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Protein

Small ubiquitin-related modifier 2

Gene

sumo2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex sae1-sae2 and linkage to the E2 enzyme ube2i, and can be promoted by an E3 ligase such as pias1-4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric sumo2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (By similarity).By similarity

GO - Biological processi

  • chordate embryonic development Source: ZFIN
  • definitive hemopoiesis Source: ZFIN
  • protein sumoylation Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-DRE-3065679. SUMO is proteolytically processed.
R-DRE-3108214. SUMOylation of DNA damage response and repair proteins.
R-DRE-3232118. SUMOylation of transcription factors.
R-DRE-4551638. SUMOylation of chromatin organization proteins.
R-DRE-4570464. SUMOylation of RNA binding proteins.
R-DRE-4615885. SUMOylation of DNA replication proteins.
R-DRE-5693607. Processing of DNA double-strand break ends.
R-DRE-5696395. Formation of Incision Complex in GG-NER.

Names & Taxonomyi

Protein namesi
Recommended name:
Small ubiquitin-related modifier 2Curated
Short name:
SUMO-2Curated
Gene namesi
Name:sumo2Curated
ORF Names:zgc:92241Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 3

Organism-specific databases

ZFINiZDB-GENE-040801-7. sumo2b.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9393Small ubiquitin-related modifier 2PRO_0000269469Add
BLAST
Propeptidei94 – 963By similarityPRO_0000269470

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki11 – 11Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
Cross-linki93 – 93Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)PROSITE-ProRule annotation

Post-translational modificationi

Polymeric chains can be formed through Lys-11 cross-linking.By similarity
Cleavage of precursor form by a sentrin-specific protease is necessary for function.By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PRIDEiQ6DHL4.

Expressioni

Gene expression databases

BgeeiQ6DHL4.

Interactioni

Subunit structurei

Interacts with sae2 and ube2i. Covalently attached to a number of proteins (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ6DHL4.
SMRiQ6DHL4. Positions 1-93.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 9681Ubiquitin-likePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ubiquitin family. SUMO subfamily.Curated
Contains 1 ubiquitin-like domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000018808.
HOGENOMiHOG000207495.
HOVERGENiHBG053025.
InParanoidiQ6DHL4.
KOiK12160.
OMAiDQMVHIN.
PhylomeDBiQ6DHL4.

Family and domain databases

InterProiIPR022617. Rad60/SUMO-like_dom.
IPR027218. SUMO_chordates.
IPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
[Graphical view]
PANTHERiPTHR10562:SF10. PTHR10562:SF10. 1 hit.
PfamiPF11976. Rad60-SLD. 1 hit.
[Graphical view]
SMARTiSM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS50053. UBIQUITIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6DHL4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADEKPKEGV KTENNDHINL KVAGQDGSVV QFKIKRHTPL SKLMKAYCER
60 70 80 90
QGLTMRQIRF RFDGQPINET DTPAQLEMED EDTIDVFQQQ TGGHRI
Length:96
Mass (Da):11,029
Last modified:August 16, 2004 - v1
Checksum:iB797B5D4B322BEF0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC075956 mRNA. Translation: AAH75956.1.
RefSeqiNP_001003422.1. NM_001003422.2.
UniGeneiDr.80492.

Genome annotation databases

EnsembliENSDART00000157771; ENSDARP00000137571; ENSDARG00000102741.
ENSDART00000166758; ENSDARP00000131145; ENSDARG00000102741.
GeneIDi445027.
KEGGidre:445027.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC075956 mRNA. Translation: AAH75956.1.
RefSeqiNP_001003422.1. NM_001003422.2.
UniGeneiDr.80492.

3D structure databases

ProteinModelPortaliQ6DHL4.
SMRiQ6DHL4. Positions 1-93.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ6DHL4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000157771; ENSDARP00000137571; ENSDARG00000102741.
ENSDART00000166758; ENSDARP00000131145; ENSDARG00000102741.
GeneIDi445027.
KEGGidre:445027.

Organism-specific databases

CTDi445027.
ZFINiZDB-GENE-040801-7. sumo2b.

Phylogenomic databases

GeneTreeiENSGT00390000018808.
HOGENOMiHOG000207495.
HOVERGENiHBG053025.
InParanoidiQ6DHL4.
KOiK12160.
OMAiDQMVHIN.
PhylomeDBiQ6DHL4.

Enzyme and pathway databases

ReactomeiR-DRE-3065679. SUMO is proteolytically processed.
R-DRE-3108214. SUMOylation of DNA damage response and repair proteins.
R-DRE-3232118. SUMOylation of transcription factors.
R-DRE-4551638. SUMOylation of chromatin organization proteins.
R-DRE-4570464. SUMOylation of RNA binding proteins.
R-DRE-4615885. SUMOylation of DNA replication proteins.
R-DRE-5693607. Processing of DNA double-strand break ends.
R-DRE-5696395. Formation of Incision Complex in GG-NER.

Miscellaneous databases

PROiQ6DHL4.

Gene expression databases

BgeeiQ6DHL4.

Family and domain databases

InterProiIPR022617. Rad60/SUMO-like_dom.
IPR027218. SUMO_chordates.
IPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
[Graphical view]
PANTHERiPTHR10562:SF10. PTHR10562:SF10. 1 hit.
PfamiPF11976. Rad60-SLD. 1 hit.
[Graphical view]
SMARTiSM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS50053. UBIQUITIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiSUMO2_DANRE
AccessioniPrimary (citable) accession number: Q6DHL4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: August 16, 2004
Last modified: June 8, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.