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Protein

F-box only protein 27

Gene

Fbxo27

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind complex-type oligosaccharides.By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 27
Gene namesi
Name:Fbxo27
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2685007. Fbxo27.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 280280F-box only protein 27PRO_0000119916Add
BLAST

Proteomic databases

PaxDbiQ6DIA9.
PRIDEiQ6DIA9.

Expressioni

Tissue specificityi

Detected in brain, heart and muscle.1 Publication

Gene expression databases

BgeeiQ6DIA9.
CleanExiMM_FBXO27.
ExpressionAtlasiQ6DIA9. baseline and differential.
GenevisibleiQ6DIA9. MM.

Interactioni

Subunit structurei

Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Interacts with SKP1 and CUL1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000103916.

Structurei

3D structure databases

ProteinModelPortaliQ6DIA9.
SMRiQ6DIA9. Positions 20-276.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 6748F-boxPROSITE-ProRule annotationAdd
BLAST
Domaini101 – 277177FBAPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 F-box domain.PROSITE-ProRule annotation
Contains 1 FBA (F-box associated) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410J91C. Eukaryota.
ENOG4111NAA. LUCA.
GeneTreeiENSGT00390000003865.
HOGENOMiHOG000231084.
HOVERGENiHBG003593.
InParanoidiQ6DIA9.
KOiK10102.
OMAiQQWNNNA.
OrthoDBiEOG7DRJ3R.
PhylomeDBiQ6DIA9.
TreeFamiTF320527.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
InterProiIPR007397. F-box-assoc_dom.
IPR001810. F-box_dom.
IPR008979. Galactose-bd-like.
[Graphical view]
PfamiPF00646. F-box. 1 hit.
PF04300. FBA. 1 hit.
[Graphical view]
SMARTiSM01198. FBA. 1 hit.
SM00256. FBOX. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEiPS51114. FBA. 1 hit.
PS50181. FBOX. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6DIA9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGAWISRTRV PTPEPDPQEV LDLSRLPPEL LLLVLSHVPP RTLLMHCRRV
60 70 80 90 100
CRAWRALVDG QALWLLLLAR DHSAAGRALL TLARRCLPPA HEDTPCPLGQ
110 120 130 140 150
FCALRPLGRN LISNPCGQEG LRKWMVRHGG DGWVVEKNRK PVPGAPSQTC
160 170 180 190 200
FVTSFSWCRK KQVVDLVEKG LWPELLDSGG VEIAVSDWWG ARHDSGCKYR
210 220 230 240 250
LFVTLLDAHQ NVIDKFSAVP DPIEQWNNDI YLQVTHVFSG IRRGIRFVSF
260 270 280
EHWGQDTQFW AGHYGARVTN SSVIIRVCQS
Length:280
Mass (Da):31,633
Last modified:August 16, 2004 - v1
Checksum:i36FF90947DFAE86B
GO
Isoform 2 (identifier: Q6DIA9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     119-119: Missing.

Note: May be due to a competing acceptor splice site.
Show »
Length:279
Mass (Da):31,503
Checksum:i9EC601ED4C5A34DD
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei119 – 1191Missing in isoform 2. 1 PublicationVSP_013054

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK053292 mRNA. Translation: BAC35334.1.
AK140275 mRNA. Translation: BAE24311.1.
AK158463 mRNA. Translation: BAE34522.1.
BC075656 mRNA. Translation: AAH75656.1.
CCDSiCCDS21051.1. [Q6DIA9-2]
CCDS52164.1. [Q6DIA9-1]
RefSeqiNP_001157174.1. NM_001163702.1. [Q6DIA9-1]
NP_997121.1. NM_207238.3. [Q6DIA9-2]
XP_006539929.1. XM_006539866.1. [Q6DIA9-1]
XP_006539930.1. XM_006539867.2. [Q6DIA9-1]
UniGeneiMm.116116.

Genome annotation databases

EnsembliENSMUST00000039998; ENSMUSP00000038432; ENSMUSG00000037463. [Q6DIA9-2]
ENSMUST00000108281; ENSMUSP00000103916; ENSMUSG00000037463. [Q6DIA9-1]
GeneIDi233040.
KEGGimmu:233040.
UCSCiuc009fzk.2. mouse. [Q6DIA9-1]
uc012fgv.1. mouse. [Q6DIA9-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK053292 mRNA. Translation: BAC35334.1.
AK140275 mRNA. Translation: BAE24311.1.
AK158463 mRNA. Translation: BAE34522.1.
BC075656 mRNA. Translation: AAH75656.1.
CCDSiCCDS21051.1. [Q6DIA9-2]
CCDS52164.1. [Q6DIA9-1]
RefSeqiNP_001157174.1. NM_001163702.1. [Q6DIA9-1]
NP_997121.1. NM_207238.3. [Q6DIA9-2]
XP_006539929.1. XM_006539866.1. [Q6DIA9-1]
XP_006539930.1. XM_006539867.2. [Q6DIA9-1]
UniGeneiMm.116116.

3D structure databases

ProteinModelPortaliQ6DIA9.
SMRiQ6DIA9. Positions 20-276.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000103916.

Proteomic databases

PaxDbiQ6DIA9.
PRIDEiQ6DIA9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000039998; ENSMUSP00000038432; ENSMUSG00000037463. [Q6DIA9-2]
ENSMUST00000108281; ENSMUSP00000103916; ENSMUSG00000037463. [Q6DIA9-1]
GeneIDi233040.
KEGGimmu:233040.
UCSCiuc009fzk.2. mouse. [Q6DIA9-1]
uc012fgv.1. mouse. [Q6DIA9-2]

Organism-specific databases

CTDi126433.
MGIiMGI:2685007. Fbxo27.

Phylogenomic databases

eggNOGiENOG410J91C. Eukaryota.
ENOG4111NAA. LUCA.
GeneTreeiENSGT00390000003865.
HOGENOMiHOG000231084.
HOVERGENiHBG003593.
InParanoidiQ6DIA9.
KOiK10102.
OMAiQQWNNNA.
OrthoDBiEOG7DRJ3R.
PhylomeDBiQ6DIA9.
TreeFamiTF320527.

Enzyme and pathway databases

ReactomeiR-MMU-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

NextBioi381486.
PROiQ6DIA9.
SOURCEiSearch...

Gene expression databases

BgeeiQ6DIA9.
CleanExiMM_FBXO27.
ExpressionAtlasiQ6DIA9. baseline and differential.
GenevisibleiQ6DIA9. MM.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
InterProiIPR007397. F-box-assoc_dom.
IPR001810. F-box_dom.
IPR008979. Galactose-bd-like.
[Graphical view]
PfamiPF00646. F-box. 1 hit.
PF04300. FBA. 1 hit.
[Graphical view]
SMARTiSM01198. FBA. 1 hit.
SM00256. FBOX. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEiPS51114. FBA. 1 hit.
PS50181. FBOX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Corpora quadrigemina, Eye and Inner ear.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Eye.
  3. "Diversity in tissue expression, substrate binding, and SCF complex formation for a lectin family of ubiquitin ligases."
    Glenn K.A., Nelson R.F., Wen H.M., Mallinger A.J., Paulson H.L.
    J. Biol. Chem. 283:12717-12729(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiFBX27_MOUSE
AccessioniPrimary (citable) accession number: Q6DIA9
Secondary accession number(s): Q3TYP0, Q8BKF7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: August 16, 2004
Last modified: May 11, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.