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Q6DIJ4

- UBP10_XENTR

UniProt

Q6DIJ4 - UBP10_XENTR

Protein

Ubiquitin carboxyl-terminal hydrolase 10

Gene

usp10

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (16 Aug 2004)
      Previous versions | rss
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    Functioni

    Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/tp53. Acts as an essential regulator of p53/tp53 stability: in unstressed cells, specifically deubiquitinates p53/tp53 in the cytoplasm, leading to counteracts MDM2 action and stabilize p53/tp53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/tp53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/tp53 levels By similarity.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei431 – 4311NucleophilePROSITE-ProRule annotation
    Active sitei756 – 7561Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. cysteine-type endopeptidase activity Source: UniProtKB
    2. ion channel binding Source: UniProtKB
    3. p53 binding Source: UniProtKB
    4. ubiquitin-specific protease activity Source: UniProtKB
    5. ubiquitin thiolesterase activity Source: UniProtKB

    GO - Biological processi

    1. autophagy Source: UniProtKB-KW
    2. DNA damage response, signal transduction by p53 class mediator Source: UniProtKB
    3. DNA repair Source: UniProtKB-KW
    4. protein deubiquitination Source: UniProtKB
    5. regulation of autophagy Source: UniProtKB
    6. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Autophagy, DNA damage, DNA repair, Ubl conjugation pathway

    Protein family/group databases

    MEROPSiC19.018.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 10 (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme 10
    Ubiquitin thioesterase 10
    Ubiquitin-specific-processing protease 10
    Gene namesi
    Name:usp10
    ORF Names:TGas137m11.1
    OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
    Taxonomic identifieri8364 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
    ProteomesiUP000008143: Unplaced

    Organism-specific databases

    XenbaseiXB-GENE-966184. usp10.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. early endosome Source: UniProtKB
    3. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 805805Ubiquitin carboxyl-terminal hydrolase 10PRO_0000393004Add
    BLAST

    Proteomic databases

    PaxDbiQ6DIJ4.

    Interactioni

    Protein-protein interaction databases

    STRINGi8364.ENSXETP00000029355.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6DIJ4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini422 – 802381USPAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C19 family. USP10 subfamily.Curated
    Contains 1 USP domain.Curated

    Phylogenomic databases

    eggNOGiCOG5533.
    HOGENOMiHOG000285959.
    HOVERGENiHBG059823.
    InParanoidiQ6DIJ4.
    KOiK11841.

    Family and domain databases

    InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    IPR028767. USP10.
    [Graphical view]
    PANTHERiPTHR24006:SF69. PTHR24006:SF69. 1 hit.
    PfamiPF00443. UCH. 1 hit.
    [Graphical view]
    PROSITEiPS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6DIJ4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASPSGQYIF GEFSDDEFKQ FFVTARCTVE LPPYNEHFFP CGPQSSGDFQ    50
    DDMHLKFSEV IHGISGEDCP RIEFGIEEVI DHSTALPNNT DYSISSNLNP 100
    QAPEFILTCS SSPKTSNNVL HENNFDAINC QFSECAIPDG SGNADSDGTS 150
    GTGQRERKKK KKRPPGYYSY LEGVGDVPSE TLVNGHANST GLNSISTDDP 200
    DLAEDIPIST TSPRTCNSPD NFVDLNNEAL SNDASMHNAL DNARTAGQPE 250
    ECSVTSSEQS CIPSDNGRES PVRTAVVQPF AGTDTTENLG VTNGQTLESS 300
    EEGTASNGVV LLPEVSSLSE EAKPEETSTA QAVVHLPGSA SANPPAKSWA 350
    SLFHNSKPSS TTQVAYVETK NATPVTSPQV TEKQVEIKEG PVPVSEDPVA 400
    IKIAELLEEV KLVHKPVSLQ PRGLINKGNW CYINATLQAL VACPPMYHLM 450
    KSIPVYTKAQ RPCTSTPMID SFVRLMNEFT NMPILPKAKQ ASGEKVIRDI 500
    RPGAPFEPAY IYRLLTVFKS SLSEKGRQED AEEYLGFILN GLHEEMLSLK 550
    KLLLPQNDKI HINNGPDPVS EKEEINKDEQ EGSDEEWEQV GPRHKSSVTR 600
    QADFVQTPIT DIFGGHMRSV VYQQSSKESA TLQPFFTLQL DIQSEKIRTV 650
    QDALESLVAR ESVQGYTTKT KQEVEICRRV TLEELPPVLV LHLKRFVFEK 700
    TGGCQKLIKN IEYPVDLEIS KDLLSPGVKS KIFKGQRTYR LFAVVYHHGN 750
    SATGGHYTTD VFQIGLNGWL RIDDQTVKVI NQYQVVKQTV ERTAYLLYYR 800
    RVDLL 805
    Length:805
    Mass (Da):88,936
    Last modified:August 16, 2004 - v1
    Checksum:iF95A8A2A4FB60DD1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR855702 mRNA. Translation: CAJ83514.1.
    BC075544 mRNA. Translation: AAH75544.1.
    RefSeqiNP_001006761.1. NM_001006760.1.
    UniGeneiStr.51.

    Genome annotation databases

    GeneIDi448441.
    KEGGixtr:448441.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR855702 mRNA. Translation: CAJ83514.1 .
    BC075544 mRNA. Translation: AAH75544.1 .
    RefSeqi NP_001006761.1. NM_001006760.1.
    UniGenei Str.51.

    3D structure databases

    ProteinModelPortali Q6DIJ4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 8364.ENSXETP00000029355.

    Protein family/group databases

    MEROPSi C19.018.

    Proteomic databases

    PaxDbi Q6DIJ4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 448441.
    KEGGi xtr:448441.

    Organism-specific databases

    CTDi 9100.
    Xenbasei XB-GENE-966184. usp10.

    Phylogenomic databases

    eggNOGi COG5533.
    HOGENOMi HOG000285959.
    HOVERGENi HBG059823.
    InParanoidi Q6DIJ4.
    KOi K11841.

    Family and domain databases

    InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    IPR028767. USP10.
    [Graphical view ]
    PANTHERi PTHR24006:SF69. PTHR24006:SF69. 1 hit.
    Pfami PF00443. UCH. 1 hit.
    [Graphical view ]
    PROSITEi PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Sanger Xenopus tropicalis EST/cDNA project
      Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Gastrula.
    2. NIH - Xenopus Gene Collection (XGC) project
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo.

    Entry informationi

    Entry nameiUBP10_XENTR
    AccessioniPrimary (citable) accession number: Q6DIJ4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 23, 2010
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3