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Protein

NAD(P)H-hydrate epimerase

Gene

naxe

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.UniRule annotation

Catalytic activityi

(6R)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide = (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide.
(6R)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate = (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate.

Cofactori

K+UniRule annotationNote: Binds 1 potassium ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi116PotassiumUniRule annotation1
Metal bindingi180PotassiumUniRule annotation1
Binding sitei213NAD(P)HXUniRule annotation1
Metal bindingi216PotassiumUniRule annotation1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Ligandi

Metal-binding, NAD, NADP, Nucleotide-binding, Potassium

Enzyme and pathway databases

ReactomeiR-DRE-197264. Nicotinamide salvaging.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD(P)H-hydrate epimeraseUniRule annotation (EC:5.1.99.6)
Alternative name(s):
Apolipoprotein A-I-binding proteinUniRule annotation
Short name:
AI-BPUniRule annotation
NAD(P)HX epimeraseBy similarity
Gene namesi
Name:naxeBy similarity
Synonyms:aibp, apoa1bp
ORF Names:si:dkeyp-84f11.6, zgc:92263
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 19

Organism-specific databases

ZFINiZDB-GENE-040718-362. apoa1bp.

Subcellular locationi

  • Mitochondrion UniRule annotation
  • Secreted UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 28MitochondrionUniRule annotationAdd BLAST28
ChainiPRO_000029242529 – 283NAD(P)H-hydrate epimeraseAdd BLAST255

Proteomic databases

PaxDbiQ6DHK1.
PRIDEiQ6DHK1.

Expressioni

Gene expression databases

BgeeiENSDARG00000058806.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000076185.

Structurei

3D structure databases

ProteinModelPortaliQ6DHK1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini61 – 270YjeF N-terminalUniRule annotationAdd BLAST210

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni115 – 119NAD(P)HXUniRule annotation5
Regioni184 – 190NAD(P)HXUniRule annotation7

Sequence similaritiesi

Belongs to the NnrE/AIBP family.UniRule annotation
Contains 1 YjeF N-terminal domain.UniRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2585. Eukaryota.
COG0062. LUCA.
GeneTreeiENSGT00390000007227.
HOGENOMiHOG000174236.
HOVERGENiHBG058276.
InParanoidiQ6DHK1.
KOiK17759.
OMAiELMSTGA.
OrthoDBiEOG091G0J79.
PhylomeDBiQ6DHK1.
TreeFamiTF300197.

Family and domain databases

Gene3Di3.40.50.10260. 1 hit.
HAMAPiMF_01966. NADHX_epimerase. 1 hit.
InterProiIPR004443. YjeF_N_dom.
IPR032976. YJEFN_prot_eukaryotes.
[Graphical view]
PANTHERiPTHR13232. PTHR13232. 1 hit.
PfamiPF03853. YjeF_N. 1 hit.
[Graphical view]
SUPFAMiSSF64153. SSF64153. 1 hit.
TIGRFAMsiTIGR00197. yjeF_nterm. 1 hit.
PROSITEiPS51385. YJEF_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6DHK1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGVRALFGI GLLVTSRGGF VLTHTRACSS AASNIYSKHL THRPTCTMAN
60 70 80 90 100
TGVKYLGQEE AQQIDEELFS DFSFSVDQLM ELAGLSCATA VAKGYPVTSL
110 120 130 140 150
LKSPARVLVI CGPGNNGGDG LVCARHLKLF GYEPSVLYPK RPNKQLFQNL
160 170 180 190 200
SIQCQKMEIP FLTEMPEADL IDEAYSLVVD AIFGFSFKGA VREPFGEILS
210 220 230 240 250
QLKKITVPIA SVDIPSGWDV EKGCPDGIQP DMLISLTAPK KSAALFKGRF
260 270 280
HFLGGRFVPP VLEQKYQLNL PQYPGTECVF QLN
Length:283
Mass (Da):30,882
Last modified:August 16, 2004 - v1
Checksum:i036930E12F0324BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX890617 Genomic DNA. Translation: CAK11463.1.
BC075969 mRNA. Translation: AAH75969.1.
RefSeqiNP_001002618.1. NM_001002618.1.
UniGeneiDr.85107.

Genome annotation databases

EnsembliENSDART00000081746; ENSDARP00000076185; ENSDARG00000058806.
GeneIDi436891.
KEGGidre:436891.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX890617 Genomic DNA. Translation: CAK11463.1.
BC075969 mRNA. Translation: AAH75969.1.
RefSeqiNP_001002618.1. NM_001002618.1.
UniGeneiDr.85107.

3D structure databases

ProteinModelPortaliQ6DHK1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000076185.

Proteomic databases

PaxDbiQ6DHK1.
PRIDEiQ6DHK1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000081746; ENSDARP00000076185; ENSDARG00000058806.
GeneIDi436891.
KEGGidre:436891.

Organism-specific databases

CTDi246703.
ZFINiZDB-GENE-040718-362. apoa1bp.

Phylogenomic databases

eggNOGiKOG2585. Eukaryota.
COG0062. LUCA.
GeneTreeiENSGT00390000007227.
HOGENOMiHOG000174236.
HOVERGENiHBG058276.
InParanoidiQ6DHK1.
KOiK17759.
OMAiELMSTGA.
OrthoDBiEOG091G0J79.
PhylomeDBiQ6DHK1.
TreeFamiTF300197.

Enzyme and pathway databases

ReactomeiR-DRE-197264. Nicotinamide salvaging.

Miscellaneous databases

PROiQ6DHK1.

Gene expression databases

BgeeiENSDARG00000058806.

Family and domain databases

Gene3Di3.40.50.10260. 1 hit.
HAMAPiMF_01966. NADHX_epimerase. 1 hit.
InterProiIPR004443. YjeF_N_dom.
IPR032976. YJEFN_prot_eukaryotes.
[Graphical view]
PANTHERiPTHR13232. PTHR13232. 1 hit.
PfamiPF03853. YjeF_N. 1 hit.
[Graphical view]
SUPFAMiSSF64153. SSF64153. 1 hit.
TIGRFAMsiTIGR00197. yjeF_nterm. 1 hit.
PROSITEiPS51385. YJEF_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNNRE_DANRE
AccessioniPrimary (citable) accession number: Q6DHK1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: August 16, 2004
Last modified: October 5, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.