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Protein
Submitted name:

Lysophosphatidic acid receptor 1

Gene

lpar1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • lysophosphatidic acid receptor activity Source: ZFIN

GO - Biological processi

  • angiogenesis Source: ZFIN
  • hemangioblast cell differentiation Source: ZFIN
  • lymphangiogenesis Source: ZFIN
  • primitive hemopoiesis Source: ZFIN
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptorUniRule annotation, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-DRE-416476. G alpha (q) signalling events.
R-DRE-418594. G alpha (i) signalling events.
R-DRE-419408. Lysosphingolipid and LPA receptors.

Names & Taxonomyi

Protein namesi
Submitted name:
Lysophosphatidic acid receptor 1Imported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:lpar1Imported
Synonyms:edg2Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 10

Organism-specific databases

ZFINiZDB-GENE-030616-499. lpar1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei33 – 59HelicalSequence analysisAdd BLAST27
Transmembranei66 – 87HelicalSequence analysisAdd BLAST22
Transmembranei107 – 126HelicalSequence analysisAdd BLAST20
Transmembranei146 – 168HelicalSequence analysisAdd BLAST23
Transmembranei188 – 214HelicalSequence analysisAdd BLAST27
Transmembranei235 – 262HelicalSequence analysisAdd BLAST28

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSDARG00000044213.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000108379.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini48 – 293G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST246

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118804.
HOGENOMiHOG000233501.
HOVERGENiHBG103071.
KOiK04289.
OMAiCCQRQEN.
OrthoDBiEOG091G0DD4.
TreeFamiTF330052.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR004065. LPA_rcpt.
IPR002277. LPA_rcpt_EDG2.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01148. EDG2RECEPTOR.
PR00237. GPCRRHODOPSN.
PR01527. LPARECEPTOR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6DHQ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDRQCYYNE TIAFFYNRSQ KYLATEWNAV SKLVMGLGIT VCIFIMLANL
60 70 80 90 100
LVMVAIYINR RFHFPIYYLM ANLAAADFFA GLAYFYLMFN TGPNTRRLTV
110 120 130 140 150
STWLLRQGLI DTSLTASVAN LLAIAIERHI TVFRMQLHTR MSNRRVVVVI
160 170 180 190 200
VIIWTMSIVM GAIPSVGWNC ICAIDTCSNM APLYSNSYLG FWAIFNLVTF
210 220 230 240 250
VVMVVLYAHI FMYVRQRTMR MSRHSSGQRR NRDTMMSLLK TVVIVLGAFI
260 270 280 290 300
VCWTPGLVIL LLDVVCANCN VLTYEKFFLL LAEFNSAMNP IIYSYRDKEM
310 320 330 340
SITFKQILCC QRQENVNGTA EGSDRSASSI NHTVLSGAHH NDHSVV
Length:346
Mass (Da):39,482
Last modified:August 16, 2004 - v1
Checksum:iA50A0A3C257F1395
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CABZ01032935 Genomic DNA. No translation available.
CABZ01032936 Genomic DNA. No translation available.
CU694479 Genomic DNA. No translation available.
BC075909 mRNA. Translation: AAH75909.1.
RefSeqiNP_001004502.2. NM_001004502.2.
UniGeneiDr.32070.

Genome annotation databases

EnsembliENSDART00000172625; ENSDARP00000140290; ENSDARG00000099840.
GeneIDi368461.
KEGGidre:368461.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CABZ01032935 Genomic DNA. No translation available.
CABZ01032936 Genomic DNA. No translation available.
CU694479 Genomic DNA. No translation available.
BC075909 mRNA. Translation: AAH75909.1.
RefSeqiNP_001004502.2. NM_001004502.2.
UniGeneiDr.32070.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000108379.

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000172625; ENSDARP00000140290; ENSDARG00000099840.
GeneIDi368461.
KEGGidre:368461.

Organism-specific databases

CTDi1902.
ZFINiZDB-GENE-030616-499. lpar1.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118804.
HOGENOMiHOG000233501.
HOVERGENiHBG103071.
KOiK04289.
OMAiCCQRQEN.
OrthoDBiEOG091G0DD4.
TreeFamiTF330052.

Enzyme and pathway databases

ReactomeiR-DRE-416476. G alpha (q) signalling events.
R-DRE-418594. G alpha (i) signalling events.
R-DRE-419408. Lysosphingolipid and LPA receptors.

Gene expression databases

BgeeiENSDARG00000044213.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR004065. LPA_rcpt.
IPR002277. LPA_rcpt_EDG2.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01148. EDG2RECEPTOR.
PR00237. GPCRRHODOPSN.
PR01527. LPARECEPTOR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ6DHQ8_DANRE
AccessioniPrimary (citable) accession number: Q6DHQ8
Entry historyi
Integrated into UniProtKB/TrEMBL: August 16, 2004
Last sequence update: August 16, 2004
Last modified: September 7, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.