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Q6DI37 (UBCP1_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin-like domain-containing CTD phosphatase 1

EC=3.1.3.16
Alternative name(s):
Nuclear proteasome inhibitor UBLCP1
Gene names
Name:ublcp1
ORF Names:zgc:86634
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length318 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S proteasome By similarity.

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactor

Magnesium By similarity.

Subcellular location

Nucleus By similarity. Note: Colocalizes with nuclear proteasomes By similarity.

Domain

The Ubiquitin-like domain mediates interaction with proteasomes By similarity.

Sequence similarities

Contains 1 FCP1 homology domain.

Contains 1 ubiquitin-like domain.

Ontologies

Keywords
   Cellular componentNucleus
   Molecular functionHydrolase
Protein phosphatase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionphosphoprotein phosphatase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 318318Ubiquitin-like domain-containing CTD phosphatase 1
PRO_0000242645

Regions

Domain3 – 8179Ubiquitin-like
Domain133 – 294162FCP1 homology
Region133 – 294162Phosphatase By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6DI37 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: ED57FD31B4D25748

FASTA31836,822
        10         20         30         40         50         60 
MSVSVIIKWG GQEYSINTLS EEDTVLDLKQ SIKSLTGVLP ERQKLLGLKL KGKPADDNVK 

        70         80         90        100        110        120 
LGDLKLKPNT KIMMMGTREE SLEDVLAPPP ENDDVVNDFD IEEEVTEVEN REENLAKIAR 

       130        140        150        160        170        180 
RVKDYKVEEL NPPRPGKRLL VLDIDYTLFD HKSCAETGHE LMRPFLHEFL TSAYEDFDIV 

       190        200        210        220        230        240 
IWSATSMKWI DAKMKELGVT DNPNYKITFM LDSAAMITVH TPKRGVVEVK PLGVIWGKYS 

       250        260        270        280        290        300 
EFYNRKNTIM FDDIGRNFLM NPQNGLKIRP FMKAHLNREK DKELYKLSQY LKEIAKLDDF 

       310 
SGLNHKHWER YLSKKQNQ 

« Hide

References

[1]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC075753 mRNA. Translation: AAH75753.1.
RefSeqNP_001002319.1. NM_001002319.2.
NP_001186304.1. NM_001199375.1.
UniGeneDr.122081.
Dr.76865.

3D structure databases

ProteinModelPortalQ6DI37.
SMRQ6DI37. Positions 5-79.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ6DI37.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSDART00000065341; ENSDARP00000065340; ENSDARG00000044492.
ENSDART00000076715; ENSDARP00000071186; ENSDARG00000044492.
GeneID792145.
KEGGdre:792145.

Organism-specific databases

CTD134510.
ZFINZDB-GENE-040718-3. ublcp1.

Phylogenomic databases

eggNOGNOG310886.
GeneTreeENSGT00390000010107.
HOGENOMHOG000231279.
HOVERGENHBG080207.
InParanoidQ6DI37.
KOK17618.
OMAELNPPRE.
OrthoDBEOG74TX01.
PhylomeDBQ6DI37.
TreeFamTF323786.

Gene expression databases

BgeeQ6DI37.

Family and domain databases

Gene3D3.40.50.1000. 1 hit.
InterProIPR023214. HAD-like_dom.
IPR011943. HAD-SF_hydro_IIID.
IPR004274. NIF.
IPR000626. Ubiquitin-like.
[Graphical view]
PfamPF03031. NIF. 1 hit.
PF00240. ubiquitin. 1 hit.
[Graphical view]
SMARTSM00577. CPDc. 1 hit.
SM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMSSF56784. SSF56784. 1 hit.
TIGRFAMsTIGR02245. HAD_IIID1. 1 hit.
PROSITEPS50969. FCP1. 1 hit.
PS50053. UBIQUITIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20930929.
PROQ6DI37.

Entry information

Entry nameUBCP1_DANRE
AccessionPrimary (citable) accession number: Q6DI37
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: August 16, 2004
Last modified: April 16, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families