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Q6DIJ4

- UBP10_XENTR

UniProt

Q6DIJ4 - UBP10_XENTR

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Protein
Ubiquitin carboxyl-terminal hydrolase 10
Gene
usp10, TGas137m11.1
Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/tp53. Acts as an essential regulator of p53/tp53 stability: in unstressed cells, specifically deubiquitinates p53/tp53 in the cytoplasm, leading to counteracts MDM2 action and stabilize p53/tp53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/tp53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/tp53 levels By similarity.

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei431 – 4311Nucleophile By similarity
Active sitei756 – 7561Proton acceptor By similarity

GO - Molecular functioni

  1. cysteine-type endopeptidase activity Source: UniProtKB
  2. ion channel binding Source: UniProtKB
  3. p53 binding Source: UniProtKB
  4. ubiquitin thiolesterase activity Source: UniProtKB
  5. ubiquitin-specific protease activity Source: UniProtKB

GO - Biological processi

  1. DNA damage response, signal transduction by p53 class mediator Source: UniProtKB
  2. DNA repair Source: UniProtKB-KW
  3. autophagy Source: UniProtKB-KW
  4. protein deubiquitination Source: UniProtKB
  5. regulation of autophagy Source: UniProtKB
  6. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Autophagy, DNA damage, DNA repair, Ubl conjugation pathway

Protein family/group databases

MEROPSiC19.018.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 10 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 10
Ubiquitin thioesterase 10
Ubiquitin-specific-processing protease 10
Gene namesi
Name:usp10
ORF Names:TGas137m11.1
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143: Unplaced

Organism-specific databases

XenbaseiXB-GENE-966184. usp10.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. early endosome Source: UniProtKB
  3. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 805805Ubiquitin carboxyl-terminal hydrolase 10
PRO_0000393004Add
BLAST

Proteomic databases

PaxDbiQ6DIJ4.

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000029355.

Structurei

3D structure databases

ProteinModelPortaliQ6DIJ4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini422 – 802381USP
Add
BLAST

Sequence similaritiesi

Contains 1 USP domain.

Phylogenomic databases

eggNOGiCOG5533.
HOGENOMiHOG000285959.
HOVERGENiHBG059823.
InParanoidiQ6DIJ4.
KOiK11841.

Family and domain databases

InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
IPR028767. USP10.
[Graphical view]
PANTHERiPTHR24006:SF69. PTHR24006:SF69. 1 hit.
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6DIJ4-1 [UniParc]FASTAAdd to Basket

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MASPSGQYIF GEFSDDEFKQ FFVTARCTVE LPPYNEHFFP CGPQSSGDFQ    50
DDMHLKFSEV IHGISGEDCP RIEFGIEEVI DHSTALPNNT DYSISSNLNP 100
QAPEFILTCS SSPKTSNNVL HENNFDAINC QFSECAIPDG SGNADSDGTS 150
GTGQRERKKK KKRPPGYYSY LEGVGDVPSE TLVNGHANST GLNSISTDDP 200
DLAEDIPIST TSPRTCNSPD NFVDLNNEAL SNDASMHNAL DNARTAGQPE 250
ECSVTSSEQS CIPSDNGRES PVRTAVVQPF AGTDTTENLG VTNGQTLESS 300
EEGTASNGVV LLPEVSSLSE EAKPEETSTA QAVVHLPGSA SANPPAKSWA 350
SLFHNSKPSS TTQVAYVETK NATPVTSPQV TEKQVEIKEG PVPVSEDPVA 400
IKIAELLEEV KLVHKPVSLQ PRGLINKGNW CYINATLQAL VACPPMYHLM 450
KSIPVYTKAQ RPCTSTPMID SFVRLMNEFT NMPILPKAKQ ASGEKVIRDI 500
RPGAPFEPAY IYRLLTVFKS SLSEKGRQED AEEYLGFILN GLHEEMLSLK 550
KLLLPQNDKI HINNGPDPVS EKEEINKDEQ EGSDEEWEQV GPRHKSSVTR 600
QADFVQTPIT DIFGGHMRSV VYQQSSKESA TLQPFFTLQL DIQSEKIRTV 650
QDALESLVAR ESVQGYTTKT KQEVEICRRV TLEELPPVLV LHLKRFVFEK 700
TGGCQKLIKN IEYPVDLEIS KDLLSPGVKS KIFKGQRTYR LFAVVYHHGN 750
SATGGHYTTD VFQIGLNGWL RIDDQTVKVI NQYQVVKQTV ERTAYLLYYR 800
RVDLL 805
Length:805
Mass (Da):88,936
Last modified:August 16, 2004 - v1
Checksum:iF95A8A2A4FB60DD1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR855702 mRNA. Translation: CAJ83514.1.
BC075544 mRNA. Translation: AAH75544.1.
RefSeqiNP_001006761.1. NM_001006760.1.
UniGeneiStr.51.

Genome annotation databases

GeneIDi448441.
KEGGixtr:448441.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR855702 mRNA. Translation: CAJ83514.1 .
BC075544 mRNA. Translation: AAH75544.1 .
RefSeqi NP_001006761.1. NM_001006760.1.
UniGenei Str.51.

3D structure databases

ProteinModelPortali Q6DIJ4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 8364.ENSXETP00000029355.

Protein family/group databases

MEROPSi C19.018.

Proteomic databases

PaxDbi Q6DIJ4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 448441.
KEGGi xtr:448441.

Organism-specific databases

CTDi 9100.
Xenbasei XB-GENE-966184. usp10.

Phylogenomic databases

eggNOGi COG5533.
HOGENOMi HOG000285959.
HOVERGENi HBG059823.
InParanoidi Q6DIJ4.
KOi K11841.

Family and domain databases

InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
IPR028767. USP10.
[Graphical view ]
PANTHERi PTHR24006:SF69. PTHR24006:SF69. 1 hit.
Pfami PF00443. UCH. 1 hit.
[Graphical view ]
PROSITEi PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Sanger Xenopus tropicalis EST/cDNA project
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Gastrula.
  2. NIH - Xenopus Gene Collection (XGC) project
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiUBP10_XENTR
AccessioniPrimary (citable) accession number: Q6DIJ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 23, 2010
Last sequence update: August 16, 2004
Last modified: April 16, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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