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Q6DJT9

- PLAG1_HUMAN

UniProt

Q6DJT9 - PLAG1_HUMAN

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Protein
Zinc finger protein PLAG1
Gene
PLAG1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Transcription factor whose activation results in up-regulation of target genes, such as IGFII, leading to uncontrolled cell proliferation: when overexpressed in cultured cells, higher proliferation rate and transformation are observed. Other target genes such as CRLF1, CRABP2, CRIP2, PIGF are strongly induced in cells with PLAG1 induction. Proto-oncogene whose ectopic expression can trigger the development of pleomorphic adenomas of the salivary gland and lipoblastomas. Overexpression is associated with up-regulation of IGFII, is frequently observed in hepatoblastoma, common primary liver tumor in childhood. Cooperates with CBFB-MYH11, a fusion gene important for myeloid leukemia.3 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri34 – 5623C2H2-type 1
Add
BLAST
Zinc fingeri62 – 8625C2H2-type 2
Add
BLAST
Zinc fingeri92 – 11423C2H2-type 3
Add
BLAST
Zinc fingeri121 – 14323C2H2-type 4
Add
BLAST
Zinc fingeri150 – 17223C2H2-type 5
Add
BLAST
Zinc fingeri185 – 20723C2H2-type 6
Add
BLAST
Zinc fingeri213 – 23624C2H2-type 7
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: RefGenome
  4. sequence-specific DNA binding transcription factor activity Source: ProtInc
Complete GO annotation...

GO - Biological processi

  1. gland morphogenesis Source: Ensembl
  2. multicellular organism growth Source: Ensembl
  3. negative regulation of gene expression Source: Ensembl
  4. organ growth Source: Ensembl
  5. positive regulation of gene expression Source: Ensembl
  6. positive regulation of glial cell proliferation Source: Ensembl
  7. prostate gland growth Source: Ensembl
  8. regulation of transcription from RNA polymerase II promoter Source: GOC
  9. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

SignaLinkiQ6DJT9.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein PLAG1
Alternative name(s):
Pleiomorphic adenoma gene 1 protein
Gene namesi
Name:PLAG1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:9045. PLAG1.

Subcellular locationi

Nucleus
Note: Strong nucleolar localization when sumoylation is inhibited.3 Publications

GO - Cellular componenti

  1. nucleus Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving PLAG1 is found in salivary gland pleiomorphic adenomas, the most common benign epithelial tumors of the salivary gland. Translocation t(3;8)(p21;q12) with constituvely expressed beta-catenin/CTNNB1. Fusion occurs in the 5'-regulatory regions, leading to promoter swapping between the 2 genes and activation of PLAG1 expression in adenomas. The chimeric transcript is formed by fusion of CTNNB1 exon 1 to PLAG1 exon 3. Reciprocal fusion transcript consisting of PLAG1 exon 1 and CTNNB1 exon 2-16 is also revealed in some adenomas. Translocation t(3;8)(p21;q12) with transcription elongation factor SII/TCEA1. The fusion transcript is composed of 5'-non-coding sequences as well as 63 nucleotides of the coding region of TCEA1 fused to the acceptor splice site of PLAG1 exon 3. The fusion transcript encodes a truncated TCEA1-PLAG1 protein of 90 AA as well as an apparently normal PLAG1 protein. Reciprocal fusion transcript PLAG1-TCEA1 is also present in one adenoma. Translocation t(5;8)(p13;q12) with leukemia inhibitory factor receptor LIFR. This fusion occured in the 5'-non-coding sequences of both genes, exchanging regulatory control element while preserving the coding sequences. Translocation t(6;8)(p21.3-22;q13) with Coiled-coil-helix-coiled-coil-helix domain-containing protein 7/CHCHD7. Fusion occurs in the 5' regulatory regions, leading to promoter swapping and up-regulation of PLAG1 expression. Ectopic expression of PLAG1 under the control of promoters of distinct translocation partner genes is a general pathogenetic mechanism for pleiomorphic adenomas with 8q aberrations. These fusion genes are likely to be found in adenomas with normal karyotype as this subgroup of tumors also exhibit PLAG1 activation.
A chromosomal aberration involving PLAG1 may be a cause of lipoblastomas, which are benign tumors resulting from transformation of adipocytes, usually diagnosed in children. 8q12.1 to 8q24.1 intrachromosomal rearrangement with hyaluronic acid synthase 2/HAS2 results in promoter swapping and activation of PLAG1 expression. The breakpoint of HAS2 gene is in PLAG1 intron 1, whereas its coding sequence starts at exon 2 or exon 3. Translocation t(7;8)(p22;q13) with collagen 1A2/COL1A2. Fusion transcript COL1A2-PLAG1 as well as HAS2-PLAG1 encode a full-length PLAG1 protein.

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi23 – 242RK → AA: Inhibition of KPNA2 interaction when mutation occurs in the NLS; decreased nuclear import with localization in the nucleus but also in the cytoplasm; Complete inhibition of nuclear import when associated with a lack of zinc-finger domains. 1 Publication
Mutagenesisi31 – 322RK → AA: No inhibition of KPNA2 interaction and no change in nuclear import. 1 Publication
Mutagenesisi92 – 921H → A: Prevents formation of functional zinc-finger 3; induces drastic decrease of DNA affinity and complete modification of DNA binding specificity. 2 Publications
Mutagenesisi227 – 2271H → A: Prevents formation of functional zinc-finger 7 and inhibits DNA binding; No proliferation and transformation of cultured cells. 3 Publications
Mutagenesisi244 – 2441K → R: Abolishes single and double sumoylation; nuclear localization conserved. Increases transcriptional activity and inhibits repression domain activity; when associated with R-263 and R-353. 3 Publications
Mutagenesisi263 – 2631K → R: Decreases sumoylation; Abolishes double sumoylation only; Nuclear localization conserved. Increases transcriptional activity and inhibits repression domain activity; when associated with R-244 and R-353. 3 Publications
Mutagenesisi339 – 3391T → A: No effect on transcription activation capacity. 2 Publications
Mutagenesisi340 – 3401S → A: No effect on transcription activation capacity. 2 Publications
Mutagenesisi353 – 3531K → R: No effect on sumoylation. Increases transcriptional activity and inhibits repression domain activity; when associated with R-244 and R-263. 3 Publications

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

MIMi181030. phenotype.
PharmGKBiPA33378.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 500500Zinc finger protein PLAG1
PRO_0000295107Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki244 – 244Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)
Cross-linki263 – 263Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)

Post-translational modificationi

Sumoylated with SUMO1; which inhibits transcriptional activity, but does not affect nuclear localization. Blockers of sumoylation pathway such as SENP3 and inactive UBE2I increases transcriptional capacity. Sumoylation is increased in the presence of PIAS1.2 Publications
Acetylated by lysine acetyltransferase EP300; which activates transcriptional capacity. Lysine residues that are sumoylated also seem to be target for acetylation.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiQ6DJT9.
PaxDbiQ6DJT9.
PRIDEiQ6DJT9.

PTM databases

PhosphoSiteiQ6DJT9.

Expressioni

Tissue specificityi

Expressed in fetal tissues such as lung, liver and kidney. Not detected or weak detection in normal adult tissues, but highly expressed in salivary gland with benign or malignant pleiomorphic adenomas with or without 8q12 aberrations, with preferential occurrence in benign tumors.4 Publications

Gene expression databases

ArrayExpressiQ6DJT9.
BgeeiQ6DJT9.
CleanExiHS_PLAG1.
GenevestigatoriQ6DJT9.

Interactioni

Subunit structurei

Interacts with KPNA2, which escorts protein to the nucleus via interaction with nuclear localization signal. Interacts with E3 SUMO-protein ligase PIAS1, PIAS2 and PIAS4.2 Publications

Protein-protein interaction databases

BioGridi111340. 7 interactions.
IntActiQ6DJT9. 3 interactions.
MINTiMINT-1188755.
STRINGi9606.ENSP00000325546.

Structurei

3D structure databases

ProteinModelPortaliQ6DJT9.
SMRiQ6DJT9. Positions 32-239.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2 – 8483Interacts with KPNA2
Add
BLAST
Regioni41 – 242202Decreased nuclear import with localization in the nucleus but also in the cytoplasm
Add
BLAST
Regioni243 – 500258Activates transcription; Inhibition of nuclear import due to lack of NLS and KPNA2 interaction
Add
BLAST
Regioni243 – 384142Repression domain; contains 3 sumoylation motifs and massively decrease transcription activity
Add
BLAST
Regioni385 – 500116Massively activates transcription
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi22 – 254Nuclear localization signal

Domaini

C2H2-type zinc fingers 3 interacts with DNA-binding site G-clusterinc fingers. C2H2-type zinc fingers 6 and 7 interact with DNA-binding site core sequence.

Sequence similaritiesi

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
HOGENOMiHOG000294191.
HOVERGENiHBG053608.
InParanoidiQ6DJT9.
OMAiIDMDAVH.
OrthoDBiEOG71K62Q.
PhylomeDBiQ6DJT9.
TreeFamiTF332024.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR027775. C2H2_Znf_fam.
IPR027765. PLAG1.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR10032. PTHR10032. 1 hit.
PTHR10032:SF124. PTHR10032:SF124. 1 hit.
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 7 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6DJT9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MATVIPGDLS EVRDTQKVPS GKRKRGETKP RKNFPCQLCD KAFNSVEKLK    50
VHSYSHTGER PYKCIQQDCT KAFVSKYKLQ RHMATHSPEK THKCNYCEKM 100
FHRKDHLKNH LHTHDPNKET FKCEECGKNY NTKLGFKRHL ALHAATSGDL 150
TCKVCLQTFE STGVLLEHLK SHAGKSSGGV KEKKHQCEHC DRRFYTRKDV 200
RRHMVVHTGR KDFLCQYCAQ RFGRKDHLTR HMKKSHNQEL LKVKTEPVDF 250
LDPFTCNVSV PIKDELLPVM SLPSSELLSK PFTNTLQLNL YNTPFQSMQS 300
SGSAHQMITT LPLGMTCPID MDTVHPSHHL SFKYPFSSTS YAISIPEKEQ 350
PLKGEIESYL MELQGGVPSS SQDSQASSSS KLGLDPQIGS LDDGAGDLSL 400
SKSSISISDP LNTPALDFSQ LFNFIPLNGP PYNPLSVGSL GMSYSQEEAH 450
SSVSQLPPQT QDLQDPANTI GLGSLHSLSA AFTSSLSTST TLPRFHQAFQ 500
Length:500
Mass (Da):55,909
Last modified:August 16, 2004 - v1
Checksum:iCF022A132A1BFD43
GO
Isoform 2 (identifier: Q6DJT9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-82: Missing.

Note: No experimental confirmation available.

Show »
Length:418
Mass (Da):46,474
Checksum:i00BA4A605A99B39C
GO

Sequence cautioni

The sequence BAD92368.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti458 – 4581P → T.1 Publication
Corresponds to variant rs35883156 [ dbSNP | Ensembl ].
VAR_033212

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8282Missing in isoform 2.
VSP_045183Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti276 – 2761E → D in BAD92368. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U65002 mRNA. Translation: AAC50995.1.
AK296933 mRNA. Translation: BAG59484.1.
AB209131 mRNA. Translation: BAD92368.1. Different initiation.
AC107952 Genomic DNA. No translation available.
BC075047 mRNA. Translation: AAH75047.1.
BC075048 mRNA. Translation: AAH75048.1.
CCDSiCCDS47860.1. [Q6DJT9-2]
CCDS6165.1. [Q6DJT9-1]
RefSeqiNP_001108106.1. NM_001114634.1. [Q6DJT9-1]
NP_001108107.1. NM_001114635.1. [Q6DJT9-2]
NP_002646.2. NM_002655.2. [Q6DJT9-1]
XP_005251317.1. XM_005251260.1. [Q6DJT9-1]
UniGeneiHs.14968.

Genome annotation databases

EnsembliENST00000316981; ENSP00000325546; ENSG00000181690. [Q6DJT9-1]
ENST00000423799; ENSP00000404067; ENSG00000181690. [Q6DJT9-2]
ENST00000429357; ENSP00000416537; ENSG00000181690. [Q6DJT9-1]
GeneIDi5324.
KEGGihsa:5324.
UCSCiuc003xsq.4. human. [Q6DJT9-1]

Polymorphism databases

DMDMi74757442.

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U65002 mRNA. Translation: AAC50995.1 .
AK296933 mRNA. Translation: BAG59484.1 .
AB209131 mRNA. Translation: BAD92368.1 . Different initiation.
AC107952 Genomic DNA. No translation available.
BC075047 mRNA. Translation: AAH75047.1 .
BC075048 mRNA. Translation: AAH75048.1 .
CCDSi CCDS47860.1. [Q6DJT9-2 ]
CCDS6165.1. [Q6DJT9-1 ]
RefSeqi NP_001108106.1. NM_001114634.1. [Q6DJT9-1 ]
NP_001108107.1. NM_001114635.1. [Q6DJT9-2 ]
NP_002646.2. NM_002655.2. [Q6DJT9-1 ]
XP_005251317.1. XM_005251260.1. [Q6DJT9-1 ]
UniGenei Hs.14968.

3D structure databases

ProteinModelPortali Q6DJT9.
SMRi Q6DJT9. Positions 32-239.
ModBasei Search...

Protein-protein interaction databases

BioGridi 111340. 7 interactions.
IntActi Q6DJT9. 3 interactions.
MINTi MINT-1188755.
STRINGi 9606.ENSP00000325546.

PTM databases

PhosphoSitei Q6DJT9.

Polymorphism databases

DMDMi 74757442.

Proteomic databases

MaxQBi Q6DJT9.
PaxDbi Q6DJT9.
PRIDEi Q6DJT9.

Protocols and materials databases

DNASUi 5324.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000316981 ; ENSP00000325546 ; ENSG00000181690 . [Q6DJT9-1 ]
ENST00000423799 ; ENSP00000404067 ; ENSG00000181690 . [Q6DJT9-2 ]
ENST00000429357 ; ENSP00000416537 ; ENSG00000181690 . [Q6DJT9-1 ]
GeneIDi 5324.
KEGGi hsa:5324.
UCSCi uc003xsq.4. human. [Q6DJT9-1 ]

Organism-specific databases

CTDi 5324.
GeneCardsi GC08M057073.
HGNCi HGNC:9045. PLAG1.
MIMi 181030. phenotype.
603026. gene.
neXtProti NX_Q6DJT9.
PharmGKBi PA33378.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
HOGENOMi HOG000294191.
HOVERGENi HBG053608.
InParanoidi Q6DJT9.
OMAi IDMDAVH.
OrthoDBi EOG71K62Q.
PhylomeDBi Q6DJT9.
TreeFami TF332024.

Enzyme and pathway databases

SignaLinki Q6DJT9.

Miscellaneous databases

ChiTaRSi PLAG1. human.
GeneWikii PLAG1.
GenomeRNAii 5324.
NextBioi 20594.
PROi Q6DJT9.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q6DJT9.
Bgeei Q6DJT9.
CleanExi HS_PLAG1.
Genevestigatori Q6DJT9.

Family and domain databases

Gene3Di 3.30.160.60. 5 hits.
InterProi IPR027775. C2H2_Znf_fam.
IPR027765. PLAG1.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
PANTHERi PTHR10032. PTHR10032. 1 hit.
PTHR10032:SF124. PTHR10032:SF124. 1 hit.
Pfami PF00096. zf-C2H2. 1 hit.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 7 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Promoter swapping between the genes for a novel zinc finger protein and beta-catenin in pleiomorphic adenomas with t(3;8)(p21;q12) translocations."
    Kas K., Voz M.L., Roeijer E., Astroem A.-K., Meyen E., Stenman G., Van de Ven W.J.M.
    Nat. Genet. 15:170-174(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, CHROMOSOMAL TRANSLOCATION WITH CTNNB1, VARIANT THR-458.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Tongue.
  3. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  4. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  6. "Transcriptional activation capacity of the novel PLAG family of zinc finger proteins."
    Kas K., Voz M.L., Hensen K., Meyen E., Van de Ven W.J.M.
    J. Biol. Chem. 273:23026-23032(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, MUTAGENESIS OF THR-339 AND SER-340.
  7. "The recurrent translocation t(5;8)(p13;q12) in pleomorphic adenomas results in upregulation of PLAG1 gene expression under control of the LIFR promoter."
    Voz M.L., Astrom A.-K., Kas K., Mark J., Stenman G., Van de Ven W.J.M.
    Oncogene 16:1409-1416(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHROMOSOMAL TRANSLOCATION WITH LIFR.
  8. "Conserved mechanism of PLAG1 activation in salivary gland tumors with and without chromosome 8q12 abnormalities: identification of SII as a new fusion partner gene."
    Astroem A.-K., Voz M.L., Kas K., Roeijer E., Wedell B., Mandahl N., Van de Ven W., Mark J., Stenman G.
    Cancer Res. 59:918-923(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHROMOSOMAL TRANSLOCATION WITH CTNNB1 AND TCEA1, TISSUE SPECIFICITY.
  9. "PLAG1, the main translocation target in pleomorphic adenoma of the salivary glands, is a positive regulator of IGF-II."
    Voz M.L., Agten N.S., Van de Ven W.J.M., Kas K.
    Cancer Res. 60:106-113(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, DNA-BINDING, MUTAGENESIS OF HIS-92 AND HIS-227.
  10. "PLAG1 fusion oncogenes in lipoblastoma."
    Hibbard M.K., Kozakewich H.P., Dal Cin P., Sciot R., Tan X., Xiao S., Fletcher J.A.
    Cancer Res. 60:4869-4872(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHROMOSOMAL REARRANGEMENT WITH HAS2 AND COL1A2.
  11. "The tumorigenic diversity of the three PLAG family members is associated with different DNA binding capacities."
    Hensen K., Van Valckenborgh I.C.C., Kas K., Van de Ven W.J.M., Voz M.L.
    Cancer Res. 62:1510-1517(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, MUTAGENESIS OF HIS-227.
  12. "Identification of a karyopherin alpha 2 recognition site in PLAG1, which functions as a nuclear localization signal."
    Braem C.V., Kas K., Meyen E., Debiec-Rychter M., Van De Ven W.J.M., Voz M.L.
    J. Biol. Chem. 277:19673-19678(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH KPNA2, SUBCELLULAR LOCATION, MUTAGENESIS OF 23-ARG-LYS-24 AND 31-ARG-LYS-32.
  13. Cited for: FUNCTION, TISSUE SPECIFICITY.
  14. "Repression of the transactivating capacity of the oncoprotein PLAG1 by SUMOylation."
    Van Dyck F., Delvaux E.L.D., Van de Ven W.J.M., Chavez M.V.
    J. Biol. Chem. 279:36121-36131(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUMOYLATION, MUTAGENESIS OF LYS-244; LYS-263 AND LYS-353, INTERACTION WITH PIAS PROTEINS.
  15. Cited for: FUNCTION.
  16. "PLAG1-HAS2 fusion in lipoblastoma with masked 8q intrachromosomal rearrangement."
    Morerio C., Rapella A., Rosanda C., Tassano E., Gambini C., Romagnoli G., Panarello C.
    Cancer Genet. Cytogenet. 156:183-184(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHROMOSOMAL REARRANGEMENT WITH HAS2.
  17. "Sumoylation and acetylation play opposite roles in the transactivation of PLAG1 and PLAGL2."
    Zheng G., Yang Y.-C.
    J. Biol. Chem. 280:40773-40781(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUMOYLATION, ACETYLATION, MUTAGENESIS OF LYS-244; LYS-263 AND LYS-353, SUBCELLULAR LOCATION.
  18. "CHCHD7-PLAG1 and TCEA1-PLAG1 gene fusions resulting from cryptic, intrachromosomal 8q rearrangements in pleomorphic salivary gland adenomas."
    Asp J., Persson F., Kost-Alimova M., Stenman G.
    Genes Chromosomes Cancer 45:820-828(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHROMOSOMAL REARRANGEMENT WITH CHCHD7 AND TCEA1.

Entry informationi

Entry nameiPLAG1_HUMAN
AccessioniPrimary (citable) accession number: Q6DJT9
Secondary accession number(s): B4DLC2, Q59GH8, Q9Y4L2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: August 16, 2004
Last modified: July 9, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Residual nuclear import after mutation of the nuclear localization signal is assigned to zinc finger domains of PLAG1.
When cultured cells transformed by PLAG1 overexpression are injected in nude mouse, rapidly growing tumors (fibrosarcomaS) are observed at the site of inoculation.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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