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Protein
Submitted name:

Lysophosphatidic acid receptor 1

Gene

lpar1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • lysophosphatidic acid receptor activity Source: ZFIN

GO - Biological processi

  • angiogenesis Source: ZFIN
  • cartilage development Source: ZFIN
  • hemangioblast cell differentiation Source: ZFIN
  • lymphangiogenesis Source: ZFIN
  • primitive hemopoiesis Source: ZFIN

Keywordsi

Molecular functionG-protein coupled receptorUniRule annotation, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-DRE-416476 G alpha (q) signalling events
R-DRE-418594 G alpha (i) signalling events
R-DRE-419408 Lysosphingolipid and LPA receptors

Names & Taxonomyi

Protein namesi
Submitted name:
Lysophosphatidic acid receptor 1Imported
Gene namesi
Name:lpar1Imported
Synonyms:edg2Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 10

Organism-specific databases

ZFINiZDB-GENE-030616-499 lpar1

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei33 – 59HelicalSequence analysisAdd BLAST27
Transmembranei66 – 87HelicalSequence analysisAdd BLAST22
Transmembranei107 – 126HelicalSequence analysisAdd BLAST20
Transmembranei146 – 168HelicalSequence analysisAdd BLAST23
Transmembranei188 – 214HelicalSequence analysisAdd BLAST27
Transmembranei235 – 262HelicalSequence analysisAdd BLAST28

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSDARG00000099840

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000108379

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini48 – 293G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST246

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000118804
HOGENOMiHOG000233501
HOVERGENiHBG103071
KOiK04289
OMAiCCQRQEN
OrthoDBiEOG091G0DD4
TreeFamiTF330052

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR004065 LPA_rcpt
IPR002277 LPA_rcpt_EDG2
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01148 EDG2RECEPTOR
PR00237 GPCRRHODOPSN
PR01527 LPARECEPTOR
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q6DHQ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDRQCYYNE TIAFFYNRSQ KYLATEWNAV SKLVMGLGIT VCIFIMLANL
60 70 80 90 100
LVMVAIYINR RFHFPIYYLM ANLAAADFFA GLAYFYLMFN TGPNTRRLTV
110 120 130 140 150
STWLLRQGLI DTSLTASVAN LLAIAIERHI TVFRMQLHTR MSNRRVVVVI
160 170 180 190 200
VIIWTMSIVM GAIPSVGWNC ICAIDTCSNM APLYSNSYLG FWAIFNLVTF
210 220 230 240 250
VVMVVLYAHI FMYVRQRTMR MSRHSSGQRR NRDTMMSLLK TVVIVLGAFI
260 270 280 290 300
VCWTPGLVIL LLDVVCANCN VLTYEKFFLL LAEFNSAMNP IIYSYRDKEM
310 320 330 340
SITFKQILCC QRQENVNGTA EGSDRSASSI NHTVLSGAHH NDHSVV
Length:346
Mass (Da):39,482
Last modified:August 16, 2004 - v1
Checksum:iA50A0A3C257F1395
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CABZ01032935 Genomic DNA No translation available.
CABZ01032936 Genomic DNA No translation available.
CU694479 Genomic DNA No translation available.
BC075909 mRNA Translation: AAH75909.1
RefSeqiNP_001004502.2, NM_001004502.2
UniGeneiDr.32070

Genome annotation databases

EnsembliENSDART00000172625; ENSDARP00000140290; ENSDARG00000099840
GeneIDi368461
KEGGidre:368461

Similar proteinsi

Entry informationi

Entry nameiQ6DHQ8_DANRE
AccessioniPrimary (citable) accession number: Q6DHQ8
Entry historyiIntegrated into UniProtKB/TrEMBL: August 16, 2004
Last sequence update: August 16, 2004
Last modified: March 28, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health