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Q6DI37

- UBCP1_DANRE

UniProt

Q6DI37 - UBCP1_DANRE

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Protein

Ubiquitin-like domain-containing CTD phosphatase 1

Gene

ublcp1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S proteasome By similarity.By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Magnesium.By similarity

GO - Molecular functioni

  1. phosphoprotein phosphatase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-like domain-containing CTD phosphatase 1 (EC:3.1.3.16)
Alternative name(s):
Nuclear proteasome inhibitor UBLCP1
Gene namesi
Name:ublcp1
ORF Names:zgc:86634
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Chromosome 21

Organism-specific databases

ZFINiZDB-GENE-040718-3. ublcp1.

Subcellular locationi

Nucleus By similarity
Note: Colocalizes with nuclear proteasomes.By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 318318Ubiquitin-like domain-containing CTD phosphatase 1PRO_0000242645Add
BLAST

Proteomic databases

PRIDEiQ6DI37.

Expressioni

Gene expression databases

BgeeiQ6DI37.

Structurei

3D structure databases

ProteinModelPortaliQ6DI37.
SMRiQ6DI37. Positions 5-79.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 8179Ubiquitin-likePROSITE-ProRule annotationAdd
BLAST
Domaini133 – 294162FCP1 homologyPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni133 – 294162PhosphataseBy similarityAdd
BLAST

Domaini

The Ubiquitin-like domain mediates interaction with proteasomes.By similarity

Sequence similaritiesi

Contains 1 FCP1 homology domain.PROSITE-ProRule annotation
Contains 1 ubiquitin-like domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG310886.
GeneTreeiENSGT00390000010107.
HOGENOMiHOG000231279.
HOVERGENiHBG080207.
InParanoidiQ6DI37.
KOiK17618.
OMAiELNPPRE.
OrthoDBiEOG74TX01.
PhylomeDBiQ6DI37.
TreeFamiTF323786.

Family and domain databases

Gene3Di3.40.50.1000. 1 hit.
InterProiIPR023214. HAD-like_dom.
IPR011943. HAD-SF_hydro_IIID.
IPR004274. NIF.
IPR000626. Ubiquitin-like.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF03031. NIF. 1 hit.
PF00240. ubiquitin. 1 hit.
[Graphical view]
SMARTiSM00577. CPDc. 1 hit.
SM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
SSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR02245. HAD_IIID1. 1 hit.
PROSITEiPS50969. FCP1. 1 hit.
PS50053. UBIQUITIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6DI37-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSVSVIIKWG GQEYSINTLS EEDTVLDLKQ SIKSLTGVLP ERQKLLGLKL
60 70 80 90 100
KGKPADDNVK LGDLKLKPNT KIMMMGTREE SLEDVLAPPP ENDDVVNDFD
110 120 130 140 150
IEEEVTEVEN REENLAKIAR RVKDYKVEEL NPPRPGKRLL VLDIDYTLFD
160 170 180 190 200
HKSCAETGHE LMRPFLHEFL TSAYEDFDIV IWSATSMKWI DAKMKELGVT
210 220 230 240 250
DNPNYKITFM LDSAAMITVH TPKRGVVEVK PLGVIWGKYS EFYNRKNTIM
260 270 280 290 300
FDDIGRNFLM NPQNGLKIRP FMKAHLNREK DKELYKLSQY LKEIAKLDDF
310
SGLNHKHWER YLSKKQNQ
Length:318
Mass (Da):36,822
Last modified:August 16, 2004 - v1
Checksum:iED57FD31B4D25748
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC075753 mRNA. Translation: AAH75753.1.
RefSeqiNP_001002319.1. NM_001002319.2.
NP_001186304.1. NM_001199375.1.
UniGeneiDr.122081.
Dr.76865.

Genome annotation databases

EnsembliENSDART00000065341; ENSDARP00000065340; ENSDARG00000044492.
ENSDART00000076715; ENSDARP00000071186; ENSDARG00000044492.
GeneIDi792145.
KEGGidre:792145.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC075753 mRNA. Translation: AAH75753.1 .
RefSeqi NP_001002319.1. NM_001002319.2.
NP_001186304.1. NM_001199375.1.
UniGenei Dr.122081.
Dr.76865.

3D structure databases

ProteinModelPortali Q6DI37.
SMRi Q6DI37. Positions 5-79.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q6DI37.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSDART00000065341 ; ENSDARP00000065340 ; ENSDARG00000044492 .
ENSDART00000076715 ; ENSDARP00000071186 ; ENSDARG00000044492 .
GeneIDi 792145.
KEGGi dre:792145.

Organism-specific databases

CTDi 134510.
ZFINi ZDB-GENE-040718-3. ublcp1.

Phylogenomic databases

eggNOGi NOG310886.
GeneTreei ENSGT00390000010107.
HOGENOMi HOG000231279.
HOVERGENi HBG080207.
InParanoidi Q6DI37.
KOi K17618.
OMAi ELNPPRE.
OrthoDBi EOG74TX01.
PhylomeDBi Q6DI37.
TreeFami TF323786.

Miscellaneous databases

NextBioi 20930929.
PROi Q6DI37.

Gene expression databases

Bgeei Q6DI37.

Family and domain databases

Gene3Di 3.40.50.1000. 1 hit.
InterProi IPR023214. HAD-like_dom.
IPR011943. HAD-SF_hydro_IIID.
IPR004274. NIF.
IPR000626. Ubiquitin-like.
IPR029071. Ubiquitin-rel_dom.
[Graphical view ]
Pfami PF03031. NIF. 1 hit.
PF00240. ubiquitin. 1 hit.
[Graphical view ]
SMARTi SM00577. CPDc. 1 hit.
SM00213. UBQ. 1 hit.
[Graphical view ]
SUPFAMi SSF54236. SSF54236. 1 hit.
SSF56784. SSF56784. 1 hit.
TIGRFAMsi TIGR02245. HAD_IIID1. 1 hit.
PROSITEi PS50969. FCP1. 1 hit.
PS50053. UBIQUITIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiUBCP1_DANRE
AccessioniPrimary (citable) accession number: Q6DI37
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: August 16, 2004
Last modified: October 29, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3