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Protein

Ras-related protein Rab-18-B

Gene

rab18b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a role in apical endocytosis/recycling. May be implicated in transport between the plasma membrane and early endosomes. Plays a key role in eye and brain development and neurodegeneration.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi15 – 22GTPBy similarity8
Nucleotide bindingi63 – 67GTPBy similarity5
Nucleotide bindingi122 – 125GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

  • brain development Source: UniProtKB
  • chordate embryonic development Source: ZFIN
  • eye development Source: UniProtKB
  • lipid particle organization Source: GO_Central
  • protein transport Source: UniProtKB-KW

Keywordsi

Molecular functionDevelopmental protein
Biological processProtein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DRE-6798695 Neutrophil degranulation
R-DRE-6811436 COPI-independent Golgi-to-ER retrograde traffic
R-DRE-8873719 RAB geranylgeranylation
R-DRE-8876198 RAB GEFs exchange GTP for GDP on RABs

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-18-B
Gene namesi
Name:rab18b
Synonyms:rab18
ORF Names:zgc:92523
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 2

Organism-specific databases

ZFINiZDB-GENE-040801-185 rab18b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Disruption phenotypei

The most common abnormalities observed at 3 days post-fertilization are microphthalmia, microcephaly, pericardial edema, delayed jaw formation, a reduced overall body size, and a general developmental delay. Further characterization revealed that the rab18b morphants have delayed retinal development and abnormal retinal lamination, residual nucleated lens fiber cells, widely open choroid fissure, and microphthalmia at day 3.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001211981 – 202Ras-related protein Rab-18-BAdd BLAST202
PropeptideiPRO_0000370820203 – 205Removed in mature formSequence analysis3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi198S-palmitoyl cysteineSequence analysis1
Modified residuei202Cysteine methyl esterSequence analysis1
Lipidationi202S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Palmitate, Prenylation

Proteomic databases

PaxDbiQ6DHC1
PRIDEiQ6DHC1

Expressioni

Gene expression databases

BgeeiENSDARG00000098344

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000042736

Structurei

3D structure databases

ProteinModelPortaliQ6DHC1
SMRiQ6DHC1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi37 – 45Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0080 Eukaryota
ENOG410XPD0 LUCA
GeneTreeiENSGT00760000119101
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiQ6DHC1
KOiK07910
OMAiCGGYCSI
OrthoDBiEOG091G0MOO
PhylomeDBiQ6DHC1
TreeFamiTF313448

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR025662 Sigma_54_int_dom_ATP-bd_1
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6DHC1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDDVLTTLK ILIIGESGVG KSSLLLRFTD DTFDPELAAT IGVDFKVKTI
60 70 80 90 100
AIDGNRAKLA IWDTAGQERF RTLTPSYYRG AQGVILVYDV TKRDTFTKLE
110 120 130 140 150
NWLNELETYC TRNDLVKMLV GNKIDKDNRE VDRNEGLKFA RKHSMLFIEA
160 170 180 190 200
SAKTRDGVQC AFEELVEKIL QTPGLWESSI QNHGVQLSDN EPQRQGACGG

YCSLV
Length:205
Mass (Da):23,013
Last modified:August 16, 2004 - v1
Checksum:i4854D8252A2E2B21
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC076054 mRNA Translation: AAH76054.1
RefSeqiNP_001003449.1, NM_001003449.1
UniGeneiDr.79683

Genome annotation databases

EnsembliENSDART00000158335; ENSDARP00000133937; ENSDARG00000098344
GeneIDi445055
KEGGidre:445055

Similar proteinsi

Entry informationi

Entry nameiRB18B_DANRE
AccessioniPrimary (citable) accession number: Q6DHC1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: August 16, 2004
Last modified: May 23, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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