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Protein

Probable global transcription activator SNF2L2

Gene

Smarca2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi754 – 761ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Helicase, Hydrolase

Keywords - Biological processi

Neurogenesis, Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable global transcription activator SNF2L2 (EC:3.6.4.-)
Alternative name(s):
ATP-dependent helicase SMARCA2
BRG1-associated factor 190B
Short name:
BAF190B
Protein brahma homolog
SNF2-alpha
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2
Gene namesi
Name:Smarca2Imported
Synonyms:Baf190b, Brm, Snf2a, Snf2l21 Publication
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:99603. Smarca2.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  • BAF-type complex Source: MGI
  • intermediate filament cytoskeleton Source: MGI
  • intracellular membrane-bounded organelle Source: MGI
  • nBAF complex Source: UniProtKB
  • npBAF complex Source: UniProtKB
  • nuclear chromatin Source: MGI
  • nucleoplasm Source: MGI
  • nucleus Source: MGI
  • SWI/SNF complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Impaired social interaction and prepulse inhibition.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003916181 – 1577Probable global transcription activator SNF2L2Add BLAST1577

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei166PhosphoserineBy similarity1
Modified residuei169PhosphoserineBy similarity1
Modified residuei321PhosphoserineCombined sources1
Modified residuei334PhosphoserineCombined sources1
Modified residuei596PhosphoserineCombined sources1
Modified residuei609N6-acetyllysineCombined sources1
Modified residuei671PhosphoserineBy similarity1
Modified residuei1002N6-acetyllysineBy similarity1
Modified residuei1004N6-acetyllysineBy similarity1
Modified residuei1382PhosphoserineBy similarity1
Modified residuei1499PhosphoserineCombined sources1
Modified residuei1503PhosphoserineCombined sources1
Modified residuei1515PhosphoserineCombined sources1
Modified residuei1555PhosphoserineBy similarity1
Modified residuei1559PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ6DIC0.
MaxQBiQ6DIC0.
PaxDbiQ6DIC0.
PRIDEiQ6DIC0.

PTM databases

iPTMnetiQ6DIC0.
PhosphoSitePlusiQ6DIC0.

Expressioni

Tissue specificityi

Expressed in the cortex and the hippocampus. Expressed in the cortical plate in the embryo.1 Publication

Gene expression databases

BgeeiENSMUSG00000024921.

Interactioni

Subunit structurei

Component of the BAF complex, which includes at least actin (ACTB), ARID1A, ARID1B/BAF250, SMARCA2, SMARCA4/BRG1/BAF190A, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57, SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more of SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C. In muscle cells, the BAF complex also contains DPF3. Binds TOPBP1 (By similarity). Component of neural progenitors-specific chromatin remodeling complex (npBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A and actin. Component of neuron-specific chromatin remodeling complex (nBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B and actin. Interacts with PHF10/BAF45A. Interacts with CEBPA (when phosphorylated)(PubMed:15107404). Interacts with CEBPB (when not methylated)(PubMed:20111005).By similarity3 Publications

Protein-protein interaction databases

BioGridi211982. 33 interactors.
DIPiDIP-48888N.
IntActiQ6DIC0. 1 interactor.
STRINGi10090.ENSMUSP00000025862.

Structurei

3D structure databases

ProteinModelPortaliQ6DIC0.
SMRiQ6DIC0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini167 – 202QLQPROSITE-ProRule annotationAdd BLAST36
Domaini441 – 513HSAPROSITE-ProRule annotationAdd BLAST73
Domaini741 – 906Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST166
Domaini1059 – 1221Helicase C-terminalPROSITE-ProRule annotationAdd BLAST163
Domaini1406 – 1476BromoPROSITE-ProRule annotationAdd BLAST71

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi856 – 859DEGH box4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi4 – 170Pro-richAdd BLAST167
Compositional biasi172 – 340Gln-richAdd BLAST169
Compositional biasi648 – 655Poly-Glu8
Compositional biasi1302 – 1306Poly-Glu5
Compositional biasi1496 – 1518Glu-richAdd BLAST23

Sequence similaritiesi

Belongs to the SNF2/RAD54 helicase family.Curated
Contains 1 bromo domain.PROSITE-ProRule annotation
Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation
Contains 1 HSA domain.PROSITE-ProRule annotation
Contains 1 QLQ domain.PROSITE-ProRule annotation

Keywords - Domaini

Bromodomain

Phylogenomic databases

eggNOGiKOG0386. Eukaryota.
COG0553. LUCA.
COG5076. LUCA.
HOGENOMiHOG000172363.
HOVERGENiHBG056636.
InParanoidiQ6DIC0.
KOiK11647.
PhylomeDBiQ6DIC0.

Family and domain databases

Gene3Di1.20.920.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR006576. BRK_domain.
IPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR014978. Gln-Leu-Gln_QLQ.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR014012. HSA_dom.
IPR027417. P-loop_NTPase.
IPR030088. SMARCA2.
IPR029295. SnAC.
IPR000330. SNF2_N.
[Graphical view]
PANTHERiPTHR10799:SF541. PTHR10799:SF541. 4 hits.
PfamiPF07533. BRK. 1 hit.
PF00439. Bromodomain. 1 hit.
PF00271. Helicase_C. 1 hit.
PF07529. HSA. 1 hit.
PF14619. SnAC. 1 hit.
PF00176. SNF2_N. 1 hit.
[Graphical view]
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00592. BRK. 1 hit.
SM00297. BROMO. 1 hit.
SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SM00573. HSA. 1 hit.
SM00951. QLQ. 1 hit.
SM01314. SnAC. 1 hit.
[Graphical view]
SUPFAMiSSF47370. SSF47370. 1 hit.
SSF52540. SSF52540. 2 hits.
PROSITEiPS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51204. HSA. 1 hit.
PS51666. QLQ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6DIC0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTPTDPAAM PHPGPSPGPG PSPGPILGPS PGPGPSPGSV HSMMGPSPGP
60 70 80 90 100
PSVSHPLSTM GSADFPQEGM HQLHKPMDGI HDKGIVEDVH CGSMKGTSMR
110 120 130 140 150
PPHPGMGPPQ SPMDQHSQGY MSPHPSPLGA PEHVSSPTPP QMPPSQPGAL
160 170 180 190 200
IPGDPQAMNQ PNRGPSPFSP VQLHQLRAQI LAYKMLARGQ PLPETLQLAV
210 220 230 240 250
QGKRTLPGMQ QQQQQQQQQQ QQQQQQQQQQ QQQQQPQQPQ QQAQAQPQQQ
260 270 280 290 300
QQQQQQPALV SYNRPSGPGQ ELLLSGQSAP QKLSAPAPSG RPSPAPQAAV
310 320 330 340 350
QPTATAVPGP SVQQPAPGQP SPVLQLQQKQ SRISPIQKPQ GLDPVEILQE
360 370 380 390 400
REYRLQARIA HRIQELESLP GSLPPDLRTK ATVELKALRL LNFQRQLRQE
410 420 430 440 450
VVACMRRDTT LETALNSKAY KRSKRQTLRE ARMTEKLEKQ QKIEQERKRR
460 470 480 490 500
QKHQEYLNSI LQHAKDFKEY HRSVAGKIQK LSKAVATWHA NTEREQKKET
510 520 530 540 550
ERIEKERMRR LMAEDEEGYR KLIDQKKDRR LAYLLQQTDE YVANLTNLVW
560 570 580 590 600
EHKQAQAAKE KKKRRRRKKK AEENAEGGEP ALGPDGEPID ESSQMSDLPV
610 620 630 640 650
KVTHTETGKV LFGPEAPKAS QLDAWLEMNP GYEVAPRSDS EESESDYEEE
660 670 680 690 700
DEEEESSRQE TEEKILLDPN SEEVSEKDAK QIIETAKQDV DDEYSMQYSA
710 720 730 740 750
RGSQSYYTVA HAISERVEKQ SALLINGTLK HYQLQGLEWM VSLYNNNLNG
760 770 780 790 800
ILADEMGLGK TIQTIALITY LMEHKRLNGP YLIIVPLSTL SNWTYEFDKW
810 820 830 840 850
APSVVKISYK GTPAMRRSLV PQLRSGKFNV LLTTYEYIIK DKHILAKIRW
860 870 880 890 900
KYMIVDEGHR MKNHHCKLTQ VLNTHYVAPR RILLTGTPLQ NKLPELWALL
910 920 930 940 950
NFLLPTIFKS CSTFEQWFNA PFAMTGERVD LNEEETILII RRLHKVLRPF
960 970 980 990 1000
LLRRLKKEVE SQLPEKVEYV IKCDMSALQK ILYRHMQAKG ILLTDGSEKD
1010 1020 1030 1040 1050
KKGKGGAKTL MNTIMQLRKI CNHPYMFQHI EESFAEHLGY SNGVINGAEL
1060 1070 1080 1090 1100
YRASGKFELL DRILPKLRAT NHRVLLFCQM TSLMTIMEDY FAFRNFLYLR
1110 1120 1130 1140 1150
LDGTTKSEDR AALLKKFNEP GSQYFIFLLS TRAGGLGLNL QAADTVVIFD
1160 1170 1180 1190 1200
SDWNPHQDLQ AQDRAHRIGQ QNEVRVLRLC TVNSVEEKIL AAAKYKLNVD
1210 1220 1230 1240 1250
QKVIQAGMFD QKSSSHERRA FLQAILEHEE ENEEEDEVPD DETLNQMIAR
1260 1270 1280 1290 1300
REEEFDLFMR MDMDRRREDA RNPKRKPRLM EEDELPSWII KDDAEVERLT
1310 1320 1330 1340 1350
CEEEEEKIFG RGSRQRRDVD YSDALTEKQW LRAIEDGNLE EMEEEVRLKK
1360 1370 1380 1390 1400
RKRRRNVDKD PVKEDVEKAK KRRGRPPAEK LSPNPPKLTK QMNAIIDTVI
1410 1420 1430 1440 1450
NYKDSSGRQL SEVFIQLPSR KDLPEYYELI RKPVDFKKIK ERIRNHKYRS
1460 1470 1480 1490 1500
LGDLEKDVML LCHNAQTFNL EGSQIYEDSI VLQSVFKSAR QKIAKEEESE
1510 1520 1530 1540 1550
EESNEEEEED DEEESESEAK SVKVKIKLNK KEEKGRDTGK GKKRPNRGKA
1560 1570
KPVVSDFDSD EEQEENEQSE ASGTDNE
Length:1,577
Mass (Da):180,253
Last modified:August 16, 2004 - v1
Checksum:i5D79E8FFC66085BE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC075641 mRNA. Translation: AAH75641.1.
RefSeqiNP_035546.2. NM_011416.2.
UniGeneiMm.342988.
Mm.491146.

Genome annotation databases

GeneIDi67155.
KEGGimmu:67155.
UCSCiuc012bjw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC075641 mRNA. Translation: AAH75641.1.
RefSeqiNP_035546.2. NM_011416.2.
UniGeneiMm.342988.
Mm.491146.

3D structure databases

ProteinModelPortaliQ6DIC0.
SMRiQ6DIC0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211982. 33 interactors.
DIPiDIP-48888N.
IntActiQ6DIC0. 1 interactor.
STRINGi10090.ENSMUSP00000025862.

PTM databases

iPTMnetiQ6DIC0.
PhosphoSitePlusiQ6DIC0.

Proteomic databases

EPDiQ6DIC0.
MaxQBiQ6DIC0.
PaxDbiQ6DIC0.
PRIDEiQ6DIC0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi67155.
KEGGimmu:67155.
UCSCiuc012bjw.1. mouse.

Organism-specific databases

CTDi6595.
MGIiMGI:99603. Smarca2.

Phylogenomic databases

eggNOGiKOG0386. Eukaryota.
COG0553. LUCA.
COG5076. LUCA.
HOGENOMiHOG000172363.
HOVERGENiHBG056636.
InParanoidiQ6DIC0.
KOiK11647.
PhylomeDBiQ6DIC0.

Miscellaneous databases

ChiTaRSiSmarca2. mouse.
PROiQ6DIC0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024921.

Family and domain databases

Gene3Di1.20.920.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR006576. BRK_domain.
IPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR014978. Gln-Leu-Gln_QLQ.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR014012. HSA_dom.
IPR027417. P-loop_NTPase.
IPR030088. SMARCA2.
IPR029295. SnAC.
IPR000330. SNF2_N.
[Graphical view]
PANTHERiPTHR10799:SF541. PTHR10799:SF541. 4 hits.
PfamiPF07533. BRK. 1 hit.
PF00439. Bromodomain. 1 hit.
PF00271. Helicase_C. 1 hit.
PF07529. HSA. 1 hit.
PF14619. SnAC. 1 hit.
PF00176. SNF2_N. 1 hit.
[Graphical view]
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00592. BRK. 1 hit.
SM00297. BROMO. 1 hit.
SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SM00573. HSA. 1 hit.
SM00951. QLQ. 1 hit.
SM01314. SnAC. 1 hit.
[Graphical view]
SUPFAMiSSF47370. SSF47370. 1 hit.
SSF52540. SSF52540. 2 hits.
PROSITEiPS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51204. HSA. 1 hit.
PS51666. QLQ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSMCA2_MOUSE
AccessioniPrimary (citable) accession number: Q6DIC0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 9, 2010
Last sequence update: August 16, 2004
Last modified: November 2, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.