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Protein

POU domain, class 3, transcription factor 4-B

Gene

pou3f4-b

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional activator. Induces neural-specific gene expression to act as a key regulator of neural differentiation (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi273 – 332HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
POU domain, class 3, transcription factor 4-B
Gene namesi
Name:pou3f4-b
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003896161 – 356POU domain, class 3, transcription factor 4-BAdd BLAST356

Structurei

3D structure databases

ProteinModelPortaliQ6DJN3.
SMRiQ6DJN3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini181 – 255POU-specificPROSITE-ProRule annotationAdd BLAST75

Sequence similaritiesi

Belongs to the POU transcription factor family. Class-3 subfamily.Sequence analysis

Keywords - Domaini

Homeobox

Phylogenomic databases

HOVERGENiHBG053120.
KOiK09365.

Family and domain databases

CDDicd00086. homeodomain. 1 hit.
InterProiView protein in InterPro
IPR009057. Homeobox-like.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_dom.
IPR016362. TF_POU_3.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
PIRSFiPIRSF002629. Transcription_factor_POU. 1 hit.
PRINTSiPR00028. POUDOMAIN.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiView protein in PROSITE
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6DJN3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATAASNPYS ILSSSSLVHA DSAVMQQGSP FRNPQKLLQS DYLQGIPSNG
60 70 80 90 100
HPLGHHWVTS LSDANPWSSL ASSPLDQQDI KPGREDLQLG AIIHHRSPHV
110 120 130 140 150
SHHSPHNNHP NTWGASPVHN SSGQPINVYS QPGFTVSGML DHGGLTPPPP
160 170 180 190 200
SGTTQSLHPV LREATDHGDL GSHHCHDHSD EETPTSDELE QFAKLFKQRR
210 220 230 240 250
IKLGFTQADV GLALGTLYGN VFSQTTICRF EALQLSFKNM CKLKPLLNKW
260 270 280 290 300
LEEADSSTGS PTSIDKIAAQ GRKRKKRTSI EVSVKGVLET HFLKCPKPAA
310 320 330 340 350
LEISSLADSL QLEKEVVRVW FCNRRQKEKR MTPPGDPQQH EIYSHSVKTD

TSCNEL
Length:356
Mass (Da):39,174
Last modified:August 16, 2004 - v1
Checksum:i9D32C537C04980B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC075142 mRNA. Translation: AAH75142.1.
RefSeqiNP_001086347.1. NM_001092878.1.
UniGeneiXl.81580.

Genome annotation databases

GeneIDi444776.
KEGGixla:444776.

Similar proteinsi

Entry informationi

Entry nameiP3F4B_XENLA
AccessioniPrimary (citable) accession number: Q6DJN3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 2009
Last sequence update: August 16, 2004
Last modified: September 27, 2017
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families