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Protein

Fatty-acid amide hydrolase 2-A

Gene

faah2a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Anandamide + H2O = arachidonic acid + ethanolamine.
Oleamide + H2O = oleic acid + NH3.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei129 – 1291Charge relay systemBy similarity
Active sitei204 – 2041Charge relay systemBy similarity
Active sitei228 – 2281Acyl-ester intermediateBy similarity

GO - Molecular functioni

  1. carbon-nitrogen ligase activity, with glutamine as amido-N-donor Source: InterPro
  2. hydrolase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Fatty-acid amide hydrolase 2-A (EC:3.5.1.99)
Gene namesi
Name:faah2a
ORF Names:zgc:92625
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Chromosome 1

Organism-specific databases

ZFINiZDB-GENE-040718-453. faah2a.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei9 – 2921HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 532532Fatty-acid amide hydrolase 2-APRO_0000291994Add
BLAST

Proteomic databases

PRIDEiQ6DH69.

Expressioni

Gene expression databases

BgeeiQ6DH69.

Structurei

3D structure databases

ProteinModelPortaliQ6DH69.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi46 – 494Poly-Leu

Sequence similaritiesi

Belongs to the amidase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0154.
GeneTreeiENSGT00550000074673.
HOGENOMiHOG000116697.
HOVERGENiHBG101001.
InParanoidiQ6DH69.
OMAiRTKNAYH.
OrthoDBiEOG7PZRX7.
PhylomeDBiQ6DH69.
TreeFamiTF313781.

Family and domain databases

Gene3Di3.90.1300.10. 1 hit.
InterProiIPR000120. Amidase.
IPR020556. Amidase_CS.
IPR023631. Amidase_dom.
[Graphical view]
PANTHERiPTHR11895. PTHR11895. 1 hit.
PfamiPF01425. Amidase. 1 hit.
[Graphical view]
SUPFAMiSSF75304. SSF75304. 1 hit.
PROSITEiPS00571. AMIDASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6DH69-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALTRFERFL GRLLRAVVWI LFAAFKLFAP QQRHGVSRLP PITNPLLLLS
60 70 80 90 100
AMQLARKIRR KEVTSVEVVQ AYIDRIQEVN PLINAMVKDR FSAALQEAAQ
110 120 130 140 150
VDKLIEEETG GEDVLEDRLP LLGVPITVKE AFALQGMPNS TGLLTRRDLV
160 170 180 190 200
SGADAPSVAL LKRAGAIPLG VTNCSELCMW LESHNHLYGI TNNPYDFERI
210 220 230 240 250
VGGSSGGEGS ILGAGSSVIG IGSDIGGSIR IPCFFNGIFG HKPSVGIVNN
260 270 280 290 300
EGQYPPASGQ QMGFLCTGPM CRYAEDLIPM LSIMGGPNAE KLSLFTEVDL
310 320 330 340 350
KKLRFFSVPH NGGSHLVSPV EPQLLHAQKM VVKRLEADLG VKVQELLIPQ
360 370 380 390 400
LKYSFQIWGT MMASPGKDGK PPTTFAELMS EGGKKVWPAW ELFKWFLGFS
410 420 430 440 450
SHTLAAIGLA LVELFQSSHP SPFIMQQKES LQQELEELLG TDGVLLYPSH
460 470 480 490 500
PLIAQKHHHP IFTPFNFSYT GIFNILGLPV TQCPLGLSAE GLPLGVQIVA
510 520 530
GKLQDRLSLA TALYLEKAFG GWREPGKTTI KP
Length:532
Mass (Da):58,093
Last modified:August 16, 2004 - v1
Checksum:iD986716F9702E59E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC076113 mRNA. Translation: AAH76113.1.
RefSeqiNP_001002700.1. NM_001002700.2.
UniGeneiDr.76507.

Genome annotation databases

EnsembliENSDART00000037553; ENSDARP00000037509; ENSDARG00000008457.
GeneIDi436973.
KEGGidre:436973.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC076113 mRNA. Translation: AAH76113.1.
RefSeqiNP_001002700.1. NM_001002700.2.
UniGeneiDr.76507.

3D structure databases

ProteinModelPortaliQ6DH69.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ6DH69.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000037553; ENSDARP00000037509; ENSDARG00000008457.
GeneIDi436973.
KEGGidre:436973.

Organism-specific databases

CTDi436973.
ZFINiZDB-GENE-040718-453. faah2a.

Phylogenomic databases

eggNOGiCOG0154.
GeneTreeiENSGT00550000074673.
HOGENOMiHOG000116697.
HOVERGENiHBG101001.
InParanoidiQ6DH69.
OMAiRTKNAYH.
OrthoDBiEOG7PZRX7.
PhylomeDBiQ6DH69.
TreeFamiTF313781.

Miscellaneous databases

NextBioi20831394.
PROiQ6DH69.

Gene expression databases

BgeeiQ6DH69.

Family and domain databases

Gene3Di3.90.1300.10. 1 hit.
InterProiIPR000120. Amidase.
IPR020556. Amidase_CS.
IPR023631. Amidase_dom.
[Graphical view]
PANTHERiPTHR11895. PTHR11895. 1 hit.
PfamiPF01425. Amidase. 1 hit.
[Graphical view]
SUPFAMiSSF75304. SSF75304. 1 hit.
PROSITEiPS00571. AMIDASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: AB.
    Tissue: Liver.
  2. "A shifted repertoire of endocannabinoid genes in the zebrafish (Danio rerio)."
    McPartland J.M., Glass M., Matias I., Norris R.W., Kilpatrick C.W.
    Mol. Genet. Genomics 277:555-570(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION AS FAAH2A.

Entry informationi

Entry nameiFAH2A_DANRE
AccessioniPrimary (citable) accession number: Q6DH69
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: August 16, 2004
Last modified: January 7, 2015
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.