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Protein

Cyclin-dependent kinase 14

Gene

cdk14

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of lrp6, leading to the activation of the Wnt signaling pathway (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei130ATPPROSITE-ProRule annotation1
Active sitei222Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi107 – 115ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processCell cycle, Cell division, Wnt signaling pathway
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 14 (EC:2.7.11.22)
Alternative name(s):
Cell division protein kinase 14
Gene namesi
Name:cdk14
Synonyms:pftk1
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-943254. cdk14.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003919031 – 435Cyclin-dependent kinase 14Add BLAST435

Proteomic databases

PRIDEiQ6DJM7.

Interactioni

Subunit structurei

Interacts with ccny; ccny mediates its recruitment to the plasma membrane and promotes phosphorylation of lrp6.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ6DJM7.
SMRiQ6DJM7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini101 – 385Protein kinasePROSITE-ProRule annotationAdd BLAST285

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG014652.
KOiK08821.

Family and domain databases

InterProiView protein in InterPro
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
PfamiView protein in Pfam
PF00069. Pkinase. 1 hit.
SMARTiView protein in SMART
SM00220. S_TKc. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6DJM7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCDMIESQPA QKIGKMKKLR RTLSDSFSRI ALKKDENAID EICVTKMSTR
60 70 80 90 100
NCQGIDSVIK HLDPIPEDKK VRVQRTQSSF DPFEKTSNQP TSPKFGKADS
110 120 130 140 150
YEKLEKLGEG SYATVFKGKS KVNGKLVALK VIRLQEEEGT PFTAIREASL
160 170 180 190 200
LKGLKHANIV LLHDIIHTKE TLTLVFEYVH TDLCQYMDKH PGGLNPENVK
210 220 230 240 250
LFLFQLLRGL SYIHQGHILH RDLKPQNLLI SDTGELKLAD FGLARAKSVP
260 270 280 290 300
SHTYSNEVVT LWYRPPDVLL GSTDYSTCLD MWGVGCIFVE MIQGVAAFPG
310 320 330 340 350
MKDIQDQLER IFLILGTPIE ETWPAVHSLP HFEPERFTLY GPKNLRQAWN
360 370 380 390 400
KLSYVNHAED LASKLLQCFP KNRLSAQAAL NHDYFSDLPP RLWELSDMSS
410 420 430
IFTVPNVKLQ PEAGESMRVF GKNNSFSKSL SNSKH
Length:435
Mass (Da):49,230
Last modified:August 16, 2004 - v1
Checksum:i1EECF4593408FD2C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC075148 mRNA. Translation: AAH75148.1.
RefSeqiNP_001086352.1. NM_001092883.1.
UniGeneiXl.47481.

Genome annotation databases

GeneIDi444781.
KEGGixla:444781.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCDK14_XENLA
AccessioniPrimary (citable) accession number: Q6DJM7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 2, 2010
Last sequence update: August 16, 2004
Last modified: February 15, 2017
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families