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Q6DI37

- UBCP1_DANRE

UniProt

Q6DI37 - UBCP1_DANRE

Protein

Ubiquitin-like domain-containing CTD phosphatase 1

Gene

ublcp1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (16 Aug 2004)
      Previous versions | rss
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    Functioni

    Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S proteasome By similarity.By similarity

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Magnesium.By similarity

    GO - Molecular functioni

    1. phosphoprotein phosphatase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin-like domain-containing CTD phosphatase 1 (EC:3.1.3.16)
    Alternative name(s):
    Nuclear proteasome inhibitor UBLCP1
    Gene namesi
    Name:ublcp1
    ORF Names:zgc:86634
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Chromosome 21

    Organism-specific databases

    ZFINiZDB-GENE-040718-3. ublcp1.

    Subcellular locationi

    Nucleus By similarity
    Note: Colocalizes with nuclear proteasomes.By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 318318Ubiquitin-like domain-containing CTD phosphatase 1PRO_0000242645Add
    BLAST

    Proteomic databases

    PRIDEiQ6DI37.

    Expressioni

    Gene expression databases

    BgeeiQ6DI37.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6DI37.
    SMRiQ6DI37. Positions 5-79.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini3 – 8179Ubiquitin-likePROSITE-ProRule annotationAdd
    BLAST
    Domaini133 – 294162FCP1 homologyPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni133 – 294162PhosphataseBy similarityAdd
    BLAST

    Domaini

    The Ubiquitin-like domain mediates interaction with proteasomes.By similarity

    Sequence similaritiesi

    Contains 1 FCP1 homology domain.PROSITE-ProRule annotation
    Contains 1 ubiquitin-like domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG310886.
    GeneTreeiENSGT00390000010107.
    HOGENOMiHOG000231279.
    HOVERGENiHBG080207.
    InParanoidiQ6DI37.
    KOiK17618.
    OMAiELNPPRE.
    OrthoDBiEOG74TX01.
    PhylomeDBiQ6DI37.
    TreeFamiTF323786.

    Family and domain databases

    Gene3Di3.40.50.1000. 1 hit.
    InterProiIPR023214. HAD-like_dom.
    IPR011943. HAD-SF_hydro_IIID.
    IPR004274. NIF.
    IPR000626. Ubiquitin-like.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view]
    PfamiPF03031. NIF. 1 hit.
    PF00240. ubiquitin. 1 hit.
    [Graphical view]
    SMARTiSM00577. CPDc. 1 hit.
    SM00213. UBQ. 1 hit.
    [Graphical view]
    SUPFAMiSSF54236. SSF54236. 1 hit.
    SSF56784. SSF56784. 1 hit.
    TIGRFAMsiTIGR02245. HAD_IIID1. 1 hit.
    PROSITEiPS50969. FCP1. 1 hit.
    PS50053. UBIQUITIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6DI37-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSVSVIIKWG GQEYSINTLS EEDTVLDLKQ SIKSLTGVLP ERQKLLGLKL    50
    KGKPADDNVK LGDLKLKPNT KIMMMGTREE SLEDVLAPPP ENDDVVNDFD 100
    IEEEVTEVEN REENLAKIAR RVKDYKVEEL NPPRPGKRLL VLDIDYTLFD 150
    HKSCAETGHE LMRPFLHEFL TSAYEDFDIV IWSATSMKWI DAKMKELGVT 200
    DNPNYKITFM LDSAAMITVH TPKRGVVEVK PLGVIWGKYS EFYNRKNTIM 250
    FDDIGRNFLM NPQNGLKIRP FMKAHLNREK DKELYKLSQY LKEIAKLDDF 300
    SGLNHKHWER YLSKKQNQ 318
    Length:318
    Mass (Da):36,822
    Last modified:August 16, 2004 - v1
    Checksum:iED57FD31B4D25748
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC075753 mRNA. Translation: AAH75753.1.
    RefSeqiNP_001002319.1. NM_001002319.2.
    NP_001186304.1. NM_001199375.1.
    UniGeneiDr.122081.
    Dr.76865.

    Genome annotation databases

    EnsembliENSDART00000065341; ENSDARP00000065340; ENSDARG00000044492.
    ENSDART00000076715; ENSDARP00000071186; ENSDARG00000044492.
    GeneIDi792145.
    KEGGidre:792145.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC075753 mRNA. Translation: AAH75753.1 .
    RefSeqi NP_001002319.1. NM_001002319.2.
    NP_001186304.1. NM_001199375.1.
    UniGenei Dr.122081.
    Dr.76865.

    3D structure databases

    ProteinModelPortali Q6DI37.
    SMRi Q6DI37. Positions 5-79.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q6DI37.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSDART00000065341 ; ENSDARP00000065340 ; ENSDARG00000044492 .
    ENSDART00000076715 ; ENSDARP00000071186 ; ENSDARG00000044492 .
    GeneIDi 792145.
    KEGGi dre:792145.

    Organism-specific databases

    CTDi 134510.
    ZFINi ZDB-GENE-040718-3. ublcp1.

    Phylogenomic databases

    eggNOGi NOG310886.
    GeneTreei ENSGT00390000010107.
    HOGENOMi HOG000231279.
    HOVERGENi HBG080207.
    InParanoidi Q6DI37.
    KOi K17618.
    OMAi ELNPPRE.
    OrthoDBi EOG74TX01.
    PhylomeDBi Q6DI37.
    TreeFami TF323786.

    Miscellaneous databases

    NextBioi 20930929.
    PROi Q6DI37.

    Gene expression databases

    Bgeei Q6DI37.

    Family and domain databases

    Gene3Di 3.40.50.1000. 1 hit.
    InterProi IPR023214. HAD-like_dom.
    IPR011943. HAD-SF_hydro_IIID.
    IPR004274. NIF.
    IPR000626. Ubiquitin-like.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view ]
    Pfami PF03031. NIF. 1 hit.
    PF00240. ubiquitin. 1 hit.
    [Graphical view ]
    SMARTi SM00577. CPDc. 1 hit.
    SM00213. UBQ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54236. SSF54236. 1 hit.
    SSF56784. SSF56784. 1 hit.
    TIGRFAMsi TIGR02245. HAD_IIID1. 1 hit.
    PROSITEi PS50969. FCP1. 1 hit.
    PS50053. UBIQUITIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo.

    Entry informationi

    Entry nameiUBCP1_DANRE
    AccessioniPrimary (citable) accession number: Q6DI37
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3