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Protein

F-box only protein 27

Gene

Fbxo27

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind complex-type oligosaccharides.By similarity

GO - Molecular functioni

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-8951664. Neddylation.
R-MMU-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 27
Gene namesi
Name:Fbxo27
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2685007. Fbxo27.

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001199161 – 280F-box only protein 27Add BLAST280

Proteomic databases

PaxDbiQ6DIA9.
PRIDEiQ6DIA9.

Expressioni

Tissue specificityi

Detected in brain, heart and muscle.1 Publication

Gene expression databases

BgeeiENSMUSG00000037463.
CleanExiMM_FBXO27.
ExpressionAtlasiQ6DIA9. baseline and differential.
GenevisibleiQ6DIA9. MM.

Interactioni

Subunit structurei

Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Interacts with SKP1 and CUL1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000103916.

Structurei

3D structure databases

ProteinModelPortaliQ6DIA9.
SMRiQ6DIA9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 67F-boxPROSITE-ProRule annotationAdd BLAST48
Domaini101 – 277FBAPROSITE-ProRule annotationAdd BLAST177

Phylogenomic databases

eggNOGiENOG410J91C. Eukaryota.
ENOG4111NAA. LUCA.
GeneTreeiENSGT00390000003865.
HOGENOMiHOG000231084.
HOVERGENiHBG003593.
InParanoidiQ6DIA9.
KOiK10102.
OMAiTSFSWCR.
OrthoDBiEOG091G0G3L.
PhylomeDBiQ6DIA9.
TreeFamiTF320527.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
InterProiView protein in InterPro
IPR007397. F-box-assoc_dom.
IPR001810. F-box_dom.
IPR008979. Galactose-bd-like.
PfamiView protein in Pfam
PF00646. F-box. 1 hit.
PF04300. FBA. 1 hit.
SMARTiView protein in SMART
SM01198. FBA. 1 hit.
SM00256. FBOX. 1 hit.
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEiView protein in PROSITE
PS51114. FBA. 1 hit.
PS50181. FBOX. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6DIA9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGAWISRTRV PTPEPDPQEV LDLSRLPPEL LLLVLSHVPP RTLLMHCRRV
60 70 80 90 100
CRAWRALVDG QALWLLLLAR DHSAAGRALL TLARRCLPPA HEDTPCPLGQ
110 120 130 140 150
FCALRPLGRN LISNPCGQEG LRKWMVRHGG DGWVVEKNRK PVPGAPSQTC
160 170 180 190 200
FVTSFSWCRK KQVVDLVEKG LWPELLDSGG VEIAVSDWWG ARHDSGCKYR
210 220 230 240 250
LFVTLLDAHQ NVIDKFSAVP DPIEQWNNDI YLQVTHVFSG IRRGIRFVSF
260 270 280
EHWGQDTQFW AGHYGARVTN SSVIIRVCQS
Length:280
Mass (Da):31,633
Last modified:August 16, 2004 - v1
Checksum:i36FF90947DFAE86B
GO
Isoform 2 (identifier: Q6DIA9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     119-119: Missing.

Note: May be due to a competing acceptor splice site.
Show »
Length:279
Mass (Da):31,503
Checksum:i9EC601ED4C5A34DD
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_013054119Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK053292 mRNA. Translation: BAC35334.1.
AK140275 mRNA. Translation: BAE24311.1.
AK158463 mRNA. Translation: BAE34522.1.
BC075656 mRNA. Translation: AAH75656.1.
CCDSiCCDS21051.1. [Q6DIA9-2]
CCDS52164.1. [Q6DIA9-1]
RefSeqiNP_001157174.1. NM_001163702.1. [Q6DIA9-1]
NP_997121.1. NM_207238.3. [Q6DIA9-2]
XP_006539929.1. XM_006539866.1. [Q6DIA9-1]
XP_006539930.1. XM_006539867.3. [Q6DIA9-1]
UniGeneiMm.116116.

Genome annotation databases

EnsembliENSMUST00000039998; ENSMUSP00000038432; ENSMUSG00000037463. [Q6DIA9-2]
ENSMUST00000108281; ENSMUSP00000103916; ENSMUSG00000037463. [Q6DIA9-1]
GeneIDi233040.
KEGGimmu:233040.
UCSCiuc009fzk.2. mouse. [Q6DIA9-1]
uc012fgv.1. mouse. [Q6DIA9-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiFBX27_MOUSE
AccessioniPrimary (citable) accession number: Q6DIA9
Secondary accession number(s): Q3TYP0, Q8BKF7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: August 16, 2004
Last modified: September 27, 2017
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot