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Q6DJM7 (CDK14_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cyclin-dependent kinase 14

EC=2.7.11.22
Alternative name(s):
Cell division protein kinase 14
Gene names
Name:cdk14
Synonyms:pftk1
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length435 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of lrp6, leading to the activation of the Wnt signaling pathway By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Subunit structure

Interacts with ccny; ccny mediates its recruitment to the plasma membrane and promotes phosphorylation of lrp6 By similarity.

Subcellular location

Cell membrane; Peripheral membrane protein By similarity. Note: Recruited to the cell membrane by CCNY By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 435435Cyclin-dependent kinase 14
PRO_0000391903

Regions

Domain101 – 385285Protein kinase
Nucleotide binding107 – 1159ATP By similarity

Sites

Active site2221Proton acceptor By similarity
Binding site1301ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6DJM7 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: 1EECF4593408FD2C

FASTA43549,230
        10         20         30         40         50         60 
MCDMIESQPA QKIGKMKKLR RTLSDSFSRI ALKKDENAID EICVTKMSTR NCQGIDSVIK 

        70         80         90        100        110        120 
HLDPIPEDKK VRVQRTQSSF DPFEKTSNQP TSPKFGKADS YEKLEKLGEG SYATVFKGKS 

       130        140        150        160        170        180 
KVNGKLVALK VIRLQEEEGT PFTAIREASL LKGLKHANIV LLHDIIHTKE TLTLVFEYVH 

       190        200        210        220        230        240 
TDLCQYMDKH PGGLNPENVK LFLFQLLRGL SYIHQGHILH RDLKPQNLLI SDTGELKLAD 

       250        260        270        280        290        300 
FGLARAKSVP SHTYSNEVVT LWYRPPDVLL GSTDYSTCLD MWGVGCIFVE MIQGVAAFPG 

       310        320        330        340        350        360 
MKDIQDQLER IFLILGTPIE ETWPAVHSLP HFEPERFTLY GPKNLRQAWN KLSYVNHAED 

       370        380        390        400        410        420 
LASKLLQCFP KNRLSAQAAL NHDYFSDLPP RLWELSDMSS IFTVPNVKLQ PEAGESMRVF 

       430 
GKNNSFSKSL SNSKH 

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC075148 mRNA. Translation: AAH75148.1.
RefSeqNP_001086352.1. NM_001092883.1.
UniGeneXl.47481.

3D structure databases

ProteinModelPortalQ6DJM7.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ6DJM7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID444781.
KEGGxla:444781.

Organism-specific databases

CTD5218.
XenbaseXB-GENE-943254. cdk14.

Phylogenomic databases

HOVERGENHBG014652.
KOK08821.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCDK14_XENLA
AccessionPrimary (citable) accession number: Q6DJM7
Entry history
Integrated into UniProtKB/Swiss-Prot: March 2, 2010
Last sequence update: August 16, 2004
Last modified: February 19, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families