Q6DIZ0 (3HAO_XENTR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-hydroxyanthranilate 3,4-dioxygenase
EC=1.13.11.6

Alternative name(s):
3-hydroxyanthranilate oxygenase
Short name=3-HAO
3-hydroxyanthranilic acid dioxygenase
Short name=HAD

Gene names

Name:

haao

Organism

Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

Taxonomic identifier

8364 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana

Protein attributes

Sequence length	280 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate By similarity.
Catalytic activity	3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde.
Cofactor	Fe2+ ion By similarity.
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 3/3.
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the 3-HAO family.

Ontologies

Keywords
Biological process	Pyridine nucleotide biosynthesis
Cellular component	Cytoplasm
Ligand	Iron Metal-binding
Molecular function	Dioxygenase Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	pyridine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-hydroxyanthranilate 3,4-dioxygenase activity Inferred from electronic annotation. Source: EC iron ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 280	280	3-hydroxyanthranilate 3,4-dioxygenase		PRO_0000245468
Regions
	Region	1 – 160	160	Domain A (catalytic) By similarity
	Region	161 – 177	17	Linker By similarity
	Region	178 – 280	103	Domain B By similarity
Sites
	Metal binding	47	1	Iron; catalytic By similarity
	Metal binding	53	1	Iron; catalytic By similarity
	Metal binding	91	1	Iron; catalytic By similarity
	Binding site	43	1	Dioxygen By similarity
	Binding site	53	1	Substrate By similarity
	Binding site	95	1	Substrate By similarity
	Binding site	105	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6DIZ0 [UniParc]. Last modified August 16, 2004. Version 1. Checksum: 4E679AB7C625FA97	FASTA	280	32,335
	10 20 30 40 50 60 MAIPVNVKKW IDENREYFLP PVCNKLMQNH QLKVMFVGGP NQRKDYHIEE GEELFYQVQG 70 80 90 100 110 120 DMCLKIVENG KHKDVHIKEG EMFLLPGRIP HSPQRYADTV GLVFERRRLD TEKDGLRYYV 130 140 150 160 170 180 EGTTEVLFEK WFYCEDLGTQ LAPIMKEFFS SEQYKSGKPD PAQPIGKMPF FLNTEQVMEP 190 200 210 220 230 240 FSFQNWLNKH RLEINQKKRV SLFGHNQETK AVVYGSGESK DSKAQTDTWI WQLEGTSCVT 250 260 270 280 LGNEVLKLGS GDSLLIPEKS LYSWIREDCS IALSTSQVPA

References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC075395 mRNA. Translation: AAH75395.1.
RefSeq	NP_001006914.1. NM_001006913.1.
UniGene	Str.24494.
3D structure databases
ProteinModelPortal	Q6DIZ0.
SMR	Q6DIZ0. Positions 3-280.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6DIZ0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	448761.
KEGG	xtr:448761.
Organism-specific databases
CTD	23498.
Xenbase	XB-GENE-5800903. haao.
Phylogenomic databases
GeneTree	ENSGT00390000013008.
HOVERGEN	HBG000018.
InParanoid	Q6DIZ0.
OrthoDB	EOG4F4SBR.
Gene expression databases
Bgee	Q6DIZ0.
Family and domain databases
InterPro	IPR010329. 3hydroanth_dOase. IPR016700. 3hydroanth_dOase_met. IPR011051. Cupin_RmlC_type. IPR014710. RmlC-like_jellyroll. [Graphical view]
Gene3D	G3DSA:2.60.120.10. RmlC-like_jellyroll. 2 hits.
KO	K00452.
PANTHER	PTHR15497. PTHR15497. 1 hit.
Pfam	PF06052. 3-HAO. 1 hit. [Graphical view]
PIRSF	PIRSF017681. 3hydroanth_dOase_animal. 1 hit.
SUPFAM	SSF51182. RmlC_like_cupin. 2 hits.
TIGRFAMs	TIGR03037. Anthran_nbaC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

3HAO_XENTR

Accession

Primary (citable) accession number: Q6DIZ0

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2006
Last sequence update:	August 16, 2004
Last modified:	November 16, 2011
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program