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Protein

Ras-related protein Rab-18-B

Gene

rab18b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a role in apical endocytosis/recycling. May be implicated in transport between the plasma membrane and early endosomes. Plays a key role in eye and brain development and neurodegeneration.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi15 – 22GTPBy similarity8
Nucleotide bindingi63 – 67GTPBy similarity5
Nucleotide bindingi122 – 125GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

  • brain development Source: UniProtKB
  • chordate embryonic development Source: ZFIN
  • eye development Source: UniProtKB
  • lipid particle organization Source: GO_Central
  • protein transport Source: UniProtKB-KW
  • small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DRE-6798695. Neutrophil degranulation.
R-DRE-6811436. COPI-independent Golgi-to-ER retrograde traffic.
R-DRE-8876198. RAB GEFs exchange GTP for GDP on RABs.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-18-B
Gene namesi
Name:rab18b
Synonyms:rab18
ORF Names:zgc:92523
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 2

Organism-specific databases

ZFINiZDB-GENE-040801-185. rab18b.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Disruption phenotypei

The most common abnormalities observed at 3 days post-fertilization are microphthalmia, microcephaly, pericardial edema, delayed jaw formation, a reduced overall body size, and a general developmental delay. Further characterization revealed that the rab18b morphants have delayed retinal development and abnormal retinal lamination, residual nucleated lens fiber cells, widely open choroid fissure, and microphthalmia at day 3.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001211981 – 202Ras-related protein Rab-18-BAdd BLAST202
PropeptideiPRO_0000370820203 – 205Removed in mature formSequence analysis3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi198S-palmitoyl cysteineSequence analysis1
Modified residuei202Cysteine methyl esterSequence analysis1
Lipidationi202S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Palmitate, Prenylation

Proteomic databases

PaxDbiQ6DHC1.
PRIDEiQ6DHC1.

Expressioni

Gene expression databases

BgeeiENSDARG00000035084.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000042736.

Structurei

3D structure databases

ProteinModelPortaliQ6DHC1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi37 – 45Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0080. Eukaryota.
ENOG410XPD0. LUCA.
GeneTreeiENSGT00860000133677.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiQ6DHC1.
KOiK07910.
OMAiNTSPIGA.
OrthoDBiEOG091G0MOO.
PhylomeDBiQ6DHC1.
TreeFamiTF313448.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR025662. Sigma_54_int_dom_ATP-bd_1.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6DHC1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDDVLTTLK ILIIGESGVG KSSLLLRFTD DTFDPELAAT IGVDFKVKTI
60 70 80 90 100
AIDGNRAKLA IWDTAGQERF RTLTPSYYRG AQGVILVYDV TKRDTFTKLE
110 120 130 140 150
NWLNELETYC TRNDLVKMLV GNKIDKDNRE VDRNEGLKFA RKHSMLFIEA
160 170 180 190 200
SAKTRDGVQC AFEELVEKIL QTPGLWESSI QNHGVQLSDN EPQRQGACGG

YCSLV
Length:205
Mass (Da):23,013
Last modified:August 16, 2004 - v1
Checksum:i4854D8252A2E2B21
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC076054 mRNA. Translation: AAH76054.1.
RefSeqiNP_001003449.1. NM_001003449.1.
UniGeneiDr.79683.

Genome annotation databases

EnsembliENSDART00000158335; ENSDARP00000133937; ENSDARG00000098344.
GeneIDi445055.
KEGGidre:445055.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC076054 mRNA. Translation: AAH76054.1.
RefSeqiNP_001003449.1. NM_001003449.1.
UniGeneiDr.79683.

3D structure databases

ProteinModelPortaliQ6DHC1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000042736.

Proteomic databases

PaxDbiQ6DHC1.
PRIDEiQ6DHC1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000158335; ENSDARP00000133937; ENSDARG00000098344.
GeneIDi445055.
KEGGidre:445055.

Organism-specific databases

CTDi445055.
ZFINiZDB-GENE-040801-185. rab18b.

Phylogenomic databases

eggNOGiKOG0080. Eukaryota.
ENOG410XPD0. LUCA.
GeneTreeiENSGT00860000133677.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiQ6DHC1.
KOiK07910.
OMAiNTSPIGA.
OrthoDBiEOG091G0MOO.
PhylomeDBiQ6DHC1.
TreeFamiTF313448.

Enzyme and pathway databases

ReactomeiR-DRE-6798695. Neutrophil degranulation.
R-DRE-6811436. COPI-independent Golgi-to-ER retrograde traffic.
R-DRE-8876198. RAB GEFs exchange GTP for GDP on RABs.

Miscellaneous databases

PROiQ6DHC1.

Gene expression databases

BgeeiENSDARG00000035084.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR025662. Sigma_54_int_dom_ATP-bd_1.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRB18B_DANRE
AccessioniPrimary (citable) accession number: Q6DHC1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: August 16, 2004
Last modified: November 30, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.