098.1. NM_001092629.1.
    UniGeneiXl.51017.

    Genome annotation databases

    GeneIDi444527.
    KEGGixla:444527.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC074187 mRNA. Translation: AAH74187.1 .
    RefSeqi NP_001086098.1. NM_001092629.1.
    UniGenei Xl.51017.

    3D structure databases

    ProteinModelPortali Q6DKE2.
    SMRi Q6DKE2. Positions 246-334, 405-495.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 444527.
    KEGGi xla:444527.

    Organism-specific databases

    CTDi 1857.
    Xenbasei XB-GENE-977365. dvl3.

    Phylogenomic databases

    HOVERGENi HBG005542.
    KOi K02353.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    2.30.42.10. 1 hit.
    InterProi IPR000591. DEP_dom.
    IPR008342. Dishevelled_3.
    IPR024580. Dishevelled_C-dom.
    IPR008339. Dishevelled_fam.
    IPR003351. Dishevelled_protein_dom.
    IPR001158. DIX.
    IPR015506. Dsh/Dvl-rel.
    IPR001478. PDZ.
    IPR029071. Ubiquitin-rel_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    PANTHERi PTHR10878. PTHR10878. 1 hit.
    PTHR10878:SF6. PTHR10878:SF6. 1 hit.
    Pfami PF00610. DEP. 1 hit.
    PF02377. Dishevelled. 1 hit.
    PF00778. DIX. 1 hit.
    PF12316. Dsh_C. 1 hit.
    PF00595. PDZ. 1 hit.
    [Graphical view ]
    PRINTSi PR01760. DISHEVELLED.
    SMARTi SM00021. DAX. 1 hit.
    SM00049. DEP. 1 hit.
    SM00228. PDZ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50156. SSF50156. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEi PS50186. DEP. 1 hit.
    PS50841. DIX. 1 hit.
    PS50106. PDZ. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: KidneyImported.
    2. "Dishevelled controls apical docking and planar polarization of basal bodies in ciliated epithelial cells."
      Park T.J., Mitchell B.J., Abitua P.B., Kintner C., Wallingford J.B.
      Nat. Genet. 40:871-879(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiDVL3_XENLA
    AccessioniPrimary (citable) accession number: Q6DKE2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 25, 2008
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3