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Protein

Segment polarity protein dishevelled homolog DVL-3

Gene

dvl3

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in the signal transduction pathway mediated by multiple Wnt genes (By similarity). Required during ciliogenesis for the docking of basal bodies to the apical plasma membrane.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

  • ciliary basal body organization Source: UniProtKB
  • cilium assembly Source: UniProtKB
  • intracellular signal transduction Source: InterPro
  • multicellular organism development Source: UniProtKB-KW
  • Wnt signaling pathway Source: UniProtKB-KW

Keywordsi

Molecular functionDevelopmental protein
Biological processCilium biogenesis/degradation, Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Segment polarity protein dishevelled homolog DVL-3By similarity
Short name:
Dishevelled-3By similarity
Alternative name(s):
DSH homolog 3
Gene namesi
Name:dvl3By similarity
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-977365 dvl3

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003546661 – 717Segment polarity protein dishevelled homolog DVL-3Add BLAST717

Expressioni

Tissue specificityi

Expressed throughout the epidermis.1 Publication

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ6DKE2
SMRiQ6DKE2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 82DIXPROSITE-ProRule annotationAdd BLAST82
Domaini248 – 333PDZPROSITE-ProRule annotationAdd BLAST86
Domaini421 – 495DEPPROSITE-ProRule annotationAdd BLAST75

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi627 – 645His-richSequence analysisAdd BLAST19

Sequence similaritiesi

Belongs to the DSH family.Sequence analysis

Phylogenomic databases

HOVERGENiHBG005542
KOiK02353

Family and domain databases

Gene3Di1.10.10.10, 1 hit
3.10.20.380, 1 hit
InterProiView protein in InterPro
IPR000591 DEP_dom
IPR024580 Dishevelled_C-dom
IPR008339 Dishevelled_fam
IPR003351 Dishevelled_protein_dom
IPR001158 DIX
IPR038207 DIX_dom_sf
IPR015506 Dsh/Dvl-rel
IPR008342 DVL3
IPR001478 PDZ
IPR036034 PDZ_sf
IPR029071 Ubiquitin-like_domsf
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR10878 PTHR10878, 1 hit
PTHR10878:SF6 PTHR10878:SF6, 1 hit
PfamiView protein in Pfam
PF00610 DEP, 1 hit
PF02377 Dishevelled, 1 hit
PF00778 DIX, 1 hit
PF12316 Dsh_C, 1 hit
PF00595 PDZ, 1 hit
PRINTSiPR01760 DISHEVELLED
SMARTiView protein in SMART
SM00021 DAX, 1 hit
SM00049 DEP, 1 hit
SM00228 PDZ, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF50156 SSF50156, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50186 DEP, 1 hit
PS50841 DIX, 1 hit
PS50106 PDZ, 1 hit

Sequencei

Sequence statusi: Complete.

Q6DKE2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGETKVIYHL DEQETPYLVK LPVPAEKVTL GDFKNILNKP NYKFFFKSMD
60 70 80 90 100
DDFGVVKEEI SDDNAKLPCF NGRVVCWLVS ADGSQSDAGS VCADIQSDLP
110 120 130 140 150
PPIERTGGIG DSRPPSFHPN TRGSQENLDN ETETDSVVSA RRERPGRKET
160 170 180 190 200
SEHATRINGT SKMERRRDTG GYESSSTLMS SELDSTSFFD SDEDDSTSRF
210 220 230 240 250
SNSTEQSSAS RLMRRHKRRR RKPKAPQIER SSSFSSITDS TMSLNIITVT
260 270 280 290 300
LNMEKYNFLG ISIVGQSNER GDGGIYIGSI MKGGAVAADG RIEPGDMLLQ
310 320 330 340 350
VNDTNFENMS NDDAVRVLRD IVHKPGPITL TVAKCWDPSP RNCFTLPRSE
360 370 380 390 400
PIRPIDPAAW VSHTAAMTGT YPAYGMSPSM STITSTSSSI TSSIPETERF
410 420 430 440 450
DDFQLSIHSD MVTIVKAMSS SESGLEVRDR MWLKITIPNA FIGSDVVDWL
460 470 480 490 500
YHHVEGFTDR REARKYASNL LKAGYIRHTV NKITFSEQCY YIFGDLCGNM
510 520 530 540 550
ANLSLNDHDG SSGTSDQDTL APLPHPGAAP WPIAFQYQYP LPHPYSPHPG
560 570 580 590 600
FPDPAYIYGG GSAGSQHSEG SRSSGSNRSS TEKRKDRETK GGDSKSGGSG
610 620 630 640 650
SESDHTTRSS LRRDRAASER SVPASEHSHR SHHSIAHSIR SHHTHQSFGP
660 670 680 690 700
PGIPPLYGAP MMMMPAPVSV MGPPGAPPSR DLASVPPELT ASRQSFRMAM
710
GNPSEFFVDV IKEFWGV
Length:717
Mass (Da):78,770
Last modified:August 16, 2004 - v1
Checksum:i19A97688E4C1BC01
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC074187 mRNA Translation: AAH74187.1
RefSeqiNP_001086098.1, NM_001092629.1
UniGeneiXl.51017

Genome annotation databases

GeneIDi444527
KEGGixla:444527

Similar proteinsi

Entry informationi

Entry nameiDVL3_XENLA
AccessioniPrimary (citable) accession number: Q6DKE2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: August 16, 2004
Last modified: March 28, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health