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Q6DH69

- FAH2A_DANRE

UniProt

Q6DH69 - FAH2A_DANRE

Protein

Fatty-acid amide hydrolase 2-A

Gene

faah2a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (16 Aug 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Anandamide + H2O = arachidonic acid + ethanolamine.
    Oleamide + H2O = oleic acid + NH3.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei129 – 1291Charge relay systemBy similarity
    Active sitei204 – 2041Charge relay systemBy similarity
    Active sitei228 – 2281Acyl-ester intermediateBy similarity

    GO - Molecular functioni

    1. carbon-nitrogen ligase activity, with glutamine as amido-N-donor Source: InterPro
    2. hydrolase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fatty-acid amide hydrolase 2-A (EC:3.5.1.99)
    Gene namesi
    Name:faah2a
    ORF Names:zgc:92625
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Chromosome 1

    Organism-specific databases

    ZFINiZDB-GENE-040718-453. faah2a.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 532532Fatty-acid amide hydrolase 2-APRO_0000291994Add
    BLAST

    Proteomic databases

    PRIDEiQ6DH69.

    Expressioni

    Gene expression databases

    BgeeiQ6DH69.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6DH69.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei9 – 2921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi46 – 494Poly-Leu

    Sequence similaritiesi

    Belongs to the amidase family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0154.
    GeneTreeiENSGT00550000074673.
    HOGENOMiHOG000116697.
    HOVERGENiHBG101001.
    InParanoidiQ6DH69.
    OMAiEKTFGGW.
    OrthoDBiEOG7PZRX7.
    PhylomeDBiQ6DH69.
    TreeFamiTF313781.

    Family and domain databases

    Gene3Di3.90.1300.10. 1 hit.
    InterProiIPR000120. Amidase.
    IPR020556. Amidase_CS.
    IPR023631. Amidase_dom.
    [Graphical view]
    PANTHERiPTHR11895. PTHR11895. 1 hit.
    PfamiPF01425. Amidase. 1 hit.
    [Graphical view]
    SUPFAMiSSF75304. SSF75304. 1 hit.
    PROSITEiPS00571. AMIDASES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6DH69-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALTRFERFL GRLLRAVVWI LFAAFKLFAP QQRHGVSRLP PITNPLLLLS    50
    AMQLARKIRR KEVTSVEVVQ AYIDRIQEVN PLINAMVKDR FSAALQEAAQ 100
    VDKLIEEETG GEDVLEDRLP LLGVPITVKE AFALQGMPNS TGLLTRRDLV 150
    SGADAPSVAL LKRAGAIPLG VTNCSELCMW LESHNHLYGI TNNPYDFERI 200
    VGGSSGGEGS ILGAGSSVIG IGSDIGGSIR IPCFFNGIFG HKPSVGIVNN 250
    EGQYPPASGQ QMGFLCTGPM CRYAEDLIPM LSIMGGPNAE KLSLFTEVDL 300
    KKLRFFSVPH NGGSHLVSPV EPQLLHAQKM VVKRLEADLG VKVQELLIPQ 350
    LKYSFQIWGT MMASPGKDGK PPTTFAELMS EGGKKVWPAW ELFKWFLGFS 400
    SHTLAAIGLA LVELFQSSHP SPFIMQQKES LQQELEELLG TDGVLLYPSH 450
    PLIAQKHHHP IFTPFNFSYT GIFNILGLPV TQCPLGLSAE GLPLGVQIVA 500
    GKLQDRLSLA TALYLEKAFG GWREPGKTTI KP 532
    Length:532
    Mass (Da):58,093
    Last modified:August 16, 2004 - v1
    Checksum:iD986716F9702E59E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC076113 mRNA. Translation: AAH76113.1.
    RefSeqiNP_001002700.1. NM_001002700.2.
    UniGeneiDr.76507.

    Genome annotation databases

    EnsembliENSDART00000037553; ENSDARP00000037509; ENSDARG00000008457.
    GeneIDi436973.
    KEGGidre:436973.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC076113 mRNA. Translation: AAH76113.1 .
    RefSeqi NP_001002700.1. NM_001002700.2.
    UniGenei Dr.76507.

    3D structure databases

    ProteinModelPortali Q6DH69.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q6DH69.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSDART00000037553 ; ENSDARP00000037509 ; ENSDARG00000008457 .
    GeneIDi 436973.
    KEGGi dre:436973.

    Organism-specific databases

    CTDi 436973.
    ZFINi ZDB-GENE-040718-453. faah2a.

    Phylogenomic databases

    eggNOGi COG0154.
    GeneTreei ENSGT00550000074673.
    HOGENOMi HOG000116697.
    HOVERGENi HBG101001.
    InParanoidi Q6DH69.
    OMAi EKTFGGW.
    OrthoDBi EOG7PZRX7.
    PhylomeDBi Q6DH69.
    TreeFami TF313781.

    Miscellaneous databases

    NextBioi 20831394.
    PROi Q6DH69.

    Gene expression databases

    Bgeei Q6DH69.

    Family and domain databases

    Gene3Di 3.90.1300.10. 1 hit.
    InterProi IPR000120. Amidase.
    IPR020556. Amidase_CS.
    IPR023631. Amidase_dom.
    [Graphical view ]
    PANTHERi PTHR11895. PTHR11895. 1 hit.
    Pfami PF01425. Amidase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF75304. SSF75304. 1 hit.
    PROSITEi PS00571. AMIDASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: AB.
      Tissue: Liver.
    2. "A shifted repertoire of endocannabinoid genes in the zebrafish (Danio rerio)."
      McPartland J.M., Glass M., Matias I., Norris R.W., Kilpatrick C.W.
      Mol. Genet. Genomics 277:555-570(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION AS FAAH2A.

    Entry informationi

    Entry nameiFAH2A_DANRE
    AccessioniPrimary (citable) accession number: Q6DH69
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 26, 2007
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3