Reviewed, UniProtKB/Swiss-Prot Q6DIZ0 (3HAO_XENTR)

Names and origin

Protein names

Recommended name:
    3-hydroxyanthranilate 3,4-dioxygenase
    EC=1.13.11.6
Alternative name(s):
    3-hydroxyanthranilic acid dioxygenase
      Short name=HAD
    3-hydroxyanthranilate oxygenase
      Short name=3-HAO

Gene names

Name:

haao

Organism

Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

Taxonomic identifier

8364 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana

Protein attributes

Sequence length	280 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate By similarity.
Catalytic activity	3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde.
Cofactor	Fe2+ ion By similarity.
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 3/3.
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the 3-HAO family.

Ontologies

Keywords
Biological process	Pyridine nucleotide biosynthesis
Cellular component	Cytoplasm
Ligand	Iron Metal-binding
Molecular function	Dioxygenase Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW pyridine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-hydroxyanthranilate 3,4-dioxygenase activity Inferred from electronic annotation. Source: EC iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 280	280	3-hydroxyanthranilate 3,4-dioxygenase		PRO_0000245468
Sites
	Metal binding	47	1	Iron; catalytic By similarity
	Metal binding	53	1	Iron; catalytic By similarity
	Metal binding	91	1	Iron; catalytic By similarity
	Binding site	43	1	Dioxygen By similarity
	Binding site	53	1	Substrate By similarity
	Binding site	95	1	Substrate By similarity
	Binding site	105	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6DIZ0-1 [UniParc]. Last modified August 16, 2004. Version 1. Checksum: 4E679AB7C625FA97	FASTA	280	32,335
	10 20 30 40 50 60 MAIPVNVKKW IDENREYFLP PVCNKLMQNH QLKVMFVGGP NQRKDYHIEE GEELFYQVQG 70 80 90 100 110 120 DMCLKIVENG KHKDVHIKEG EMFLLPGRIP HSPQRYADTV GLVFERRRLD TEKDGLRYYV 130 140 150 160 170 180 EGTTEVLFEK WFYCEDLGTQ LAPIMKEFFS SEQYKSGKPD PAQPIGKMPF FLNTEQVMEP 190 200 210 220 230 240 FSFQNWLNKH RLEINQKKRV SLFGHNQETK AVVYGSGESK DSKAQTDTWI WQLEGTSCVT 250 260 270 280 LGNEVLKLGS GDSLLIPEKS LYSWIREDCS IALSTSQVPA

References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC075395 mRNA. Translation: AAH75395.1.
RefSeq	NP_001006914.1.
UniGene	Str.24494
3D structure databases
SMR	Q6DIZ0. Positions 3-280.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6DIZ0.
Genome annotation databases
Ensembl	ENSXETT00000034366; ENSXETP00000034366; ENSXETG00000015771; Xenopus tropicalis. [Genome view]
GeneID	448761.
KEGG	xtr:448761.
Organism-specific databases
CTD	448761.
Xenbase	XB-FEAT-5800902. haao.
Phylogenomic databases
HOVERGEN	Q6DIZ0.
InParanoid	Q6DIZ0.
Enzyme and pathway databases
BRENDA	1.13.11.6. 279072.
Gene expression databases
Bgee	Q6DIZ0.
Family and domain databases
InterPro	IPR010329. 3hydroanth_dOase. IPR016700. 3hydroanth_dOase_met. IPR011051. Cupin_RmlC_type. [Graphical view]
Pfam	PF06052. 3-HAO. 1 hit. [Graphical view]
PIRSF	PIRSF017681. 3hydroanth_dOase_animal. 1 hit.
TIGRFAMs	TIGR03037. anthran_nbaC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

3HAO_XENTR

Accession

Primary (citable) accession number: Q6DIZ0

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2006
Last sequence update:	August 16, 2004
Last modified:	February 9, 2010
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Xenopus annotation project