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Protein

Adenosine deaminase-like protein

Gene

ADAL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Putative nucleoside deaminase. May catalyze the hydrolytic deamination of adenosine or some similar substrate and play a role in purine metabolism (By similarity).By similarity

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi24Zinc; catalyticBy similarity1
Metal bindingi26Zinc; catalyticBy similarity1
Binding sitei26SubstrateBy similarity1
Binding sitei181Substrate; via amide nitrogen and carbonyl oxygenBy similarity1
Metal bindingi208Zinc; catalyticBy similarity1
Active sitei211Proton donorBy similarity1
Sitei232Important for catalytic activityBy similarity1
Metal bindingi293Zinc; catalyticBy similarity1
Binding sitei294SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-2161541. Abacavir metabolism.
R-HSA-74217. Purine salvage.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosine deaminase-like protein (EC:3.5.4.-)
Gene namesi
Name:ADAL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:31853. ADAL.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000168803.
PharmGKBiPA142672643.

Chemistry databases

ChEMBLiCHEMBL1795150.

Polymorphism and mutation databases

BioMutaiADAL.
DMDMi146286026.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002850901 – 355Adenosine deaminase-like proteinAdd BLAST355

Proteomic databases

EPDiQ6DHV7.
MaxQBiQ6DHV7.
PeptideAtlasiQ6DHV7.
PRIDEiQ6DHV7.

Expressioni

Gene expression databases

BgeeiENSG00000168803.
CleanExiHS_ADAL.
ExpressionAtlasiQ6DHV7. baseline and differential.
GenevisibleiQ6DHV7. HS.

Organism-specific databases

HPAiHPA046215.
HPA048175.

Interactioni

Protein-protein interaction databases

BioGridi127803. 3 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ6DHV7.
SMRiQ6DHV7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00730000111081.
HOGENOMiHOG000205847.
HOVERGENiHBG055638.
InParanoidiQ6DHV7.
OMAiHHFGYWY.
OrthoDBiEOG091G0UAU.
PhylomeDBiQ6DHV7.
TreeFamiTF314270.

Family and domain databases

InterProiIPR001365. A/AMP_deaminase_dom.
IPR032466. Metal_Hydrolase.
[Graphical view]
PfamiPF00962. A_deaminase. 1 hit.
[Graphical view]
SUPFAMiSSF51556. SSF51556. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6DHV7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIEAEEQQPC KTDFYSELPK VELHAHLNGS ISSHTMKKLI AQKPDLKIHD
60 70 80 90 100
QMTVIDKGKK RTLEECFQMF QTIHQLTSSP EDILMVTKDV IKEFADDGVK
110 120 130 140 150
YLELRSTPRR ENATGMTKKT YVESILEGIK QSKQENLDID VRYLIAVDRR
160 170 180 190 200
GGPLVAKETV KLAEEFFLST EGTVLGLDLS GDPTVGQAKD FLEPLLEAKK
210 220 230 240 250
AGLKLALHLS EIPNQKKETQ ILLDLLPDRI GHGTFLNSGE GGSLDLVDFV
260 270 280 290 300
RQHRIPLELC LTSNVKSQTV PSYDQHHFGF WYSIAHPSVI CTDDKGVFAT
310 320 330 340 350
HLSQEYQLAA ETFNLTQSQV WDLSYESINY IFASDSTRSE LRKKWNHLKP

RVLHI
Length:355
Mass (Da):40,264
Last modified:May 1, 2007 - v2
Checksum:i02810E9BC5F56CD5
GO
Isoform 2 (identifier: Q6DHV7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     258-355: ELCLTSNVKS...NHLKPRVLHI → GKAWSFRSSR

Show »
Length:267
Mass (Da):30,040
Checksum:iC4ED476D40B4C512
GO
Isoform 3 (identifier: Q6DHV7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     185-211: Missing.

Show »
Length:328
Mass (Da):37,362
Checksum:iF3AE94C2AF38E5FD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti119K → E in AK126583 (PubMed:14702039).Curated1
Sequence conflicti139I → T in AK126583 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_042782185 – 211Missing in isoform 3. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_024821258 – 355ELCLT…RVLHI → GKAWSFRSSR in isoform 2. 1 PublicationAdd BLAST98

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK126583 mRNA. No translation available.
AK298870 mRNA. Translation: BAG60990.1.
AC009852 Genomic DNA. No translation available.
AC018924 Genomic DNA. No translation available.
BC075857 mRNA. Translation: AAH75857.1.
CCDSiCCDS32214.1. [Q6DHV7-2]
CCDS53936.1. [Q6DHV7-3]
CCDS81868.1. [Q6DHV7-1]
RefSeqiNP_001012987.1. NM_001012969.3. [Q6DHV7-2]
NP_001152752.1. NM_001159280.2. [Q6DHV7-3]
NP_001311293.1. NM_001324364.1. [Q6DHV7-2]
NP_001311294.1. NM_001324365.1. [Q6DHV7-2]
NP_001311295.1. NM_001324366.1. [Q6DHV7-1]
NP_001311297.1. NM_001324368.1. [Q6DHV7-2]
XP_011519593.1. XM_011521291.2. [Q6DHV7-1]
XP_016877453.1. XM_017021964.1. [Q6DHV7-1]
XP_016877454.1. XM_017021965.1. [Q6DHV7-1]
XP_016877455.1. XM_017021966.1. [Q6DHV7-1]
UniGeneiHs.533913.

Genome annotation databases

EnsembliENST00000389651; ENSP00000374302; ENSG00000168803. [Q6DHV7-2]
ENST00000422466; ENSP00000398744; ENSG00000168803. [Q6DHV7-3]
ENST00000428046; ENSP00000413074; ENSG00000168803. [Q6DHV7-3]
ENST00000562188; ENSP00000456242; ENSG00000168803. [Q6DHV7-1]
ENST00000610420; ENSP00000478575; ENSG00000168803. [Q6DHV7-2]
GeneIDi161823.
KEGGihsa:161823.
UCSCiuc001zrh.5. human. [Q6DHV7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK126583 mRNA. No translation available.
AK298870 mRNA. Translation: BAG60990.1.
AC009852 Genomic DNA. No translation available.
AC018924 Genomic DNA. No translation available.
BC075857 mRNA. Translation: AAH75857.1.
CCDSiCCDS32214.1. [Q6DHV7-2]
CCDS53936.1. [Q6DHV7-3]
CCDS81868.1. [Q6DHV7-1]
RefSeqiNP_001012987.1. NM_001012969.3. [Q6DHV7-2]
NP_001152752.1. NM_001159280.2. [Q6DHV7-3]
NP_001311293.1. NM_001324364.1. [Q6DHV7-2]
NP_001311294.1. NM_001324365.1. [Q6DHV7-2]
NP_001311295.1. NM_001324366.1. [Q6DHV7-1]
NP_001311297.1. NM_001324368.1. [Q6DHV7-2]
XP_011519593.1. XM_011521291.2. [Q6DHV7-1]
XP_016877453.1. XM_017021964.1. [Q6DHV7-1]
XP_016877454.1. XM_017021965.1. [Q6DHV7-1]
XP_016877455.1. XM_017021966.1. [Q6DHV7-1]
UniGeneiHs.533913.

3D structure databases

ProteinModelPortaliQ6DHV7.
SMRiQ6DHV7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127803. 3 interactors.

Chemistry databases

ChEMBLiCHEMBL1795150.

Polymorphism and mutation databases

BioMutaiADAL.
DMDMi146286026.

Proteomic databases

EPDiQ6DHV7.
MaxQBiQ6DHV7.
PeptideAtlasiQ6DHV7.
PRIDEiQ6DHV7.

Protocols and materials databases

DNASUi161823.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000389651; ENSP00000374302; ENSG00000168803. [Q6DHV7-2]
ENST00000422466; ENSP00000398744; ENSG00000168803. [Q6DHV7-3]
ENST00000428046; ENSP00000413074; ENSG00000168803. [Q6DHV7-3]
ENST00000562188; ENSP00000456242; ENSG00000168803. [Q6DHV7-1]
ENST00000610420; ENSP00000478575; ENSG00000168803. [Q6DHV7-2]
GeneIDi161823.
KEGGihsa:161823.
UCSCiuc001zrh.5. human. [Q6DHV7-1]

Organism-specific databases

CTDi161823.
GeneCardsiADAL.
HGNCiHGNC:31853. ADAL.
HPAiHPA046215.
HPA048175.
neXtProtiNX_Q6DHV7.
OpenTargetsiENSG00000168803.
PharmGKBiPA142672643.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00730000111081.
HOGENOMiHOG000205847.
HOVERGENiHBG055638.
InParanoidiQ6DHV7.
OMAiHHFGYWY.
OrthoDBiEOG091G0UAU.
PhylomeDBiQ6DHV7.
TreeFamiTF314270.

Enzyme and pathway databases

ReactomeiR-HSA-2161541. Abacavir metabolism.
R-HSA-74217. Purine salvage.

Miscellaneous databases

GenomeRNAii161823.
PROiQ6DHV7.

Gene expression databases

BgeeiENSG00000168803.
CleanExiHS_ADAL.
ExpressionAtlasiQ6DHV7. baseline and differential.
GenevisibleiQ6DHV7. HS.

Family and domain databases

InterProiIPR001365. A/AMP_deaminase_dom.
IPR032466. Metal_Hydrolase.
[Graphical view]
PfamiPF00962. A_deaminase. 1 hit.
[Graphical view]
SUPFAMiSSF51556. SSF51556. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiADAL_HUMAN
AccessioniPrimary (citable) accession number: Q6DHV7
Secondary accession number(s): A6NHZ3, B4DQM8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 1, 2007
Last modified: November 2, 2016
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.