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Q6DJM7

- CDK14_XENLA

UniProt

Q6DJM7 - CDK14_XENLA

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Protein

Cyclin-dependent kinase 14

Gene
cdk14, pftk1
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of lrp6, leading to the activation of the Wnt signaling pathway By similarity.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei130 – 1301ATP By similarity
Active sitei222 – 2221Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi107 – 1159ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB

GO - Biological processi

  1. cell division Source: UniProtKB-KW
  2. G2/M transition of mitotic cell cycle Source: UniProtKB
  3. regulation of canonical Wnt signaling pathway Source: UniProtKB
  4. Wnt signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Cell cycle, Cell division, Wnt signaling pathway

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 14 (EC:2.7.11.22)
Alternative name(s):
Cell division protein kinase 14
Gene namesi
Name:cdk14
Synonyms:pftk1
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-943254. cdk14.

Subcellular locationi

Cell membrane; Peripheral membrane protein By similarity
Note: Recruited to the cell membrane by CCNY By similarity.

GO - Cellular componenti

  1. cytoplasmic cyclin-dependent protein kinase holoenzyme complex Source: UniProtKB
  2. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 435435Cyclin-dependent kinase 14PRO_0000391903Add
BLAST

Proteomic databases

PRIDEiQ6DJM7.

Interactioni

Subunit structurei

Interacts with ccny; ccny mediates its recruitment to the plasma membrane and promotes phosphorylation of lrp6 By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ6DJM7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini101 – 385285Protein kinaseAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG014652.
KOiK08821.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6DJM7-1 [UniParc]FASTAAdd to Basket

« Hide

MCDMIESQPA QKIGKMKKLR RTLSDSFSRI ALKKDENAID EICVTKMSTR    50
NCQGIDSVIK HLDPIPEDKK VRVQRTQSSF DPFEKTSNQP TSPKFGKADS 100
YEKLEKLGEG SYATVFKGKS KVNGKLVALK VIRLQEEEGT PFTAIREASL 150
LKGLKHANIV LLHDIIHTKE TLTLVFEYVH TDLCQYMDKH PGGLNPENVK 200
LFLFQLLRGL SYIHQGHILH RDLKPQNLLI SDTGELKLAD FGLARAKSVP 250
SHTYSNEVVT LWYRPPDVLL GSTDYSTCLD MWGVGCIFVE MIQGVAAFPG 300
MKDIQDQLER IFLILGTPIE ETWPAVHSLP HFEPERFTLY GPKNLRQAWN 350
KLSYVNHAED LASKLLQCFP KNRLSAQAAL NHDYFSDLPP RLWELSDMSS 400
IFTVPNVKLQ PEAGESMRVF GKNNSFSKSL SNSKH 435
Length:435
Mass (Da):49,230
Last modified:August 16, 2004 - v1
Checksum:i1EECF4593408FD2C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC075148 mRNA. Translation: AAH75148.1.
RefSeqiNP_001086352.1. NM_001092883.1.
UniGeneiXl.47481.

Genome annotation databases

GeneIDi444781.
KEGGixla:444781.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC075148 mRNA. Translation: AAH75148.1 .
RefSeqi NP_001086352.1. NM_001092883.1.
UniGenei Xl.47481.

3D structure databases

ProteinModelPortali Q6DJM7.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q6DJM7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 444781.
KEGGi xla:444781.

Organism-specific databases

CTDi 5218.
Xenbasei XB-GENE-943254. cdk14.

Phylogenomic databases

HOVERGENi HBG014652.
KOi K08821.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiCDK14_XENLA
AccessioniPrimary (citable) accession number: Q6DJM7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 2, 2010
Last sequence update: August 16, 2004
Last modified: February 19, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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