Q6DHV7 (ADAL_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adenosine deaminase-like protein
EC=3.5.4.-

Gene names

Name:

ADAL

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	355 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Putative nucleoside deaminase. May catalyze the hydrolytic deamination of adenosine or some similar substrate and play a role in purine metabolism By similarity.
Cofactor	Binds 1 zinc ion per subunit By similarity.
Sequence similarities	Belongs to the adenosine and AMP deaminases family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Coding sequence diversity	Alternative splicing
Ligand	Metal-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	adenosine catabolic process Inferred from Biological aspect of Ancestor. Source: RefGenome inosine biosynthetic process Inferred from Biological aspect of Ancestor. Source: RefGenome purine ribonucleoside monophosphate biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	adenosine deaminase activity Inferred from Biological aspect of Ancestor. Source: RefGenome metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6DHV7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6DHV7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     258-355: ELCLTSNVKS...NHLKPRVLHI → GKAWSFRSSR

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 355	355	Adenosine deaminase-like protein		PRO_0000285090
Sites
	Active site	211	1	Proton donor By similarity
	Metal binding	24	1	Zinc; catalytic By similarity
	Metal binding	26	1	Zinc; catalytic By similarity
	Metal binding	208	1	Zinc; catalytic By similarity
	Metal binding	293	1	Zinc; catalytic By similarity
	Binding site	26	1	Substrate By similarity
	Binding site	181	1	Substrate; via amide nitrogen and carbonyl oxygen By similarity
	Binding site	294	1	Substrate By similarity
	Site	232	1	Important for catalytic activity By similarity
Natural variations
	Alternative sequence	258 – 355	98	ELCLT…RVLHI → GKAWSFRSSR in isoform 2.		VSP_024821
Experimental info
	Sequence conflict	119	1	K → E in AK126583. Ref.3
	Sequence conflict	139	1	I → T in AK126583. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 1, 2007. Version 2. Checksum: 02810E9BC5F56CD5	FASTA	355	40,264
	10 20 30 40 50 60 MIEAEEQQPC KTDFYSELPK VELHAHLNGS ISSHTMKKLI AQKPDLKIHD QMTVIDKGKK 70 80 90 100 110 120 RTLEECFQMF QTIHQLTSSP EDILMVTKDV IKEFADDGVK YLELRSTPRR ENATGMTKKT 130 140 150 160 170 180 YVESILEGIK QSKQENLDID VRYLIAVDRR GGPLVAKETV KLAEEFFLST EGTVLGLDLS 190 200 210 220 230 240 GDPTVGQAKD FLEPLLEAKK AGLKLALHLS EIPNQKKETQ ILLDLLPDRI GHGTFLNSGE 250 260 270 280 290 300 GGSLDLVDFV RQHRIPLELC LTSNVKSQTV PSYDQHHFGF WYSIAHPSVI CTDDKGVFAT 310 320 330 340 350 HLSQEYQLAA ETFNLTQSQV WDLSYESINY IFASDSTRSE LRKKWNHLKP RVLHI
	Isoform 2 [UniParc]. Checksum: C4ED476D40B4C512	FASTA	267	30,040
	10 20 30 40 50 60 MIEAEEQQPC KTDFYSELPK VELHAHLNGS ISSHTMKKLI AQKPDLKIHD QMTVIDKGKK 70 80 90 100 110 120 RTLEECFQMF QTIHQLTSSP EDILMVTKDV IKEFADDGVK YLELRSTPRR ENATGMTKKT 130 140 150 160 170 180 YVESILEGIK QSKQENLDID VRYLIAVDRR GGPLVAKETV KLAEEFFLST EGTVLGLDLS 190 200 210 220 230 240 GDPTVGQAKD FLEPLLEAKK AGLKLALHLS EIPNQKKETQ ILLDLLPDRI GHGTFLNSGE 250 260 GGSLDLVDFV RQHRIPLGKA WSFRSSR

References

[1]	"Analysis of the DNA sequence and duplication history of human chromosome 15." Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A. , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C. Nature 440:671-675(2006) [PubMed: 16572171] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 92-355 (ISOFORM 1).

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC018924 Genomic DNA. No translation available. AC009852 Genomic DNA. No translation available. BC075857 mRNA. Translation: AAH75857.1. AK126583 mRNA. No translation available.
IPI	IPI00238031. IPI00783550.
RefSeq	NP_001012987.1. NM_001012969.2. NP_001152752.1. NM_001159280.1.
UniGene	Hs.533913.
3D structure databases
ProteinModelPortal	Q6DHV7.
SMR	Q6DHV7. Positions 17-348.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6DHV7.
Polymorphism databases
DMDM	146286026.
Proteomic databases
PRIDE	Q6DHV7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000422466; ENSP00000398744; ENSG00000168803.
GeneID	161823.
KEGG	hsa:161823.
NMPDR	fig|9606.3.peg.10595.
UCSC	uc001zrh.1. human. uc001zri.1. human.
Organism-specific databases
CTD	161823.
GeneCards	GC15P043622.
HGNC	HGNC:31853. ADAL.
neXtProt	NX_Q6DHV7.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG11044.
GeneTree	ENSGT00510000047133.
HOGENOM	HBG630382.
HOVERGEN	HBG055638.
InParanoid	Q6DHV7.
OMA	GIKQCKQ.
OrthoDB	EOG43N7D3.
PhylomeDB	Q6DHV7.
Gene expression databases
ArrayExpress	Q6DHV7.
Bgee	Q6DHV7.
CleanEx	HS_ADAL.
Genevestigator	Q6DHV7.
Family and domain databases
InterPro	IPR001365. A/AMP_deaminase_dom. [Graphical view]
Pfam	PF00962. A_deaminase. 1 hit. [Graphical view]
PROSITE	PS00485. A_DEAMINASE. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	88114.

Entry information

Entry name

ADAL_HUMAN

Accession

Primary (citable) accession number: Q6DHV7
Secondary accession number(s): A6NHZ3

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 2007
Last sequence update:	May 1, 2007
Last modified:	January 25, 2012
This is version 59 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.