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Q6DH69 (FAH2A_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified March 6, 2013. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Fatty-acid amide hydrolase 2-A
EC=3.5.1.99
Gene names
Name:faah2a
ORF Names:zgc:92625
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length532 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Anandamide + H2O = arachidonic acid + ethanolamine.

Oleamide + H2O = oleic acid + NH3.

Subcellular location

Membrane; Single-pass membrane protein Potential.

Sequence similarities

Belongs to the amidase family.

Ontologies

Keywords
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functioncarbon-nitrogen ligase activity, with glutamine as amido-N-donor

Inferred from electronic annotation. Source: InterPro

hydrolase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 532532Fatty-acid amide hydrolase 2-A
PRO_0000291994

Regions

Transmembrane9 – 2921Helical; Potential
Compositional bias46 – 494Poly-Leu

Sites

Active site1291Charge relay system By similarity
Active site2041Charge relay system By similarity
Active site2281Acyl-ester intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6DH69 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: D986716F9702E59E

FASTA53258,093
        10         20         30         40         50         60 
MALTRFERFL GRLLRAVVWI LFAAFKLFAP QQRHGVSRLP PITNPLLLLS AMQLARKIRR 

        70         80         90        100        110        120 
KEVTSVEVVQ AYIDRIQEVN PLINAMVKDR FSAALQEAAQ VDKLIEEETG GEDVLEDRLP 

       130        140        150        160        170        180 
LLGVPITVKE AFALQGMPNS TGLLTRRDLV SGADAPSVAL LKRAGAIPLG VTNCSELCMW 

       190        200        210        220        230        240 
LESHNHLYGI TNNPYDFERI VGGSSGGEGS ILGAGSSVIG IGSDIGGSIR IPCFFNGIFG 

       250        260        270        280        290        300 
HKPSVGIVNN EGQYPPASGQ QMGFLCTGPM CRYAEDLIPM LSIMGGPNAE KLSLFTEVDL 

       310        320        330        340        350        360 
KKLRFFSVPH NGGSHLVSPV EPQLLHAQKM VVKRLEADLG VKVQELLIPQ LKYSFQIWGT 

       370        380        390        400        410        420 
MMASPGKDGK PPTTFAELMS EGGKKVWPAW ELFKWFLGFS SHTLAAIGLA LVELFQSSHP 

       430        440        450        460        470        480 
SPFIMQQKES LQQELEELLG TDGVLLYPSH PLIAQKHHHP IFTPFNFSYT GIFNILGLPV 

       490        500        510        520        530 
TQCPLGLSAE GLPLGVQIVA GKLQDRLSLA TALYLEKAFG GWREPGKTTI KP

« Hide

References

« Hide 'large scale' references
[1]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: AB.
Tissue: Liver.
[2]"A shifted repertoire of endocannabinoid genes in the zebrafish (Danio rerio)."
McPartland J.M., Glass M., Matias I., Norris R.W., Kilpatrick C.W.
Mol. Genet. Genomics 277:555-570(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION AS FAAH2A.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC076113 mRNA. Translation: AAH76113.1.
IPIIPI00510940.
RefSeqNP_001002700.1. NM_001002700.2.
UniGeneDr.76507.

3D structure databases

ProteinModelPortalQ6DH69.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSDART00000037553; ENSDARP00000037509; ENSDARG00000008457.
GeneID436973.
KEGGdre:436973.

Organism-specific databases

CTD436973.
ZFINZDB-GENE-040718-453. faah2a.

Phylogenomic databases

eggNOGCOG0154.
GeneTreeENSGT00550000074673.
HOGENOMHOG000116697.
HOVERGENHBG101001.
InParanoidQ6DH69.
OMAYIHRIEQ.
OrthoDBEOG4P5K8W.

Gene expression databases

BgeeQ6DH69.

Family and domain databases

Gene3D3.90.1300.10. 1 hit.
InterProIPR000120. Amidase.
IPR020556. Amidase_CS.
IPR023631. Amidase_dom.
[Graphical view]
PANTHERPTHR11895. PTHR11895. 1 hit.
PfamPF01425. Amidase. 1 hit.
[Graphical view]
SUPFAMSSF75304. Amidase_sig_enz. 1 hit.
PROSITEPS00571. AMIDASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20831394.

Entry information

Entry nameFAH2A_DANRE
AccessionPrimary (citable) accession number: Q6DH69
Entry history
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: August 16, 2004
Last modified: March 6, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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