Q6DKE0 (DHDH_XENLA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
EC=1.3.1.20

Alternative name(s):
D-xylose 1-dehydrogenase
D-xylose-NADP dehydrogenase
EC=1.1.1.179
Dimeric dihydrodiol dehydrogenase

Gene names

Name:

dhdh

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	330 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	Trans-1,2-dihydrobenzene-1,2-diol + NADP+ = catechol + NADPH. D-xylose + NADP+ = D-xylono-1,5-lactone + NADPH.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the gfo/idh/mocA family.

Ontologies

Keywords
Ligand	NADP
Molecular function	Oxidoreductase
Gene Ontology (GO)
Molecular function	D-xylose 1-dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 330	330	Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase		PRO_0000315369
Sites
	Site	71	1	May play an important role in coenzyme binding By similarity
	Site	79	1	May play an important role in coenzyme binding By similarity
	Site	97	1	May play an important role in coenzyme binding By similarity
	Site	176	1	May play an important role for the adaptation of the alcohol substrate into the binding site By similarity
	Site	180	1	May play an important role in catalytic activity By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6DKE0 [UniParc]. Last modified August 16, 2004. Version 1. Checksum: 7D82C9FC1FA0D6D4	FASTA	330	36,346
	10 20 30 40 50 60 MATKWGICST GRISNDFVVA LSTLPAVDHQ VVAVAARDLE KAKNFAQIHN IPKAYGSYEE 70 80 90 100 110 120 LAKDPDIDVI YVGAIHPVHR DVVLMCLQNG KNVLCEKPLA MNSAQVRELI AAARKFNVFL 130 140 150 160 170 180 MEAFWSRFFP VYEEIRTLLS QKAIGDVKFI RAEFGTPIYT VPRAVEKELG GGALLDIGCY 190 200 210 220 230 240 CVQFVTMVFN GEKPESVTAR GFLHETGVDE TISIILEYSG KRQAILSSTI MAALPNQTAI 250 260 270 280 290 300 CGTKGIIQIP SFMWSPTSVI VNGKETKFDV PHTTEPMNFS NGTGMSYEAE HVRQCLLKGL 310 320 330 KESPIMSLAD SEMIATIMDE ALEQLGVMYP

References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC074201 mRNA. Translation: AAH74201.1.
RefSeq	NP_001086110.1. NM_001092641.1.
UniGene	Xl.33526.
3D structure databases
ProteinModelPortal	Q6DKE0.
SMR	Q6DKE0. Positions 2-330.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	444539.
KEGG	xla:444539.
Organism-specific databases
CTD	27294.
Xenbase	XB-GENE-968491.
Phylogenomic databases
HOVERGEN	HBG105348.
Family and domain databases
InterPro	IPR016040. NAD(P)-bd_dom. IPR000683. Oxidoreductase_N. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00078.
Pfam	PF01408. GFO_IDH_MocA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DHDH_XENLA

Accession

Primary (citable) accession number: Q6DKE0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	August 16, 2004
Last modified:	December 14, 2011
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program