Q6DIZ8 (KMO_XENTR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Kynurenine 3-monooxygenase
EC=1.14.13.9

Alternative name(s):
Kynurenine 3-hydroxylase

Gene names

Name:

kmo

Organism

Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

Taxonomic identifier

8364 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana

Protein attributes

Sequence length	473 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid By similarity.
Catalytic activity	L-kynurenine + NADPH + O2 = 3-hydroxy-L-kynurenine + NADP+ + H2O.
Cofactor	FAD By similarity.
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 1/3.
Subcellular location	Mitochondrion outer membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the aromatic-ring hydroxylase family. KMO subfamily.

Ontologies

Keywords
Biological process	Pyridine nucleotide biosynthesis
Cellular component	Membrane Mitochondrion Mitochondrion outer membrane
Domain	Transmembrane Transmembrane helix
Ligand	FAD Flavoprotein NADP
Molecular function	Monooxygenase Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	NAD metabolic process Inferred from sequence or structural similarity. Source: UniProtKB pyridine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial outer membrane Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	kynurenine 3-monooxygenase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 473	473	Kynurenine 3-monooxygenase		PRO_0000229746
Regions
	Transmembrane	385 – 404	20	Helical; Potential
	Transmembrane	425 – 445	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q6DIZ8 [UniParc]. Last modified August 16, 2004. Version 1. Checksum: A0981E438BCB18DC	FASTA	473	54,261
	10 20 30 40 50 60 MEIQGNRKKT VSVVGGGLVG SLNACFFAKK GFQVELYEAR EDIRYARMVS GRSINLALSH 70 80 90 100 110 120 RGLQALKAVG LDEKIAAMGI PMRARMIHSV KGRKSSIPYG KQHQYILSVD RANLNKELLS 130 140 150 160 170 180 AAEKYSNVTM HFEHKLRDCN VDSGTMTFLN NMENIIEKKA DLIVGCDGAF SVVRKQFMRK 190 200 210 220 230 240 SRFNYSHVYI PHGYKELTIP PRKGEFAMEP NYLHIWPRNT FMMIALPNLD KSFTCTLFMP 250 260 270 280 290 300 FEDFEKLTTG DQVLDFFKTY FPDSIELIGE KKLTEDFFLL PPQAMISVKC SSFCIDHKCV 310 320 330 340 350 360 IMGDAAHAVV PFYGQGMNAG FEDCLVFSEL MEQYQNNLRI CLHEFSRLRV PDAHAISDLA 370 380 390 400 410 420 MYNYKEMRAH VNSKWFIFRK QVDNILNAIM PTTFIPLYTM VTFSRIRYHE VILRWKWQKK 430 440 450 460 470 IINVGLFTVG TTGSVGAAYL VIKYLPFNKY IEHVGNCLTH LKGNAYLSRL WAK

References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC075387 mRNA. Translation: AAH75387.1.
RefSeq	NP_001006690.1. NM_001006689.1.
UniGene	Str.24340.
3D structure databases
ProteinModelPortal	Q6DIZ8.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6DIZ8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	448312.
KEGG	xtr:448312.
Organism-specific databases
CTD	8564.
Xenbase	XB-GENE-966665. kmo.
Phylogenomic databases
eggNOG	veNOG05745.
GeneTree	ENSGT00390000000747.
HOGENOM	HBG430104.
HOVERGEN	HBG057213.
InParanoid	Q6DIZ8.
OrthoDB	EOG4WH8KP.
Gene expression databases
Bgee	Q6DIZ8.
Family and domain databases
InterPro	IPR002938. mOase_FAD-bd. IPR003042. Rng_hydrolase-like. [Graphical view]
KO	K00486.
Pfam	PF01494. FAD_binding_3. 1 hit. [Graphical view]
PRINTS	PR00420. RNGMNOXGNASE.
ProtoNet	Search...

Entry information

Entry name

KMO_XENTR

Accession

Primary (citable) accession number: Q6DIZ8

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	August 16, 2004
Last modified:	November 16, 2011
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program