Unreviewed, UniProtKB/TrEMBL Q6DHZ9 (Q6DHZ9_HUMAN)

Names and origin

Protein names

Recommended name:
    Ubiquitin carboxyl-terminal hydrolase RuleBase RU004435V0
    EC=3.1.2.15

Gene names

Name:	USP25 EMBL AAH75792.1
ORF Names:	hCG_401138 EMBL EAX10041.1

Organism

Homo sapiens (Human) EMBL AAH75792.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1055 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	Ubiquitin C-terminal thioester + H(2)O = ubiquitin + a thiol. RuleBase RU004435V0
Sequence similarities	Belongs to the peptidase C19 family. RuleBase RU004434V0

Ontologies

Keywords
Biological process	Ubl conjugation pathway RuleBase RU004434V0
Molecular function	Hydrolase Protease Thiol protease RuleBase RU004434V0
Gene Ontology (GO)
Uncategorized	ubiquitin cycle Inferred from electronic annotation. Source: UniProtKB-KW
Biological process	ubiquitin-dependent protein catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	ubiquitin thiolesterase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q6DHZ9-1 [UniParc]. Last modified May 10, 2005. Version 1. Checksum: 0B9CECDCAD619CF2	FASTA	1,055	122,218
	10 20 30 40 50 60 MTVEQNVLQQ SAAQKHQQTF LNQLREITGI NDTQILQQAL KDSNGNLELA VAFLTAKNAK 70 80 90 100 110 120 TPQQEETTYY QTALPGNDRY ISVGSQADTN VIDLTGDDKD DLQRAIALSL AESNRAFRET 130 140 150 160 170 180 GITDEEQAIS RVLEASIAEN KACLKRTPTE VWRDSRNPYD RKRQDKAPVG LKNVGNTCWF 190 200 210 220 230 240 SAVIQSLFNL LEFRRLVLNY KPPSNAQDLP RNQKEHRNLP FMRELRYLFA LLVGTKRKYV 250 260 270 280 290 300 DPSRAVEILK DAFKSNDSQQ QDVSEFTHKL LDWLEDAFQM KAEEETDEEK PKNPMVELFY 310 320 330 340 350 360 GRFLAVGVLE GKKFENTEMF GQYPLQVNGF KDLHECLEAA MIEGEIESLH SENSGKSGQE 370 380 390 400 410 420 HWFTELPPVL TFELSRFEFN QALGRPEKIH NKLEFPQVLY LDRYMHRNRE ITRIKREEIK 430 440 450 460 470 480 RLKDYLTVLQ QRLERYLSYG SGPKRFPLVD VLQYALEFAS SKPVCTSPVD DIDASSPPSG 490 500 510 520 530 540 SIPSQTLPST TEQQGALSSE LPSTSPSSVA AISSRSVIHK PFTQSRIPPD LPMHPAPRHI 550 560 570 580 590 600 TEEELSVLES CLHRWRTEIE NDTRDLQESI SRIHRTIELM YSDKSMIQVP YRLHAVLVHE 610 620 630 640 650 660 GQANAGHYWA YIFDHRESRW MKYNDIAVTK SSWEELVRDS FGGYRNASAY CLMYINDKAQ 670 680 690 700 710 720 FLIQEEFNKE TGQPLVGIET LPPDLRDFVE EDNQRFEKEL EEWDAQLAQK ALQEKLLASQ 730 740 750 760 770 780 KLRESETSVT TAQAAGDPEY LEQPSRSDFS KHLKEETIQI ITKASHEHED KSPETVLQSA 790 800 810 820 830 840 IKLEYARLVK LAQEDTPPET DYRLHHVVVY FIQNQAPKKI IEKTLLEQFG DRNLSFDERC 850 860 870 880 890 900 HNIMKVAQAK LEMIKPEEVN LEEYEEWHQD YRKFRETTMY LIIGLENFQR ESYIDSLLFL 910 920 930 940 950 960 ICAYQNNKEL LSKGLYRGHD EELISHYRRE CLLKLNEQAA ELFESGEDRE VNNGLIIMNE 970 980 990 1000 1010 1020 FIVPFLPLLL VDEMEEKDIL AVEDMRNRWC SYLGQEMEPH LQEKLTDFLP KLLDCSMEIK 1030 1040 1050 SFHEPPKLPS YSTHELCERF ARIMLSLSRT PADGR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta EMBL AAH75792.1.
[2]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC075792 mRNA. Translation: AAH75792.1. CH471079 Genomic DNA. Translation: EAX10041.1.
RefSeq	NP_037528.3.
UniGene	Hs.473370
3D structure databases
SMR	Q6DHZ9. Positions 1-68.
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000155313. Homo sapiens. [Contig view]
GeneID	29761.
KEGG	hsa:29761.
Organism-specific databases
HGNC	HGNC:12624. USP25.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOVERGEN	Q6DHZ9.
Gene expression databases
ArrayExpress	Q6DHZ9.
Family and domain databases
InterPro	IPR001394. Peptidase_C19. IPR000449. UBA/transl_elong_EF1B_N. IPR003903. UIM. [Graphical view]
Pfam	PF00627. UBA. 1 hit. PF00443. UCH. 1 hit. PF02809. UIM. 2 hits. [Graphical view]
SMART	SM00726. UIM. 1 hit. [Graphical view]
PROSITE	PS00972. UCH_2_1. 1 hit. PS00973. UCH_2_2. 1 hit. PS50235. UCH_2_3. 1 hit. PS50330. UIM. 1 hit. [Graphical view]
Other Resources
NextBio	52254.

Entry information

Entry name

Q6DHZ9_HUMAN

Accession

Primary (citable) accession number: Q6DHZ9

Entry history

Integrated into UniProtKB/TrEMBL:	May 10, 2005
Last sequence update:	May 10, 2005
Last modified:	November 4, 2008
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)