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Protein
Submitted name:

Hydroxyacyl-Coenzyme A dehydrogenase

Gene

hadh

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei68 – 681Coenzyme AUniRule annotation
Binding sitei75 – 751Coenzyme AUniRule annotation
Binding sitei144 – 1441Coenzyme AUniRule annotation
Sitei165 – 1651Important for catalytic activityUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-DRE-77310. Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA.
R-DRE-77346. Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA.
R-DRE-77348. Beta oxidation of octanoyl-CoA to hexanoyl-CoA.
R-DRE-77350. Beta oxidation of hexanoyl-CoA to butanoyl-CoA.
R-DRE-77352. Beta oxidation of butanoyl-CoA to acetyl-CoA.

Names & Taxonomyi

Protein namesi
Submitted name:
Hydroxyacyl-Coenzyme A dehydrogenaseImported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:hadhImported
Synonyms:hadhscImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 1

Organism-specific databases

ZFINiZDB-GENE-040801-261. hadh.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000050602.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 2091863HCDH_NInterPro annotationAdd
BLAST
Domaini211 – 307973HCDHInterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiKOG2304. Eukaryota.
COG1250. LUCA.
GeneTreeiENSGT00720000108673.
HOGENOMiHOG000141498.
HOVERGENiHBG000832.
KOiK00022.
OMAiCPLLKEM.
OrthoDBiEOG7K3TMS.
TreeFamiTF300886.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR022694. 3-OHacyl-CoA_DH.
IPR006180. 3-OHacyl-CoA_DH_CS.
IPR006176. 3-OHacyl-CoA_DH_NAD-bd.
IPR006108. 3HC_DH_C.
IPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00725. 3HCDH. 1 hit.
PF02737. 3HCDH_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000105. HCDH. 1 hit.
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiPS00067. 3HCDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6DI22-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFVTRQFSR SFSSSQALHH TIKHVTVIGG GLMGAGIAQV AASTGHSVVL
60 70 80 90 100
VDTSADILNK SAKGIENSLK RVAKKKFAEK PEDGEAFVQK VLKNVSTSTD
110 120 130 140 150
AASVVHGTDL VVEAIVENLK VKQDLFGALD KVAPEHTIFA SNTSSLPIAD
160 170 180 190 200
IASCTARLDR FGGLHFFNPV PMMKLVEVIK TPATSQQTFD ALLEFSKALG
210 220 230 240 250
KHPVSCKDTP GFIVNRLLVP YMLEAVRLHE RGHGSKEDID VAMKLGAGYP
260 270 280 290 300
MGPFELLDYV GLDTSKFIID GWHAKDPDNP LFAPSPLLNK LVSEGKLGKK

TGEGFYKHK
Length:309
Mass (Da):33,336
Last modified:August 16, 2004 - v1
Checksum:i893A07AB0778890B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX572104 Genomic DNA. No translation available.
BC075768 mRNA. Translation: AAH75768.1.
RefSeqiNP_001003515.1. NM_001003515.1.
UniGeneiDr.34131.

Genome annotation databases

EnsembliENSDART00000050603; ENSDARP00000050602; ENSDARG00000030765.
GeneIDi445121.
KEGGidre:445121.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX572104 Genomic DNA. No translation available.
BC075768 mRNA. Translation: AAH75768.1.
RefSeqiNP_001003515.1. NM_001003515.1.
UniGeneiDr.34131.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000050602.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000050603; ENSDARP00000050602; ENSDARG00000030765.
GeneIDi445121.
KEGGidre:445121.

Organism-specific databases

CTDi3033.
ZFINiZDB-GENE-040801-261. hadh.

Phylogenomic databases

eggNOGiKOG2304. Eukaryota.
COG1250. LUCA.
GeneTreeiENSGT00720000108673.
HOGENOMiHOG000141498.
HOVERGENiHBG000832.
KOiK00022.
OMAiCPLLKEM.
OrthoDBiEOG7K3TMS.
TreeFamiTF300886.

Enzyme and pathway databases

ReactomeiR-DRE-77310. Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA.
R-DRE-77346. Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA.
R-DRE-77348. Beta oxidation of octanoyl-CoA to hexanoyl-CoA.
R-DRE-77350. Beta oxidation of hexanoyl-CoA to butanoyl-CoA.
R-DRE-77352. Beta oxidation of butanoyl-CoA to acetyl-CoA.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR022694. 3-OHacyl-CoA_DH.
IPR006180. 3-OHacyl-CoA_DH_CS.
IPR006176. 3-OHacyl-CoA_DH_NAD-bd.
IPR006108. 3HC_DH_C.
IPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00725. 3HCDH. 1 hit.
PF02737. 3HCDH_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000105. HCDH. 1 hit.
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiPS00067. 3HCDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: EmbryoImported.
  2. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: TuebingenImported.
  3. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TuebingenImported.

Entry informationi

Entry nameiQ6DI22_DANRE
AccessioniPrimary (citable) accession number: Q6DI22
Entry historyi
Integrated into UniProtKB/TrEMBL: August 16, 2004
Last sequence update: August 16, 2004
Last modified: July 6, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.