Reviewed, UniProtKB/Swiss-Prot Q6DIP5 (EMAL4_XENTR)

Names and origin

Protein names

Recommended name:
Echinoderm microtubule-associated protein-like 4
Short name=EMAP-4

Gene names

Name:

eml4

Organism

Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

Taxonomic identifier

8364 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana

Protein attributes

Sequence length	928 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic By similarity.
Subcellular location	Cytoplasm Potential.
Sequence similarities	Belongs to the WD repeat EMAP family. Contains 9 WD repeats.

Ontologies

Keywords
Cellular component	Cytoplasm Microtubule
Domain	Repeat WD repeat
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell microtubule Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 928	928	Echinoderm microtubule-associated protein-like 4		PRO_0000284394
Regions
	Repeat	247 – 296	50	WD 1
	Repeat	301 – 344	44	WD 2
	Repeat	347 – 388	42	WD 3
	Repeat	394 – 432	39	WD 4
	Repeat	449 – 488	40	WD 5
	Repeat	532 – 571	40	WD 6
	Repeat	615 – 654	40	WD 7
	Repeat	661 – 700	40	WD 8
	Repeat	774 – 814	41	WD 9

Sequences

	Sequence		Length	Mass (Da)
	Q6DIP5-1 [UniParc]. Last modified August 16, 2004. Version 1. Checksum: C27953BAFD1E22DE	FASTA	928	102,611
	10 20 30 40 50 60 MDGFAGSLDD SVSAASTSDV QDRLSALELR VQQQEDEITV LKAALADVLR RLAISEDQVA 70 80 90 100 110 120 TVRKAVPSKG PATMREALSM SCITNGGAGT RKPSHITSVA KKDTLSSAAK SVKRSSTIEK 130 140 150 160 170 180 SHNSWDASEE SRNKLMRAAS TSKLTSKVAK ATDKHKDIVI SPEGEYIKMF MRGRPITMFI 190 200 210 220 230 240 PSDVENYDDI RTELPPEKLK LEWVFGYRGR DCRANVYLLP TGEIVYFIAS VVVLFNYEER 250 260 270 280 290 300 TQRHYLGHTD CVKCIAVHPD KIRIATGQIA GVDKDGRPLQ PHVRVWDSVS LSTLQVIGLG 310 320 330 340 350 360 TFERGVGCLA FSKADSGVHL SVIDDSNEHM LTVWDWQKKS KIAEIKTTNE VVLTVEFHPT 370 380 390 400 410 420 DACTIVTCGK SHIFFWTWSG NSLARKQGIF GKYEKPKFVQ CLAFLANGDV LAGDSGGVML 430 440 450 460 470 480 IWSKTTVEST ASKGAKVLGV YQISRQIKAH DGSVFTLCQM RNGMLLTGGG KDRKVIMWDH 490 500 510 520 530 540 DLNPEREIEV PDQYGTIRAV AEGKGDQFLI GTSRNFILRG TFNDGFQVEV QGHTDELWGL 550 560 570 580 590 600 ATHPFKDLLL TCAQDKQVCL WNSVDHSLEW TRVLDEPGHC ADFHPTGTVV AIGTHSGRWF 610 620 630 640 650 660 VLDAETRDLV SIHTDGNEQL SVMRYSVDGA LLAVGSHDNF IYLYNVSENG RKYSRYGKCT 670 680 690 700 710 720 GHSSYITHLD WSPDNQYIMS NSGDYEILYW DIPSGCKLIR NRSDCKDINW ATYTCVLGFQ 730 740 750 760 770 780 VFGVWPEGSD GTDINALVRS HNRKVIALAD DFCKVHLFQY PCSKPKAPSH KYSAHSSHVT 790 800 810 820 830 840 NVSFTHKDSH LISTGGKDMS IMQWRLIEKV SHSQNDNIVE SSSAVNSPVV TEKPLQPNTP 850 860 870 880 890 900 TNLPQAVNEV PKEDDKTPAE SPVPAEDALE QPEELNEVQS EKCSSQPEGA NGQEPSNEVS 910 920 EDPTDSAAIN NTPEDAQDEN QDDSSPLS

References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC075490 mRNA. Translation: AAH75490.1.
RefSeq	NP_001006917.1.
UniGene	Str.47720
3D structure databases
SMR	Q6DIP5. Positions 198-806.
ModBase	Search...
Genome annotation databases
Ensembl	ENSXETT00000013206; ENSXETP00000013206; ENSXETG00000006002; Xenopus tropicalis. [Genome view]
GeneID	448764.
KEGG	xtr:448764.
Organism-specific databases
CTD	448764.
Xenbase	XB-FEAT-971026. eml4.
Phylogenomic databases
eggNOG	veNOG07283.
HOGENOM	HBG356915.
HOVERGEN	HBG051470.
InParanoid	Q6DIP5.
Family and domain databases
InterPro	IPR005108. HELP. IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR011046. WD40_repeat-like_dom. IPR019782. WD40_repeat_2. IPR019775. WD40_repeat_CS. IPR017986. WD40_repeat_dom. IPR019781. WD40_repeat_sg. [Graphical view]
Gene3D	G3DSA:2.130.10.10. WD40/YVTN_repeat-like. 2 hits.
Pfam	PF03451. HELP. 1 hit. PF00400. WD40. 5 hits. [Graphical view]
SMART	SM00320. WD40. 9 hits. [Graphical view]
SUPFAM	SSF50978. WD40_like. 3 hits.
PROSITE	PS00678. WD_REPEATS_1. 1 hit. PS50082. WD_REPEATS_2. 4 hits. PS50294. WD_REPEATS_REGION. 3 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

EMAL4_XENTR

Accession

Primary (citable) accession number: Q6DIP5

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 17, 2007
Last sequence update:	August 16, 2004
Last modified:	March 2, 2010
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)