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Protein

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform

Gene

ppp2r2d

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

B regulatory subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. The activity of PP2A complexes containing ppp2r2d (PR55-delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis. During mitosis, activity of PP2A is inhibited via interaction with phosphorylated ensa and arpp19 inhibitors. PP2A complexes containing ppp2r2d (PR55-delta) also regulate the activity of TGF-beta/Activin/Nodal signaling by restricting receptor activity. Within the PP2A complexes, the B regulatory subunits modulate substrate selectivity and catalytic activity, and also may direct the localization of the catalytic enzyme to a particular subcellular compartment (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform
Alternative name(s):
PP2A subunit B isoform B55-delta
PP2A subunit B isoform PR55-delta
PP2A subunit B isoform R2-delta
PP2A subunit B isoform delta
Gene namesi
Name:ppp2r2d
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-940312. ppp2r2d.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 447447Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoformPRO_0000408326Add
BLAST

Interactioni

Subunit structurei

PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with ensa (when phosphorylated at 'Ser-67') and arpp19 (when phosphorylated at 'Ser-67'), leading to inhibit PP2A activity (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ6DIY3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati26 – 6540WD 1Add
BLAST
Repeati91 – 13242WD 2Add
BLAST
Repeati175 – 21339WD 3Add
BLAST
Repeati224 – 26441WD 4Add
BLAST
Repeati283 – 32139WD 5Add
BLAST
Repeati338 – 37942WD 6Add
BLAST
Repeati414 – 44734WD 7Add
BLAST

Sequence similaritiesi

Contains 7 WD repeats.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

HOVERGENiHBG000012.
InParanoidiQ6DIY3.
KOiK04354.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR000009. PP2A_PR55.
IPR018067. PP2A_PR55_CS.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR11871. PTHR11871. 1 hit.
PIRSFiPIRSF037309. PP2A_PR55. 1 hit.
PRINTSiPR00600. PP2APR55.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 3 hits.
PROSITEiPS01024. PR55_1. 1 hit.
PS01025. PR55_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6DIY3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGVGGGNDF QWCFSQVKGA IDEDVAEADI ISTVEFNCSG DLLATGDKGG
60 70 80 90 100
RVVIFQREQE NKSRPHSRGE YNVYSTFQSH EPEFDYLKSL EIEEKINKIR
110 120 130 140 150
WLPQQNAAHF LLSTNDKTIK LWKISERDKR VEGYNLKDDD GRLRDPFRIT
160 170 180 190 200
SLRVPILKPM DLMVEASPRR IFANAHTYHI NSISVNSDHE TYLSADDLRI
210 220 230 240 250
NLWHLEITDR SFNIVDIKPA NMEELTEVIT AAEFHPHHCN VFVYSSSKGT
260 270 280 290 300
IRLCDMRDSA LCDRHSKFFE EPEDPSSRSF FSEIISSISD VKFSNSGRYM
310 320 330 340 350
MTRDYLSVKV WDLNMESRPV ETYQVHEYLR SKLCSLYEND CIFDKFECCW
360 370 380 390 400
NGSDSAIMTG SYNNFFRMFD RNTRRDITLE ASRESSKPRA ILKPRKVCTG
410 420 430 440
GKRKKDEINV DSLDFNKKIL HTAWHPTDNI IAVAATNNLY IFQDKVN
Length:447
Mass (Da):51,678
Last modified:August 16, 2004 - v1
Checksum:iD0BEE3CA74503492
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC075402 mRNA. Translation: AAH75402.1.
RefSeqiNP_001006697.1. NM_001006696.1.
UniGeneiStr.2036.

Genome annotation databases

GeneIDi448324.
KEGGixtr:448324.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC075402 mRNA. Translation: AAH75402.1.
RefSeqiNP_001006697.1. NM_001006696.1.
UniGeneiStr.2036.

3D structure databases

ProteinModelPortaliQ6DIY3.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi448324.
KEGGixtr:448324.

Organism-specific databases

CTDi55844.
XenbaseiXB-GENE-940312. ppp2r2d.

Phylogenomic databases

HOVERGENiHBG000012.
InParanoidiQ6DIY3.
KOiK04354.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR000009. PP2A_PR55.
IPR018067. PP2A_PR55_CS.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR11871. PTHR11871. 1 hit.
PIRSFiPIRSF037309. PP2A_PR55. 1 hit.
PRINTSiPR00600. PP2APR55.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 3 hits.
PROSITEiPS01024. PR55_1. 1 hit.
PS01025. PR55_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry namei2ABD_XENTR
AccessioniPrimary (citable) accession number: Q6DIY3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: August 16, 2004
Last modified: July 6, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.