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Q6DH46

- PXYP1_DANRE

UniProt

Q6DH46 - PXYP1_DANRE

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Protein

2-phosphoxylose phosphatase 1

Gene

pxylp1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Responsible for the 2-O-dephosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature glycosaminoglycan (GAG) chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei98 – 981NucleophileBy similarity
Active sitei396 – 3961Proton donorBy similarity

GO - Molecular functioni

  1. acid phosphatase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
2-phosphoxylose phosphatase 1By similarity (EC:3.1.3.-By similarity)
Alternative name(s):
Acid phosphatase-like protein 2
Gene namesi
Name:pxylp1By similarity
Synonyms:acpl2
ORF Names:zgc:92652
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Unplaced

Organism-specific databases

ZFINiZDB-GENE-040718-127. pxylp1.

Subcellular locationi

Golgi apparatus membrane By similarity; Single-pass type II membrane protein Sequence Analysis

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 66CytoplasmicSequence Analysis
Transmembranei7 – 2721Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini28 – 503476LumenalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 5035032-phosphoxylose phosphatase 1PRO_0000314927Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi73 – 731N-linked (GlcNAc...)PROSITE-ProRule annotation
Glycosylationi365 – 3651N-linked (GlcNAc...)PROSITE-ProRule annotation
Glycosylationi490 – 4901N-linked (GlcNAc...)PROSITE-ProRule annotation

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ6DH46.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000059507.

Structurei

3D structure databases

ProteinModelPortaliQ6DH46.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidine acid phosphatase family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG321954.
HOGENOMiHOG000033787.
HOVERGENiHBG106056.
InParanoidiQ6DH46.
PhylomeDBiQ6DH46.

Family and domain databases

Gene3Di3.40.50.1240. 2 hits.
InterProiIPR000560. His_Pase_superF_clade-2.
IPR029033. His_PPase_superfam.
[Graphical view]
PfamiPF00328. His_Phos_2. 1 hit.
[Graphical view]
SUPFAMiSSF53254. SSF53254. 1 hit.
PROSITEiPS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6DH46-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLARSRFILV LVVGALLAVL SFSLQYLHLI PTNPVAEQRS AGRSRKRVNP
60 70 80 90 100
VLHTDPPAPD PIRDTHQYCN YPNLTEHGWE GHCPPDYKLL SVQVMIRHGD
110 120 130 140 150
RFPLYSIPKT KKPTIDCILS EKRKPSHPLL ASFISHMALG GRGHWDASLG
160 170 180 190 200
SLPRLPSHST CEMGELTQTG VVRQLKNGDH LRQAYISRHN LLAADWLPRQ
210 220 230 240 250
LWAETTGKSR TLQSGLAFLF GFLPHFDWSR LTVRQQWSTL FCGQSCDCPA
260 270 280 290 300
RNRYLDQEQR RQYRQRIADA ELERTYVTMA KTLGVATKTL RAANPVDALL
310 320 330 340 350
CHFCHGLPFP CSSTQTSSNA PDEGACLTLE HFAVIRRQQK DDELERREAG
360 370 380 390 400
LYRRYAVLAA HPYLNRSAAR LERIARGSQM RKSKEDAVFA LASAHDVTMA
410 420 430 440 450
PLLSALGLEG AGFPKFAARL VFELWSSPET KERRSDRKLD NMFIRVLYNG
460 470 480 490 500
EDLTFDTAFC REHNRRSTQP LCPLGNFLSF VRKDMFSVVN ATSYQQACHQ

TVL
Length:503
Mass (Da):57,021
Last modified:August 16, 2004 - v1
Checksum:i6A7AC989468E8D12
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC076136 mRNA. Translation: AAH76136.1.
RefSeqiNP_001002430.1. NM_001002430.1.
UniGeneiDr.108758.

Genome annotation databases

GeneIDi436703.
KEGGidre:436703.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC076136 mRNA. Translation: AAH76136.1 .
RefSeqi NP_001002430.1. NM_001002430.1.
UniGenei Dr.108758.

3D structure databases

ProteinModelPortali Q6DH46.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7955.ENSDARP00000059507.

Proteomic databases

PRIDEi Q6DH46.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 436703.
KEGGi dre:436703.

Organism-specific databases

CTDi 92370.
ZFINi ZDB-GENE-040718-127. pxylp1.

Phylogenomic databases

eggNOGi NOG321954.
HOGENOMi HOG000033787.
HOVERGENi HBG106056.
InParanoidi Q6DH46.
PhylomeDBi Q6DH46.

Miscellaneous databases

NextBioi 20831146.
PROi Q6DH46.

Family and domain databases

Gene3Di 3.40.50.1240. 2 hits.
InterProi IPR000560. His_Pase_superF_clade-2.
IPR029033. His_PPase_superfam.
[Graphical view ]
Pfami PF00328. His_Phos_2. 1 hit.
[Graphical view ]
SUPFAMi SSF53254. SSF53254. 1 hit.
PROSITEi PS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Larval eye.

Entry informationi

Entry nameiPXYP1_DANRE
AccessioniPrimary (citable) accession number: Q6DH46
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 16, 2004
Last modified: November 26, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3