ID   Q6DIR0_XENTR            Unreviewed;       216 AA.
AC   Q6DIR0; F6PIY8;
DT   16-AUG-2004, integrated into UniProtKB/TrEMBL.
DT   16-AUG-2004, sequence version 1.
DT   27-MAR-2024, entry version 142.
DE   RecName: Full=Glutathione S-transferase {ECO:0000256|RuleBase:RU003494};
DE            EC=2.5.1.18 {ECO:0000256|RuleBase:RU003494};
GN   Name=gstm1 {ECO:0000313|EMBL:CAJ82196.1,
GN   ECO:0000313|Ensembl:ENSXETP00000004318,
GN   ECO:0000313|RefSeq:NP_001004964.1,
GN   ECO:0000313|Xenbase:XB-GENE-971384};
GN   Synonyms=gst-mu {ECO:0000313|RefSeq:NP_001004964.1}, gst1
GN   {ECO:0000313|RefSeq:NP_001004964.1}, gth4
GN   {ECO:0000313|RefSeq:NP_001004964.1}, gtm1
GN   {ECO:0000313|RefSeq:NP_001004964.1}, MGC89299
GN   {ECO:0000313|EMBL:AAH75475.1};
GN   ORFNames=TEgg064b21.1-001 {ECO:0000313|EMBL:CAJ82196.1};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364 {ECO:0000313|EMBL:AAH75475.1};
RN   [1] {ECO:0000313|RefSeq:NP_001004964.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=12454917; DOI=10.1002/dvdy.10174;
RA   Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA   Richardson P.;
RT   "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT   initiative.";
RL   Dev. Dyn. 225:384-391(2002).
RN   [2] {ECO:0000313|EMBL:AAH75475.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo {ECO:0000313|EMBL:AAH75475.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:CAJ82196.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Amaya E., Ashurst J.L., Bonfield J.K., Croning M.D.R., Chen C-K.,
RA   Davies R.M., Francis M.D., Garrett N., Gilchrist M.J., Grafham D.V.,
RA   McLaren S.R., Papalopulu N., Rogers J., Smith J.C., Taylor R.G., Voigt J.,
RA   Zorn A.M.;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|Ensembl:ENSXETP00000004318}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000004318};
RX   PubMed=20431018; DOI=10.1126/science.1183670;
RA   Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA   Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA   Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA   Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA   Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA   Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA   Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA   Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA   Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT   "The genome of the Western clawed frog Xenopus tropicalis.";
RL   Science 328:633-636(2010).
RN   [5] {ECO:0000313|Ensembl:ENSXETP00000004318}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUN-2011) to UniProtKB.
RN   [6] {ECO:0000313|RefSeq:NP_001004964.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=glutathione + RX = a halide anion + an S-substituted
CC         glutathione + H(+); Xref=Rhea:RHEA:16437, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16042, ChEBI:CHEBI:17792, ChEBI:CHEBI:57925,
CC         ChEBI:CHEBI:90779; EC=2.5.1.18;
CC         Evidence={ECO:0000256|RuleBase:RU003494};
CC   -!- SIMILARITY: Belongs to the GST superfamily. Mu family.
CC       {ECO:0000256|ARBA:ARBA00005861, ECO:0000256|RuleBase:RU003494}.
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DR   EMBL; BC075475; AAH75475.1; -; mRNA.
DR   EMBL; CR761400; CAJ82196.1; -; mRNA.
DR   RefSeq; NP_001004964.1; NM_001004964.1.
DR   DNASU; 448387; -.
DR   Ensembl; ENSXETT00000004318; ENSXETP00000004318; ENSXETG00000002017.
DR   GeneID; 448387; -.
DR   KEGG; xtr:448387; -.
DR   AGR; Xenbase:XB-GENE-971384; -.
DR   CTD; 2944; -.
DR   Xenbase; XB-GENE-971384; gstm1.
DR   eggNOG; KOG1695; Eukaryota.
DR   HOGENOM; CLU_039475_2_0_1; -.
DR   OMA; KANCATI; -.
DR   OrthoDB; 5488107at2759; -.
DR   TreeFam; TF353040; -.
DR   Reactome; R-XTR-156590; Glutathione conjugation.
DR   Reactome; R-XTR-9026762; Biosynthesis of maresin conjugates in tissue regeneration (MCTR).
DR   Reactome; R-XTR-9748787; Azathioprine ADME.
DR   Reactome; R-XTR-9753281; Paracetamol ADME.
DR   Proteomes; UP000008143; Chromosome 2.
DR   Bgee; ENSXETG00000002017; Expressed in mesonephros and 17 other cell types or tissues.
DR   GO; GO:0004364; F:glutathione transferase activity; IEA:UniProtKB-EC.
DR   CDD; cd03209; GST_C_Mu; 1.
DR   CDD; cd03075; GST_N_Mu; 1.
DR   Gene3D; 1.20.1050.10; -; 1.
DR   Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR   InterPro; IPR010987; Glutathione-S-Trfase_C-like.
DR   InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR   InterPro; IPR004045; Glutathione_S-Trfase_N.
DR   InterPro; IPR004046; GST_C.
DR   InterPro; IPR003081; GST_mu.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   PANTHER; PTHR11571; GLUTATHIONE S-TRANSFERASE; 1.
DR   PANTHER; PTHR11571:SF222; GLUTATHIONE S-TRANSFERASE 2-RELATED; 1.
DR   Pfam; PF00043; GST_C; 1.
DR   Pfam; PF02798; GST_N; 1.
DR   PRINTS; PR01267; GSTRNSFRASEM.
DR   SFLD; SFLDG01205; AMPS.1; 1.
DR   SFLD; SFLDG00363; AMPS_(cytGST):_Alpha-__Mu-__Pi; 1.
DR   SUPFAM; SSF47616; GST C-terminal domain-like; 1.
DR   SUPFAM; SSF52833; Thioredoxin-like; 1.
DR   PROSITE; PS50405; GST_CTER; 1.
DR   PROSITE; PS50404; GST_NTER; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW   Transferase {ECO:0000256|RuleBase:RU003494, ECO:0000313|EMBL:CAJ82196.1}.
FT   DOMAIN          1..86
FT                   /note="GST N-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS50404"
FT   DOMAIN          88..206
FT                   /note="GST C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS50405"
SQ   SEQUENCE   216 AA;  25250 MW;  B45EF084AABD70D5 CRC64;
     MILGYWDIRG LAHSIRLLLE YTGTQYEEKK YITGDAPNYD KTQWLDEKEK LGLDFPNLPY
     LLDGDVKLSQ SNAILRYIAR KHGLCGESEK EKMYVDLIEN QTMDFRMGLV VIAYNPQFET
     LKGPYLEKLP IALKRFSCFL GDRSWFAGDK ITFVDFVVYD VLDQHQILEP TCLQNFKNLQ
     DFLKRFEALP AIDAYMKSSR FMKMPLNNRM ASWGNK
//