Q6DI37 (UBCP1_DANRE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ubiquitin-like domain-containing CTD phosphatase 1
EC=3.1.3.16

Alternative name(s):
Nuclear proteasome inhibitor UBLCP1

Gene names

Name:	ublcp1
ORF Names:	zgc:86634

Organism

Danio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Actinopterygii › Actinopteri › Neopterygii › Teleostei › Elopocephala › Clupeocephala › Otocephala › Ostariophysi › Otophysi › Cypriniphysi › Cypriniformes › Cyprinoidea › Cyprinidae › Danio

Protein attributes

Sequence length	318 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S proteasome By similarity.
Catalytic activity	A phosphoprotein + H2O = a protein + phosphate.
Cofactor	Magnesium By similarity.
Subcellular location	Nucleus By similarity. Note: Colocalizes with nuclear proteasomes By similarity.
Domain	The Ubiquitin-like domain mediates interaction with proteasomes By similarity.
Sequence similarities	Contains 1 FCP1 homology domain. Contains 1 ubiquitin-like domain.

Ontologies

Keywords
Cellular component	Nucleus
Molecular function	Hydrolase Protein phosphatase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	phosphoprotein phosphatase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 318	318	Ubiquitin-like domain-containing CTD phosphatase 1		PRO_0000242645
Regions
	Domain	3 – 81	79	Ubiquitin-like
	Domain	133 – 294	162	FCP1 homology
	Region	133 – 294	162	Phosphatase By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6DI37 [UniParc]. Last modified August 16, 2004. Version 1. Checksum: ED57FD31B4D25748	FASTA	318	36,822
	10 20 30 40 50 60 MSVSVIIKWG GQEYSINTLS EEDTVLDLKQ SIKSLTGVLP ERQKLLGLKL KGKPADDNVK 70 80 90 100 110 120 LGDLKLKPNT KIMMMGTREE SLEDVLAPPP ENDDVVNDFD IEEEVTEVEN REENLAKIAR 130 140 150 160 170 180 RVKDYKVEEL NPPRPGKRLL VLDIDYTLFD HKSCAETGHE LMRPFLHEFL TSAYEDFDIV 190 200 210 220 230 240 IWSATSMKWI DAKMKELGVT DNPNYKITFM LDSAAMITVH TPKRGVVEVK PLGVIWGKYS 250 260 270 280 290 300 EFYNRKNTIM FDDIGRNFLM NPQNGLKIRP FMKAHLNREK DKELYKLSQY LKEIAKLDDF 310 SGLNHKHWER YLSKKQNQ

References

[1]	NIH - Zebrafish Gene Collection (ZGC) project Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC075753 mRNA. Translation: AAH75753.1.
IPI	IPI00502602.
RefSeq	NP_001002319.1. NM_001002319.2. NP_001186304.1. NM_001199375.1.
UniGene	Dr.122081. Dr.76865.
3D structure databases
ProteinModelPortal	Q6DI37.
SMR	Q6DI37. Positions 5-79.
ModBase	Search...
Proteomic databases
PRIDE	Q6DI37.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSDART00000065341; ENSDARP00000065340; ENSDARG00000044492. ENSDART00000076715; ENSDARP00000071186; ENSDARG00000044492.
GeneID	792145.
KEGG	dre:792145.
Organism-specific databases
CTD	134510.
ZFIN	ZDB-GENE-040718-3. ublcp1.
Phylogenomic databases
eggNOG	NOG310886.
GeneTree	ENSGT00390000010107.
HOGENOM	HOG000231279.
HOVERGEN	HBG080207.
InParanoid	Q6DI37.
KO	K01090.
OMA	KWIDAKM.
OrthoDB	EOG476K0P.
Gene expression databases
ArrayExpress	Q6DI37.
Bgee	Q6DI37.
Family and domain databases
Gene3D	3.40.50.1000. 1 hit.
InterPro	IPR023214. HAD-like_dom. IPR011943. HAD-SF_hydro_IIID. IPR004274. NIF. IPR000626. Ubiquitin. IPR019955. Ubiquitin_supergroup. [Graphical view]
Pfam	PF03031. NIF. 1 hit. PF00240. ubiquitin. 1 hit. [Graphical view]
SMART	SM00577. CPDc. 1 hit. SM00213. UBQ. 1 hit. [Graphical view]
SUPFAM	SSF56784. HAD-like_dom. 1 hit.
TIGRFAMs	TIGR02245. HAD_IIID1. 1 hit.
PROSITE	PS50969. FCP1. 1 hit. PS00299. UBIQUITIN_1. False negative. PS50053. UBIQUITIN_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20930929.

Entry information

Entry name

UBCP1_DANRE

Accession

Primary (citable) accession number: Q6DI37

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	August 16, 2004
Last modified:	March 6, 2013
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program