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Q6DK72

- SUMO3_XENTR

UniProt

Q6DK72 - SUMO3_XENTR

Protein

Small ubiquitin-related modifier 3

Gene

sumo3

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex sae1-sae2 and linkage to the E2 enzyme ube2i By similarity.By similarity

    GO - Biological processi

    1. protein sumoylation Source: InterPro

    Keywords - Biological processi

    Ubl conjugation pathway

    Enzyme and pathway databases

    ReactomeiREACT_208326. SUMO is proteolytically processed.
    REACT_213256. SUMO is transferred from E1 to E2 (UBE2I, UBC9).
    REACT_223838. SUMO is conjugated to E1 (UBA2:SAE1).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Small ubiquitin-related modifier 3
    Short name:
    SUMO-3
    Gene namesi
    Name:sumo3
    ORF Names:TEgg028f07.1
    OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
    Taxonomic identifieri8364 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
    ProteomesiUP000008143: Unplaced

    Organism-specific databases

    XenbaseiXB-GENE-1004211. sumo3.

    Subcellular locationi

    Cytoplasm By similarity. NucleusPML body By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. PML body Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 9292Small ubiquitin-related modifier 3PRO_0000267636Add
    BLAST
    Propeptidei93 – 942By similarityPRO_0000267637

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki11 – 11Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
    Cross-linki92 – 92Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)PROSITE-ProRule annotation

    Post-translational modificationi

    Polymeric chains can be formed through Lys-11 cross-linking.By similarity
    Cleavage of precursor form by a sentrin-specific protease is necessary for function.By similarity

    Keywords - PTMi

    Isopeptide bond, Ubl conjugation

    Proteomic databases

    PaxDbiQ6DK72.
    PRIDEiQ6DK72.

    Expressioni

    Gene expression databases

    BgeeiQ6DK72.

    Interactioni

    Subunit structurei

    Interacts with sae2 and ube2i. Covalently attached to a number of proteins By similarity.By similarity

    Protein-protein interaction databases

    STRINGi8364.ENSXETP00000027382.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6DK72.
    SMRiQ6DK72. Positions 1-93.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini15 – 9278Ubiquitin-likePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ubiquitin family. SUMO subfamily.Curated
    Contains 1 ubiquitin-like domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5227.
    GeneTreeiENSGT00390000018808.
    HOGENOMiHOG000207495.
    HOVERGENiHBG053025.
    InParanoidiQ6DK72.
    KOiK12160.
    OrthoDBiEOG76X62R.

    Family and domain databases

    InterProiIPR022617. Rad60/SUMO_like.
    IPR027218. SUMO_chordates.
    IPR000626. Ubiquitin-like.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view]
    PANTHERiPTHR10562:SF10. PTHR10562:SF10. 1 hit.
    PfamiPF11976. Rad60-SLD. 1 hit.
    [Graphical view]
    SMARTiSM00213. UBQ. 1 hit.
    [Graphical view]
    SUPFAMiSSF54236. SSF54236. 1 hit.
    PROSITEiPS50053. UBIQUITIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6DK72-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSEEKPKEGV KTENDHINLK VAGQDGSVVQ FKIKRHTPLS KLMKAYCDRQ   50
    GLSMRQIRFR FDGQPINETD TPAQLEMEDE DTIDVFQQQT GGVC 94
    Length:94
    Mass (Da):10,713
    Last modified:August 16, 2004 - v1
    Checksum:iB315887FB123B46F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR761360 mRNA. Translation: CAJ81372.1.
    BC074674 mRNA. Translation: AAH74674.1.
    RefSeqiNP_001004853.1. NM_001004853.1.
    UniGeneiStr.47504.

    Genome annotation databases

    EnsembliENSXETT00000027382; ENSXETP00000027382; ENSXETG00000027487.
    GeneIDi100125978.
    KEGGixtr:100125978.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR761360 mRNA. Translation: CAJ81372.1 .
    BC074674 mRNA. Translation: AAH74674.1 .
    RefSeqi NP_001004853.1. NM_001004853.1.
    UniGenei Str.47504.

    3D structure databases

    ProteinModelPortali Q6DK72.
    SMRi Q6DK72. Positions 1-93.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 8364.ENSXETP00000027382.

    Proteomic databases

    PaxDbi Q6DK72.
    PRIDEi Q6DK72.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSXETT00000027382 ; ENSXETP00000027382 ; ENSXETG00000027487 .
    GeneIDi 100125978.
    KEGGi xtr:100125978.

    Organism-specific databases

    CTDi 6612.
    Xenbasei XB-GENE-1004211. sumo3.

    Phylogenomic databases

    eggNOGi COG5227.
    GeneTreei ENSGT00390000018808.
    HOGENOMi HOG000207495.
    HOVERGENi HBG053025.
    InParanoidi Q6DK72.
    KOi K12160.
    OrthoDBi EOG76X62R.

    Enzyme and pathway databases

    Reactomei REACT_208326. SUMO is proteolytically processed.
    REACT_213256. SUMO is transferred from E1 to E2 (UBE2I, UBC9).
    REACT_223838. SUMO is conjugated to E1 (UBA2:SAE1).

    Gene expression databases

    Bgeei Q6DK72.

    Family and domain databases

    InterProi IPR022617. Rad60/SUMO_like.
    IPR027218. SUMO_chordates.
    IPR000626. Ubiquitin-like.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view ]
    PANTHERi PTHR10562:SF10. PTHR10562:SF10. 1 hit.
    Pfami PF11976. Rad60-SLD. 1 hit.
    [Graphical view ]
    SMARTi SM00213. UBQ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54236. SSF54236. 1 hit.
    PROSITEi PS50053. UBIQUITIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Sanger Xenopus tropicalis EST/cDNA project
      Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Egg.
    2. NIH - Xenopus Gene Collection (XGC) project
      Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Tail bud.

    Entry informationi

    Entry nameiSUMO3_XENTR
    AccessioniPrimary (citable) accession number: Q6DK72
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 12, 2006
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3