Q6DI51 (NDK6_DANRE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Nucleoside diphosphate kinase 6
Short name=NDK 6
Short name=NDP kinase 6
EC=2.7.4.6

Gene names

Name:	nme6
Synonyms:	ndpkz6

Organism

Danio rerio (Zebrafish) (Brachydanio rerio)

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length	175 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
Catalytic activity	ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.
Cofactor	Magnesium By similarity.
Sequence similarities	Belongs to the NDK family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	CTP biosynthetic process Inferred from electronic annotation. Source: InterPro GTP biosynthetic process Inferred from electronic annotation. Source: InterPro UTP biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW nucleoside diphosphate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 175	175	Nucleoside diphosphate kinase 6		PRO_0000369546
Sites
	Active site	124	1	Pros-phosphohistidine intermediate By similarity
	Binding site	15	1	ATP By similarity
	Binding site	63	1	ATP By similarity
	Binding site	91	1	ATP By similarity
	Binding site	97	1	ATP By similarity
	Binding site	111	1	ATP By similarity
	Binding site	121	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6DI51 [UniParc]. Last modified August 16, 2004. Version 1. Checksum: 48E39AFDA005DF61	FASTA	175	20,612
	10 20 30 40 50 60 MRCVKALQLT LAVIKPDAMA HPLILEALHQ KILENFIIIR KKDLIWRKAD SEMFYAEHSG 70 80 90 100 110 120 RFFFQRLVEF MSSGPMRAYI LAREDAITHW RTMMGPTKVF RARFSSPETL RGKYGLTDTR 130 140 150 160 170 NTTHGSDSIE SAKREISFFF PEFSAEEWMM REEPHFRLGH TEYNEESQIH TVKHT

References

[1]	The Danio rerio sequencing project at the Sanger Institute Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Tuebingen.
[2]	NIH - Zebrafish Gene Collection (ZGC) project Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX276101 Genomic DNA. Translation: CAI11539.1. BC075738 mRNA. Translation: AAH75738.1.
IPI	IPI00493150.
UniGene	Dr.7209.
3D structure databases
HSSP	HSSP built from PDB template 2AZ1 based on UniProtKB P61136.
ProteinModelPortal	Q6DI51.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6DI51.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSDART00000103798; ENSDARP00000094574; ENSDARG00000016138.
NMPDR	fig|7955.3.peg.12298.
Organism-specific databases
ZFIN	ZDB-GENE-000710-3. nme6.
Phylogenomic databases
eggNOG	fiNOG15369.
HOGENOM	HBG445152.
OrthoDB	EOG4SQWXQ.
PhylomeDB	Q6DI51.
Gene expression databases
ArrayExpress	Q6DI51.
Bgee	Q6DI51.
Family and domain databases
InterPro	IPR001564. Nucleoside_diP_kinase. IPR023005. Nucleoside_diP_kinase_AS. [Graphical view]
Gene3D	G3DSA:3.30.70.141. NDK. 1 hit.
PANTHER	PTHR11349. Nuc_diP_kinase_core. 1 hit.
Pfam	PF00334. NDK. 1 hit. [Graphical view]
PRINTS	PR01243. NUCDPKINASE.
SMART	SM00562. NDK. 1 hit. [Graphical view]
SUPFAM	SSF54919. NDK. 1 hit.
PROSITE	PS00469. NDP_KINASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NDK6_DANRE

Accession

Primary (citable) accession number: Q6DI51

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	August 16, 2004
Last modified:	September 21, 2011
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program