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Q6DK72

- SUMO3_XENTR

UniProt

Q6DK72 - SUMO3_XENTR

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Protein
Small ubiquitin-related modifier 3
Gene
sumo3, TEgg028f07.1
Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex sae1-sae2 and linkage to the E2 enzyme ube2i By similarity.

GO - Biological processi

  1. protein sumoylation Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiREACT_208326. SUMO is proteolytically processed.
REACT_213256. SUMO is transferred from E1 to E2 (UBE2I, UBC9).
REACT_223838. SUMO is conjugated to E1 (UBA2:SAE1).

Names & Taxonomyi

Protein namesi
Recommended name:
Small ubiquitin-related modifier 3
Short name:
SUMO-3
Gene namesi
Name:sumo3
ORF Names:TEgg028f07.1
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143: Unplaced

Organism-specific databases

XenbaseiXB-GENE-1004211. sumo3.

Subcellular locationi

Cytoplasm By similarity. NucleusPML body By similarity

GO - Cellular componenti

  1. PML body Source: UniProtKB-SubCell
  2. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9292Small ubiquitin-related modifier 3
PRO_0000267636Add
BLAST
Propeptidei93 – 942 By similarity
PRO_0000267637

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki11 – 11Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) By similarity
Cross-linki92 – 92Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins) By similarity

Post-translational modificationi

Polymeric chains can be formed through Lys-11 cross-linking By similarity.
Cleavage of precursor form by a sentrin-specific protease is necessary for function By similarity.

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ6DK72.
PRIDEiQ6DK72.

Expressioni

Gene expression databases

BgeeiQ6DK72.

Interactioni

Subunit structurei

Interacts with sae2 and ube2i. Covalently attached to a number of proteins By similarity.

Protein-protein interaction databases

STRINGi8364.ENSXETP00000027382.

Structurei

3D structure databases

ProteinModelPortaliQ6DK72.
SMRiQ6DK72. Positions 1-93.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini15 – 9278Ubiquitin-like
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5227.
GeneTreeiENSGT00390000018808.
HOGENOMiHOG000207495.
HOVERGENiHBG053025.
InParanoidiQ6DK72.
KOiK12160.
OrthoDBiEOG76X62R.

Family and domain databases

InterProiIPR022617. Rad60/SUMO_like.
IPR027218. SUMO_chordates.
IPR000626. Ubiquitin-like.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PANTHERiPTHR10562:SF10. PTHR10562:SF10. 1 hit.
PfamiPF11976. Rad60-SLD. 1 hit.
[Graphical view]
SMARTiSM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS50053. UBIQUITIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6DK72-1 [UniParc]FASTAAdd to Basket

« Hide

MSEEKPKEGV KTENDHINLK VAGQDGSVVQ FKIKRHTPLS KLMKAYCDRQ   50
GLSMRQIRFR FDGQPINETD TPAQLEMEDE DTIDVFQQQT GGVC 94
Length:94
Mass (Da):10,713
Last modified:August 16, 2004 - v1
Checksum:iB315887FB123B46F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR761360 mRNA. Translation: CAJ81372.1.
BC074674 mRNA. Translation: AAH74674.1.
RefSeqiNP_001004853.1. NM_001004853.1.
UniGeneiStr.47504.

Genome annotation databases

EnsembliENSXETT00000027382; ENSXETP00000027382; ENSXETG00000027487.
GeneIDi100125978.
KEGGixtr:100125978.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR761360 mRNA. Translation: CAJ81372.1 .
BC074674 mRNA. Translation: AAH74674.1 .
RefSeqi NP_001004853.1. NM_001004853.1.
UniGenei Str.47504.

3D structure databases

ProteinModelPortali Q6DK72.
SMRi Q6DK72. Positions 1-93.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 8364.ENSXETP00000027382.

Proteomic databases

PaxDbi Q6DK72.
PRIDEi Q6DK72.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSXETT00000027382 ; ENSXETP00000027382 ; ENSXETG00000027487 .
GeneIDi 100125978.
KEGGi xtr:100125978.

Organism-specific databases

CTDi 6612.
Xenbasei XB-GENE-1004211. sumo3.

Phylogenomic databases

eggNOGi COG5227.
GeneTreei ENSGT00390000018808.
HOGENOMi HOG000207495.
HOVERGENi HBG053025.
InParanoidi Q6DK72.
KOi K12160.
OrthoDBi EOG76X62R.

Enzyme and pathway databases

Reactomei REACT_208326. SUMO is proteolytically processed.
REACT_213256. SUMO is transferred from E1 to E2 (UBE2I, UBC9).
REACT_223838. SUMO is conjugated to E1 (UBA2:SAE1).

Gene expression databases

Bgeei Q6DK72.

Family and domain databases

InterProi IPR022617. Rad60/SUMO_like.
IPR027218. SUMO_chordates.
IPR000626. Ubiquitin-like.
IPR029071. Ubiquitin-rel_dom.
[Graphical view ]
PANTHERi PTHR10562:SF10. PTHR10562:SF10. 1 hit.
Pfami PF11976. Rad60-SLD. 1 hit.
[Graphical view ]
SMARTi SM00213. UBQ. 1 hit.
[Graphical view ]
SUPFAMi SSF54236. SSF54236. 1 hit.
PROSITEi PS50053. UBIQUITIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Sanger Xenopus tropicalis EST/cDNA project
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Egg.
  2. NIH - Xenopus Gene Collection (XGC) project
    Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Tail bud.

Entry informationi

Entry nameiSUMO3_XENTR
AccessioniPrimary (citable) accession number: Q6DK72
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: August 16, 2004
Last modified: September 3, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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