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Q6DKE2 (DVL3_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Segment polarity protein dishevelled homolog DVL-3

Short name=Dishevelled-3
Alternative name(s):
DSH homolog 3
Gene names
Name:dvl3
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length717 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May play a role in the signal transduction pathway mediated by multiple Wnt genes By similarity. Required during ciliogenesis for the docking of basal bodies to the apical plasma membrane. Ref.2

Subcellular location

Cytoplasm By similarity UniProtKB O14641.

Tissue specificity

Expressed throughout the epidermis. Ref.2

Sequence similarities

Belongs to the DSH family.

Contains 1 DEP domain.

Contains 1 DIX domain.

Contains 1 PDZ (DHR) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 717717Segment polarity protein dishevelled homolog DVL-3
PRO_0000354666

Regions

Domain1 – 8282DIX
Domain248 – 33386PDZ
Domain421 – 49575DEP
Compositional bias627 – 64519His-rich

Sequences

Sequence LengthMass (Da)Tools
Q6DKE2 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: 19A97688E4C1BC01

FASTA71778,770
        10         20         30         40         50         60 
MGETKVIYHL DEQETPYLVK LPVPAEKVTL GDFKNILNKP NYKFFFKSMD DDFGVVKEEI 

        70         80         90        100        110        120 
SDDNAKLPCF NGRVVCWLVS ADGSQSDAGS VCADIQSDLP PPIERTGGIG DSRPPSFHPN 

       130        140        150        160        170        180 
TRGSQENLDN ETETDSVVSA RRERPGRKET SEHATRINGT SKMERRRDTG GYESSSTLMS 

       190        200        210        220        230        240 
SELDSTSFFD SDEDDSTSRF SNSTEQSSAS RLMRRHKRRR RKPKAPQIER SSSFSSITDS 

       250        260        270        280        290        300 
TMSLNIITVT LNMEKYNFLG ISIVGQSNER GDGGIYIGSI MKGGAVAADG RIEPGDMLLQ 

       310        320        330        340        350        360 
VNDTNFENMS NDDAVRVLRD IVHKPGPITL TVAKCWDPSP RNCFTLPRSE PIRPIDPAAW 

       370        380        390        400        410        420 
VSHTAAMTGT YPAYGMSPSM STITSTSSSI TSSIPETERF DDFQLSIHSD MVTIVKAMSS 

       430        440        450        460        470        480 
SESGLEVRDR MWLKITIPNA FIGSDVVDWL YHHVEGFTDR REARKYASNL LKAGYIRHTV 

       490        500        510        520        530        540 
NKITFSEQCY YIFGDLCGNM ANLSLNDHDG SSGTSDQDTL APLPHPGAAP WPIAFQYQYP 

       550        560        570        580        590        600 
LPHPYSPHPG FPDPAYIYGG GSAGSQHSEG SRSSGSNRSS TEKRKDRETK GGDSKSGGSG 

       610        620        630        640        650        660 
SESDHTTRSS LRRDRAASER SVPASEHSHR SHHSIAHSIR SHHTHQSFGP PGIPPLYGAP 

       670        680        690        700        710 
MMMMPAPVSV MGPPGAPPSR DLASVPPELT ASRQSFRMAM GNPSEFFVDV IKEFWGV 

« Hide

References

« Hide 'large scale' references
[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.
[2]"Dishevelled controls apical docking and planar polarization of basal bodies in ciliated epithelial cells."
Park T.J., Mitchell B.J., Abitua P.B., Kintner C., Wallingford J.B.
Nat. Genet. 40:871-879(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC074187 mRNA. Translation: AAH74187.1.
RefSeqNP_001086098.1. NM_001092629.1.
UniGeneXl.51017.

3D structure databases

ProteinModelPortalQ6DKE2.
SMRQ6DKE2. Positions 246-334, 405-495.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID444527.
KEGGxla:444527.

Organism-specific databases

CTD1857.
XenbaseXB-GENE-977365. dvl3.

Phylogenomic databases

HOVERGENHBG005542.
KOK02353.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
2.30.42.10. 1 hit.
InterProIPR000591. DEP_dom.
IPR008342. Dishevelled_3.
IPR024580. Dishevelled_C-dom.
IPR008339. Dishevelled_fam.
IPR003351. Dishevelled_protein_dom.
IPR001158. DIX.
IPR015506. Dsh/Dvl-rel.
IPR001478. PDZ.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERPTHR10878. PTHR10878. 1 hit.
PTHR10878:SF6. PTHR10878:SF6. 1 hit.
PfamPF00610. DEP. 1 hit.
PF02377. Dishevelled. 1 hit.
PF00778. DIX. 1 hit.
PF12316. Dsh_C. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view]
PRINTSPR01760. DISHEVELLED.
SMARTSM00021. DAX. 1 hit.
SM00049. DEP. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMSSF50156. SSF50156. 1 hit.
PROSITEPS50186. DEP. 1 hit.
PS50841. DIX. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDVL3_XENLA
AccessionPrimary (citable) accession number: Q6DKE2
Entry history
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: August 16, 2004
Last modified: April 16, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families