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Protein

Small ubiquitin-related modifier 3

Gene

sumo3

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex sae1-sae2 and linkage to the E2 enzyme ube2i (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiREACT_294542. SUMO is conjugated to E1 (UBA2:SAE1).
REACT_303094. SUMO is proteolytically processed.
REACT_330136. SUMO is transferred from E1 to E2 (UBE2I, UBC9).
REACT_359106. SUMOylation of DNA damage response and repair proteins.

Names & Taxonomyi

Protein namesi
Recommended name:
Small ubiquitin-related modifier 3
Short name:
SUMO-3
Gene namesi
Name:sumo3
ORF Names:TEgg028f07.1
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-1004211. sumo3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9292Small ubiquitin-related modifier 3PRO_0000267636Add
BLAST
Propeptidei93 – 942By similarityPRO_0000267637

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki11 – 11Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
Cross-linki92 – 92Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)PROSITE-ProRule annotation

Post-translational modificationi

Polymeric chains can be formed through Lys-11 cross-linking.By similarity
Cleavage of precursor form by a sentrin-specific protease is necessary for function.By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ6DK72.
PRIDEiQ6DK72.

Expressioni

Gene expression databases

BgeeiQ6DK72.
ExpressionAtlasiQ6DK72. baseline.

Interactioni

Subunit structurei

Interacts with sae2 and ube2i. Covalently attached to a number of proteins (By similarity).By similarity

Protein-protein interaction databases

STRINGi8364.ENSXETP00000027383.

Structurei

3D structure databases

ProteinModelPortaliQ6DK72.
SMRiQ6DK72. Positions 1-93.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini15 – 9278Ubiquitin-likePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ubiquitin family. SUMO subfamily.Curated
Contains 1 ubiquitin-like domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5227.
GeneTreeiENSGT00390000018808.
HOGENOMiHOG000207495.
HOVERGENiHBG053025.
InParanoidiQ6DK72.
KOiK12160.
OrthoDBiEOG76X62R.

Family and domain databases

InterProiIPR022617. Rad60/SUMO_like.
IPR027218. SUMO_chordates.
IPR000626. Ubiquitin-like.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PANTHERiPTHR10562:SF10. PTHR10562:SF10. 1 hit.
PfamiPF11976. Rad60-SLD. 1 hit.
[Graphical view]
SMARTiSM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS50053. UBIQUITIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6DK72-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEEKPKEGV KTENDHINLK VAGQDGSVVQ FKIKRHTPLS KLMKAYCDRQ
60 70 80 90
GLSMRQIRFR FDGQPINETD TPAQLEMEDE DTIDVFQQQT GGVC
Length:94
Mass (Da):10,713
Last modified:August 16, 2004 - v1
Checksum:iB315887FB123B46F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR761360 mRNA. Translation: CAJ81372.1.
BC074674 mRNA. Translation: AAH74674.1.
RefSeqiNP_001004853.1. NM_001004853.1.
UniGeneiStr.47504.

Genome annotation databases

EnsembliENSXETT00000027382; ENSXETP00000027382; ENSXETG00000027487.
GeneIDi100125978.
KEGGixtr:100125978.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR761360 mRNA. Translation: CAJ81372.1.
BC074674 mRNA. Translation: AAH74674.1.
RefSeqiNP_001004853.1. NM_001004853.1.
UniGeneiStr.47504.

3D structure databases

ProteinModelPortaliQ6DK72.
SMRiQ6DK72. Positions 1-93.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000027383.

Proteomic databases

PaxDbiQ6DK72.
PRIDEiQ6DK72.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSXETT00000027382; ENSXETP00000027382; ENSXETG00000027487.
GeneIDi100125978.
KEGGixtr:100125978.

Organism-specific databases

CTDi6612.
XenbaseiXB-GENE-1004211. sumo3.

Phylogenomic databases

eggNOGiCOG5227.
GeneTreeiENSGT00390000018808.
HOGENOMiHOG000207495.
HOVERGENiHBG053025.
InParanoidiQ6DK72.
KOiK12160.
OrthoDBiEOG76X62R.

Enzyme and pathway databases

ReactomeiREACT_294542. SUMO is conjugated to E1 (UBA2:SAE1).
REACT_303094. SUMO is proteolytically processed.
REACT_330136. SUMO is transferred from E1 to E2 (UBE2I, UBC9).
REACT_359106. SUMOylation of DNA damage response and repair proteins.

Gene expression databases

BgeeiQ6DK72.
ExpressionAtlasiQ6DK72. baseline.

Family and domain databases

InterProiIPR022617. Rad60/SUMO_like.
IPR027218. SUMO_chordates.
IPR000626. Ubiquitin-like.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PANTHERiPTHR10562:SF10. PTHR10562:SF10. 1 hit.
PfamiPF11976. Rad60-SLD. 1 hit.
[Graphical view]
SMARTiSM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS50053. UBIQUITIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Sanger Xenopus tropicalis EST/cDNA project
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Egg.
  2. NIH - Xenopus Gene Collection (XGC) project
    Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Tail bud.

Entry informationi

Entry nameiSUMO3_XENTR
AccessioniPrimary (citable) accession number: Q6DK72
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: August 16, 2004
Last modified: June 24, 2015
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.